keyword
MENU ▼
Read by QxMD icon Read
search

prostate adenocarcinoma

keyword
https://www.readbyqxmd.com/read/29323728/3d-reconstruction-of-prostate-cancer-architecture-with-serial-immunohistochemical-sections-hallmarks-of-tumour-growth-tumour-compartmentalization-and-implications-for-grading-and-heterogeneity
#1
Yuri Tolkach, Stefan Thomann, Glen Kristiansen
BACKGROUND: Conventional morphology of the prostate cancer (PCA) considers only two-dimensional architecture of the tumour. Our aim was to examine the feasibility of 3D-reconstruction of tumour morphology based on multiple consecutive histological sections and to decipher relevant features of PCA architecture. METHODS: Seventy-five consecutive histological sections (5μm) of a typical prostate adenocarcinoma (Gleason-Score 3+4=7) were immunostained (Pan-Cytokeratin) and scanned for further 3D reconstructions with Fiji / ImageJ software...
January 11, 2018: Histopathology
https://www.readbyqxmd.com/read/29315911/promoter-hypermethylation-of-sox11-correlates-with-adverse-clinicopathological-features-of-human-prostate-cancer
#2
Apiwat Pugongchai, Andrey Bychkov, Pichet Sampatanukul
Currently available tools for early diagnosis and prognosis of prostate cancer lack sufficient accuracy. There is a need to identify novel biomarkers for this common malignancy. SOX family genes play an important role in embryogenesis and are also implicated in various cancers. SOX11 has been recently recognized as a potential tumour suppressor that is downregulated in prostate cancer. We hypothesized that hypermethylation may be responsible for SOX11 silencing in human prostate cancer. The aim of the study was to investigate SOX11 promoter methylation in prostate adenocarcinoma by comparing it with benign prostatic hyperplasia (BPH)...
January 8, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29307052/prognostic-factors-in-chinese-patients-with-prostate-cancer-receiving-primary-androgen-deprivation-therapy-validation-of-japan-cancer-of-the-prostate-risk-assessment-j-capra-score-and-impacts-of-pre-existing-obesity-and-diabetes-mellitus
#3
Meng-Bo Hu, Tian Yang, Ji-Meng Hu, Wen-Hui Zhu, Hao-Wen Jiang, Qiang Ding
PURPOSE: Our aim was to determine the prognostic factors in Chinese patients with prostate cancer receiving primary androgen deprivation therapy (PADT), validate the Japan Cancer of the Prostate Risk Assessment (J-CAPRA) score, and investigate the impacts of pre-existing obesity and diabetes mellitus (DM). METHODS: The study enrolled Chinese patients diagnosed with prostatic adenocarcinoma and treated with bilateral orchiectomy as PADT at Huashan Hospital, Fudan University (Shanghai, China), from January 2003 to December 2015...
January 6, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29303624/optimization-of-risk-stratification-in-localized-prostate-cancer
#4
Alicia Katherine Morgans
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
January 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29301413/potential-anticancer-activity-of-biogenic-silver-nanoparticles-using-leaf-extract-of-rhynchosia-suaveolens-an-insight-into-the-mechanism
#5
Murali Satyanarayana Bethu, Vasudeva Reddy Netala, Latha Domdi, Vijaya Tartte, Venkateswara Rao Janapala
The present study reports a simple and eco-friendly synthesis of silver nanoparticles (AgNPs) using leaf extract of Rhynchosia suaveolens. UV-Vis analysis of R. suaveolens synthesized AgNPs (RS-AgNPs) showed surface plasmon resonance (SPR) peak at 426 nm. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis revealed that RS-AgNPs were 10-30 nm in size with spherical shape. X-ray diffraction (XRD) analysis of RS-AgNPs confirmed the crystalline nature with face-centered cubic (FCC) lattice...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29301373/potential-anticancer-properties-of-osthol-a-comprehensive-mechanistic-review
#6
REVIEW
Yalda Shokoohinia, Fataneh Jafari, Zeynab Mohammadi, Leili Bazvandi, Leila Hosseinzadeh, Nicholas Chow, Piyali Bhattacharyya, Mohammad Hosein Farzaei, Ammad Ahmad Farooqi, Seyed Mohammad Nabavi, Mükerrem Betül Yerer, Anupam Bishayee
Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29300814/body-mass-index-and-20-specific-cancers-re-analyses-of-dose-response-meta-analyses-of-observational-studies
#7
E K Choi, H B Park, K H Lee, J H Park, M Eisenhut, H J van der Vliet, G Kim, J I Shin
Background: Objectives were to provide an overview and understand the strength of evidence and extent of potential biases and validity of claimed associations between Body Mass Index (BMI) and risk of developing cancer. Methods: We performed an umbrella review and comprehensively re-analysed the data of dose-response meta-analyses on associations between BMI and risk of 20-specific cancers (bladder, brain, breast, colonic, rectal, endometrial, gallbladder, gastric, leukemia, liver, lung, melanoma, multiple myeloma, non-Hodgkins lymphoma, oesophagus, ovarian, pancreatic, prostate, renal, thyroid) by adding big data or missed individual studies...
