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https://www.readbyqxmd.com/read/28393024/biomechanics-of-sclera-crosslinked-using-genipin-in-rabbit
#1
Tai-Xiang Liu, Zheng Wang
AIM: To strengthen the biomechanics of collagen by crosslinking rabbit scleral collagen with genipin to develop a new therapy for preventing myopic progression. METHODS: Ten New Zealand rabbits were treated with 0.5 mmol/L genipin injected into the sub-Tenon's capsule in the right eyes. Untreated contralateral eyes served as the control. The treated area was cut into scleral strips measuring 4.0 mm×10.0 mm for stress-strain measurements (n=5). The remaining five treated eyes were prepared for histological examination...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392939/thinner-corneas-appear-to-have-more-striking-effects-of-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#2
Yunfei Han, Yanyun Xu, Wei Zhu, Yuling Liu, Zhen Liu, Xiaoxiao Dou, Guoying Mu
Purpose. To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus. Methods. Retrospective study. Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400 µm; group 2, 400 µm < TCT ≤ 450 µm; group 3, 450 µm < TCT ≤ 500 µm; group 4, TCT ≥ 500 µm. Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28385234/hyaluronic-acid-and-beta-cyclodextrins-films-for-the-release-of-corneal-epithelial-cells-and-dexamethasone
#3
Calogero Fiorica, Fabio Salvatore Palumbo, Giovanna Pitarresi, Flavia Bongiovì, Gaetano Giammona
In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28384251/modeling-the-efficacy-profiles-of-uv-light-activated-corneal-collagen-crosslinking
#4
Jui-Teng Lin, Da-Chuan Cheng
OBJECTIVE: Analysis of the crosslink time, depth and efficacy profiles of UV-light-activated corneal collagen crosslinking (CXL). METHODS: A modeling system described by a coupled dynamic equations are numerically solved and analytic formulas are derived for the crosslinking time (T*) and crosslinking depth (z*). The z-dependence of the CXL efficacy is numerically produced to show the factors characterizing the profiles. RESULTS: Optimal crosslink depth (z*) and maximal CXL efficacy (Ceff) have opposite trend with respective to the UV light intensity and RF concentration, where z* is a decreasing function of the riboflavin concentration (C0)...
2017: PloS One
https://www.readbyqxmd.com/read/28366375/measuring-the-depth-of-crosslinking-demarcation-line-in%C3%A2-vivo-comparison-of-methods-and-devices
#5
Andreas Thorsrud, Gunhild F Sandvik, Anne M Hagem, Liv Drolsum
PURPOSE: To assess the interrelationship of different methods of measuring the demarcation line depth after corneal collagen crosslinking (CXL). SETTING: University eye clinic, Oslo, Norway. DESIGN: Prospective case series. METHODS: Eyes having CXL for progressive keratoconus were evaluated 1 month after CXL by in vitro confocal microscopy (IVCM), optical coherence tomography (OCT), and Scheimpflug imaging. When applying IVCM, the depth of the CXL demarcation line was measured with 2 methods; that is, IVCM keratocyte disappearance and IVCM intensity increase...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28341606/safety-and-efficacy-of-sequential-intracorneal-ring-segment-implantation-and-crosslinking-in-pediatric-keratoconus
#6
Youssef Abdelmassih, Sylvain El-Khoury, Ali Dirani, Rafic Antonios, Ali Fadlallah, Carole G Cherfan, Elias Chelala, Elias F Jarade
PURPOSE: To evaluate the safety and visual outcome of intracorneal ring segment (ICRS) implantation followed by crosslinking in pediatric keratoconus patients. DESIGN: Retrospective interventional case series METHODS: This retrospective study included pediatric patients (≤14 years) with keratoconus and poor corrected distance visual acuity (CDVA) that underwent ICRS implantation and crosslinking (CXL). ICRS were inserted under topical anesthesia after creating a corneal tunnel with an Intralase femtosecond laser...
March 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28336222/evaluation-of-the-shifting-of-the-line-of-sight-and-higher-order-aberrations-of-eyes-with-keratoconus-after-corneal-cross-linking
#7
Pinar Kosekahya, Mustafa Koc, Kemal Tekin, Murat Uzel, Cemile Ucgul Atilgan, Mehtap Caglayan, Pelin Yilmazbas
AIM: To evaluate changes in the coordinates of the line of sight (LoS) and higher order aberrations (HOAs) of eyes with keratoconus, following corneal cross-linking (CXL). METHODS: All patients (93 eyes) underwent detailed ophthalmologic examination and Pentacam HR measurements at baseline and at 3, 6, and 12 months after corneal CXL. LoS coordinates on the horizontal (x) and vertical (y) axes, vertical coma, vertical trefoil, spherical aberration, total root-mean square (RMS), and HOA-RMS values were recorded along with visual acuity and topographical parameters...
