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https://www.readbyqxmd.com/read/29660668/supercritical-fluid-chromatography-applied-to-the-highly-selective-isolation-of-urinary-steroid-hormones-prior-to-gc-ms-analysis
#1
Mickael Doué, Caroline West, Emmanuelle Bichon, Bruno Le Bizec, Eric Lesellier
To assess the presence of prohibited anabolic substances used to promote growth in livestock, calf urine is the most relevant matrix. However, the sample preparation methods (required to remove unwanted matrix components and fractionate isobaric species that may be unresolved by gas chromatography- mass spectrometry GC/MS) are long and complex. In this context, semi-preparative supercritical fluid chromatography (SFC) was considered to possibly simplify the sample preparation in reducing the number of procedures...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29657200/complementary-bodybuilding-a-potential-risk-for-permanent-kidney-disease
#2
Wael El-Reshaid, Kamel El-Reshaid, Shaikha Al-Bader, Ahmad Ramadan, John Patrick Madda
We report our experience of renal disease associated with bodybuilders who had been on high-protein diet, anabolic androgenic steroids (AASs), and growth hormone (GH) for years. A total of 22 adult males who volunteered information about use of high protein diet and AAS or GH were seen over a six-year period with renal disease. Kidney biopsy revealed focal segmental glomerulosclerosis (FSGS) in eight, nephroangiosclerosis in four, chronic interstitial nephritis in three, acute interstitial nephritis in two, nephrocalcinosis with chronic interstitial nephritis in two, and single patients with membranous glomerulopathy, crescentic glomerulopathy, and sclerosing glomerulonephritis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29651261/defining-the-construct-of-synthetic-androgen-intoxication-an-application-of-general-brain-arousal
#3
Tom Hildebrandt, Ashley Heywood, Daniel Wesley, Kurt Schulz
Synthetic androgens (i. e., anabolic-androgenic steroids) are the primary component to the majority of problematic appearance and performance enhancing drug (APED) use. Despite evidence that these substances are associated with increased risk for aggression, violence, body image disturbances, and polypharmacy and can develop a pattern of chronic use consistent with drug dependence, there are no formal definitions of androgen intoxication. Consequently, the purpose of this paper is to establish a testable theory of androgen intoxication...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29621580/use-of-nutritional-supplements-contaminated-with-banned-doping-substances-by-recreational-adolescent-athletes-in-athens-greece
#4
Konstantinos Tsarouhas, Nassia Kioukia-Fougia, Petros Papalexis, Aristidis Tsatsakis, Dimitrios Kouretas, Flora Bacopoulou, Christina Tsitsimpikou
Although the use of nutritional supplements by adult athletes has been extensively studied, information on supplements consumption by adolescent athletes is still limited. The present study reports on the use of nutritional supplements contaminated with banned doping substances among 170 recreational adolescent athletes from eleven, randomly selected, gym centres, in Athens, Greece. Nutritional supplements consumption was reported by almost 60% of the study population, with proteins/amino acids and vitamins being the most popular...
April 2, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29618151/procoagulant-state-in-current-and-former-anabolic-androgenic-steroid-abusers
#5
Simon Chang, Jon J Rasmussen, Mikkel N Frandsen, Morten Schou, Marie L Johansen, Jens Faber, Anna-Marie B Münster, Johannes J Sidelmann, Caroline Kistorp
BACKGROUND:  Anabolic androgenic steroid (AAS) abusers are considered at increased risk of cardiovascular morbidity and mortality. We hypothesized that current and former AAS abuse would induce a procoagulant shift in the haemostatic balance. METHODS:  Men 18 to 50 years of age were included as current AAS abusers, former AAS abusers or controls. Morning blood samples were collected after overnight fasting. Thrombin generation (lag time, time to peak, peak height, and endogenous thrombin potential [ETP]) and coagulation factor II (prothrombin), VII and X, antithrombin, protein C, free protein S and tissue factor pathway inhibitor (TFPI) were assessed...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29601260/sensitive-enzyme-immunoassay-for-screening-methandienone-in-dietary-supplements
#6
Sandra Sýkorová, Lucie Fojtíková, Martin Kuchař, Petra Mikšátková, Ludmila Karamonová, Ladislav Fukal, Oldřich Lapčík, Barbora Holubová
Methandienone is a synthetic exogenous steroid which, like other anabolic steroids, is strictly regulated in many countries. In recent years, increasing numbers have been detected of illegal additions into dietary supplements of methandienone and other anabolic androgenic steroids (AAS). In this work, a competitive indirect enzyme-linked immunosorbent assay (ELISA) has been constructed for the detection of methandienone using an antiserum against methandienone. Under optimal experimental conditions, the ELISA achieved a limit of detection of 0...
March 30, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29589203/anabolic-therapy-for-the-treatment-of-osteoporosis-in-childhood
#7
REVIEW
Leanne M Ward, Frank Rauch
PURPOSE OF REVIEW: Numerous forms of osteoporosis in childhood are characterized by low bone turnover (for example, osteoporosis due to neuromuscular disorders and glucocorticoid exposure). Anti-resorptive therapy, traditionally used to treat osteoporosis in the young, is associated with further reductions in bone turnover, raising concerns about the long-term safety and efficacy of such therapy. These observations have led to increasing interest in the role of anabolic therapy to treat pediatric osteoporosis...
