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nasal allergen challenge

B R Leaker, V A Malkov, R Mogg, M K Ruddy, G C Nicholson, A J Tan, C Tribouley, G Chen, I De Lepeleire, N A Calder, H Chung, P Lavender, L N Carayannopoulos, T T Hansel
Non-invasive mucosal sampling (nasosorption and nasal curettage) was used following nasal allergen challenge with grass pollen in subjects with allergic rhinitis, in order to define the molecular basis of the late allergic reaction (LAR). It was found that the nasal LAR to grass pollen involves parallel changes in pathways of type 2 inflammation (IL-4, IL-5 and IL-13), inflammasome-related (IL-1β), and complement and circadian-associated genes. A grass pollen nasal spray was given to subjects with hay fever followed by serial sampling, in which cytokines and chemokines were measured in absorbed nasal mucosal lining fluid, and global gene expression (transcriptomics) assessed in nasal mucosal curettage samples...
September 28, 2016: Mucosal Immunology
Sunil K Ahuja, Muthu Saravanan Manoharan, Nathan L Harper, Fabio Jimenez, Benjamin D Hobson, Hernan Martinez, Puraskar Ingale, Ya-Guang Liu, Andrew Carrillo, Zheng Lou, Dean L Kellog, Seema S Ahuja, Cynthia G Rather, Robert E Esch, Daniel A Ramirez, Robert A Clark, Kari Nadeau, Charles P Andrews, Robert L Jacobs, Weijing He
BACKGROUND: An emerging paradigm holds that resistance to the development of allergic diseases, including allergic rhinoconjunctivitis (AR), relates to an intact epithelial/epidermal barrier during early childhood. Conceivably, the immunologic and genomic footprint of this resistance is preserved in nonatopic, nonallergic adults and is unmasked during exposure to an aeroallergen. OBJECTIVE: To obtain direct support of the epithelial/epidermal barrier model for AR...
September 19, 2016: Journal of Allergy and Clinical Immunology
Mena Soliman, Lisa Steacy, Jenny Thiele, Dan Adams, Helen Neighbour, Anne K Ellis
No abstract text is available yet for this article.
September 2016: Annals of Allergy, Asthma & Immunology
Radoslaw Gawlik, Alicja Grzanka, Barbara Jawor, Eugeniusz Czecior
INTRODUCTION: A pathomechanism of allergic rhinitis is complex. A neurogenic mechanism seems to play a significant role in this phenomenon. AIM: The evaluation of influence of specific immunotherapy of mugwort pollen allergic patients on the bradykinin concentration in the nasal lavage fluid. MATERIAL AND METHODS: The study included 22 seasonal allergic rhinitis patients. Thirty persons with monovalent allergy to mugwort pollen, confirmed with skin prick tests and allergen-specific immunoglobulin E, underwent a 3-year-long allergen immunotherapy with the mugwort extract (Allergovit, Allergopharma, Germany)...
August 2016: Postȩpy Dermatologii i Alergologii
John A Gebe, Koshika Yadava, Shannon M Ruppert, Payton Marshall, Paul Hill, Ben A Falk, Johanna M Sweere, Hongwei Han, Gernot Kaber, Carlos Medina, Katalin Mikecz, Steven F Ziegler, Swathi Balaji, Sundeep G Keswani, Vinicio A de Jesus Perez, Manish J Butte, Kari Nadeau, William A Altemeier, Neil Fanger, Paul L Bollyky
BACKGROUND: The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan (LMW-HA) and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan, typical of un-inflamed tissues, is known to suppress inflammation. OBJECTIVE: We asked whether HMW-HA can be adapted to adapted to promote tolerance to airway allergens. METHODS: HMW-HA was thiolated to prevent its catabolism and tethered it to allergens via thiol linkages...
September 6, 2016: American Journal of Respiratory Cell and Molecular Biology
Marianella Paz Lansberg, Marcy DeTineo, James Lane, Jayant M Pinto, Fuad M Baroody, Robert M Naclerio
BACKGROUND: Allergic rhinitis is a common disorder that leads to a negative impact on quality of life. Multiple options are available for treatment of the symptoms, but preventing the reaction should be an effective strategy. OBJECTIVE: We tested a nasal spray that contained microcrystalline cellulose designed to limit airborne allergens from penetrating the nasal mucosa (nasal blocker) and, therefore, prevent the initiation of the allergic reaction. METHODS: We performed a randomized, double-blind, placebo-controlled, two-way crossover clinical trial with 20 subjects who had a history of seasonal grass and/or ragweed allergy symptoms...
July 2016: American Journal of Rhinology & Allergy
Carmen Rondón, Gador Bogas, Esther Barrionuevo, Miguel Blanca, Maria J Torres, Paloma Campo
In the past years several investigators have demonstrated the existence of local nasal responses in some patients with typical allergic rhinitis symptoms but without atopy, and have defined a new phenotype called local allergic rhinitis (LAR) or "entopy". In a percentage of LAR subjects, the upper airway disease is also associated with lower airway symptoms. After the description of this phenotype, the differential diagnosis between LAR and non-allergic rhinitis (NAR) has become a challenge for the clinician...