March 20, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28317666/transepithelial-crosslinking-retreatment-of-progressive-corneal-ectasia-unresponsive-to-classic-crosslinking
#8
Roy S Rubinfeld, Rachel H Epstein, Parag A Majmudar, Deborah Kim, Michael Choi, Randy J Epstein
A 41-year-old man presented 10 years after uneventful laser in situ keratomileusis (LASIK) with symptomatic post-LASIK ectasia. He had treatment with the classic Dresden epithelium-off technique and presented 4 years later with progression of the ectasia. He was subsequently retreated with conductive keratoplasty (CK) followed by a new proprietary epithelium-on corneal collagen crosslinking (CXL) procedure using a proprietary transepithelial riboflavin formulation and delivery system on the following day...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28272223/outcomes-of-corneal-crosslinking-for-central-and-paracentral-keratoconus
#9
COMPARATIVE STUDY
Mingxia Tian, Ping Ma, Weiyan Zhou, Jie Feng, Guoying Mu
BACKGROUND: The aim of the study was to compare the therapy of corneal collagen crosslinking (CXL) for central and paracentral keratoconus. METHODS: 64 eyes of 43 central keratoconus patients whose highest power of the cornea located in the central 3 mm zone and 24 eyes of 16 paracentral keratoconus patients whose highest power located out of the central 3 mm zone received standard corneal CXL were included. Maximum keratometry (Kmax) and astigmatism according to topography, uncorrected distant visual acuity (UDVA), corrected distant visual acuity (CDVA) were studied preoperatively and 2 years postoperatively...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28196224/loss-of-tryptophan-fluorescence-correlates-with-mechanical-stiffness-following-photo-crosslinking-treatment-of-rabbit-cornea
#10
Maura Williams, William Lewis, Walfre Franco
Purpose: A clinical treatment option for keratoconus involves the use of UV-initiated photo-crosslinking with riboflavin to increase corneal stiffness. Our study investigates whether endogenous fluorescence changes following treatment for keratoconus can be correlated to alterations in the stiffness of the cornea, thereby guiding treatment of keratoconus. Methods: A total of 78 ex vivo rabbit eyes were treated with either riboflavin-dextran solution plus UV light, dextran solution plus UV light, or riboflavin-dextran solution only for half treatment (2...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28192838/topography-guided-prk-and-crosslinking-in-eyes-with-keratoconus-and-post-lasik-ectasia
#11
T M Müller, A P Lange
Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28106466/phototoxic-effect-of-topical-fluoroquinolones-administered-before-corneal-crosslinking-in-a-murine-model
#12
Victor E Reviglio, Matias Osaba, Gabriela Sambuelli, Irene C Kuo
PURPOSE: Corneal crosslinking by UV light (UV-CXL) has become a popular treatment for keratoconus and corneal ectasia. Fluoroquinolones (FQs), commonly administered topically before UV-CXL, are known to be phototoxic to the skin and lens. The purpose of this study was to investigate phototoxic effects of topical FQ treatment on murine corneas before UV-CXL, in which the corneal epithelium was kept intact. METHODS: Murine corneas were treated with various antibiotics with or without riboflavin before UV-CXL...
March 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28101423/assessing-the-effects-of-riboflavin-uv-a-crosslinking-on-porcine-corneal-mechanical-anisotropy-with-optical-coherence-elastography
#13
Manmohan Singh, Jiasong Li, Zhaolong Han, Raksha Raghunathan, Achuth Nair, Chen Wu, Chih-Hao Liu, Salavat Aglyamov, Michael D Twa, Kirill V Larin
In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28079590/the-evaluation-of-corneal-fragility-after-uva-riboflavin-crosslinking
#14
Zhiwei Li, Yumeng Wang, Yanyun Xu, Vishal Jhanji, Chunxiao Zhang, Guoying Mu
PURPOSE: To evaluate the fragility of cornea after UVA/riboflavin crosslinking (CXL). METHODS: Sixty New Zealand rabbits received UVA/riboflavin crosslinking treatment (wavelength 365 nm, irradiance 3.0 mW/cm, and total dose 5.4 J/cm) on right eyes. Animals were sacrificed before and immediately after treatment (day 0), day 1, 3, 7, and 28 after treatment. A 4×10 mm corneal strip for biomechanical evaluation was harvested after sacrifice. The corneal fragility was evaluated by measurement of elongation rate, whereby the elongation rate equals elongation length/baseline length...
