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https://www.readbyqxmd.com/read/28346276/comparison-of-noncontact-specular-and-confocal-microscopy-for-evaluation-of-corneal-endothelium
#1
Jianyan Huang, Jyotsna Maram, Tudor C Tepelus, Srinivas R Sadda, Vikas Chopra, Olivia L Lee
PURPOSE: To compare endothelial cell analysis obtained by noncontact specular and confocal microscopy, using the Konan NSP-9900 and Nidek ConfoScan4 systems, respectively. METHODS: Three groups including 70 healthy eyes, 49 eyes with Fuchs endothelial corneal dystrophy (FECD), and 78 eyes with glaucoma were examined with both the Konan NSP-9900 specular microscope and the Nidek ConfocScan4 confocal microscope. Certified graders at the Doheny Image Reading Center compared corneal endothelial images from both instruments side by side to assess image quality...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28337063/a-novel-mutation-and-in-vivo-confocal-microscopic-findings-in-fabry-disease
#2
Cumali Degirmenci, Suzan Guven Yilmaz, Huseyin Onay, Melis Palamar, Sema Kalkan Ucar, Meral Kayikcioglu, Mahmut Coker
Fabry disease is a hereditary, X-linked lysosomal storage disease due to a deficiency of the alpha galactosidase A enzyme. Globotriaosylceramide accumulates in tissues and results in multiorgan dysfunction. The most common ocular finding in Fabry disease is cornea verticillata. Increase in conjunctival vascular tortuosity, and cataract may also be seen. Herein, we demonstrate the in vivo confocal microscopic findings of a genetically proven Fabry disease patient with a novel hemizygous R112L mutation in GLA gene...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28316191/-in-vivo-confocal-microscopic-observation-of-corneal-changes-in-patients-with-chronic-stevens-johnson-syndrome-or-toxic-epidermal-necrolysis
#3
T T Gao, Y Li, J Liu, Q Long
Objective: To describe corneal alterations visible on in vivo confocal microscopy in patients with debilitating ocular sequelae caused by Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Methods: Twenty-two eyes of 11 consecutive patients suffering from chronic SJS or TEN were studied using slit lamp and in vivo confocal microscopy in the Ophthalmology Outpatient Department of Peking Union Medical College Hospital from March 2014 to April 2015. Results: Dry eye with meibomian gland dysfunction (19 eyes of 10 patients, 86...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28302098/in-vivo-confocal-microscopy-of-pre-descemet-corneal-dystrophy-associated-with-x-linked-ichthyosis-a-case-report
#4
Hui Shi, Xiao-Feng Qi, Tao-Tao Liu, Qian Hao, Xiao-Hong Li, Ling-Ling Liang, Yi-Miao Wang, Zhi-Hua Cui
BACKGROUND: Pre-Descemet corneal dystrophy (PDCD) is characterized by the presence of numerous, tiny, polymorphic opacities immediately anterior to Descemet membrane, which is a rare form of corneal stromal dystrophy and hard to be diagnosed. In vivo confocal microscopy (IVCM) is a useful tool to examine the minimal lesions of the cornea at the cellular level. In this article, we report a rare case of PDCD associated with X-linked ichthyosis and evaluate IVCM findings. CASE PRESENTATION: We present a 34-year-old male Chinese patient with PDCD associated with X-linked ichthyosis...
