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Rocky Mountain spotted fever

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https://www.readbyqxmd.com/read/28722584/rocky-mountain-spotted-fever-and-pregnancy-four-cases-from-sonora-mexico
#1
Jesus David Licona-Enriquez, Jesus Delgado-de la Mora, Christopher D Paddock, Carlos Arturo Ramirez-Rodriguez, María Del Carmen Candia-Plata, Gerardo Álvarez Hernández
We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015-2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of Rickettsia rickettsii by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Each of the women and one full-term infant delivered at 36 weeks gestation survived the infection...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28701428/a-mercury-toxicity-case-complicated-by-hyponatremia-and-abnormal-endocrinological-test-results
#2
Matthew Carter, Abdul Abdi, Fareeha Naz, Farouq Thabet, Arpita Vyas
Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. This is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, and profuse sweating after returning from a summer camp...
July 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/28698491/microrna-signature-of-human-microvascular-endothelium-infected-with-rickettsia-rickettsii
#3
Abha Sahni, Hema P Narra, Jignesh Patel, Sanjeev K Sahni
MicroRNAs (miRNAs) mediate gene silencing by destabilization and/or translational repression of target mRNA. Infection of human microvascular endothelial cells as primary targets of Rickettsiarickettsii, the etiologic agent of Rocky Mountain spotted fever, triggers host responses appertaining to alterations in cellular gene expression. Microarray-based profiling of endothelial cells infected with R.rickettsii for 3 or 24 h revealed differential expression of 33 miRNAs, of which miRNAs129-5p, 200a-3p, 297, 200b-3p, and 595 were identified as the top five up-regulated miRNAs (5 to 20-fold, p ≤ 0...
July 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28598270/investigating-the-adult-ixodid-tick-populations-and-their-associated-anaplasma-ehrlichia-and-rickettsia-bacteria-at-a-rocky-mountain-spotted-fever-hotspot-in-western-tennessee
#4
Rebecca T Trout Fryxell, Brain M Hendricks, Kimberly Pompo, Sarah E Mays, Dave J Paulsen, Darwin J Operario, Allan E Houston
Ehrlichiosis and rickettsiosis are two common bacterial tick-borne diseases in the southeastern United States. Ehrlichiosis is caused by ehrlichiae transmitted by Amblyomma americanum and rickettsiosis is caused by rickettsiae transmitted by Amblyomma maculatum and Dermacentor variabilis. These ticks are common and have overlapping distributions in the region. The objective of this study was to identify Anaplasma, Ehrlichia, and Rickettsia species associated with questing ticks in a Rocky Mountain spotted fever (RMSF) hotspot, and identify habitats, time periods, and collection methods for collecting questing-infected ticks...
June 9, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28576950/retrospective-case-reports-of-two-central-north-carolina-residents-frequency-of-tick-bites-and-associated-illnesses-2001-2014
#5
Marcia E Herman-Giddens, D Marcus Herman-Giddens
BACKGROUND Tick bites are a source of illness and disease agents that may lead to morbidity and occasional fatalities in North Carolina. Public health interest in tick-borne illness and disease has increased due to continuing discoveries of tick-borne diseases and their increasing geographic spread and disease incidence. There are no data published on lay individuals with cumulative tick bites and associated illnesses over a period of years.METHODS We learned of a married couple living on a central North Carolina property who had used reasonable bite prevention methods, kept attached ticks after removal, and recorded dates and related illness records from 2001-2014...
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28503490/the-distinct-transcriptional-response-of-the-midgut-of-amblyomma-sculptum-and-amblyomma-aureolatum-ticks-to-rickettsia-rickettsii-correlates-to-their-differences-in-susceptibility-to-infection
#6
Larissa A Martins, Maria F B de Melo Galletti, José M Ribeiro, André Fujita, Francisco B Costa, Marcelo B Labruna, Sirlei Daffre, Andréa C Fogaça
Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain Spotted Fever (RMSF). In Brazil, two species of ticks in the genus Amblyomma, A. sculptum and A. aureolatum, are incriminated as vectors of this bacterium. Importantly, these two species present remarkable differences in susceptibility to R. rickettsii infection, where A. aureolatum is more susceptible than A. sculptum. In the current study, A. aureolatum and A. sculptum ticks were fed on suitable hosts previously inoculated with R...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28503372/endosymbiont-interference-and-microbial-diversity-of-the-pacific-coast-tick-dermacentor-occidentalis-in-san-diego-county-california
#7
Nikos Gurfield, Saran Grewal, Lynnie S Cua, Pedro J Torres, Scott T Kelley
The Pacific coast tick, Dermacentor occidentalis Marx, is found throughout California and can harbor agents that cause human diseases such as anaplasmosis, ehrlichiosis, tularemia, Rocky Mountain spotted fever and rickettsiosis 364D. Previous studies have demonstrated that nonpathogenic endosymbiotic bacteria can interfere with Rickettsia co-infections in other tick species. We hypothesized that within D. occidentalis ticks, interference may exist between different nonpathogenic endosymbiotic or nonendosymbiotic bacteria and Spotted Fever group Rickettsia (SFGR)...
