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nasal allergen challenge

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https://www.readbyqxmd.com/read/28196255/effect-of-2-years-of-treatment-with-sublingual-grass-pollen-immunotherapy-on-nasal-response-to-allergen-challenge-at-3-years-among-patients-with-moderate-to-severe-seasonal-allergic-rhinitis-the-grass-randomized-clinical-trial
#1
Guy W Scadding, Moises A Calderon, Mohamed H Shamji, Aarif O Eifan, Martin Penagos, Florentina Dumitru, Michelle L Sever, Henry T Bahnson, Kaitie Lawson, Kristina M Harris, Audrey G Plough, Joy Laurienzo Panza, Tielin Qin, Noha Lim, Nadia K Tchao, Alkis Togias, Stephen R Durham
Importance: Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. Objective: To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28139053/anti-inflammatory-effects-of-the-petasin-phyto-drug-ze339-are-mediated-by-inhibition-of-the-stat-pathway
#2
Sabrina A Steiert, Ulrich M Zissler, Adam M Chaker, Julia Esser-von-Bieren, Daniela Dittlein, Ferdinand Guerth, Constanze A Jakwerth, Guido Piontek, Catherine Zahner, Juergen Drewe, Claudia Traidl-Hoffmann, Carsten B Schmidt-Weber, Stefanie Gilles
Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339...
January 31, 2017: BioFactors
https://www.readbyqxmd.com/read/28094875/neuroendocrinology-of-mast-cells-challenges-and-controversies
#3
REVIEW
Theoharis C Theoharides
Mast cells (MC) are hemopoietically-derived tissue immune cells that are ubiquitous in the body, including neuroendocrine organs such as the hypothalamus, pineal, pituitary, ovaries, pancreas and uterus where their action is not well understood. Mast cells have historically been associated with allergies because of their rich content of histamine and tryptase, but more recently with regulation of immunity and inflammation due their synthesis and release of numerous cytokines and chemokines. Mast cells are located perivascularly and express numerous receptors for diverse ligands such as allergens, pathogens, neurotransmitters, neuropeptides and hormones including acetylcholine, calcitonin gene-related peptide (CGRP), corticosteroids, corticotropin-releasing hormone (CRH), β-endorphin, epinephrine, 17β-estradiol, gonadotrophins, hemokinin-A (HKA), leptin, melatonin, neurotensin (NT), parathyroid hormone (PTH), substance P (SP) and vasoactive instestinal peptide (VIP)...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28073613/effect-of-nasal-allergen-challenge-in-allergic-rhinitis-on-mitochondrial-function-of-peripheral-blood-mononuclear-cells
#4
Shanshan Qi, Cindy Barnig, Anne-Laure Charles, Anh Poirot, Alain Meyer, Raphaël Clere-Jehl, Fréderic de Blay, Bernard Geny
No abstract text is available yet for this article.
January 7, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28042527/pediatric-rhinosinusitis
#5
Dana T Badr, Jonathan M Gaffin, Wanda Phipatanakul
Rhinosinusitis, is defined as an inflammation of the paranasal and nasal sinus mucosae. Chronic rhinosinusitis (CRS)is a common problem in the pediatric age group and the diagnosis and treatment are challenging due to the chronicity and similarity of symptoms with allergic rhinitis and adenoid hypertrophy. Although it is less common than acute rhinosinusitis, CRS is becoming more frequent and significantly affects the quality of life in children and can substantially impair daily function. CRS is characterized by sinus symptoms lasting more than 3 months despite medical therapy...
September 2016: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/27993536/neutrophils-are-a-major-source-of-the-epithelial-barrier-disrupting-cytokine-oncostatin-m-in-patients-with-mucosal-airways-disease
#6
Kathryn L Pothoven, James E Norton, Lydia A Suh, Roderick G Carter, Kathleen E Harris, Assel Biyasheva, Kevin Welch, Stephanie Shintani-Smith, David B Conley, Mark C Liu, Atsushi Kato, Pedro C Avila, Qutayba Hamid, Leslie C Grammer, Anju T Peters, Robert C Kern, Bruce K Tan, Robert P Schleimer
BACKGROUND: We have previously shown that oncostatin M (OSM) levels are increased in nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in bronchoalveolar lavage fluid, after segmental allergen challenge in allergic asthmatic patients. We also showed in vitro that physiologic levels of OSM impair barrier function in differentiated airway epithelium. OBJECTIVE: We sought to determine which hematopoietic or resident cell type or types were the source of the OSM expressed in patients with mucosal airways disease...
December 18, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27992712/usefulness-of-allerkin-house-dust-mite-extract-for-nasal-provocation-testing
#7
Kyu-Sung Kim, Tae Young Jang, Young Hyo Kim
Objectives: We evaluated the clinical usefulness of Allerkin (Lofarma) for nasal provocation testing (NPT) in patients with rhinitis symptoms, by examining changes in nasal symptoms and acoustic parameters after exposure to house dust mite (HDM) extract. Methods: Twenty patients (16 males and 4 females, mean age: 29.6±14.6 years) were enrolled. We performed skin prick test (SPT) before and 15 and 30 minutes after intranasal challenge with Allerkin HDM extract, and we evaluated symptom changes (nasal obstruction, rhinorrhea, sneezing, and itching) using a visual analogue scale...
