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https://www.readbyqxmd.com/read/29448243/impact-of-health-authority-control-measures-aimed-at-reducing-the-illicit-use-of-anabolic-androgenic-steroids
#1
Raquel Vázquez-Mourelle, Eduardo Carracedo-Martinez, Adolfo Figueiras
OBJECTIVE: To evaluate two interventions on anabolic-androgenic-steroids (AAS) dispensation in retail pharmacies. MATERIAL AND METHODS: The study was conducted in a north-western region of Spain. Data were the AAS supplied by wholesale drug distributors to retail pharmacies over a period of 102 months. It is designed as an ecological time-series study; the dependent variables were daily defined doses per 1,000 inhabitants per day of each drug. The two interventions evaluated were: (1) an inspection program intended for those retail pharmacies where there was an irregular dispensation and (2) a regulation put forth forcing these pharmacies to carry out additional registers...
February 15, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29430877/detection-of-prohibited-substances-in-equine-hair-by-ultra-high-performance-liquid-chromatography-triple-quadrupole-mass-spectrometry-application-to-doping-control-samples
#2
B Gray, M Viljanto, E Menzies, L Vanhaecke
The detection of drugs in human hair samples has been performed by laboratories around the world for many years and the matrix is popular in disciplines such as workplace drug testing. To date, however, hair has not become a routinely utilised matrix in sports drug detection. The analysis of hair samples offers a number of potential advantages to doping control laboratories, not least of which are the greatly extended detection window and the ease of sample collection and storage. This paper describes the development, validation and utilisation of a sensitive ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS) method for the detection of 50 compounds...
February 12, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29429521/sex-steroid-receptors-profiling-is-influenced-by-nandrolone-decanoate-in-the-ampulla-of-the-fallopian-tube-post-treatment-and-post-recovery-analyses
#3
G H B Andrade, V A Simão, B R Souza, L G A Chuffa, I C C Camargo
Anabolic androgenic steroids (AAS) are recommended for therapeutic clinic, but their use has increased in recent decades for aesthetic reasons. No study has evaluated the impact of AAS in the fallopian tube, after treatment and recovery periods. Herein, the aim of study was to investigate the effects of Nandrolone Decanoate (ND), administered in different doses (1.87; 3.75; 7.5 and 15 mg/kg) on the ampulla of the fallopian tube in rats, following post-treatment (PT; 15 consecutive days) and post-recovery (PR; 30 consecutive days) periods...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29425789/refining-androstenedione-and-bisnorcholenaldehyde-from-mother-liquor-of-phytosterol-fermentation-using-macroporous-resin-column-chromatography-followed-by-crystallization
#4
Shi-Dong Xu, Fang-Hong Ning, Bang-He Jiang, Huan-Xin Xu, Zuo-Zhen Liu
Androstenedione is an androgen and intermediate in the biosynthesis of most adrenocortical, anabolic, sex and synthetic steroids, such as canrenone, eplerenone, norethindrone and spironolactone. Bisnorcholenaldehyde is an important intermediate in the synthesis of progesterone. This study established an androstenedione and bisnorcholenaldehyde separation method that used a macroporous adsorption resin and an ethanol-water mixture as eluent. The adsorption properties of 12 non-polar or weakly polar macroporous adsorption resins were compared, and three resins exhibited a high adsorption capacity and high desorption rate for both androstenedione and bisnorcholenaldehyde...