2017: PeerJ
https://www.readbyqxmd.com/read/28441217/an-unusual-case-of-sepsis-and-petechial-rash
#8
Christina Gardner
This article describes a man who presented to the ED in acute distress with signs and symptoms of sepsis, pneumonia, and a new petechial rash on his chest. He was eventually diagnosed with Rocky Mountain spotted fever. Aggressive treatment of sepsis and timely administration of empiric antibiotics were lifesaving in this situation.
May 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28433728/vector-competence-of-amblyomma-americanum-acari-ixodidae-for-rickettsia-rickettsii
#9
Michael L Levin, Galina E Zemtsova, Lindsay F Killmaster, Alyssa Snellgrove, Lauren B M Schumacher
Rickettsia rickettsii - the etiologic agent of Rocky Mountain spotted fever (RMSF) - is widely spread across the Americas. In the US, Dermacentor spp. ticks are identified as primary vectors of R. rickettsii and Rhipicephalus sanguineus s.l. has been implicated in transmission of this pathogen in several locations in the Southwest. Conversely, ticks of the genus Amblyomma are recognized vectors of RMSF in Central and South America, but not in the US. A. americanum is one of the most aggressive human-biting ticks in the US, whose geographical range overlaps with that of reported RMSF cases...
April 12, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28365226/rocky-mountain-spotted-fever-in-mexico-past-present-and-future
#10
REVIEW
Gerardo Álvarez-Hernández, Jesús Felipe González Roldán, Néstor Saúl Hernández Milan, R Ryan Lash, Casey Barton Behravesh, Christopher D Paddock
Rocky Mountain spotted fever, a tick-borne zoonosis caused by Rickettsia rickettsii, is among the most lethal of all infectious diseases in the Americas. In Mexico, the disease was first described during the early 1940s by scientists who carefully documented specific environmental determinants responsible for devastating outbreaks in several communities in the states of Sinaloa, Sonora, Durango, and Coahuila. These investigators also described the pivotal roles of domesticated dogs and Rhipicephalus sanguineus sensu lato (brown dog ticks) as drivers of epidemic levels of Rocky Mountain spotted fever...
June 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28289173/child-neurology-rocky-mountain-spotted-fever-encephalitis
#11
Michael J Bradshaw, Kathryn B Lalor, NgocHanh Vu, Sumit Pruthi, Karen C Bloch
No abstract text is available yet for this article.
March 14, 2017: Neurology
https://www.readbyqxmd.com/read/28213544/unique-strain-of-rickettsia-parkeri-associated-with-the-hard-tick-dermacentor-parumapertus-neumann-in-the-western-united-states
#12
Christopher D Paddock, Michelle E J Allerdice, Sandor E Karpathy, William L Nicholson, Michael L Levin, Travis C Smith, Tom Becker, Robert J Delph, Robert N Knight, Jana M Ritter, Jeanine H Sanders, Jerome Goddard
In 1953, investigators at the Rocky Mountain Laboratories in Hamilton, MT, described the isolation of a spotted fever group Rickettsia (SFGR) species from Dermacentor parumapertus ticks collected from black-tailed jackrabbits (Lepus californicus) in northern Nevada. Several decades later, investigators characterized this SFGR (designated the parumapertus agent) by using mouse serotyping methods and determined that it represented a distinct rickettsial serotype closely related to Rickettsia parkeri; nonetheless, the parumapertus agent was not further characterized or studied...
May 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28097845/-fatal-case-of-rickettsiosis-in-a-toddler-from-southeastern-mexico
#13
César Lugo-Caballero, Karla Dzul-Rosado, Georgina Rodríguez-Moreno, Raúl Tello-Martín, Karina López-Ávila, Jorge Zavala-Castro
Rocky Mountain spotted fever is a disease caused by Rickettsia rickettsii, a bacteria transmitted by infected ticks. It is characterized by fever, exanthema, arthralgias and myalgias; but sometimes its clinical presentation is non specific. Due to its similarities with other exanthematic diseases like dengue or chikungunya, Rocky Mountain spotted fever is not a first line diagnosis, even though countries like Mexico show the ecologic and socioeconomic characteristics that favor its transmission, with a 30% mortality rate among pediatric patients...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28055518/rocky-mountain-spotted-fever
#14
REVIEW
Jennan Phillips
The tick-borne disease Rocky Mountain spotted fever (RMSF) can have deadly outcomes unless treated appropriately, yet nonspecific flu-like symptoms complicate diagnosis. Occupational health nurses must have a high index of suspicion with symptomatic workers and recognize that recent recreational or occupational activities with potential tick exposure may suggest RMSF.
