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Anabolic androgenic

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https://www.readbyqxmd.com/read/29904303/anabolic-androgenic-steroid-induced-acute-myocardial-infarction-with-multiorgan-failure
#1
Frederick J Flo, Obiajulu Kanu, Mohamed Teleb, Yuefeng Chen, Tariq Siddiqui
The abuse of anabolic androgenic steroids (AAS) has remained on the rise despite their well-known deleterious effects. We describe a case of AAS-induced multisystem failure following an extensive history of abuse in a 41-year-old bodybuilder. Furthermore, we review pertinent literature and discuss the different pathophysiologic mechanisms through which AAS affect the heart and other organs. This case points to the possibility of multiorgan involvement and severe cardiac effects of AAS abuse in young individuals who may not have any past medical history...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29895558/novel-trifluoromethylated-enobosarm-analogues-with-potent-anti-androgenic-activity-in-vitro-and-tissue-selectivity-in-vivo
#2
Dafydd Alwyn Dart, Sahar Kandil, Serena Tommasini-Ghelfi, Gilberto Serrano de Almeida, Charlotte L Bevan, Andrew D Westwell, Andrew D Westwell
Prostate cancer often develops anti-androgen resistance, possibly via androgen receptor (AR) mutations which change antagonists to agonists. Novel therapies with increased anticancer activity, whilst overcoming current drug resistance are urgently needed. Enobosarm has anabolic effects on muscle and bone whilst having no effect on the prostate. Here we describe the activity of novel chemically modified enobosarm analogues. The rational addition of bis-trifluoromethyl groups into ring B of enobosarm, profoundly modified their activity, pharmacokinetic and tissue distribution profiles...
June 12, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29886559/novel-therapy-for-male-hypogonadism
#3
REVIEW
Robert Carrasquillo, Kevin Chu, Ranjith Ramasamy
PURPOSE OF REVIEW: Hypogonadism and the treatment of low testosterone is increasingly a subject of medical inquiry and controversy. The few treatments that are FDA-approved such as testosterone topicals, injections, and pellets create significant demand from patients for treatments with more convenient means of administration, fewer adverse effects, and the ability to maintain male fertility. Off-label drugs are in abundant use for low testosterone, including selective estrogen receptor modulators, gonadotropins, and aromatase inhibitors...
June 9, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29845939/outpatient-clinic-for-users-of-anabolic-androgenic-steroids-an-overview
#4
D L Smit, W de Ronde
BACKGROUND: Anabolic androgenic steroids (AAS) are used by approximately 20,000 amateur athletes in the Netherlands. AAS are harmful but data are lacking as to precisely how harmful they are. An outpatient clinic for past and current users of AAS was established in 2011 to acquire more knowledge about the health risks associated with AAS abuse. METHODS: All case files of the patients who visited the AAS clinic were reviewed retrospectively. RESULTS: 180 patients visited the AAS clinic between May 2011 and May 2016...
May 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29845937/adverse-effects-of-anabolic-androgen-steroid-abuse-in-the-netherlands-tip-of-the-iceberg
#5
Adverse Effects Of Anabolic Androgen Steroid Abuse In The Netherlands Tip Of The Iceberg
No abstract text is available yet for this article.
May 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29809043/anabolic-androgenic-steroids-alter-decision-making-in-a-balanced-rodent-model-of-the-iowa-gambling-task
#6
Kathryn Wallin-Miller, Grace Li, Diana Kelishani, Ruth I Wood
Anabolic-androgenic steroid (AAS) abuse is implicated in maladaptive decision making such as increased risk taking and problem gambling. Endogenous testosterone correlates with economic risk taking in both the stock market (Coates & Herbert, 2008) and in the laboratory, as measured by the Iowa Gambling Task (Stanton, Liening, & Schultheiss, 2011). Additionally, AAS use has been associated with problem gambling behavior in adolescents (Proimos, DuRant, Pierce, & Goodman, 1998). Thus, AAS may impair economic decision making...
June 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29797686/direct-quantitation-of-endogenous-steroid-sulfates-in-human-urine-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#7
Argitxu Esquivel, Élida Alechaga, Núria Monfort, Rosa Ventura
A method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the direct quantitation of endogenous steroid sulfates has been developed to be able to evaluate these metabolites as biomarkers to detect the misuse of endogenous androgenic anabolic steroids in sports. For sample preparation, a mixed-mode solid-phase extraction was optimized to eliminate the glucuronide fraction in the washing step thus obtaining only the sulfate fraction. Chromatographic separation was optimized to achieve adequate resolution between isomers...
May 24, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29791601/resting-spontaneous-baroreflex-sensitivity-and-cardiac-autonomic-control-in-anabolic-androgenic-steroid-users
#8
Marcelo R Dos Santos, Ana L C Sayegh, Rafael Armani, Valéria Costa-Hong, Francis R de Souza, Edgar Toschi-Dias, Luiz A Bortolotto, Mauricio Yonamine, Carlos E Negrão, Maria-Janieire N N Alves
OBJECTIVES: Misuse of anabolic androgenic steroids in athletes is a strategy used to enhance strength and skeletal muscle hypertrophy. However, its abuse leads to an imbalance in muscle sympathetic nerve activity, increased vascular resistance, and increased blood pressure. However, the mechanisms underlying these alterations are still unknown. Therefore, we tested whether anabolic androgenic steroids could impair resting baroreflex sensitivity and cardiac sympathovagal control. In addition, we evaluate pulse wave velocity to ascertain the arterial stiffness of large vessels...
