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https://www.readbyqxmd.com/read/29787746/two-photon-microscopy-of-fungal-keratitis-affected-rabbit-cornea-ex-vivo-using-moxifloxacin-as-a-labeling-agent
#1
Jun Ho Lee, Viet-Hoan Le, Seunghun Lee, Jin Hyoung Park, Jin Ah Lee, Hungwon Tchah, Sungjee Kim, Myoung Joon Kim, Ki Hean Kim
Two-photon microscopy (TPM) is a three dimensional (3D) microscopic technique based on nonlinear two-photon fluorescence, which has been tested as an alternative to reflectance confocal microscopy (RCM) for detecting fungal keratitis via optical imaging. Although TPM provided images with better contrast than RCM for fungal keratitis, its imaging speed was relatively low because of weak intrinsic signal. Moxifloxacin, a Food and Drug Administration (FDA)-approved antibiotic, was recently used as a cell-labeling agent for TPM...
May 19, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29781927/a-case-of-corneal-neovascularization-misdiagnosed-as-total-limbal-stem-cell-deficiency
#2
Qihua Le, C Michael Samson, Sophie X Deng
PURPOSE: To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). METHODS: This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29780928/spontaneous-regression-of-epithelial-downgrowth-from-clear-corneal-phacoemulsification-wound
#3
Ryan M Jaber, Mark Harrod, Jeffrey M Goshe
Purpose: To report a case of spontaneous regression of optical coherence tomography (OCT) and confocal microscopy-supported epithelial downgrowth associated with clear corneal phacoemulsification wound. Observations: A 66-year-old Caucasian male presented two years after phacoemulsification in the left eye with an enlarging cornea endothelial lesion in that eye. His early post-operative course had been complicated by corneal edema and iris transillumination defects...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29771882/-morphological-changes-of-cornea-in-children-with-hyperopia-in-the-immediate-and-remote-postoperative-period-after-laser-keratomieleusis-according-to-confocal-microscopy-data
#4
I L Kulikova, N P Pashtaev, O V Shlenskaya
Studying morphological changes of cornea in the remote postoperative period is becoming increasingly relevant with refractive surgeries being adapted for children. PURPOSE: comparative analysis of keratocyte density and hystomorphologic changes of cornea after laser in situ keratomieleusis (LASIK) and femtosecond laser-assisted LASIK (FS-LASIK) in children with hyperopia. MATERIAL AND METHODS: 109 patients aged 6-17 years in 2 groups were examined with 'Confoscan-4' confocal microscope...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29750121/-in-vivo-confocal-microscopic-observations-of-vortex-keratopathy-in-patients-with-amiodarone-induced-keratopathy-and-fabry-disease
#5
Yasuhito Ikegawa, Atsushi Shiraishi, Yasuhito Hayashi, Akiyoshi Ogimoto, Yuichi Ohashi
Purpose: To compare the morphology of two types of vortex keratopathy: amiodarone-induced keratopathy and the Fabry disease-associated keratopathy. Patients and Methods: Eight patients who were receiving oral amiodarone therapy and 3 patients with Fabry disease, a mother and her 2 daughters, were examined by slit-lamp biomicroscopy and in vivo confocal microscopy (IVCM) regularly. Results: Amiodarone-induced keratopathy developed in 7 of the 8 patients, and it was detected as early as 7 days by IVCM and 14 days by slit-lamp biomicroscopy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29749384/3d-confocal-laser-scanning-microscopy-for-large-area-imaging-of-the-corneal-subbasal-nerve-plexus
#6
Stephan Allgeier, Andreas Bartschat, Sebastian Bohn, Sabine Peschel, Klaus-Martin Reichert, Karsten Sperlich, Marcus Walckling, Veit Hagenmeyer, Ralf Mikut, Oliver Stachs, Bernd Köhler
The capability of corneal confocal microscopy (CCM) to acquire high-resolution in vivo images of the densely innervated human cornea has gained considerable interest in using this non-invasive technique as an objective diagnostic tool for staging peripheral neuropathies. Morphological alterations of the corneal subbasal nerve plexus (SNP) assessed by CCM have been shown to correlate well with the progression of neuropathic diseases and even predict future-incident neuropathy. Since the field of view of single CCM images is insufficient for reliable characterisation of nerve morphology, several image mosaicking techniques have been developed to facilitate the assessment of the SNP in large-area visualisations...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29746818/lymphatic-markers-in-the-human-optic-nerve
#7
A Trost, C Runge, D Bruckner, A Kaser-Eichberger, B Bogner, C Strohmaier, H A Reitsamer, F Schroedl
Tissues of the central nervous system (CNS), including the optic nerve (ON), are considered a-lymphatic. However, lymphatic structures have been described in the dura mater of human ON sheaths. Since it is known that lymphatic markers are also expressed by single non-lymphatic cells, these results need confirmation according to the consensus statement for the use of lymphatic markers in ophthalmologic research. The aim of this study was to screen for the presence of lymphatic structures in the adult human ON using a combination of four lymphatic markers...