January 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28031280/proteolytic-cleavage-of-the-immunodominant-outer-membrane-protein-rompa-in-rickettsia-rickettsii
#15
Nicholas F Noriea, Tina R Clark, David Mead, Ted Hackstadt
Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, contains two immunodominant proteins, rOmpA and rOmpB, in the outer membrane. Both rOmpA and rOmpB are conserved throughout spotted fever group rickettsiae as members of a family of autotransporter proteins. Previously, it was demonstrated that rOmpB is proteolytically processed, with the cleavage site residing near the autotransporter domain at the carboxy-terminal end of the protein, cleaving the 168-kDa precursor into apparent 120-kDa and 32-kDa fragments...
March 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/27990680/retrospective-study-of-rocky-mountain-spotted-fever-in-children
#16
Rechelle Tull, Christine Ahn, Alyssa Daniel, Gil Yosipovitch, Lindsay C Strowd
BACKGROUND/OBJECTIVES: Rocky Mountain spotted fever (RMSF), a lethal tick-borne illness, is prevalent in the south central United States. Children younger than 10 years old have the greatest risk of fatal outcome from RMSF. The objective of the current study was to review pediatric cases of RMSF seen in the dermatology consult service and to evaluate dermatology's role in the diagnosis and management of this disease. METHODS: A retrospective review was performed of inpatient dermatology consultations at a tertiary care center in North Carolina from 2001 to 2011...
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27929218/emerging-vector-borne-diseases
#17
REVIEW
Mark K Huntington, Jay Allison, Dilip Nair
Several mosquito-borne viral infections have recently emerged in North America; West Nile virus is the most common in the United States. Although West Nile virus generally causes a self-limited, flulike febrile illness, a serious neuroinvasive form may occur. Dengue is the most common vector-borne viral disease worldwide, and it has been a significant public health threat in the United States since 2009. Known as breakbone fever for its severe myalgias and arthralgias, dengue may cause a hemorrhagic syndrome...
October 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27880753/notes-from-the-field-community-based-prevention-of-rocky-mountain-spotted-fever-sonora-mexico-2016
#18
Anne Straily, Naomi Drexler, Denica Cruz-Loustaunau, Christopher D Paddock, Gerardo Alvarez-Hernandez
Rocky Mountain spotted fever (RMSF), a life-threatening tickborne zoonosis caused by Rickettsia rickettsii, is a reemerging disease in Mexico (1,2). R. rickettsii is an intracellular bacterium that infects vascular endothelium and can cause multisystem organ failure and death in the absence of timely administration of a tetracycline-class antibiotic, typically doxycycline. Epidemic RMSF, as described in parts of Arizona and Mexico, is associated with massive local infestations of the brown dog tick (Rhiphicephalus sanguineus sensu lato) on domestic dogs and in peridomestic settings that result in high rates of human exposure; for example, during 2003-2012, in Arizona the incidence of RMSF in the three most highly affected communities was 150 times the U...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27861477/-complications-and-cause-of-death-in-mexican-children-with-rocky-mountain-spotted-fever
#19
Miguel Ángel Martínez-Medina, Adela Rascón-Alcantar
BACKGROUND: Rocky Mountain spotted fever is a life threatening disease caused by Rickettsia rickettsia, characterized by multisystem involvement. METHODS: We studied 19 dead children with Rocky Mountain spotted fever. All children who were suspected of having rickettsial infections were defined as having Rocky Mountain spotted fever by serology test and clinical features. Through the analysis of each case, we identified the clinical profile and complications associated to the death of a patient...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27815656/efficacy-of-tagetes-minuta-asteraceae-essential-oil-against-rhipicephalus-sanguineus-acari-ixodidae-on-infested-dogs-and-in-vitro
#20
Elis Maressa Gonçalves da Silva, Vinicius da Silva Rodrigues, Jaciara de Oliveira Jorge, Carolina Fonseca Osava, Matias Pablo Juan Szabó, Marcos Valério Garcia, Renato Andreotti
Ticks from Rhipicephalus sanguineus complex are widely distributed in the world and one species from this complex is the most common tick on dogs in Brazil, notably in urban areas. This tick is a vector of several diseases. Among others it transmits the agent of canine Ehrlichiosis, a major dog infectious disease and the agent of Rocky Mountain spotted fever. This tick can spread rapidly and develop intolerable infestations within no time. Currently tick control is done with acaricides and demand for such drugs has grown fast...
December 2016: Experimental & Applied Acarology
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