December 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29299174/lymph-node-ratio-determines-the-benefit-of-adjuvant-radiotherapy-in-pathologically-3-or-less-lymph-node-positive-prostate-cancer-after-radical-prostatectomy-a-population-based-analysis-with-propensity-score-matching
#8
Yi-Jun Kim, Changhoon Song, Keun-Yong Eom, In Ah Kim, Jae-Sung Kim
Background: The survival benefit of adjuvant radiotherapy (ART) in prostate adenocarcinoma, with limited numbers of pathologically involved lymph nodes (LNs) after radical prostatectomy (RP), is controversial. Materials and Methods: From 2004 to 2014, data for prostate cancer patients categorized as N1M0 after RP were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. After propensity-score matching, the 10-year cancer-specific survival (CSS) rates between patients who received ART (ART group) or did not/unknown (no-ART group) were compared for each stratum of lymph node ratio (LNR) (%) according to the number of involved LNs...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297497/prostate-cancer-reporting-and-staging-needle-biopsy-and-radical-prostatectomy-specimens
#9
David J Grignon
Prostatic adenocarcinoma remains the most common cancer affecting men. A substantial majority of patients have the diagnosis made on thin needle biopsies, most often in the absence of a palpable abnormality. Treatment choices ranging from surveillance to radical prostatectomy or radiation therapy are largely driven by the pathologic findings in the biopsy specimen. The first part of this review focuses on important morphologic parameters in needle biopsy specimens that are not covered in the accompanying articles...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29297496/variants-of-acinar-adenocarcinoma-of-the-prostate-mimicking-benign-conditions
#10
Peter A Humphrey
Histological variants of acinar adenocarcinoma of the prostate may be of significance due to difficulty in diagnosis or due to differences in prognosis compared to usual acinar adenocarcinoma. The 2016 World Health Organization classification of acinar adenocarcinoma includes four variants that are deceptively benign in histological appearance, such that a misdiagnosis of a benign condition may be made. These four variants are atrophic pattern adenocarcinoma, pseudohyperplastic adenocarcinoma, microcystic adenocarcinoma, and foamy gland adenocarcinoma...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29297491/high-grade-prostatic-intraepithelial-neoplasia-pin-like-carcinoma-ductal-carcinoma-and-intraductal-carcinoma-of-the-prostate
#11
Ming Zhou
Many prostate lesions have 'large gland' morphology with gland size similar to or larger than benign glands, complex glandular architecture including papillary, cribriform, and solid, and significant cytological atypia in glandular epithelium with nucleomegaly, prominent nucleoli, or anisonucleosis. The most common and clinically important lesions with 'large gland' morphology include high-grade prostatic intraepithelial neoplasia (HGPIN), PIN-like carcinoma, ductal adenocarcinoma, and intraductal carcinoma...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29297489/benign-mimics-of-prostatic-adenocarcinoma
#12
Kiril Trpkov
Benign mimics present either as common challenges in daily routine practice or may cause diagnostic dilemmas because some are less commonly seen and one may be less familiar in recognizing them. There are a multitude of mimics of prostatic adenocarcinoma, which may represent normal gland structures, benign proliferations, atrophic lesions, hyperplastic or metaplastic changes, and inflammatory processes. Some of them are preferentially found in certain anatomic areas of the prostate, either confined to the prostate, or outside of the gland...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29297488/mucinous-and-secondary-tumors-of-the-prostate
#13
Adeboye O Osunkoya
Primary mucinous tumors and secondary tumors involving the prostate gland are relatively uncommon, however they have important diagnostic, therapeutic, and prognostic implications. The primary mucinous tumors of the prostate include mucinous (colloid) adenocarcinoma of the prostate, prostatic adenocarcinoma with mucinous features, and mucinous adenocarcinoma of the prostatic urethra (mucin-producing urothelial-type adenocarcinoma of the prostate). Mucinous adenocarcinoma of the prostate is defined as a primary prostatic acinar tumor characterized by the presence of at least 25% of the tumor composed of glands with extraluminal mucin...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29297487/prostate-cancer-grading-a-decade-after-the-2005-modified-system
#14
Jonathan I Epstein
This review article will cover the evolution of grading of prostate cancer from the original Gleason system in the 1960-1970s to a more patient-centric grading system proposed in 2013 from a group at Johns Hopkins Hospital, validated in 2014 by a large multi-institutional study, and subsequently accepted by the World Health Organization (WHO), College of American Pathology (CAP), and the AJCC TNM system. Covered topics include: (1) historical background; (2) 2005 and 2014 International Society of Urological Pathology Grading Conferences; (3) Description of Gleason patterns; (4) new approaches to display Gleason grades; (5) grading variants and variations of acinar adenocarcinoma; (6) reporting rules for Gleason grading reporting secondary patterns of higher grade when present to a limited extent; (7) reporting secondary patterns of lower grade when present to a limited extent; (8) reporting percentage pattern 4; (9) general applications of the Gleason grading system; (10) needle biopsy with different cores showing different grades; (11) radical prostatectomy specimens with separate tumor nodules; and (12) a new grading system for prostate cancer...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29284790/prostate-specific-pten-deletion-in-mice-activates-inflammatory-microrna-expression-pathways-in-the-epithelium-early-in-hyperplasia-development
#15
D Alwyn Dart, Pinar Uysal-Onganer, W G Jiang
PTen loss is one of the most frequent events in prostate cancer both at the initiation stage and during late stage metastatic development. The mouse model of prostate-specific probasin-mediated Pten deletion leads to prostate intraepithelial neoplasia (PIN) leading to adenocarcinoma. Using this model, we analysed the miR and mRNA transcriptome profile of Pten -/- PIN versus wild type age-matched prostate tissues and analysed the effects of Pten loss on miR expression in the early neoplastic process. At the PIN stage, Pten loss significantly changed the expression of over 20 miRNAs and over 4000 genes...