March 27, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29579075/effects-of-pharmacologic-sclerostin-inhibition-or-testosterone-administration-on-soleus-muscle-atrophy-in-rodents-after-spinal-cord-injury
#8
Ean G Phillips, Luke A Beggs, Fan Ye, Christine F Conover, Darren T Beck, Dana M Otzel, Payal Ghosh, Anna C F Bassit, Stephen E Borst, Joshua F Yarrow
Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on muscle morphology remain unknown. In comparison, androgen administration produces bone antiresorptive effects after SCI and some, but not all, studies have reported that testosterone treatment ameliorates skeletal muscle atrophy in this context...
2018: PloS One
https://www.readbyqxmd.com/read/29570240/unambiguous-identification-and-characterization-of-a-long-term-human-metabolite-of-dehydrochloromethyltestosterone
#9
Guro Forsdahl, Thomas Geisendorfer, Lorenz Göschl, Sandra Pfeffer, Peter Gärtner, Mario Thevis, Günter Gmeiner
In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, eight possible metabolites with a 17α-methyl-17β-hydroxymethyl - structure were synthesized and compared to a major DHCMT long-term metabolite detected in reference urine excretion samples. The confirmed structure of the metabolite was 4α-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5α-androst-13-en-3α-ol...
March 23, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29566437/effects-of-bimagrumab-an-activin-receptor-type-ii-inhibitor-on-pituitary-neurohormonal-axes
#10
Tania Garito, Marjorie Zakaria, Dimitris A Papanicolaou, Yifang Li, Pascale Pinot, Olivier Petricoul, Didier Laurent, Daniel Rooks, Juan Carlos Rondon, Ronenn Roubenoff
BACKGROUND: Bimagrumab is a human monoclonal antibody inhibitor of activin type II receptors (ActRII), with anabolic action on skeletal muscle mass by blocking binding of myostatin and other negative regulators of muscle growth. Bimagrumab is under evaluation for muscle wasting and associated functional loss in hip fracture and sarcopenia, and in obesity. Bimagrumab also blocks other endogenous ActRII ligands, such as activins, which act on the neurohormonal axes, pituitary, gonads and adrenal glands...
March 22, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29560159/prevalence-and-awareness-of-anabolic-androgenic-steroids-aas-among-gymnasts-in-the-western-province-of-riyadh-saudi-arabia
#11
Khaled Abdullah Al Bishi, Ayman Afify
Background: Anabolic Androgenic Steroids (AAS) are synthetic derivatives of the male sex hormone (testosterone) that are increasingly used by athletes as performance enhancing drugs to increase muscle mass and strength. Multiple health adverse effects may be caused by its non-medical use. Several international and regional studies showed the high prevalence of AAS usage and low level of awareness of it among different populations. Objective: To estimate the prevalence of AAS and to determine the level of awareness toward it among gymnasts in the western province of Riyadh...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29548567/metabolic-study-of-methylstenbolone-in-horses-using-liquid-chromatography-high-resolution-mass-spectrometry-and-gas-chromatography-mass-spectrometry
#12
Timmy L S Choi, Jenny K Y Wong, Wai Him Kwok, Peter Curl, Stewart Mechie, Terence S M Wan
Methylstenbolone (2,17α-dimethyl-5α-androst-1-en-17β-ol-3-one) is a synthetic anabolic and androgenic steroid (AAS) sold as an oral 'nutritional supplement' under the brand names 'Ultradrol', 'M-Sten' and 'Methyl-Sten'. Like other AASs, methylstenbolone is a prohibited substance in both human and equine sports. This paper describes the studies of the in vitro and in vivo metabolism of methylstenbolone in horses using LC/HRMS, GC/MS and GC/MS/MS. Phase I in vitro metabolic study of methylstenbolone was performed using homogenised horse liver...
February 21, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29544993/combined-chemical-and-biotechnological-production-of-20%C3%AE-oh-nordhcmt-a-long-term-metabolite-of-oral-turinabol-dhcmt
#13
Jiaxin Liu, Lei Chen, Jan Felix Joseph, Alexandra Naß, Anna Stoll, Xavier de la Torre, Francesco Botrè, Gerhard Wolber, Maria Kristina Parr, Matthias Bureik
Anabolic androgenic steroids (AAS) are misused very frequently in sport competitions as performance enhancing agents. One of the doping compounds that has been detected with increased frequency in the last few years is dehydrochloromethyltestosterone (DHCMT, 4-chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one; brand name Oral Turinabol). The long-term DHCMT metabolite 20βOH-NorDHCMT (4-chloro-17β-hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one) was reported earlier to be detectable in urine samples for more than 22 days after DHCMT administration; however, purified reference material was not available so far...