July 20, 2016: Allergy
Ji Heui Kim, Chang-Hoong Gong, Go Eun Choi, Sun A Kim, Hun Sik Kim, Yong Ju Jang
OBJECTIVE: Defective innate immune functions can contribute to chronic rhinosinusitis (RS). Recently, it has been reported that chronic RS patients show impaired function of natural killer (NK) cells. We investigated the role of NK cells in eosinophilic inflammation in an allergic RS mouse model. METHODS: Mice sensitized to ovalbumin (OVA) by intraperitoneal injection received nasal challenges with OVA for 5 weeks. NK cell depletion was achieved by intraperitoneal injections of anti-asialo ganglio-N-tetraosylceramide (ASGM1) antibodies 10 days before OVA sensitization and every 5 days thereafter until sacrifice...
2016: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Yusuke Okuma, Yoshitaka Okamoto, Syuji Yonekura, Tomohisa Iinuma, Toshioki Sakurai, Sawako Hamasaki, Yuji Ohki, Heizaburo Yamamoto, Daiju Sakurai
BACKGROUND: Immediate- and late-phase reactions are associated with nasal symptoms of patients with allergic rhinitis. OBJECTIVE: To examine the symptoms and mediators released after continuous allergen exposure in an environmental challenge chamber (ECC). METHODS: Fifteen patients with Japanese cedar pollinosis were enrolled in this study and continuously exposed to cedar pollen at a concentration of 8,000 grains/m(3) for 3 hours in an ECC...
August 2016: Annals of Allergy, Asthma & Immunology
Mei-Jun Liang, Qing-Ling Fu, Hong-Yan Jiang, Feng-Hong Chen, Dong Chen, De-Hua Chen, Zhi-Bin Lin, Rui Xu
Allergic rhinitis (AR) has been a significant healthcare burden on individuals and society. However, the detailed effect of different patterns of allergen exposure on the development of AR remains controversial. A mouse model of AR was established to address the complex relationships between allergen exposure and the development of AR. Allergic symptom, OVA-specific IgE in serum and nasal lavage fluid, allergic inflammation in nasal tissues were evaluated after intranasal sensitization and challenge of ovalbumin (OVA) in mice treated with two different doses of allergen for different sensitized durations...
June 4, 2016: European Archives of Oto-rhino-laryngology
K Lueer, H Biller, A Casper, H Windt, M Mueller, P Badorrek, D Haefner, T Framke, A Koch, H Ziehr, N Krug, W Koch, J M Hohlfeld
BACKGROUND: Efficacy testing of immunotherapy in field studies is often hampered by variation of airborne allergens. Standardized allergen exposure in challenge chamber settings might be an alternative. Therefore, we developed a universal technique to create an atmosphere loaded with allergen particles of adjustable size from aqueous solutions of licensed allergen extracts. OBJECTIVE: The aim of this study was to apply this technique and test the safety and efficacy of challenges with house dust mite (HDM) allergen in the Fraunhofer Allergen Challenge Chamber...
June 3, 2016: Allergy
Johannes Martin Schmid, Homaira Nezam, Hans Henrik Torp Madsen, Alexander Schmitz, Hans Jürgen Hoffmann
BACKGROUND: Allergen Immunotherapy is a promising treatment of allergy. Seven patients with rhinoconjunctivitis to grass allergen were treated with intralymphatic immunotherapy (ILIT) to explore whether this treatment could be performed. Effect of treatment was assessed as change in symptom medication score, response in skin prick test and nasal allergen provocation. ILIT deposits allergen in an inguinal lymph node to elicit a strong immune stimulus. This allowed us to monitor appearance of allergen specific plasmablasts 7 days after allergen injection...
2016: Clinical and Translational Allergy
G King, A Byrne, P Fleming
BACKGROUND: An allergic reaction following a dental procedure is a rare event. A local anaesthetic (LA) may initially be suspected as a causative agent but allergy to dental LA solutions is extremely rare. CASE REPORT: This report concerns a 13 year old child who underwent dental treatment and was exposed to Lignospan Special(®) LA, mouthwash, latex gloves, ibuprofen medication, and a Magnum(®) (almond) ice cream all within 45 min. He subsequently developed acute symptoms of nasal rhinorrhoea, facial flushing, peri-orbital and lip angioedema, followed by throat tightness and wheeze (respiratory compromise)...
