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https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#1
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29019018/long-term-anabolic-steroids-in-male-bodybuilders-induce-cardiovascular-structural-and-autonomic-abnormalities
#2
Octávio Barbosa Neto, Gustavo Ribeiro da Mota, Carla Cristina De Sordi, Elisabete Aparecida M R Resende, Luiz Antônio P R Resende, Marco Antônio Vieira da Silva, Moacir Marocolo, Rafael Silva Côrtes, Lucas Felipe de Oliveira, Valdo José Dias da Silva
OBJECTIVE: The aims of this study were to examine the hypothesis that users of anabolic androgenic steroids (AAS) would have cardiac autonomic disorders and that there is a correlation between sympathetic modulation, high blood pressure (BP) and alterations to cardiac dimensions. METHODS: Forty-five male subjects were enrolled in the study. They were categorized into three groups comprising bodybuilders actively using AAS (AAS users; n = 15), bodybuilders who had never used AAS (nonusers; n = 15) and age-paired healthy sedentary controls (n = 15)...
October 10, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28988314/the-prostate-response-to-prolactin-modulation-in-adult-castrated-rats-subjected-to-testosterone-replacement
#3
Flávia B Constantino, Ana C L Camargo, Sérgio A A Santos, Ketlin T Colombelli, Laura F Martin, Marcia G Silva, Sérgio L Felisbino, Luis A Justulin
Despite the androgenic dependence, other hormones, growth factors, and cytokines are necessary to support prostatic growth and maintain the glandular structure; among them, prolactin is a non-steroidal hormone secreted mainly by the pituitary gland. However, extra-pituitary expression of prolactin, such as in the prostate, has also been demonstrated, highlighting the paracrine and autocrine actions of prolactin within the prostate. Here, we investigated whether prolactin modulation alters ventral prostate (VP) morphophysiology in adult castrated rats...
October 7, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28977603/androgen-action-via-the-androgen-receptor-in-neurons-within-the-brain-positively-regulates-muscle-mass-in-male-mice
#4
Rachel A Davey, Michele V Clarke, Patricia K Russell, Kesha Rana, Jane Seto, Kelly N Roeszler, Jackie M Y How, Ling Yeong Chia, Kathryn North, Jeffrey D Zajac
Although it is well established that exogenous androgens have anabolic effects on skeletal muscle mass in humans and mice, data from muscle-specific androgen receptor (AR) knockout (ARKO) mice indicate that myocytic expression of the AR is dispensable for hind-limb muscle mass accrual in males. To identify possible indirect actions of androgens via the AR in neurons to regulate muscle, we generated neuron-ARKO mice in which the dominant DNA binding-dependent actions of the AR are deleted in neurons of the cortex, forebrain, hypothalamus, and olfactory bulb...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28974267/efficacy-of-a-multi-component-exercise-programme-and-nutritional-supplementation-on-musculoskeletal-health-in-men-treated-with-androgen-deprivation-therapy-for-prostate-cancer-impact-study-protocol-of-a-randomised-controlled-trial
#5
Patrick J Owen, Robin M Daly, Patricia M Livingston, Niamh L Mundell, Jack Dalla Via, Jeremy L Millar, Steve F Fraser
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is a systemic treatment shown to increase survival in selected patients with prostate cancer. The use of ADT continues to increase for all stages and grades of prostate cancer despite known treatment-induced adverse effects. The primary aim of this study is to examine the efficacy of a targeted, multi-component resistance and impact-loading exercise programme together with a daily protein-, calcium- and vitamin D-enriched supplement on bone health in men treated with ADT for prostate cancer...
October 3, 2017: Trials
https://www.readbyqxmd.com/read/28971665/androgenic-anabolic-steroids-the-new-insidious-killer-leading-to-heart-failure
#6
Maria V Polito, Santo Dellegrottaglie, Rosanna Matturro, Domenico Bonadies, Roberta DE Rosa, Gennaro Galasso
No abstract text is available yet for this article.
December 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28971285/the-role-of-anabolic-androgenic-steroids-in-disruption-of-the-physiological-function-in-discrete-areas-of-the-central-nervous-system
#7
REVIEW
Giuseppe Bertozzi, Francesco Sessa, Giuseppe Davide Albano, Gabriele Sani, Francesca Maglietta, Mohsin H K Roshan, Giovanni Li Volti, Renato Bernardini, Roberto Avola, Cristoforo Pomara, Monica Salerno
Anabolic-androgenic steroids (AAS) abuse is often associated with a wide spectrum of adverse effects. These drugs are frequently abused by adolescents and athletes for esthetic purposes, as well as for improvement of their endurance and performances. In this literature review, we evaluated the correlation between AAS and anxiety or aggression. Two pathways are thought to be involved in AAS-induced behavioral disorders. Direct pathway via the amygdalo-fugal pathway, which connects the central nucleus of the amygdala to the brainstem, is involved in cognitive-emotive and homeostatic processes...
