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Rocky Mountain spotted fever

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https://www.readbyqxmd.com/read/29032899/th1-epitope-peptides-induce-protective-immunity-against-rickettsia-rickettsii-infection-in-c3h-hen-mice
#1
Wenping Gong, Xiaolu Xiong, Pengcheng Wang, Jun Jiao, Xiaomei Yang, Bohai Wen
Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. In this study, 90 candidate peptides were selected from these antigens based on their high-affinity binding capacity for the MHC class II molecule H2 I-A or H2 I-E using bioinformatic methods. Six peptides were determined using ELISPOT assay to be immunodominant based on the IFN-γ recall responses of CD4(+) T cells from mice immunized with R. rickettsii. Six nucleotide sequences encoding the immunodominant peptides were linked in series and inserted into a plasmid for expression in Escherichia coli cells, resulting in a new, recombinant polypeptide termed GWP...
October 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28930006/fatal-rocky-mountain-spotted-fever-along-the-united-states-mexico-border-2013-2016
#2
Naomi A Drexler, Hayley Yaglom, Mariana Casal, Maria Fierro, Paula Kriner, Brian Murphy, Anne Kjemtrup, Christopher D Paddock
Rocky Mountain spotted fever (RMSF) is an emerging public health concern near the US-Mexico border, where it has resulted in thousands of cases and hundreds of deaths in the past decade. We identified 4 patients who had acquired RMSF in northern Mexico and subsequently died at US healthcare facilities. Two patients sought care in Mexico before being admitted to US-based hospitals. All patients initially had several nonspecific signs and symptoms, including fever, headache, nausea, vomiting, or myalgia, but deteriorated rapidly without receipt of a tetracycline-class antimicrobial drug...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28929088/microbial-invasion-vs-tick-immune-regulation
#3
REVIEW
Daniel E Sonenshine, Kevin R Macaluso
Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28863253/tick-talk-tick-borne-diseases-of-south-dakota
#4
Mark K Huntington, Jay Allison
In addition to being a nuisance, ticks can carry disease. This article presents a brief review of ticks and associated tick-borne disease relevant to South Dakota and surrounding regions. Tick-borne diseases of special relevance in South Dakota include tularemia, Rocky Mountain spotted fever, and Lyme disease. A number of others may also be encountered in the state as well. Prompt treatment of suspected cases is important to ensure a successful recovery, and tick-avoidance measures can reduce the risks of acquiring them...
September 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28764251/rickettsial-fever-presenting-with-gangrene-a-case-series
#5
Arun Prasannan, Premalatha Ramaswamy, Vinitha K Anirudhan
Rickettsial diseases comprise a wide spectrum of diseases which are reported from different parts of India quiet long ago. Many cases of rickettsial diseases go undiagnos due to lack of diagnostic techniques and the reported incidence and prevalence may be an underestimation of the actual burden of the disease. A higher index of suspicion, clinical awareness and proper use of available diagnostic tools would increase the frequency of diagnosis. Gangrene is an uncommon complication in cases of rickettsial fever...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28722584/rocky-mountain-spotted-fever-and-pregnancy-four-cases-from-sonora-mexico
#6
Jesus David Licona-Enriquez, Jesus Delgado-de la Mora, Christopher D Paddock, Carlos Arturo Ramirez-Rodriguez, María Del Carmen Candia-Plata, Gerardo Álvarez Hernández
We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015-2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of Rickettsia rickettsii by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Each of the women and one full-term infant delivered at 36 weeks gestation survived the infection...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28701428/a-mercury-toxicity-case-complicated-by-hyponatremia-and-abnormal-endocrinological-test-results
#7
Matthew Carter, Abdul Abdi, Fareeha Naz, Farouq Thabet, Arpita Vyas
Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. This is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, and profuse sweating after returning from a summer camp...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28698491/microrna-signature-of-human-microvascular-endothelium-infected-with-rickettsia-rickettsii
#8
Abha Sahni, Hema P Narra, Jignesh Patel, Sanjeev K Sahni
MicroRNAs (miRNAs) mediate gene silencing by destabilization and/or translational repression of target mRNA. Infection of human microvascular endothelial cells as primary targets of Rickettsiarickettsii, the etiologic agent of Rocky Mountain spotted fever, triggers host responses appertaining to alterations in cellular gene expression. Microarray-based profiling of endothelial cells infected with R.rickettsii for 3 or 24 h revealed differential expression of 33 miRNAs, of which miRNAs129-5p, 200a-3p, 297, 200b-3p, and 595 were identified as the top five up-regulated miRNAs (5 to 20-fold, p ≤ 0...