December 14, 2017: Oncogenesis
https://www.readbyqxmd.com/read/29281088/prediction-of-acute-gastrointestinal-and-genitourinary-radiation-toxicity-in-prostate-cancer-patients-using-lymphocyte-microrna
#16
Masanori Someya, Masakazu Hori, Toshio Gocho, Kensei Nakata, Takaaki Tsuchiya, Mio Kitagawa, Tomokazu Hasegawa, Yuuki Fukushima, Koh-Ichi Sakata
Background: To search for novel biomarkers that can predict acute radiation toxicity, we conducted microRNA expression analysis of peripheral blood lymphocytes (PBLs). Methods: The discovery cohort was 69 patients with localized adenocarcinoma of the prostate who received intensity-modulated radiation therapy between October 2007 and October 2010. The validation cohort was 72 patients treated with low-dose-rate brachytherapy between May 2008 and March 2014. After13 microRNAs were selected by TaqMan® Array analysis in a preliminary experiment, expression of these microRNAs in all samples was analyzed by RT-PCR...
December 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29274778/inhibition-of-cx3cr1-reduces-cell-motility-and-viability-in-pancreatic-adenocarcinoma-epithelial-cells
#17
Matthew C Stout, Shilpa Narayan, Emily S Pillet, Joseph M Salvino, Paul M Campbell
Increased expression of the chemokine CX3CL1 and its sole receptor, CX3CR1 have been correlated with poor pancreatic cancer patient survival and time to recurrence, as well as with pancreatic perineural invasion. We have previously shown that metastasis of prostate and breast cancer is in part driven by CX3CL1, and have developed small molecule inhibitors against the CX3CR1 receptor that diminish metastatic burden. Here we ask if inhibition of this chemokine receptor affects the phenotype of PDAC tumor cells...
December 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29261620/68ga-psma-avid-primary-adenocarcinoma-of-the-lung-with-complementary-low-18f-fdg-uptake
#18
Mads Ryø Jochumsen, Lars Christian Gormsen, Gitte Lund Nielsen
Ga-PSMA PET/CT scan on a 70-year-old man with recently diagnosed prostate cancer revealed a spiculating nodule in the apex of the left lung with intense Ga-PSMA uptake. The nodule had no pathological F-FDG uptake and turned out to be a primary adenocarcinoma of the lung. Cases with complementary pattern of uptake in F-FDG and Ga-PSMA in metastatic clear cell renal carcinoma and in well-differentiated hepatocellular carcinoma have previously been reported; however, this case illustrates that this unusual pattern can also be present in primary lung cancer...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29261618/metastasized-18f-dcfpyl-negative-prostatic-adenocarcinoma-without-neuroendocrine-differentiation
#19
Wouter A M Broos, Marielle Kocken, Friso M van der Zant, Remco J J Knol, Maurits Wondergem
A 76-year-old man with histopathologically proven prostate cancer (initial prostate-specific antigen 110 ng/mL, Gleason 3 + 4 = 7) received F-DCFPyL PET/CT for initial staging. Both the primary tumor and pathologically enlarged pelvic lymph nodes showed no increased F-DCFPyL uptake. Subsequent histopathologic lymph node biopsy revealed prostate cancer metastasis. Prostate-specific membrane antigen tracers, such as F-DCFPyL, are promising radiopharmaceuticals for prostate cancer imaging. False-negative prostate-specific membrane antigen PET/CT findings have been reported earlier for prostate tumors with neuroendocrine differentiation...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29251319/%C3%AE-catenin-promotes-tumorigenesis-and-metastasis-of-lung-adenocarcinoma
#20
Fei Huang, Junying Chen, Zeng Wang, Ruilong Lan, Lengxi Fu, Lurong Zhang
δ-Catenin coded by gene CTNND2 has been found to be overexpressed in various types of cancers, including prostate, breast, lung and ovarian cancers. However, the function of δ-catenin in lung carcinoma remains largely unknown. In the present study, we revealed that δ-catenin acts as an oncogene promoting the malignancy of lung adenocarcinoma. When δ-catenin proteins of Lewis lung cells were depleted by knocking out Ctnnd2 via CRISPR/Cas9 technology, the cells lost the tumorigenic and metastatic abilities in vivo...
February 2018: Oncology Reports
keyword
keyword
68531
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"