May 7, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29728238/a-fully-automated-cell-segmentation-and-morphometric-parameter-system-for-quantifying-corneal-endothelial-cell-morphology
#8
Shumoos Al-Fahdawi, Rami Qahwaji, Alaa S Al-Waisy, Stanley Ipson, Maryam Ferdousi, Rayaz A Malik, Arun Brahma
BACKGROUND AND OBJECTIVE: Corneal endothelial cell abnormalities may be associated with a number of corneal and systemic diseases. Damage to the endothelial cells can significantly affect corneal transparency by altering hydration of the corneal stroma, which can lead to irreversible endothelial cell pathology requiring corneal transplantation. To date, quantitative analysis of endothelial cell abnormalities has been manually performed by ophthalmologists using time consuming and highly subjective semi-automatic tools, which require an operator interaction...
July 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29722121/in-vivo-confocal-microscopy-characteristics-of-equine-epithelial-and-subepithelial-nonulcerative-keratomycosis
#9
Eric C Ledbetter, Nita L Irby, Leandro B C Teixeira
OBJECTIVE: To describe the in vivo confocal microscopy features of horses with epithelial and subepithelial nonulcerative keratomycosis. ANIMALS STUDIED: Four horses with a clinical diagnosis of epithelial or subepithelial keratomycosis. PROCEDURES: Horses were examined on one or more occasions by in vivo laser scanning confocal microscopy of the cornea. Confocal microscopic examination characteristics were correlated with clinical, cytological, and histopathological findings for the horses...
May 2, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29703291/continuous-light-versus-pulsed-light-accelerated-corneal-crosslinking-with-ultraviolet-a-and-riboflavin
#10
Yirui Zhu, Peter S Reinach, Hanlei Zhu, Ling Li, Fan Yang, Jia Qu, Wei Chen
PURPOSE: To determine whether the pulsed-light ultraviolet-A (UVA) accelerated corneal crosslinking (CXL) procedure is more efficacious and selective than its continuous-light counterpart in rabbits. SETTING: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. DESIGN: Experimental study. METHODS: Fifty-four rabbits were divided into 2 groups. Group 1 had continuous-light accelerated CXL using 9 mW/cm2 UVA for 10 minutes (5...
March 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29682341/corneal-subbasal-nerve-recovery-in-an-acute-case-of-ultraviolet-keratitis-treated-with-autologous-serum-eye-drops
#11
Farshad Abedi, Pedram Hamrah
Purpose: To report degeneration of subbasal corneal nerves and the subsequent neuroregeneration in a case of acute ultraviolet (UV) keratitis, treated with autologous serum eye drops. Methods: Case report. Results: A 37-year-old female presented with ocular discomfort and blurred vision in both eyes, after exposure to UV-C light in a laboratory. On exam, she had bilateral conjunctival injection and superficial punctate keratitis (SPK), worse in the left, consistent with acute, bilateral, but asymmetric UV-C keratitis...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29668572/atypical-presentation-of-iridocorneal-endothelial-syndrome-with-band-keratopathy-but-no-corneal-edema-managed-with-descemet-membrane-endothelial-keratoplasty
#12
Vasiliki Zygoura, Itay Lavy, Robert M Verdijk, Diana Santander-García, Lamis Baydoun, Isabel Dapena, Gerrit R J Melles
PURPOSE: To report an unusual presentation of iridocorneal endothelial (ICE) syndrome associated with band keratopathy and its management with ethylenediamine-tetraacetic acid (EDTA) chelation and Descemet membrane endothelial keratoplasty (DMEK). METHODS: A 57-year-old female patient presented with unilateral progressive painless visual impairment, corneal band keratopathy, and morphological corneal endothelial changes without corneal edema or any previous ophthalmic, medical, or family history...
April 17, 2018: Cornea
https://www.readbyqxmd.com/read/29627838/assessment-of-corneal-changes-associated-with-topical-antiglaucoma-therapy-using-in-vivo-confocal-microscopy
#13
Elmira Baghdasaryan, Tudor C Tepelus, Laura A Vickers, Ping Huang, Vikas Chopra, SriniVas R Sadda, Olivia L Lee
PURPOSE: Ocular surface disease (OSD) is highly prevalent in eyes treated with chronic, topical antiglaucoma (A/G) therapy. The purpose of this study was to utilize in vivo confocal microscopy (IVCM) to evaluate the corneal morphology, including characteristics of corneal epithelial cells, presence of epithelial dendritic cells (DCs), and characteristics of subbasal nerve plexus, of eyes under topical A/G therapy versus normal eyes. METHODS: Central corneal images were prospectively captured from 30 eyes of 16 patients under topical A/G therapy (>6 months) and 20 normal control eyes, using IVCM (HRT 3 RCM, Heidelberg, Germany)...
April 7, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29621511/spectral-domain-optical-coherence-tomography-in-limbal-stem-cell-deficiency-a-case-control-study
#14
Nilly Banayan, Cristina Georgeon, Kate Grieve, Vincent M Borderie
PURPOSE: To evaluate the efficacy of optical coherence tomography as a non-contact method for imaging the ocular surface in limbal stem cell deficiency (LSCD) and normal eyes. DESIGN: Retrospective case-control study. METHODS: SETTING: Institutional. STUDY POPULATION: 22 eyes with LSCD (study group, 22 patients) and 10 normal eyes (control group, 10 patients). OBSERVATION PROCEDURES: SD-OCT and confocal microscopy in both the limbal and central corneal zones...