October 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28959650/use-of-anabolic-androgenic-steroids-produces-greater-oxidative-stress-responses-to-resistance-exercise-in-strength-trained-men
#8
Hamid Arazi, Heidar Mohammadjafari, Abbas Asadi
The aim of this study was to determine the effect of anabolic androgenic steroids (AAS) use on oxidative stress responses to a single session of resistance exercise in strength-trained men. Twenty-three strength trained men, with 11 self-reporting regular AAS use and 12 self-reporting never taking AAS (NAAS) volunteered to participate in this study. Blood draws were obtained pre and post resistance exercise in order to evaluate changes in oxidative stress biomarkers levels (i.e., 8-hydroxy-2-deoxyguanosine [8-OHdG], malondialdehyde [MDA], and nitric oxide [NO]), antioxidant defense systems (i...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28943276/detection-of-anabolic-androgenic-steroid-use-by-elite-athletes-and-by-members-of-the-general-public
#9
REVIEW
Bradley D Anawalt
Because national and international sports competitions are sources of community pride and financial revenue, there have been great efforts to prevent and detect the use of performance-enhancing drugs such as anabolic androgenic steroids by elite athletes. The World Anti-Doping Agency and its national affiliate anti-doping agencies have created sophisticated monitoring systems and advanced testing techniques to detect the use of banned substances including anabolic androgenic steroids by participants in international and national athletic competitions...
September 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28911778/applications-of-isotope-ratio-mass-spectrometry-in-sports-drug-testing-accounting-for-isotope-fractionation-in-analysis-of-biological-samples
#10
Thomas Piper, Mario Thevis
The misuse of anabolic-androgenic steroids (AAS) in sports aiming at enhancing athletic performance has been a challenging matter for doping control laboratories for decades. While the presence of a xenobiotic AAS or its metabolite(s) in human urine immediately represents an antidoping rule violation, the detection of the misuse of endogenous steroids such as testosterone necessitates comparably complex procedures. Concentration thresholds and diagnostic analyte ratios computed from urinary steroid concentrations of, e...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28902623/chronic-endurance-exercise-antagonizes-the-cardiac-ucp2-and-ucp3-protein-up-regulation-induced-by-nandrolone-decanoate
#11
Gholamreza Bayat, Mohammad Javan, Azadeh Khalili, Fatemeh Safari, Saeed Shokri, Sohrab Hajizadeh
BACKGROUND: Several lines of evidence revealed that chronic treatment of anabolic androgenic steroids (AASs) is accompanied with some cardiovascular side effects and in addition they also negatively mask the beneficial effects of exercise training on cardiac performance. METHODS: The present study examined whether the nandrolone decanoate (ND)-induced cardiac effects were mediated by changing the cardiac uncoupling protein 2 (UCP2) and 3 (UCP3) expression. Five groups of male wistar-albino rats including sedentary control (SC), sedentary vehicle (SV), sedentary nandrolone decanoate (SND), exercise control (EC), and exercise nandrolone decanoate (END) were used...
September 13, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28891676/pornography-use-in-sexual-minority-males-associations-with-body-dissatisfaction-eating-disorder-symptoms-thoughts-about-using-anabolic-steroids-and-quality-of-life
#12
Scott Griffiths, Deborah Mitchison, Stuart B Murray, Jonathan M Mond
OBJECTIVE: We examined two hypotheses regarding the potential association of pornography use with body image-related and eating disorder-related psychopathology among sexual minority males (i.e. non-heterosexual males). Our primary hypothesis was that pornography use would be associated with males' body dissatisfaction, eating disorder symptoms, thoughts about using anabolic steroids and quality of life impairment; our secondary hypothesis was that the type of pornography, namely, professional versus amateur pornography, which contains idealised and non-idealised (i...
September 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28884514/estrogenic-regulation-of-skeletal-muscle-proteome-a-study-of-premenopausal-women-and-postmenopausal-mz-cotwins-discordant-for-hormonal-therapy
#13
Eija K Laakkonen, Rabah Soliymani, Sira Karvinen, Jaakko Kaprio, Urho M Kujala, Marc Baumann, Sarianna Sipilä, Vuokko Kovanen, Maciej Lalowski
Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function leading to low circulating level of 17β-estradiol has been suggested as a contributing factor to aging-related muscle deterioration. However, the underlying molecular mechanisms remain largely unknown and thus far androgens have been considered as a major anabolic hormone for skeletal muscle...
September 7, 2017: Aging Cell
https://www.readbyqxmd.com/read/28863033/increased-blood-pressure-and-aortic-stiffness-among-abusers-of-anabolic-androgenic-steroids-potential-effect-of-suppressed-natriuretic-peptides-in-plasma
#14
Jon J Rasmussen, Morten Schou, Per L Madsen, Christian Selmer, Marie L Johansen, Peter Hovind, Peter S Ulriksen, Jens Faber, Finn Gustafsson, Caroline Kistorp
BACKGROUND: Abuse of anabolic androgenic steroids (AAS) is prevalent among recreational athletes and adverse effects on blood pressure (BP) and arterial stiffness could be substantial. Testosterone decreases natriuretic peptides which are key components in BP-regulation and may impair BP-homeostasis in AAS abusers. OBJECTIVE: To investigate BP and aortic stiffness in relation to natriuretic peptides among current AAS abusers, former AAS abusers and controls. METHODS: In this cross-sectional study, 37 current AAS abusers, 33 former AAS abusers and 30 controls were included...