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29790034/left-atrial-myocardial-dysfunction-after-chronic-abuse-of-anabolic-androgenic-steroids-a-speckle-tracking-echocardiography-analysis
#9
Antonello D'Andrea, Juri Radmilovic, Stefano Caselli, Andreina Carbone, Raffaella Scarafile, Simona Sperlongano, Gianpaolo Tocci, Tiziana Formisano, Francesca Martone, Biagio Liccardo, Michele D'Alto, Eduardo Bossone, Maurizio Galderisi, Paolo Golino
Anabolic-androgenic steroids (AAS) are used by power athletes to improve performance. However, the real effects of the chronic consumption of AAS on cardiovascular structures are subjects of intense debate. To detect by speckle tracking echocardiography (STE) underlying left atrial (LA) dysfunction in athletes abusing AAS and assess possible correlation between LA myocardial function and exercise capacity during cardiopulmonary stress test. 65 top-level competitive bodybuilders were selected (45 males), including 35 athletes misusing AAS for at least 5 years (users), 30 anabolic-free bodybuilders (non-users), compared to 40 age- and sex-matched healthy sedentary controls...
May 22, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29766657/drug-drug-interaction-and-doping-effect-of-non-prohibited-drugs-on-the-urinary-excretion-profile-of-methandienone
#10
Monica Mazzarino, Franziska L Khevenhüller-Metsch, Ilaria Fiacco, Maria Kristina Parr, Xavier de la Torre, Francesco Botrè
The potential consequences of drug-drug interactions on the excretion profile of the anabolic androgenic steroid methandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3-one) are discussed here. More specifically, we have evaluated by in vitro and in vivo experiments the effects of seven non-prohibited drugs (fluconazole, ketoconazole, itraconazole, miconazole, fluoxetine, paroxetine and nefazodone) on the main metabolic pathways of methandienone. These are selected among those most commonly used by the athletes...
May 15, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29766147/the-non-preventive-effects-of-human-menopausal-gonadotropins-on-ovarian-tissues-in-nandrolone-decanoate-treated-female-rats-a-histochemical-and-ultra-structural-study
#11
Fakhroddin Mesbah, Hossein Bordbar, Tahereh Talaei Khozani, Farzaneh Dehghani, Hossein Mirkhani
Background: The follicular growth and development may be affected by abused drugs. Nandrolone decanoate (ND) as an anabolic androgenic steroid can damage the morphological and functional features of the ovary and may lead to reproductive failure. Objective: This study was designed to evaluate the effects of synchronized and non-synchronized administration of Human Menopausal Gonadotropins (hMG) with ND on ovarian tissue and level of sex hormones in the adult female rat...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29759662/nandrolone-decanoate-and-physical-activity-affect-quadriceps-in-peripubertal-rats
#12
Jasmina Sretenovic, Vladimir Ajdzanovic, Vladimir Zivkovic, Ivan Srejovic, Milena Corbic, Verica Milosevic, Vladimir Jakovljevic, Zoran Milosavljevic
Anabolic androgenic steroids (AASs) are synthetic analogs of testosterone often used by athletes to increase the skeletal muscle mass. Our goal was to examine the effects of physical activity and physical activity combined with supraphysiological doses of nandrolone on functional morphology of the quadriceps muscle. The study included 32 peripubertal Wistar rats, divided into 4 groups: control (T-N-), nandrolone (T-N+), physical activity (T+N-) and physical activity plus nandrolone (T+N+) groups. The T+N- and T+N+ group swam for 4 weeks, 1 h/day, 5 days/week...
May 11, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29757501/important-considerations-for-the-utilisation-of-methanolysis-in-steroid-analysis
#13
Marjaana Viljanto, Catarina Horro Pita, James Scarth, Christopher J Walker, Andrew T Kicman, Mark C Parkin
The effective analysis of anabolic-androgenic steroids in urine usually requires a suitable deconjugation method for the analysis of phase II metabolites such as sulfates and glucuronides. Acid hydrolysis using methanolysis is one adopted method of deconjugation that efficiently and rapidly cleaves both sulfates and glucuronides contemporaneously. The formation of artefactual by-products is a known disadvantage of this harsh method. However, the possible promotion of deuterium-hydrogen exchange of isotopically labelled internal standards has received little attention in the literature...