April 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29604391/macular-corneal-dystrophy-a-review
#15
REVIEW
Shruti Aggarwal, Travis Peck, Jeffrey Golen, Zeynel A Karcioglu
Macular corneal dystrophy (MCD) is a corneal stromal dystrophy which leads to progressive vision loss. MCD is an autosomal recessive condition in which there is abnormality of proteoglycan synthesis. Mutations in the carbohydrate sulphotransferase gene (CHST6) prevent normal sulfation of corneal keratan. Different immunophenotypes have been described depending on the presence of keratan sulfate in cornea and or serum. The deposition of abnormal proteoglycans leads to loss of corneal transparency and decreased vision...
March 28, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29567259/in-vitro-and-in-vivo-assessment-of-delivery-of-hydrophobic-molecules-and-plasmid-dnas-with-peo-ppo-peo-polymeric-micelles-on-cornea
#16
Feichin Hsiao, Po-Yang Huang, Takao Aoyagi, Shwu-Fen Chang, Jiahorng Liaw
The stability and bio-distribution of genes or drug complexes with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, Pluronic F-68) polymeric micelles (PM) are essential for an effective nanosized PM delivery system. We used Förster resonance energy transfer (FRET) pairs with PM and measured the FRET ratio to assess the stability of PM in vitro and in vivo on the cornea. The FRET ratio reached a plateau at 0.8 with 3% PM. Differential scanning calorimetry measurement confirmed the complex formation of FRET pairs with PM...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29561408/keratectasia-after-laser-assisted-subepithelial-keratectomy-for-myopia-a-case-report
#17
Qinghong Lin, Lin Zheng, Xiumei Lin, Qian Wang
RATIONALE: Recently, some ophthalmologists performed PRK or LASEK surgeries in FFKC suspicious patients, which is supposed to prevent FFKC evolvement via fibrotic scar formation. Our report indicates that keratectasia can occur after LASEK in FFKC suspicious patients, highlighting the importance of stricter regulation of patient recruitment before the procedure and postoperative follow-up. PATIENT CONCERNS: This is a report of a 25-year-old man with poor corrected distance visual acuity (CDVA) 6 years after LASEK...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29554816/ocular-surface-alterations-and-in-vivo-confocal-microscopic-characteristics-of-corneas-in-patients-with-myasthenia-gravis
#18
Kadriye Erkan Turan, Sibel Kocabeyoglu, Can Ebru Bekircan-Kurt, Figen Bezci, Sevim Erdem-Ozdamar, Murat Irkec
PURPOSE: To evaluate ocular surface alterations and characteristics of corneal basal epithelium and subbasal nerves in patients with myasthenia gravis. MATERIALS AND METHODS: Myasthenia gravis patients (n = 21) and healthy controls (n = 20) were enrolled. All participants underwent ocular surface testing in the following order: tear break-up time, lissamine green staining, Schirmer I test with anesthesia, and Ocular Surface Disease Index questionnaire. The Cochet-Bonnet esthesiometer was used to measure corneal sensitivity...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29550279/recovery-of-the-sub-basal-nerve-plexus-and-superficial-nerve-terminals-after-corneal-epithelial-injury-in-mice
#19
Laura E Downie, Cecilia Naranjo Golborne, Merry Chen, Ngoc Ho, Cam Hoac, Dasun Liyanapathirana, Carol Luo, Ruo Bing Wu, Holly R Chinnery
Our aim was to compare regeneration of the sub-basal nerve plexus (SBNP) and superficial nerve terminals (SNT) following corneal epithelial injury. We also sought to compare agreement when quantifying nerve parameters using different image analysis techniques. Anesthetized, female C57BL/6 mice received central 1-mm corneal epithelial abrasions. Four-weeks post-injury, eyes were enucleated and processed for PGP9.5 to visualize the corneal nerves using wholemount immunofluorescence staining and confocal microscopy...
June 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29547658/the-corneal-epitheliotrophic-abilities-of-lyophilized-powder-form-human-platelet-lysates
#20
Lily Wei Chen, Chien-Jung Huang, Wen-Hui Tu, Chia-Ju Lu, Yi-Chen Sun, Szu-Yuan Lin, Wei-Li Chen
PURPOSE: To evaluate whether lyophilized human platelet lysate (HPL) powder can preserve the growth factor concentrations and epitheliotrophic properties of liquid HPL, and potentially be used as a clinically-friendly treatment option. METHODS: Two commercialized liquid HPLs, UltraGRO TM (Helios, Atlanta, GA) and PLTMax (Mill Creek, Rochester, MI), were obtained and converted to lyophilized powder. After redissolution, lyophilized powder HPLs were compared with liquid HPLs, as well as human peripheral serum (HPS) and fetal bovine serum (FBS) in liquid or redissolved lyophilized powder forms...
2018: PloS One
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