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Rocky Mountain spotted fever

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https://www.readbyqxmd.com/read/29771344/prevalence-of-rickettsia-species-rickettsiales-rickettsiaceae-in-dermacentor-variabilis-ticks-acari-ixodidae-in-north-carolina
#1
Madhavi L Kakumanu, Loganathan Ponnusamy, Haley Sutton, Steven R Meshnick, William L Nicholson, Charles S Apperson
The American dog tick, Dermacentor variabilis (Say), is a vector of spotted fever group (SFG) rickettsiae, including Rickettsia rickettsii the causative organism of Rocky Mountain spotted fever (RMSF). In North Carolina, SFG rickettsioses (including RMSF) are a leading cause of tick-borne illness. Knowledge of the infection rate and geographic distribution of D. variabilis ticks infected with Rickettsia spp. provides information on the spatial distribution of public health risk. Accordingly, we extracted genomic DNA from adult D...
May 16, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29723166/vital-signs-trends-in-reported-vectorborne-disease-cases-united-states-and-territories-2004-2016
#2
Ronald Rosenberg, Nicole P Lindsey, Marc Fischer, Christopher J Gregory, Alison F Hinckley, Paul S Mead, Gabriela Paz-Bailey, Stephen H Waterman, Naomi A Drexler, Gilbert J Kersh, Holley Hooks, Susanna K Partridge, Susanna N Visser, Charles B Beard, Lyle R Petersen
INTRODUCTION: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. METHODS: Data reported to the National Notifiable Diseases Surveillance System for 16 notifiable vectorborne diseases during 2004-2016 were analyzed; findings were tabulated by disease, vector type, location, and year...
May 4, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29685474/the-evaluation-and-management-of-rocky-mountain-spotted-fever-in-the-emergency-department-a-review-of-the-literature
#3
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Rocky Mountain spotted fever (RMSF) is potentially deadly and can present subtly with signs and symptoms overlapping with other clinical conditions. Delayed diagnosis can be fatal. OBJECTIVE: This review provides an evidence-based summary of the current data for the evaluation and management of RMSF in the emergency department. DISCUSSION: RMSF occurs through transmission of Rickettsia rickettsii by an infected tick. Exposure in the United States occurs most commonly from April to September, and high-risk locations include wooded, shrubby, or grassy areas...
April 20, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29668136/-a-fatal-case-series-of-rocky-mountain-spotted-fever-in-sonora-m%C3%A3-xico
#4
Jesús Delgado-De la Mora, Jesús David Licona-Enríquez, Marcia Leyva-Gastélum, David Delgado-De la Mora, Adela Rascón-Alcantar, Gerardo Álvarez-Hernández
INTRODUCTION: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. OBJECTIVE: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. MATERIALS AND METHODS: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. The diagnosis of Rocky Mountain spotted fever was confirmed in a single blood sample by polymerase chain reaction (PCR) or by a four-fold increase in immunoglobulin G measured in paired samples analyzed by indirect immunofluorescence...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29619916/descriptions-of-two-new-cases-of-rocky-mountain-spotted-fever-in-panama-and-coincident-infection-with-rickettsia-rickettsii-in-rhipicephalus-sanguineus-s-l-in-an-urban-locality-of-panama-city-panama
#5
A Martínez-Caballero, B Moreno, C González, G Martínez, M Adames, J V Pachar, J B Varela-Petrucelli, J Martínez-Mandiche, J A Suárez, L Domínguez, Y Zaldívar, S Bermúdez
The clinical and pathologic characterisation of two fatal cases of tick-borne rickettsiosis in rural (El Valle) and urban (City of Panama) Panama are described. Clinical and autopsy findings were non-specific, but the molecular analysis was used to identify Rickettsia rickettsii in both cases. No ticks were collected in El Valle, while in the urban case, R. rickettsii was detected in Rhipicephalus sanguineus s.l., representing the first molecular finding in this tick in Panama and Central America.
April 5, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29617892/medical-knowledge-related-to-rocky-mountain-spotted-fever-in-sonora-mexico
#6
Gerardo Alvarez-Hernandez, Kacey Ernst, Natalia Haydee Acuña-Melendrez, Anabel Patricia Vargas-Ortega, Maria Del Carmen Candia-Plata
Background: Rocky Mountain spotted fever (RMSF) is a tick-borne disease with a high case-fatality rate unless diagnosed promptly and treated timely with doxycycline. Physician knowledge about presentation and treatment can improve outcomes of RMSF in endemic regions, such as Sonora in northern Mexico, where RMSF has caused 1348 non-fatal cases and 247 deaths from 2003 to 2016. Methods: A cross-sectional study was conducted with 343 physicians working in medical facilities in Sonora, Mexico...
