Bing Wang, Chengmin Feng, Jiafeng Dang, Yanghui Zhu, Xiaomei Yang, Ting Zhang, Ruqin Zhang, Jiawen Li, Jing Tang, Chengyi Shen, Lunhua Shen, Jun Dong, Xiaoming Zhang
Intrauterine adhesions (IUA) often occur as a result of trauma to the basal layer after curettage, postpartum hemorrhage, or surgical miscarriage. Endometrial fibrosis is the primary pathological feature of IUA. The characteristic features of IUA include excessive deposition and reorganization of the extracellular matrix, replacing the normal endometrium. To prevent uterine fibrosis after injury, we prepared and evaluated a type of fibroblast suppressive hydrogel. Poly(ethylene glycol)- b -poly(l-phenylalanine) (PEBP) copolymers were successfully synthesized by ring opening polymerization of l-Phenylalanine N-carboxyanhydride, initiated by methoxy-poly(ethylene glycol)-amine...
January 11, 2021: ACS Biomaterials Science & Engineering