July 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28598270/investigating-the-adult-ixodid-tick-populations-and-their-associated-anaplasma-ehrlichia-and-rickettsia-bacteria-at-a-rocky-mountain-spotted-fever-hotspot-in-western-tennessee
#9
Rebecca T Trout Fryxell, Brain M Hendricks, Kimberly Pompo, Sarah E Mays, Dave J Paulsen, Darwin J Operario, Allan E Houston
Ehrlichiosis and rickettsiosis are two common bacterial tick-borne diseases in the southeastern United States. Ehrlichiosis is caused by ehrlichiae transmitted by Amblyomma americanum and rickettsiosis is caused by rickettsiae transmitted by Amblyomma maculatum and Dermacentor variabilis. These ticks are common and have overlapping distributions in the region. The objective of this study was to identify Anaplasma, Ehrlichia, and Rickettsia species associated with questing ticks in a Rocky Mountain spotted fever (RMSF) hotspot, and identify habitats, time periods, and collection methods for collecting questing-infected ticks...
August 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28576950/retrospective-case-reports-of-two-central-north-carolina-residents-frequency-of-tick-bites-and-associated-illnesses-2001-2014
#10
Marcia E Herman-Giddens, D Marcus Herman-Giddens
BACKGROUND Tick bites are a source of illness and disease agents that may lead to morbidity and occasional fatalities in North Carolina. Public health interest in tick-borne illness and disease has increased due to continuing discoveries of tick-borne diseases and their increasing geographic spread and disease incidence. There are no data published on lay individuals with cumulative tick bites and associated illnesses over a period of years.METHODS We learned of a married couple living on a central North Carolina property who had used reasonable bite prevention methods, kept attached ticks after removal, and recorded dates and related illness records from 2001-2014...
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28503490/the-distinct-transcriptional-response-of-the-midgut-of-amblyomma-sculptum-and-amblyomma-aureolatum-ticks-to-rickettsia-rickettsii-correlates-to-their-differences-in-susceptibility-to-infection
#11
Larissa A Martins, Maria F B de Melo Galletti, José M Ribeiro, André Fujita, Francisco B Costa, Marcelo B Labruna, Sirlei Daffre, Andréa C Fogaça
Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus Amblyomma, A. sculptum and A. aureolatum, are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in susceptibility to R. rickettsii infection, where A. aureolatum is more susceptible than A. sculptum. In the current study, A. aureolatum and A. sculptum ticks were fed on suitable hosts previously inoculated with R...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28503372/endosymbiont-interference-and-microbial-diversity-of-the-pacific-coast-tick-dermacentor-occidentalis-in-san-diego-county-california
#12
Nikos Gurfield, Saran Grewal, Lynnie S Cua, Pedro J Torres, Scott T Kelley
The Pacific coast tick, Dermacentor occidentalis Marx, is found throughout California and can harbor agents that cause human diseases such as anaplasmosis, ehrlichiosis, tularemia, Rocky Mountain spotted fever and rickettsiosis 364D. Previous studies have demonstrated that nonpathogenic endosymbiotic bacteria can interfere with Rickettsia co-infections in other tick species. We hypothesized that within D. occidentalis ticks, interference may exist between different nonpathogenic endosymbiotic or nonendosymbiotic bacteria and Spotted Fever group Rickettsia (SFGR)...
2017: PeerJ
https://www.readbyqxmd.com/read/28441217/an-unusual-case-of-sepsis-and-petechial-rash
#13
Christina Gardner
This article describes a man who presented to the ED in acute distress with signs and symptoms of sepsis, pneumonia, and a new petechial rash on his chest. He was eventually diagnosed with Rocky Mountain spotted fever. Aggressive treatment of sepsis and timely administration of empiric antibiotics were lifesaving in this situation.
May 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28433728/vector-competence-of-amblyomma-americanum-acari-ixodidae-for-rickettsia-rickettsii
#14
Michael L Levin, Galina E Zemtsova, Lindsay F Killmaster, Alyssa Snellgrove, Lauren B M Schumacher
Rickettsia rickettsii - the etiologic agent of Rocky Mountain spotted fever (RMSF) - is widely spread across the Americas. In the US, Dermacentor spp. ticks are identified as primary vectors of R. rickettsii and Rhipicephalus sanguineus s.l. has been implicated in transmission of this pathogen in several locations in the Southwest. Conversely, ticks of the genus Amblyomma are recognized vectors of RMSF in Central and South America, but not in the US. A. americanum is one of the most aggressive human-biting ticks in the US, whose geographical range overlaps with that of reported RMSF cases...