March 16, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28291202/-comparative-analysis-of-the-value-of-information-provided-by-anterior-segment-optical-coherence-tomography-and-confocal-laser-scanning-microscopy-for-identifying-the-palisades-of-vogt-in-normal-limbus
#5
N P Pashtaev, N A Pozdeeva, A A Voskresenskaya, B V Gagloev, A A Shipunov
AIM: to conduct a comparative analysis of the value of information provided by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal laser scanning microscopy (CLSM) for identifying the palisades of Vogt (POV) in normal limbus. MATERIAL AND METHODS: POV were studied in 15 healthy participants (30 eyes) without any anterior segment disease. Two examination methods were used: AS-OCT En Face imaging (RTVue XR Avanti, 3D Cornea protocol) and CLSM (HRT3)...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28283769/-in-vivo-imaging-of-the-corneal-nerve-plexus-from-single-image-to-large-scale-map
#6
B Köhler, S Allgeier, A Bartschat, R F Guthoff, S Bohn, K-M Reichert, O Stachs, K Winter, R Mikut
The sub-basal nerve plexus (SNP) of the cornea provides the possibility of in vivo and non-invasive examination of peripheral nerve structures by corneal confocal microscopy (CCM). Thus morphological alterations of the SNP can be directly detected and quantified. A single CCM image is insufficient for a well-founded diagnosis because of the inhomogeneous distribution of the nerve fibers; therefore, there is a demand for techniques for large area imaging of the SNP. This article provides an overview of published approaches to the problem...
March 10, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28282739/in-vivo-confocal-microscopic-characteristics-of-crystalline-keratopathy-in-patients-with-sclerokeratitis
#7
Noopur Gupta, Anita Ganger, Shibal Bhartiya, Meena Verma, Radhika Tandon
PURPOSE: To report in vivo confocal features in a clinical case series of patients with sclerokeratitis presenting as crystalline keratopathy. METHODS: Five cases of crystalline keratopathy following sclerokeratitis are described. Confocal microscopic images of the cornea were captured in all cases to confirm the diagnosis by evaluating the morphology of the crystals. RESULTS: Unilateral and non-progressive peripheral crystalline keratopathy manifested after previous episodes of sclerokeratitis in the involved eye...
February 22, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28268563/automated-morphometric-description-of-human-corneal-endothelium-from-in-vivo-specular-and-confocal-microscopy
#8
F Scarpa, A Ruggeri
Corneal images acquired by in-vivo specular and confocal microscopy provide clinical information on the cornea endothelium health state. Indeed, the normal hexagonal shape of endothelial cells is usually affected by age and pathologies. At present, the analysis is based on manual or semi-automatic methods and the segmentation of a large number of endothelial cells is required for a meaningful estimation of the clinical parameters. We propose an automated method that detects the centers of endothelial cells by convolving the original image with customized two-dimensional kernels, derives a structure made by connected vertices from the recognized centers using the Euclidean distance, and fine-tunes the derived structure through a genetic algorithm, which combines information about the typical regularity of endothelial cells shape with the pixels intensity of the actual image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268149/corneal-nerve-microstructure-in-parkinson-s-disease
#9
Stuti L Misra, Hannah M Kersten, Richard H Roxburgh, Helen V Danesh-Meyer, Charles N J McGhee
Ocular surface changes and blink abnormalities are well-established in Parkinson's disease. Blink rate may be influenced by corneal sub-basal nerve density, however, this relationship has not yet been investigated in Parkinson's disease. This case-control study examined the ocular surface in patients with moderately severe Parkinson's disease, including confocal microscopy of the cornea. Fifteen patients with moderately severe Parkinson's disease (modified Hoehn and Yahr grade 3 or 4) and fifteen control participants were recruited...