March 29, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29553918/possible-northward-introgression-of-a-tropical-lineage-of-rhipicephalus-sanguineus-ticks-at-a-site-of-emerging-rocky-mountain-spotted-fever
#7
Zachary Villarreal, Nicole Stephenson, Janet Foley
Increasing rates of Rocky Mountain spotted fever (RMSF) in the southwestern United States and northern Mexico underscore the importance of studying the ecology of the brown dog tick, Rhipicephalus sanguineus, the vector in that region. This species is reported to comprise distinct tropical and temperate lineages which may differ in vectorial capacity for RMSF and which are hypothesized to be limited in their geographical range by climatic conditions. In this study, lineage was determined for ticks from nine locations in California, Arizona, and Mexico by DNA sequencing of 12S, 16S, and D-loop ribosomal RNA...
March 19, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29550216/detection-of-rickettsia-spp-in-ticks-acari-ixodidae-of-domestic-animals-in-colombia
#8
Fredy A Rivera-Páez, Thiago F Martins, Paula A Ossa-López, Bruno Rodrigues Sampieri, Maria I Camargo-Mathias
Rickettsiosis are emerging or re-emerging diseases, with a worldwide distribution associated to transmission by arthropod vectors. Rickettsia species belong to the spotted fever group (SFG) and are transmitted by hard ticks (Acari: Ixodidae) that may act as vectors and reservoirs. This study carried out a molecular detection of Rickettsia from 7 species of the family Ixodidae collected from domestic hosts by PCR amplification of fragments of the citrate synthase "gltA" gene and outer membrane protein "ompA" gene...
May 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29549965/tick-borne-illness-rocky-mountain-spotted-fever
#9
REVIEW
Robin B McFee
No abstract text is available yet for this article.
May 2018: Disease-a-month: DM
https://www.readbyqxmd.com/read/29529110/what-s-eating-you-clinical-manifestations-of-dermacentor-tick-bites
#10
Alexander B Hicks, Dirk M Elston
Dermacentor ticks are hard ticks found throughout most of North America and are easily identified by their large size, ornate scutum, and prominent dorsal pits. They are important disease vectors and are implicated in transmission of Rocky Mountain spotted fever (RMSF), Colorado tick fever, tularemia, and erlichiosis. They also are an important cause of fatal tick paralysis.
January 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29500944/rocky-mountain-spotted-fever-brain-imaging-findings
#11
Bruna Melo Coelho Loureiro, Fabiano Reis, Grazielly de Fátima Pereira, Cristina Alba Lalli
No abstract text is available yet for this article.
March 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29474831/comparative-genomic-analysis-of-rickettsia-rickettsii-for-identification-of-drug-and-vaccine-targets-tolc-as-a-proposed-candidate-for-case-study
#12
Pramod Kumar Maurya, Swati Singh, Ashutosh Mani
Antibiotic resistance is increasing rapidly in pathogenic organisms, creating more complications for treatment of diseases. Rocky Mountain spotted fever (RMSF) is a neglected tropical disease in humans caused by Rickettsia rickettsii for which no effective therapeutic is available. Subtractive genomics methods facilitate the characterization of non-homologous essential proteins that could be targeted for the discovery of potential therapeutic compounds against R. rickettsii to combat RMSF. Present study followed an in-silico based methodology, involving scanning and filtering the complete proteome of Rickettsia rickettsii by using several prioritization parameters in the search of potential candidates for drug development...
June 2018: Acta Tropica
https://www.readbyqxmd.com/read/29279696/immune-thrombocytopenia-as-a-consequence-of-rocky-mountain-spotted-fever
#13
Cherisse Baldeo, Karan Seegobin, Lara Zuberi
Primary immune thrombocytopenia (ITP) - also called idiopathic thrombocytopenic purpura or immune thrombocytopenic purpura - is an acquired thrombocytopenia caused by autoantibodies against platelet antigens. It is one of the more common causes of thrombocytopenia in otherwise asymptomatic adults. Rocky Mountain spotted fever (RMSF) is a potentially lethal, but curable, tick-borne disease. We present a case of ITP that was triggered by RMSF.