June 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28365226/rocky-mountain-spotted-fever-in-mexico-past-present-and-future
#15
REVIEW
Gerardo Álvarez-Hernández, Jesús Felipe González Roldán, Néstor Saúl Hernández Milan, R Ryan Lash, Casey Barton Behravesh, Christopher D Paddock
Rocky Mountain spotted fever, a tick-borne zoonosis caused by Rickettsia rickettsii, is among the most lethal of all infectious diseases in the Americas. In Mexico, the disease was first described during the early 1940s by scientists who carefully documented specific environmental determinants responsible for devastating outbreaks in several communities in the states of Sinaloa, Sonora, Durango, and Coahuila. These investigators also described the pivotal roles of domesticated dogs and Rhipicephalus sanguineus sensu lato (brown dog ticks) as drivers of epidemic levels of Rocky Mountain spotted fever...
June 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28289173/child-neurology-rocky-mountain-spotted-fever-encephalitis
#16
Michael J Bradshaw, Kathryn B Lalor, NgocHanh Vu, Sumit Pruthi, Karen C Bloch
No abstract text is available yet for this article.
March 14, 2017: Neurology
https://www.readbyqxmd.com/read/28213544/unique-strain-of-rickettsia-parkeri-associated-with-the-hard-tick-dermacentor-parumapertus-neumann-in-the-western-united-states
#17
Christopher D Paddock, Michelle E J Allerdice, Sandor E Karpathy, William L Nicholson, Michael L Levin, Travis C Smith, Tom Becker, Robert J Delph, Robert N Knight, Jana M Ritter, Jeanine H Sanders, Jerome Goddard
In 1953, investigators at the Rocky Mountain Laboratories in Hamilton, MT, described the isolation of a spotted fever group Rickettsia (SFGR) species from Dermacentor parumapertus ticks collected from black-tailed jackrabbits (Lepus californicus) in northern Nevada. Several decades later, investigators characterized this SFGR (designated the parumapertus agent) by using mouse serotyping methods and determined that it represented a distinct rickettsial serotype closely related to Rickettsia parkeri; nonetheless, the parumapertus agent was not further characterized or studied...
May 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28097845/-fatal-case-of-rickettsiosis-in-a-toddler-from-southeastern-mexico
#18
César Lugo-Caballero, Karla Dzul-Rosado, Georgina Rodríguez-Moreno, Raúl Tello-Martín, Karina López-Ávila, Jorge Zavala-Castro
Rocky Mountain spotted fever is a disease caused by Rickettsia rickettsii, a bacteria transmitted by infected ticks. It is characterized by fever, exanthema, arthralgias and myalgias; but sometimes its clinical presentation is non specific. Due to its similarities with other exanthematic diseases like dengue or chikungunya, Rocky Mountain spotted fever is not a first line diagnosis, even though countries like Mexico show the ecologic and socioeconomic characteristics that favor its transmission, with a 30% mortality rate among pediatric patients...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28055518/rocky-mountain-spotted-fever
#19
REVIEW
Jennan Phillips
The tick-borne disease Rocky Mountain spotted fever (RMSF) can have deadly outcomes unless treated appropriately, yet nonspecific flu-like symptoms complicate diagnosis. Occupational health nurses must have a high index of suspicion with symptomatic workers and recognize that recent recreational or occupational activities with potential tick exposure may suggest RMSF.
January 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28031280/proteolytic-cleavage-of-the-immunodominant-outer-membrane-protein-rompa-in-rickettsia-rickettsii
#20
Nicholas F Noriea, Tina R Clark, David Mead, Ted Hackstadt
Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, contains two immunodominant proteins, rOmpA and rOmpB, in the outer membrane. Both rOmpA and rOmpB are conserved throughout spotted fever group rickettsiae as members of a family of autotransporter proteins. Previously, it was demonstrated that rOmpB is proteolytically processed, with the cleavage site residing near the autotransporter domain at the carboxy-terminal end of the protein, cleaving the 168-kDa precursor into apparent 120-kDa and 32-kDa fragments...
March 15, 2017: Journal of Bacteriology
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