December 20, 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27956356/a-standardized-methanol-extract-of-eclipta-prostrata-l-l-asteraceae-reduces-bronchial-hyperresponsiveness-and-production-of-th2-cytokines-in-a-murine-model-of-asthma
#8
Lucas Junqueira de Freitas Morel, Bruna Cestari de Azevedo, Fábio Carmona, Silvia Helena Taleb Contini, Aristônio Magalhães Teles, Fernando Silva Ramalho, Bianca Waléria Bertoni, Suzelei de Castro França, Marcos de Carvalho Borges, Ana Maria Soares Pereira
ETHNOPHARMACOLOGICAL RELEVANCE: Eclipta prostrata (L.) L. (Asteraceae) has been used in Brazilian traditional medicine to treat asthma and other respiratory illnesses. AIMS OF THE STUDY: To investigate the effects of different doses of a standardized extract of E. prostrata using a murine model of allergen induced asthma. MATERIALS AND METHODS: Balb/c mice were sensitized twice with ovalbumin (OVA) administered intraperitoneally and challenged over four alternate days with nasal instillations of OVA solution...
December 9, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#9
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27852361/-lower-airway-abnormalities-in-patients-with-allergic-rhinitis
#10
J F Ji, Q P Wang, Y Zhang, Z Y Wang, Y Q Xie, W J Guan, K M Wu, L Xu, W Chen, F Xue, M J Jiang, T Y Wang, N S Zhong
Objective: To investigate the characteristics of lower airway abnormalities in allergic rhinitis(AR) patients without asthma. Methods: Between June 2008 and December 2012, 377 consecutive AR patients and 264 healthy subjects were recruited. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, induced sputum cell count and differentials, measurement of fractional exhaled nitric oxide (FeNO) and bronchial challenge test...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27777594/clinical-validation-of-controlled-exposure-to-birch-pollen-in-the-environmental-exposure-unit-eeu
#11
Anne K Ellis, Mena Soliman, Lisa M Steacy, Daniel E Adams, Barnaby Hobsbawn, Terry J B Walker
BACKGROUND: The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in clinical studies. In this study we aim to validate the use of birch pollen to challenge allergic participants. METHODS: A total of 59 volunteers were screened and 38 birch allergic participants and ten non-allergics completed the study, outside of tree pollen season...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27773851/intradermal-grass-pollen-immunotherapy-increases-th2-and-ige-responses-and-worsens-respiratory-allergic-symptoms
#12
Anna Slovick, Abdel Douiri, Rachel Muir, Andrea Guerra, Konstantinos Tsioulos, Evie Hay, Emily P S Lam, Joanna Kelly, Janet L Peacock, Sun Ying, Mohamed H Shamji, David J Cousins, Stephen R Durham, Stephen J Till
BACKGROUND: Repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcutaneous and sublingual immunotherapy. OBJECTIVE: We sought to evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis. METHODS: We randomly assigned 93 adults with grass pollen-induced allergic rhinitis to receive 7 preseasonal intradermal allergen injections (containing 7 ng of Phl p 5 major allergen) or a histamine control...
October 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27677865/the-nasal-mucosal-late-allergic-reaction-to-grass-pollen-involves-type-2-inflammation-il-5-and-il-13-the-inflammasome-il-1%C3%AE-and-complement
#13
B R Leaker, V A Malkov, R Mogg, M K Ruddy, G C Nicholson, A J Tan, C Tribouley, G Chen, I De Lepeleire, N A Calder, H Chung, P Lavender, L N Carayannopoulos, T T Hansel
Non-invasive mucosal sampling (nasosorption and nasal curettage) was used following nasal allergen challenge with grass pollen in subjects with allergic rhinitis, in order to define the molecular basis of the late allergic reaction (LAR). It was found that the nasal LAR to grass pollen involves parallel changes in pathways of type 2 inflammation (IL-4, IL-5 and IL-13), inflammasome-related (IL-1β), and complement and circadian-associated genes. A grass pollen nasal spray was given to subjects with hay fever followed by serial sampling, in which cytokines and chemokines were measured in absorbed nasal mucosal lining fluid, and global gene expression (transcriptomics) assessed in nasal mucosal curettage samples...
September 28, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27658763/preservation-of-epithelial-cell-barrier-function-and-muted-inflammation-in-resistance-to-allergic-rhinoconjunctivitis-from-house-dust-mite-challenge
#14
Sunil K Ahuja, Muthu Saravanan Manoharan, Nathan L Harper, Fabio Jimenez, Benjamin D Hobson, Hernan Martinez, Puraskar Ingale, Ya-Guang Liu, Andrew Carrillo, Zheng Lou, Dean L Kellog, Seema S Ahuja, Cynthia G Rather, Robert E Esch, Daniel A Ramirez, Robert A Clark, Kari Nadeau, Charles P Andrews, Robert L Jacobs, Weijing He
BACKGROUND: An emerging paradigm holds that resistance to the development of allergic diseases, including allergic rhinoconjunctivitis (AR), relates to an intact epithelial/epidermal barrier during early childhood. Conceivably, the immunologic and genomic footprint of this resistance is preserved in nonatopic, nonallergic adults and is unmasked during exposure to an aeroallergen. OBJECTIVE: To obtain direct support of the epithelial/epidermal barrier model for AR...