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29209593/analysis-of-the-salivary-gland-transcriptome-of-unfed-and-partially-fed-amblyomma-sculptum-ticks-and-descriptive-proteome-of-the-saliva
#14
Eliane Esteves, Sandra R Maruyama, Rebeca Kawahara, André Fujita, Larissa A Martins, Adne A Righi, Francisco B Costa, Giuseppe Palmisano, Marcelo B Labruna, Anderson Sá-Nunes, José M C Ribeiro, Andréa C Fogaça
Ticks are obligate blood feeding ectoparasites that transmit a wide variety of pathogenic microorganisms to their vertebrate hosts. Amblyomma sculptum is vector of Rickettsia rickettsii , the causative agent of Rocky Mountain spotted fever (RMSF), the most lethal rickettsiosis that affects humans. It is known that the transmission of pathogens by ticks is mainly associated with the physiology of the feeding process. Pathogens that are acquired with the blood meal must first colonize the tick gut and later the salivary glands (SG) in order to be transmitted during a subsequent blood feeding via saliva...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29032899/th1-epitope-peptides-induce-protective-immunity-against-rickettsia-rickettsii-infection-in-c3h-hen-mice
#15
Pengcheng Wang, Xiaolu Xiong, Jun Jiao, Xiaomei Yang, Yongqiang Jiang, Bohai Wen, Wenping Gong
Rickettsia rickettsii is the causative pathogen of Rocky Mountain spotted fever (RMSF). Adr2, YbgF and OmpB are protective antigens of R. rickettsii. In this study, 90 candidate peptides were selected from these antigens based on their high-affinity binding capacity for the MHC class II molecule H2 I-A or H2 I-E using bioinformatic methods. Six peptides were determined using ELISPOT assay to be immunodominant based on the IFN-γ recall responses of CD4+ T cells from mice immunized with R. rickettsii. Six nucleotide sequences encoding the immunodominant peptides were linked in series and inserted into a plasmid for expression in Escherichia coli cells, resulting in a new, recombinant polypeptide termed GWP...
December 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28930006/fatal-rocky-mountain-spotted-fever-along-the-united-states-mexico-border-2013-2016
#16
Naomi A Drexler, Hayley Yaglom, Mariana Casal, Maria Fierro, Paula Kriner, Brian Murphy, Anne Kjemtrup, Christopher D Paddock
Rocky Mountain spotted fever (RMSF) is an emerging public health concern near the US-Mexico border, where it has resulted in thousands of cases and hundreds of deaths in the past decade. We identified 4 patients who had acquired RMSF in northern Mexico and subsequently died at US healthcare facilities. Two patients sought care in Mexico before being admitted to US-based hospitals. All patients initially had several nonspecific signs and symptoms, including fever, headache, nausea, vomiting, or myalgia, but deteriorated rapidly without receipt of a tetracycline-class antimicrobial drug...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28929088/microbial-invasion-vs-tick-immune-regulation
#17
REVIEW
Daniel E Sonenshine, Kevin R Macaluso
Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28863253/tick-talk-tick-borne-diseases-of-south-dakota
#18
Mark K Huntington, Jay Allison
In addition to being a nuisance, ticks can carry disease. This article presents a brief review of ticks and associated tick-borne disease relevant to South Dakota and surrounding regions. Tick-borne diseases of special relevance in South Dakota include tularemia, Rocky Mountain spotted fever, and Lyme disease. A number of others may also be encountered in the state as well. Prompt treatment of suspected cases is important to ensure a successful recovery, and tick-avoidance measures can reduce the risks of acquiring them...
September 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28764251/rickettsial-fever-presenting-with-gangrene-a-case-series
#19
Arun Prasannan, Premalatha Ramaswamy, Vinitha K Anirudhan
Rickettsial diseases comprise a wide spectrum of diseases which are reported from different parts of India quiet long ago. Many cases of rickettsial diseases go undiagnos due to lack of diagnostic techniques and the reported incidence and prevalence may be an underestimation of the actual burden of the disease. A higher index of suspicion, clinical awareness and proper use of available diagnostic tools would increase the frequency of diagnosis. Gangrene is an uncommon complication in cases of rickettsial fever...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28722584/rocky-mountain-spotted-fever-and-pregnancy-four-cases-from-sonora-mexico
#20
Jesus David Licona-Enriquez, Jesus Delgado-de la Mora, Christopher D Paddock, Carlos Arturo Ramirez-Rodriguez, María Del Carmen Candia-Plata, Gerardo Álvarez Hernández
We present a series of four pregnant women with Rocky Mountain spotted fever (RMSF) that occurred in Sonora, Mexico, during 2015-2016. Confirmatory diagnoses were made by polymerase chain reaction or serological reactivity to antigens of Rickettsia rickettsii by using an indirect immunofluorescence antibody assay. Each patient presented with fever and petechial rash and was treated successfully with doxycycline. Each of the women and one full-term infant delivered at 36 weeks gestation survived the infection...
September 2017: American Journal of Tropical Medicine and Hygiene
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