March 3, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28264131/ex-vivo-study-of-transepithelial-corneal-cross-linking
#10
Andrea Cruzat, Anita N Shukla, Samer N Arafat, Saleh Alageel, Clara Colon, James Chodosh, Joseph B Ciolino
PURPOSE: To perform in vitro assessment of different techniques of transepithelial corneal cross-linking (CXL) and to compare the results to deepithelialized CXL. METHODS: Transepithelial CXL was performed after pre-treatment with or without penetration enhancers (gum cellulose, 0.44% sodium chloride, and 0.01% benzalkonium chloride) for 15 or 60 minutes. Deepithelialized corneas underwent CXL after pretreatment with riboflavin for 15 minutes, according to the Dresden protocol...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28258973/rapid-automated-mosaicking-of-the-human-corneal-subbasal-nerve-plexus
#11
Yash J Vaishnav, Stuart A Rucker, Keshav Saharia, Nancy A McNamara
Corneal confocal microscopy (CCM) is an in vivo technique used to study corneal nerve morphology. The largest proportion of nerves innervating the cornea lie within the subbasal nerve plexus, where their morphology is altered by refractive surgery, diabetes and dry eye. The main limitations to clinical use of CCM as a diagnostic tool are the small field of view of CCM images and the lengthy time needed to quantify nerves in collected images. Here, we present a novel, rapid, fully automated technique to mosaic individual CCM images into wide-field maps of corneal nerves...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28251081/effects-of-contact-lens-wearing-on-keratoconus-a-confocal-microscopy-observation
#12
Somnath Ghosh, Haliza A Mutalib, Sharanjeet-Kaur, Rituparna Ghoshal, Shamala Retnasabapathy
AIM: To evaluate the corneal cell morphology of new keratoconus patients wearing two different types of rigid gas-permeable (RGP) contact lenses for 1y. METHODS: Thirty nine eyes of 39 new keratoconus patients were selected and randomly fitted with two types of RGP contact lenses. Group 1 had 21 eyes with regular rigid gas-permeable (RRGP) contact lens and rest 18 eyes were in group 2 with specially designed rigid gas-permeable (SRGP) contact lens. Corneal cell morphology was evaluated using a slit scanning confocal microscope at no-lens wear and after 1y of contact lens wearing...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28226740/automated-morphometric-description-of-human-corneal-endothelium-from-in-vivo-specular-and-confocal-microscopy
#13
F Scarpa, A Ruggeri, F Scarpa, A Ruggeri, A Ruggeri, F Scarpa
Corneal images acquired by in-vivo specular and confocal microscopy provide clinical information on the cornea endothelium health state. Indeed, the normal hexagonal shape of endothelial cells is usually affected by age and pathologies. At present, the analysis is based on manual or semi-automatic methods and the segmentation of a large number of endothelial cells is required for a meaningful estimation of the clinical parameters. We propose an automated method that detects the centers of endothelial cells by convolving the original image with customized two-dimensional kernels, derives a structure made by connected vertices from the recognized centers using the Euclidean distance, and fine-tunes the derived structure through a genetic algorithm, which combines information about the typical regularity of endothelial cells shape with the pixels intensity of the actual image...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28167204/changes-in-corneal-sub-basal-nerve-morphology-and-sensitivity-during-orthokeratology-recovery-of-change
#14
Edward Lum, Blanka Golebiowski, Helen A Swarbrick
PURPOSE: To investigate the recovery of changes in corneal nerve morphology and sensitivity in orthokeratology (OK) following lens wear discontinuation, over a 3-month period. METHODS: Sixteen myopic subjects who wore OK lenses during sleep for 3 months discontinued lens wear for 3 months. Corneal nerve morphology and sensitivity were assessed 3 h after waking on the right eye only at the pre-lens wear baseline and after lens wear discontinuation. Corneal nerve fiber density (NFD) and global nerve fiber orientation (GNFO) were assessed by sampling a 1 mm(2) area of the sub-basal nerve plexus at the corneal apex and temporal mid-periphery using in vivo confocal microscopy...
February 3, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28146367/corneal-involvement-by-lichen-planus-pigmentosus
#15
Mohammad Soleimani, Seyed Ali Tabatabaei, Reza Mirshahi, Zohreh Nozarian, Amir Hasan Matini
IMPORTANCE: Lichen planus pigmentosus (LPP) is an exclusive form of lichen planus (LP) characterized by pigmentary incontinence in histopathologic slides. OBSERVATIONS: We report a known case of LPP with ocular manifestations including pigmented eyelid margins and conjunctival and corneal pigmented lesions. Histopathologic and confocal scanning findings of these lesions were compatible with the diagnosis of underlying systemic disease. CONCLUSIONS AND RELEVANCE: To our knowledge, we report the first case of cornea directly involved by LP and ophthalmic presentations of LPP...