September 21, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29421751/veterinary-drug-17%C3%AE-trenbolone-promotes-the-proliferation-of-human-prostate-cancer-cell-line-through-the-akt-ar-signaling-pathway
#5
Hee-Seok Lee, Da-Woon Jung, Songyi Han, Hui-Seung Kang, Jin-Hyang Suh, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
Trenbolone acetate (TBA) is a synthetic anabolic steroidal growth factor that is used for rapid muscle development in cattle. The absorbed TBA is hydrolyzed to the active form, 17β-trenbolone (17 TB; 17β-hydroxy-estra-4,9,11-trien-3-one) in meat and milk products, which can cause adverse health effects in humans. Similar to 5α-dihydrotestosterone (DHT), 17 TB was reported to exhibit endocrine disrupting effects on animals and humans due to its androgenic effect via binding to the androgen receptor. The purpose of this study is to investigate the molecular mechanism of cell proliferation in prostate cancer (PCa) cells treated with 17 TB...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29404794/computational-assessment-of-pharmacokinetics-and-biological-effects-of-some-anabolic-and-androgen-steroids
#6
Marin Roman, Diana Larisa Roman, Vasile Ostafe, Alecu Ciorsac, Adriana Isvoran
PURPOSE: The aim of this study is to use computational approaches to predict the ADME-Tox profiles, pharmacokinetics, molecular targets, biological activity spectra and side/toxic effects of 31 anabolic and androgen steroids in humans. METHODS: The following computational tools are used: (i) FAFDrugs4, SwissADME and admetSARfor obtaining the ADME-Tox profiles and for predicting pharmacokinetics;(ii) SwissTargetPrediction and PASS online for predicting the molecular targets and biological activities; (iii) PASS online, Toxtree, admetSAR and Endocrine Disruptomefor envisaging the specific toxicities; (iv) SwissDock to assess the interactions of investigated steroids with cytochromes involved in drugs metabolism...
February 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29383307/colonic-angioectasia-in-an-adolescent-boy-with-hoyeraal-hreidarsson-on-long-term-anabolic-steroid-therapy
#7
Racha Khalaf, Carmen Cuffari
Androgen therapy has proven efficacy in treating patients with bone marrow failure who are not candidates for bone marrow transplantation. Herein, we report on a case of colonic angioectasia secondary to oxymetholone use in an adolescent patient with Hoyeraal-Hreidarsson syndrome (HHS). A 13-year-old Caucasian male with HHS characterized by cerebellar hypoplasia, developmental delay, microcephaly, esophageal strictures and myelodysplasia presented with severe hematochezia from colonic angioectasia secondary to long-term oxymetholone therapy...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29373481/hepatic-actions-of-androgens-in-the-regulation-of-metabolism
#8
Vita Birzniece
PURPOSE OF REVIEW: The purpose of this review is to summarize recent findings on hepatic actions of androgens in the regulation of protein, lipid and glucose metabolism. The rationale for liver-targeted testosterone use will be provided. RECENT FINDINGS: Liver-targeted testosterone administration, via the oral route, induces protein anabolic effect by reducing the rate of protein oxidation to a similar extent to that of systemic testosterone administration. Recent evidence indicates that testosterone exerts whole-body anabolic effect through inhibition of nitrogen loss via the hepatic urea cycle...
January 25, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29369918/public-health-impact-of-androgens
#9
Gen Kanayama, Marc J Kaufman, Harrison G Pope
PURPOSE OF REVIEW: To summarize recent findings regarding the public health impact of androgen abuse. RECENT FINDINGS: Abuse of androgens (also called 'anabolic-androgenic steroids') has grown into a major worldwide substance abuse problem involving tens of millions of individuals, of whom about 98% are men. Most androgen abusers are still under age 50 today, and thus, the long-term effects of these drugs are only beginning to be understood. Recent studies confirm that long-term supraphysiologic androgen exposure produces cardiovascular toxicity, characterized especially by cardiomyopathy and atherosclerotic disease...
January 24, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29368538/annals-express-the-bone-remodelling-cycle
#10
Julia S Kenkre, John H Bassett
The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining mineral homeostasis. During the bone remodelling cycle osteoclastic resorption is tightly coupled to osteoblastic bone formation. The remodelling cycle occurs within the Basic Multicellular Unit and comprises five co-ordinated steps; activation, resorption, reversal, formation and termination. These steps occur simultaneously but asynchronously at multiple different locations within the skeleton...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29366731/acute-interruption-of-treatment-with-nandrolone-decanoate-is-not-sufficient-to-reverse-cardiac-autonomic-dysfunction-and-ventricular-repolarization-disturbances-in-rats
#11
Moacir Marocolo, Julio A Silva-Neto, Octávio Barbosa Neto
Anabolic androgenic steroids are a class of synthetic compounds derived from testosterone, eventually used by athletes, to improve physical performance. However, anabolic steroids can also modify normal cardiovascular function. Thus, we investigated cardiac electrophysiological and autonomic abnormalities in rats, through a electrocardiographic variability protocol during and after interruption of administration of nandrolone decanoate (DECA)anabolic steroid. Twenty male Wistar rats (60-70 days old) received DECA (10 mg...