May 14, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29721213/anabolic-androgenic-steroids-and-carcinogenicity-focusing-on-leydig-cell-a-literature-review
#14
REVIEW
Monica Salerno, Orazio Cascio, Giuseppe Bertozzi, Francesco Sessa, Antonietta Messina, Vincenzo Monda, Luigi Cipolloni, Antonio Biondi, Aurora Daniele, Cristoforo Pomara
Anabolic androgenic steroids (AAS) are some of the most common drugs used among athletes, frequently in combination with resistance training, to improve physical performance or for aesthetic purpose. A great number of scientific reports showed the detrimental effects of anabolic androgenic steroids on different organs and tissues. In this literature review, we analyzed the AAS-mediated carcinogenicity, focusing on Leydig cell tumor. AAS-induced carcinogenicity can affect DNA transcription through two pathways...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717770/stanozolol-administration-combined-with-exercise-leads-to-decreased-telomerase-activity-possibly-associated-with-liver-aging
#15
Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N Tzatzarakis, Christina Tsitsimpikou, Polychronis D Stivaktakis, Dimitrios Tsoukalas, Demetrios A Spandidos, Aristides M Tsatsakis, Buket Alpertunga
Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the most well recognized target organ. In the present study, the hepatic effects of stanozolol administration in rats at high doses resembling those used for doping purposes were investigated, in the presence or absence of exercise...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29704771/new-approach-based-on-immunochemical-techniques-for-monitoring-of-selective-estrogen-receptor-modulators-serms-in-human-urine
#16
J-Pablo Salvador, Ester Vila-Roca, Núria Monfort, Rosa Ventura, M-Pilar Marco
Antiestrogenic compounds such as tamoxifen, toremifen and chlomifen are used illegally by athletes to minimize physical impacts such as gynecomastia resulting from the secondary effects of anabolic androgenic steroids, used to increase athletic efficiency unlawfully. The use of these compounds is banned by the World Anti-Doping Agency (WADA) and controls are made through analytical methodologies such as HPLC-MS/MS, which do not fulfil the sample throughput requirements. Moreover, compounds such as tamoxifen are also used to treat hormone receptor-positive breast cancer (ER + )...
April 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29702199/androgen-and-estrogen-receptor-mediated-activities-of-4-hydroxytestosterone-4-hydroxyandrostenedione-and-their-human-metabolites-in-yeast-based-assays
#17
Annekathrin Martina Keiler, Oliver Zierau, Sylvi Wolf, Patrick Diel, Wilhelm Schänzer, Günter Vollmer, David Machalz, Gerhard Wolber, Maria Kristina Parr
4-Hydroxyandrost-4-ene-3,17-dione, also named formestane, is an irreversible aromatase inhibitor and therapeutically used as anti-breast cancer medication in post-menopausal women. Currently, no therapeutical indication led to approval of its 17-hydroxylated analog 4-hydroxytestosterone, an anabolic steroid. However, it is currently investigated in a clinical trial for breast cancer. In context with sports doping, aromatase inhibitors are administered to reduce estrogenic side effects of misused anabolic substances or their metabolites...
April 24, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29701261/a-critical-review-of-the-environmental-occurrence-and-potential-effects-in-aquatic-vertebrates-of-the-potent-androgen-receptor-agonist-17%C3%AE-trenbolone
#18
REVIEW
Gerald T Ankley, Katherine K Coady, Melanie Gross, Henrik Holbech, Steven L Levine, Gerd Maack, Mike Williams
Trenbolone acetate is widely-used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17β-trenbolone (βTRB), have been detected in at low ng/L concentrations in surface waters associated with animal feedlots. The βTRB isomer can affect androgen receptor (AR) signaling pathways in various vertebrate species at comparatively low concentrations/doses. This paper provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of βTRB, with an emphasis on potential risks to aquatic animals...
April 27, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29687691/side-effects-of-anabolic-steroids-used-by-athletes-at-unaizah-gyms-saudi-arabia-a-pilot-study
#19
Amer A Almaiman, Sulaiman H Almaiman, Elsayed I Elagamy, Osama Al Wutayd, Mohammed Almarzuqi, Rayyan Alzunaidi, Sami Alhatlani, Eltayeb E Eid
BACKGROUND: A large number of Saudi athletes are recently shown to use androgenic anabolic steroid (AAS) products to achieve rapid muscle growth without realizing the serious health risks of these drugs. Aim of this study was to elucidate the side effects encountered with prolonged use of AAS products by Saudi athletes. METHODS: A cross-sectional study was conducted, in which 16 regular gym members, 12 of them used AAS, were asked to answer a questionnaire and provide blood samples following current AAS course completion...
April 20, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29674281/effects-of-tocotrienol-from-bixa-orellana-annatto-on-bone-histomorphometry-in-a-male-osteoporosis-model-induced-by-buserelin
#20
Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin
INTRODUCTION: Osteoporosis is a debilitating skeletal side effect of androgen deprivation therapy based on gonadotropin-releasing hormone (GnRH) agonist in men. Tocotrienol from Bixa orellana (annatto) has been demonstrated to offer protection against osteoporosis by exerting anabolic effects on bone. Thus, it may prevent osteoporosis among GnRH agonist users. OBJECTIVE: This study aimed to determine the effectiveness of annatto-tocotrienol on the bone turnover markers and bone histomorphometry in a model of male osteoporosis induced by buserelin (a GnRH agonist)...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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