August 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
E Ridolo, M Caminati, I Martignago, V Melli, C Salvottini, O Rossi, A Dama, M Schiappoli, C Bovo, C Incorvaia, G Senna
INTRODUCTION: Allergic rhinitis (AR) affects 20-30% of women in reproductive age and may worsen during pregnancy. About 10% of the elderly suffer from AR, and it could be under-diagnosed in these patients. Many drugs are currently available, however AR treatment during pregnancy and old age represents a challenging issue. AREAS COVERED: A review of the literature on the topic has been performed. Expert commentary: In pregnancy, drug avoidance should be carefully balanced with the need for AR optimal control...
August 2016: Expert Review of Clinical Pharmacology
David Sherson, Jesper Bælum, Claus Rikard Johnsen, Vivi Schlünssen, Harald William Meyer, Ellen Bøtker Pedersen, Holger Mosebech, Jakob Bønnelykke, Lars P A Brandt, Hanne Madsen
Specific inhalation challenge (SIC) is the golden standard for identifying specific causes of work-related asthma and rhinoconjunctivitis. Few centres offer SIC as it requires experience, resources and acute treatment facilities. Prior to SIC treatment should be carefully reduced. A control challenge is performed on a separate day. Many new asthma causes have been identified with SIC. SIC provides the basis for optimal treatment and advice.
April 11, 2016: Ugeskrift for Laeger
Toshiaki Nakano, Rikiya Kamei, Takashi Fujimura, Yuki Takaoka, Ayane Hori, Chia-Yun Lai, Kuei-Chen Chiang, Yayoi Shimada, Naoya Ohmori, Takeshi Goto, Kazuhisa Ono, Chao-Long Chen, Shigeru Goto, Seiji Kawamoto
Nuclear antigens are known to trigger off innate and adaptive immune responses. Recent studies have found that the complex of nucleic acids and core histones that are derived from damaged cells may regulate allergic responses. However, no fundamental study has been performed concerning the role of linker histone H1 in mast cell-mediated type I hyperreactivity. In this study, we explored the impact of histone H1 on mast cell-mediated allergic responses both in vitro and in vivo. In the course of a bona-fide experimental allergen sensitization model upon co-injection with alum adjuvant, ovalbumin (OVA), but not PBS, induced elevated levels of circulating histone H1...
2016: PloS One
S Gilles-Stein, I Beck, A Chaker, M Bas, M McIntyre, L Cifuentes, A Petersen, J Gutermuth, C Schmidt-Weber, H Behrendt, C Traidl-Hoffmann
BACKGROUND: Besides allergens, pollen release bioactive, low molecular weight compounds that modulate and stimulate allergic reactions. Clinical relevance of these substances has not been investigated to date. OBJECTIVE: To elucidate the effect of a non-allergenic, low molecular weight factors from aqueous birch pollen extracts (Bet-APE < 3 kDa) on the human allergic immune response in vivo. METHODS: Birch and grass pollen allergic individuals underwent skin prick testing with allergen alone, allergen plus Bet-APE < 3 kDa, or allergen plus pre-identified candidate substances from low molecular pollen fraction...
October 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Diana Tymoszuk, Marta Wiszniewska, Jolanta Walusiak-Skorupa
This report presents a case of occupational asthma, rhinitis and conjunctivitis to papain in a 50-year-old herbs and spices packer, with documented increased eosinophilia in induced sputum and in the nasal lavage fluids after a specific inhalation challenge test (SICT) and specific nasal challenge test (SNCT) with this enzyme. Immunoglobulin E-mediated (IgE) sensitization to papain was confirmed by positive results of a skin prick test with specific solution. Specific inhalation and nasal challenge tests demonstrated a direct and significant link between the exposure to this protease and the allergic response from the respiratory system...
2016: Medycyna Pracy
Shan Shan, Yan Li, Jingjing Wang, Zhe Lv, Dawei Yi, Qiong Huang, Chris J Corrigan, Wei Wang, Zhang Quangeng, Sun Ying
The T-helper cell type 2-promoting cytokine interleukin-33 (IL-33) has been implicated in asthma pathogenesis. Angiogenesis is a feature of airways remodelling in asthma. We hypothesized that IL-33 induces airways angiogenesis and expression of angiogenic factors in an established murine surrogate of asthma. In the present study, BALB/c mice were subjected to serial intranasal challenge with IL-33 alone for up to 70 days. In parallel, ovalbumin (OVA) -sensitized mice were subjected to serial intranasal challenge with OVA or normal saline to serve as positive and negative controls, respectively...
May 2016: Immunology
B J Biagioni, S Tam, Y-W R Chen, D D Sin, C Carlsten
BACKGROUND: Air pollution is a major cause of global morbidity and mortality. Air pollution and aeroallergens aggravate respiratory illness, but the variable effects of air pollutants and allergens in the lung are poorly understood. OBJECTIVE: To determine the effects of diesel exhaust (DE) and bronchial allergen challenge as single and dual exposures on aspects of innate immunity in the airway as reflected by surfactant protein D (SPD), myeloperoxidase (MPO) and club (Clara) cell secretory protein 16 (CC16) in 18 atopic individuals...
September 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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