January 20, 2018: Steroids
https://www.readbyqxmd.com/read/29351807/vitamin-d-receptor-rs2228570-polymorphism-is-associated-with-lh-levels-in-men-exposed-to-anabolic-androgenic-steroids
#12
Linda Björkhem-Bergman, Mikael Lehtihet, Anders Rane, Lena Ekström
OBJECTIVE: The primary aim of this study was to investigate the association between the vitamin D receptor polymorphisms rs2228570 (Fok1) and rs731236 (TaqI) and LH and FSH levels in relation to anabolic androgenic steroid (AAS) use. RESULTS: Two cohorts were analyzed. Cohort 1 comprised healthy volunteers given single supra-physiological doses of 500 mg testosterone (n = 25). Cohort 2 comprised 45 self-reporting AAS users. Healthy volunteers homozygous for the C-allele of the Fok1 polymorphism exhibited 30% higher LH levels than T-carriers at baseline (p = 0...
January 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29344250/prevention-of-body-weight-loss-and-sarcopenia-by-a-novel-selective-androgen-receptor-modulator-in-cancer-cachexia-models
#13
Megumi Morimoto, Katsuji Aikawa, Takahito Hara, Masuo Yamaoka
Cancer cachexia is a syndrome that impairs the quality of life and overall survival of patients, and thus the effectiveness of anticancer agents. There are no effective therapies for cancer cachexia due to the complexity of the syndrome, and insufficient knowledge of its pathogenesis results in difficulty establishing appropriate animal models. Previously, promising results have been obtained in clinical trials using novel agents including the ghrelin receptor agonist anamorelin, and the selective androgen receptor modulator (SARM) enobosarm to treat cachexia in patients with cancer...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29334634/equine-in-vivo-derived-metabolites-of-the-sarm-lgd-4033-and-comparison-with-human-and-fungal-metabolites
#14
Annelie Hansson, Heather Knych, Scott Stanley, Emma Berndtson, Liora Jackson, Ulf Bondesson, Mario Thevis, Mikael Hedeland
LGD-4033 has been found in human doping control samples and has the potential for illicit use in racehorses as well. It belongs to the pharmacological class of selective androgen receptor modulators (SARMs) and can stimulate muscle growth, much like anabolic steroids. However, SARMs have shown superior side effect profiles compared to anabolic steroids, which arguably makes them attractive for use by individuals seeking an unfair advantage over their competitors. The purpose of this study was to investigate the metabolites formed from LGD-4033 in the horse in order to find suitable analytical targets for doping controls...
December 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29333723/nandrolone-induced-nuclear-accumulation-of-myod-protein-is-mediated-by-numb-a-notch-inhibitor-in-c2c12-myoblasts
#15
Xin-Hua Liu, Rita De Gasperi, William A Bauman, Christopher P Cardozo
Signaling via the androgen receptor (AR) stimulates myogenic progenitor differentiation. In addition, myogenic differentiation factor D (MyoD) and Numb, a Notch inhibitor, play key roles in regulating myogenic differentiation. Nandrolone, an anabolic steroid, upregulates both MyoD and Numb expression in myogenic cells. However, the molecular mechanisms by which MyoD is upregulated by nandrolone are unclear. Moreover, the potential crosstalk between nandrolone, MyoD, and Numb is not well understood. With these considerations in mind, we examined the effects of nandrolone on the expression of MyoD mRNA and protein, and determined the interactions of MyoD and Numb in the presence or absence of nandrolone in differentiating C2C12 myoblasts...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29317256/nandrolone-combined-with-strenuous-resistance-training-reduces-vascular-nitric-oxide-bioavailability-and-impairs-endothelium-dependent-vasodilation
#16
Vinicius Guzzoni, Tatiana Sousa Cunha, Vander José das Neves, Larissa Briet, Rafaela Costa, Maria José Costa Sampaio Moura, Vanessa Oliveira, Maria do Carmo Pinho Franco, Pedro Duarte Novaes, Fernanda Klein Marcondes
Anabolic Androgenic Steroids (AASs) misuse has increased among adolescents and recreational athletes due to their potential effects on muscle hypertrophy. On the other hand, AAS might induce alterations on cardiovascular system, although some controversies regarding AAS on vascular properties remain unknown. To address this question, we aimed to investigate the effects of high doses of nandrolone combined with strenuous resistance training (RT) on function and structure of thoracic aorta. Rats were randomized into four groups: non-trained vehicle (NTV), trained vehicle (TV), non-trained nandrolone (NTN), and trained nandrolone (TN), and submitted to 6 weeks of treatment with nandrolone (5mg/kg, twice a week) and/or resistance training...