February 26, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29542171/psychosocial-correlates-of-gap-time-to-anabolic-androgenic-steroid-use
#14
Patrycja Klimek, Tom Hildebrandt
OBJECTIVE: Theoretically, legal supplement use precedes and increases the risk for illicit appearance and performance enhancing drug (APED) use-also referred to as the gateway hypothesis. Little is known about associations between the speed of progression, or gap time, from legal to illicit APED use, and psychological risk factors, such as sociocultural influence, eating disorders, body image disturbance, and impulsivity. METHOD: The sample taken from two studies included 172 active steroid users (n = 143) and intense-exercising healthy controls (n = 29) between the ages of 18 and 60 (M = 34...
March 15, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29531259/identification-of-a-novel-2-oxindole-fluorinated-derivative-as-in-vivo-antitumor-agent-for-prostate-cancer-acting-via-ampk-activation
#15
Alicia Bort, Sergio Quesada, Ágata Ramos-Torres, Marta Gargantilla, Eva María Priego, Sophie Raynal, Franck Lepifre, Jose M Gasalla, Nieves Rodriguez-Henche, Ana Castro, Inés Díaz-Laviada
The key metabolic sensor adenosine monophosphate-dependent kinase (AMPK) has emerged as a promising therapeutic target for cancer prevention and treatment. Besides its role in energy homeostasis, AMPK blocks cell cycle, regulates autophagy and suppresses the anabolic processes required for rapid cell growth. AMPK is especially relevant in prostate cancer in which activation of lipogenic pathways correlate with tumor progression and aggressiveness. This study reports the discovery of a new series of 2-oxindole derivatives whose AMPK modulatory ability, as well as the antitumoral profile in prostate cancer cells, was evaluated...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29525360/identifying-a-typology-of-men-who-use-anabolic-androgenic-steroids-aas
#16
Renee Zahnow, Jim McVeigh, Geoff Bates, Vivian Hope, Joseph Kean, John Campbell, Josie Smith
BACKGROUND: Despite recognition that the Anabolic Androgenic Steroid (AAS) using population is diverse, empirical studies to develop theories to conceptualise this variance in use have been limited. METHODS: In this study, using cluster analysis and multinomial logistic regression, we identify typologies of people who use AAS and examine variations in motivations for AAS use across types in a sample of 611 men who use AAS. RESULTS: The cluster analysis identified four groups in the data with different risk profiles...
March 8, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29518637/-blood-letting-self-phlebotomy-in-injecting-anabolic-androgenic-steroids-within-performance-and-image-enhancing-drug-pied-culture
#17
Rebekah Brennan, John Wells, Marie Claire Van Hout
BACKGROUND: New evidence with regard to a previously undocumented practice - self phlebotomy, known as 'bloodletting' - incontemporary injecting performance and image enhancing drug (PIED) culture is the subject of this paper. While self phlebotomy has been evidenced in psychiatric patients previously, it was performed here in people who inject AAS as a self directed health care procedure. METHODS: Data was collected from five publicly accessible internet discussion forums and coded using NVivo software...
March 5, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29514442/effects-of-nandrolone-decanoate-on-expression-of-steroidogenic-enzymes-in-the-rat-testis
#18
TaeSun Min, Ki-Ho Lee
Objective: Nandrolone decanoate (ND) is an anabolic-androgenic steroid frequently used for clinical treatment. However, the inappropriate use of ND results in the reduction of serum testosterone level and sperm production. The suppressive effect of ND on testosterone production has not been investigated in detail. The present study was designed to examine the effect of ND on the expression of steroidogenic enzymes in the rat testis. Methods: Male Sprague Dawley rats at 50 days of age were subcutaneously administrated with either 2 or 10 mg of ND/kg body weight/week for 2 or 12 weeks...
March 2, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29491216/selective-androgen-receptor-modulator-yk11-up-regulates-osteoblastic-proliferation-and-differentiation-in-mc3t3-e1-cells
#19
Tomofumi Yatsu, Taichi Kusakabe, Keisuke Kato, Yoshio Inouye, Kiyomitsu Nemoto, Yuichiro Kanno
Androgens are key regulators that play a critical role in the male reproductive system and have anabolic effects on bone mineral density and skeletal muscle mass. We have previously reported that YK11 is a novel selective androgen receptor modulator (SARM) and induces myogenic differentiation and selective gene regulation. In this study, we show that treatment of YK11 and dihydrotestosterone (DHT) accelerated cell proliferation and mineralization in MC3T3-E1 mouse osteoblast cells. Further, YK11-treated cells increased osteoblast specific differentiation markers, such as osteoprotegerin and osteocalcin, compared to untreated cells...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29490719/associations-of-anabolic-androgenic-steroid-use-with-other-behavioral-disorders-an-analysis-using-directed-acyclic-graphs
#20
Gen Kanayama, Harrison G Pope, James I Hudson
BACKGROUND: Anabolic-androgenic steroid (AAS) use is known to be associated with other psychiatric disorders, such as body image disorders, conduct disorder/sociopathy, and other substance use disorders (SUD) - but the causal pathways among these conditions remain poorly delineated. METHODS: We created a directed acyclic graph to diagram hypothesized relationships among AAS use and dependence, body image disorder (BID), conduct disorder/sociopathy, and other SUD...
March 1, 2018: Psychological Medicine
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