February 1, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28139064/corneal-profile-in-primary-congenital-glaucoma
#16
Azadeh Doozandeh, Shahin Yazdani, Shabnam Ansari, Mohammad Pakravan, Tahmineh Motevasseli, Bagher Hosseini, Mehdi Yasseri
PURPOSE: To investigate biomechanical and ultrastructural corneal parameters and ocular biometrics in the affected eyes of patients with unilateral primary congenital glaucoma (PCG) as compared to unaffected fellow eyes and age-matched healthy controls. METHODS: A total of 12 patients with treated unilateral PCG and 10 normal subjects were evaluated. LENSTAR was performed to determine biometric parameters; the ocular response analyser was employed to determine biomechanical properties and slit-scanning confocal microscopy was used for evaluation of corneal ultrastucture...
January 31, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28133954/new-parameters-in-assessment-of-human-donor-corneal-stroma
#17
Marie Borderie, Kate Grieve, Kristina Irsch, Djida Ghoubay, Cristina Georgeon, Celine De Sousa, Laurent Laroche, Vincent M Borderie
PURPOSE: To provide quantitative parameters for assessment of human donor corneal stroma by imaging stromal features of diseased and normal human corneas with full-field optical coherence microscopy (FFOCM), using confocal microscopy (CM) and histology as reference techniques. METHODS: Bowman's layer (BL) thickness and keratocyte density were assessed ex vivo in 23 human donor corneas and 27 human pathological corneas (keratoconus and other corneal disorders) with FFOCM, CM and histology...
January 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28130350/in-vivo-confocal-microscopic-characteristics-of-microsporidial-keratoconjunctivitis-in-immunocompetent-adults
#18
Chintan Malhotra, Arun Kumar Jain, Savleen Kaur, Deepika Dhingra, Varshitha Hemanth, Surya Prakash Sharma
BACKGROUND/AIMS: To describe in vivo confocal microscopy (IVCM) features of microsporidial keratoconjunctivitis in immunocompetent adult patients. METHODS: Patients suspected clinically to be suffering from microsporidial keratoconjunctivitis (ie, presence of unilateral follicular and/or papillary conjunctivitis in conjunction with multifocal, coarse corneal epitheliopathy) were subjected to IVCM with the Rostock Cornea Module of the Heidelberg Retinal Tomograph 3, and combined potassium hydroxide and calcofluor white (KOH+CFW) staining of the corneal scrapings, to detect the microsporidial spores...
January 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28101726/development-of-timolol-loaded-galactosylated-chitosan-nanoparticles-and-evaluation-of-their-potential-for-ocular-drug-delivery
#19
Ruobing Zhao, Jing Li, Jingyi Wang, Zhenya Yin, Yongtao Zhu, Wei Liu
This study was conducted to develop timolol maleate (TM)-loaded galactosylated chitosan (GC) nanoparticles (NPs) (TM-GC-NPs) followed by optimization via a four-level and three-factor Box-Behnken statistical experimental design. The optimized nanoparticles showed a particle size of 213.3 ± 6.83 nm with entrapment efficiency of 38.58 ± 1.31% and drug loading of 17.72 ± 0.28%. The NPs were characterized with respect to zeta potential, pH, surface morphology, and differential scanning calorimetry (DSC)...
January 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28060067/patients-with-dry-eye-disease-and-low-subbasal-nerve-density-are-at-high-risk-for-accelerated-corneal-endothelial-cell-loss
#20
Ahmad Kheirkhah, Vannarut Satitpitakul, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate changes in corneal endothelial cell density over time in patients with dry eye disease (DED) and to correlate endothelial cell loss with corneal subbasal nerve density. METHODS: This retrospective study included 40 eyes of 20 patients with DED. Laser in vivo confocal microscopy had been performed in the central cornea of both eyes at an initial visit and repeated after a mean follow-up of 33.2 ± 10.2 months. The densities of corneal endothelial cells and subbasal nerves were measured in both visits and compared with 13 eyes of 13 normal age-matched controls...
February 2017: Cornea
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