August 31, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28853020/illicit-drug-use-among-gym-goers-a-cross-sectional-study-of-gym-goers-in-sweden
#15
Yasmina Molero, Ann-Sofie Bakshi, Johanna Gripenberg
BACKGROUND: The use of anabolic-androgenic steroids has increased among gym-goers, and it has been proposed that this may be part of a polysubstance use pattern that includes the use of illicit drugs. Still, epidemiological data on illicit drug use among gym-goers of both genders are meager. The aim of the present study was thus to examine the use of illicit drugs and its correlates in a large sample of men and women who engaged in weight training at gyms across Sweden. METHODS: In this cross-sectional study, a total of 1969 gym-goers who engaged in weight training in 54 gyms across Sweden were invited to fill in a questionnaire...
August 29, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28810407/intrasexual-competition-as-a-potential-influence-on-anabolic-androgenic-steroid-use-initiation
#16
Marc Harris, Michael Dunn, Tina Alwyn
An estimated 293,000 people living in the United Kingdom have used anabolic-androgenic steroids. However, there is currently no intervention to reduce usage available in practice or academic circulation throughout the United Kingdom. This study aimed to test a novel hypothesis that increased levels of intrasexual competition may play an important influential role in the use of anabolic-androgenic steroids. Significantly higher levels of intrasexual competition were evident in users compared to non-users but only in the novice group (0-2 years of experience)...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810404/sexual-orientation-bullying-for-being-labeled-gay-or-bisexual-and-steroid-use-among-us-adolescent-boys
#17
Mike C Parent, Tyler C Bradstreet
Use of anabolic-androgenic steroids is a public health concern for adolescent boys. This study examined bullying based on being labeled gay/bisexual and steroid use among US adolescent boys, including sexual orientation disparities. Data from 2660 boys from the 2015 Youth Behavior Risk Survey were used. Among heterosexual boys, steroid use was higher among those who reported being bullied due to being labeled gay or bisexual. No such relationship existed among non-heterosexual boys. The results speak to the need to address issues of masculinity in clinical work with boys and young men...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28803647/determination-of-selected-endogenous-anabolic-androgenic-steroids-and-ratios-in-urine-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-and-isotope-pattern-deconvolution
#18
J Pitarch-Motellón, J V Sancho, M Ibáñez, O Pozo, A F Roig-Navarro
An isotope dilution mass spectrometry (IDMS) method for the determination of selected endogenous anabolic androgenic steroids (EAAS) in urine by UHPLC-MS/MS has been developed using the isotope pattern deconvolution (IPD) mathematical tool. The method has been successfully validated for testosterone, epitestosterone, androsterone and etiocholanolone, employing their respective deuterated analogs using two certified reference materials (CRM). Accuracy was evaluated as recovery of the certified values and ranged from 75% to 108%...
August 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28789969/tissue-control-of-androgen-action-the-ups-and-downs-of-androgen-receptor-expression
#19
REVIEW
Irene Hunter, Colin W Hay, Bianca Esswein, Kate Watt, Iain J McEwan
The hormone testosterone plays crucial roles during male development and puberty and throughout life, as an anabolic regulator of muscle and bone structure and function. The actions of testosterone are mediated, primarily, through the androgen receptor, a member of the nuclear receptor superfamily. The androgen receptor gene is located on the X-chromosome and receptor levels are tightly controlled both at the level of transcription of the gene and post-translationally at the protein level. Sp1 has emerged as the major driver of expression of the androgen receptor gene, while auto-regulation by androgens is associated with both positive and negative regulation in a possible cell-selective manner...
August 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28777732/body-image-and-eating-disorders-are-common-among-professional-and-amateur-athletes-using-performance-and-image-enhancing-drugs-a-cross-sectional-study
#20
Daria Piacentino, Georgios D Kotzalidis, Livia Longo, Antonio Pavan, Luciano Stivali, Guido Stivali, Stefano Ferracuti, Roberto Brugnoli, Paola Frati, Vittorio Fineschi, Paolo Girardi, Gabriele Sani
The use of performance and image enhancing drugs (PIEDs) is not uncommon in athletes and appears to be associated with several psychopathological disorders of unclear prevalence. In this multicenter, cross-sectional study, we aimed to evaluate the prevalence of body image disorders (BIDs) and eating disorders (EDs) in PIED-using athletes vs. PIED nonusers. We enrolled 84 consecutive professional and amateur athletes training in sport centers in Italy, who underwent semi-structured interviews (SCID-I, SCID-II) and completed the Body Image Concern Inventory (BICI) and the Sick, Control, One, Fat, Food Eating Disorder Screening Test (SCOFF)...
August 4, 2017: Journal of Psychoactive Drugs
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