January 6, 2018: Steroids
https://www.readbyqxmd.com/read/29278450/effect-of-glucocorticoid-administration-on-the-steroid-profile
#17
Sergi Coll, Xavier Matabosch, Lorena Garrostas, Clara Perez-Maña, Rosa Ventura
The steroid profile (SP) is a powerful tool to detect the misuse of endogenous anabolic androgenic steroids in sports, and it is included in the athlete biological passport (ABP). Glucocorticoids (GCs), which are widely prescribed in sports and are only prohibited in competition by systemic routes, inhibit the hypothalamic-pituitary-adrenal axis. Since the metabolites monitored in the SP have a partial adrenal origin, their excretion in urine might be altered by GCs consumption. The aim of the present work was to investigate if GCs administered by either systemic or local routes could influence the SP parameters...
December 26, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29274404/doping-control-analysis-of-13-steroids-and-structural-like-analytes-in-human-urine-using-quadrupole-orbitrap-lc-ms-ms-with-parallel-reaction-monitoring-prm
#18
Genye He, YunWu, Jianghai Lu
Anabolic androgenic steroids (AASs) and structural-like substances are commonly prohibited substances found in doping control studies that can be difficult to accurately detect. In the present study, 11 AASs and 2 structural-like substances that are commonly detected were examined. Currently, such analytes are detected using low resolution GC-MS/MS or LC-MS/MS, with detection not always possible. Herein, the high resolution Quadrupole-Orbitrap liquid chromatography-tandem mass spectrometry (LC-MS/MS system Q Exactive was utilized to increase the specificity...
December 20, 2017: Steroids
https://www.readbyqxmd.com/read/29242988/anabolic-androgenic-steroids-aas-increase-sensitivity-to-uncertainty-by-inhibition-of-dopamine-d1-and-d2-receptors
#19
Kathryn G Wallin-Miller, Frida Kreutz, Grace Li, Ruth I Wood
BACKGROUND: Anabolic-androgenic steroid abuse is implicated in maladaptive behaviors such as impaired cognition in humans. In a rat model, our lab has shown that testosterone decreases preference for a large/uncertain reward in probability discounting. Other studies have shown that androgens decrease dopamine D1 and D2 receptors in the nucleus accumbens shell, a region important for decision-making behavior in probability discounting. Thus, we attempted to restore selection of the large/uncertain reward in testosterone-treated rats by administering the D2 receptor agonist quinpirole or the D1 receptor agonist SKF81297 and testing probability discounting...
December 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29216311/amelioration-of-sexual-behavior-and-motor-activity-deficits-in-a-castrated-rodent-model-with-a-selective-androgen-receptor-modulator-sarm-2f
#20
Megumi Morimoto, Yuichiro Amano, Masahiro Oka, Ayako Harada, Hisashi Fujita, Yukiko Hikichi, Ryuichi Tozawa, Masuo Yamaoka, Takahito Hara
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets. We previously reported that a novel SARM compound, SARM-2f, exhibits anabolic effect on muscles, with less stimulatory effect on prostate weight compared with testosterone, in rat Hershberger assays and cancer cachexia models...
2017: PloS One
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