September 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27613467/administering-multiple-cumulative-allergen-challenges-an-alternative-nasal-allergen-challenge-protocol-for-the-allergic-rhinitis-clinical-investigator-collaborative
#15
Mena Soliman, Lisa Steacy, Jenny Thiele, Dan Adams, Helen Neighbour, Anne K Ellis
No abstract text is available yet for this article.
September 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27605897/specific-immunotherapy-with-mugwort-pollen-allergoid-reduce-bradykinin-release-into-the-nasal-fluid
#16
Radoslaw Gawlik, Alicja Grzanka, Barbara Jawor, Eugeniusz Czecior
INTRODUCTION: A pathomechanism of allergic rhinitis is complex. A neurogenic mechanism seems to play a significant role in this phenomenon. AIM: The evaluation of influence of specific immunotherapy of mugwort pollen allergic patients on the bradykinin concentration in the nasal lavage fluid. MATERIAL AND METHODS: The study included 22 seasonal allergic rhinitis patients. Thirty persons with monovalent allergy to mugwort pollen, confirmed with skin prick tests and allergen-specific immunoglobulin E, underwent a 3-year-long allergen immunotherapy with the mugwort extract (Allergovit, Allergopharma, Germany)...
August 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27598620/modified-high-molecular-weight-hyaluronan-promotes-allergen-specific-immune-tolerance
#17
John A Gebe, Koshika Yadava, Shannon M Ruppert, Payton Marshall, Paul Hill, Ben A Falk, Johanna M Sweere, Hongwei Han, Gernot Kaber, Carlos Medina, Katalin Mikecz, Steven F Ziegler, Swathi Balaji, Sundeep G Keswani, Vinicio A de Jesus Perez, Manish J Butte, Kari Nadeau, William A Altemeier, Neil Fanger, Paul L Bollyky
The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan (HMW-HA), typical of uninflamed tissues, is known to suppress inflammation. We investigated whether HMW-HA can be adapted to promote tolerance to airway allergens. HMW-HA was thiolated to prevent its catabolism and was tethered to allergens via thiol linkages. This platform, which we call "XHA," delivers antigenic payloads in the context of antiinflammatory costimulation...
January 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27456597/a-clinical-trial-of-a-microcrystalline-cellulose-topical-nasal-spray-on-the-acute-response-to-allergen-challenge
#18
Marianella Paz Lansberg, Marcy DeTineo, James Lane, Jayant M Pinto, Fuad M Baroody, Robert M Naclerio
BACKGROUND: Allergic rhinitis is a common disorder that leads to a negative impact on quality of life. Multiple options are available for treatment of the symptoms, but preventing the reaction should be an effective strategy. OBJECTIVE: We tested a nasal spray that contained microcrystalline cellulose designed to limit airborne allergens from penetrating the nasal mucosa (nasal blocker) and, therefore, prevent the initiation of the allergic reaction. METHODS: We performed a randomized, double-blind, placebo-controlled, two-way crossover clinical trial with 20 subjects who had a history of seasonal grass and/or ragweed allergy symptoms...
July 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/27439024/nonallergic-rhinitis-and-lower-airway-disease
#19
REVIEW
C Rondón, G Bogas, E Barrionuevo, M Blanca, M J Torres, P Campo
In the past years, several investigators have demonstrated the existence of local nasal responses in some patients with typical allergic rhinitis symptoms but without atopy and have defined a new phenotype called local allergic rhinitis (LAR) or 'entopy'. In a percentage of LAR subjects, the upper airway disease is also associated with lower airway symptoms. After the description of this phenotype, the differential diagnosis between LAR and nonallergic rhinitis (NAR) has become a challenge for the clinician...
January 2017: Allergy
https://www.readbyqxmd.com/read/27383429/natural-killer-cell-deficits-aggravate-allergic-rhinosinusitis-in-a-murine-model
#20
Ji Heui Kim, Chang-Hoong Gong, Go Eun Choi, Sun A Kim, Hun Sik Kim, Yong Ju Jang
OBJECTIVE: Defective innate immune functions can contribute to chronic rhinosinusitis (RS). Recently, it has been reported that chronic RS patients show impaired function of natural killer (NK) cells. We investigated the role of NK cells in eosinophilic inflammation in an allergic RS mouse model. METHODS: Mice sensitized to ovalbumin (OVA) by intraperitoneal injection received nasal challenges with OVA for 5 weeks. NK cell depletion was achieved by intraperitoneal injections of anti-asialo ganglio-N-tetraosylceramide (ASGM1) antibodies 10 days before OVA sensitization and every 5 days thereafter until sacrifice...
2016: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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