January 10, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#15
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27956294/nonlinear-optical-corneal-collagen-crosslinking-of-ex%C3%A2-vivo-rabbit-eyes
#16
Samantha M Bradford, Donald J Brown, Tibor Juhasz, Eric Mikula, James V Jester
PURPOSE: To determine whether riboflavin-induced collagen crosslinking (CXL) could be precisely achieved in the corneal stroma of ex vivo rabbit eyes using nonlinear optical excitation with a low numerical aperture lens and enlarged focal volume. SETTING: Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA. DESIGN: Experimental study. METHODS: The corneal epithelium was removed and the corneas were soaked in 0...
November 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27926752/corneal-resistance-to-keratolysis-after-collagen-crosslinking-with-rose-bengal-and-green-light
#17
Ali Fadlallah, Hong Zhu, Samer Arafat, Irene Kochevar, Samir Melki, Joseph B Ciolino
Purpose: The purpose of this study was to evaluate the resistance to degradation by collagenase A of corneas that have been crosslinked with Rose Bengal and green light (RGX). Methods: The ex vivo crosslinking procedure was performed on enucleated rabbit corneas. Corneas were deepithelialized after applying 30% alcohol. Corneas were stained with Rose Bengal (RB, 0.1%) for 2 minutes and then exposed to green light (532 nm) at 0.25 W/cm2 for times to deliver doses of 50, 100, 150, or 200 J/cm2 (n = 5 per group)...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27718530/anti-angiogenic-potential-of-vegf-blocker-dendron-loaded-on-to-gellan-gum-hydrogels-for-tissue-engineering-applications
#18
Valeria Perugini, Anna L Guildford, Joana Silva-Correia, Joaquim M Oliveira, Steven T Meikle, Rui L Reis, Matteo Santin
Damage of non-vascularised tissues such as cartilage and cornea can result in healing processes accompanied by a non-physiological angiogenesis. Peptidic aptamers have recently been reported to block the vascular endothelial growth factor (VEGF). However, the therapeutic applications of these aptamers are limited due to their short half-life in vivo. In this work, an enhanced stability and bioavailability of a known VEGF blocker aptamer sequence (WHLPFKC) was pursued through its tethering of molecular scaffolds based on hyperbranched peptides, the poly(ɛ-lysine) dendrons, bearing three branching generations...
October 8, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27710923/in-vitro-characterization-of-electrochemically-compacted-collagen-matrices-for-corneal-applications
#19
Vipuil Kishore, Ranjani Iyer, Athela Frandsen, Thuy-Uyen Nguyen
Loss of vision due to corneal disease is a significant problem worldwide. Transplantation of donor corneas is a viable treatment option but limitations such as short supply and immune-related complications call for alternative options for the treatment of corneal disease. A tissue engineering-based approach using a collagen scaffold is a promising alternative to develop a bioengineered cornea that mimics the functionality of native cornea. In this study, an electrochemical compaction method was employed to synthesize highly dense and transparent collagen matrices...
October 6, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27613085/characterization-of-rabbit-corneas-subjected-to-stromal-stiffening-by-the-a%C3%A3-a%C3%A3-extract-euterpe-oleracea
#20
Patrícia A Bersanetti, Tatiane L N Bueno, Andreia de A Morandim-Giannetti, Regina F Nogueira, Jivaldo R Matos, Paulo Schor
PURPOSE: In this study, we characterized rabbit corneas subjected to corneal cross-linking (CXL) with açaí extract compared with a riboflavin photo-stimulated procedure. MATERIALS AND METHODS: The corneas of the slaughterhouse rabbits were divided into three groups: control, consisting of untreated corneal samples; riboflavin/UVA, where corneas were treated with 0.1% riboflavin photo-stimulated at 365 nm as the standard protocol; and açaí, where the samples were subjected to 4% açaí extract for 0...
September 9, 2016: Current Eye Research
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