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https://www.readbyqxmd.com/read/28731879/peripheral-endothelial-cell-count-is-a-predictor-of-disease-severity-in-advanced-fuchs-endothelial-corneal-dystrophy
#1
Zeba A Syed, Jennifer A Tran, Ula V Jurkunas
PURPOSE: In advanced Fuchs endothelial corneal dystrophy (FECD), central endothelial changes do not correlate with disease severity. The peripheral endothelial cell count (ECC) has not been studied as a marker of FECD severity. The goal of this study was to determine the relationship between the peripheral ECC and known clinical markers of FECD in advanced cases. METHODS: Patients with FECD examined between January 1, 2013, and September 1, 2016, by 1 cornea specialist were identified...
July 19, 2017: Cornea
https://www.readbyqxmd.com/read/28698011/clinical-and-morphological-manifestations-of-aniridia-associated-keratopathy-on-anterior-segment-optical-coherence-tomography-and-in-vivo-confocal-microscopy
#2
Anna Voskresenskaya, Nadezhda Pozdeyeva, Tatyana Vasilyeva, Yevgeniy Batkov, Aleksandr Shipunov, Boris Gagloev, Rena Zinchenko
PURPOSE: The study aimed to evaluate clinical and morphological changes in the limbal palisades of Vogt (POV) at different stages of aniridia-associated keratopathy (AAK) and to assess possible utility of anterior segment optical coherence tomography (AS-OCT) for the visualization of limbal progenitor structures as it correlates to laser scanning confocal microscopy (LSCM) data. METHODS: The study involved 32 patients (59 eyes) with congenital aniridia. AAK stage was defined based on biomicroscopy...
July 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28679130/efficacy-of-2-month-treatment-with-cord-blood-serum-eye-drops-in-ocular-surface-disease-an-in-vivo-confocal-microscopy-study
#3
Giuseppe Giannaccare, Marina Buzzi, Michela Fresina, Claudio Velati, Piera Versura
PURPOSE: To investigate the morphological changes of corneal epithelium and subbasal nerves by in vivo confocal microscopy in patients with ocular surface disease (OSD) treated with cord blood serum (CBS) eye drops. METHODS: Twenty patients with OSD (mean age 61.1 ± 12.6 years) were included in this prospective 1-arm study and treated with CBS eye drops for 2 months. Corneal sensitivity, Schirmer test score, breakup time, subjective symptoms [Ocular Surface Disease Index (OSDI) and Visual Analogue Scale (VAS)], and corneal staining were evaluated before (T0) and after (T1) treatment...
August 2017: Cornea
https://www.readbyqxmd.com/read/28666677/microstructural-evaluation-of-the-mucin-balls-and-their-relations-to-the-corneal-surface-insights-by-in-vivo-confocal-microscopy
#4
Christina N Grupcheva, Dimitar I Grupchev, Mladena N Radeva, Desislava I Vankova, Yana M Manolova
PURPOSE: The purpose of the current study was to observe and correlate the characteristics of mucin balls to the ocular surface properties, and furthermore, to report the effect of different mucin balls size and number on structural alteration of the anterior cornea. METHODS: The study included, two groups of patients fitted with one-month continuous, extended wear lenses for therapeutic (group 1) and optical (group 2) purposes; the later serving as a control group...
June 27, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28656670/the-corneal-nerve-density-in-the-sub-basal-plexus-decreases-with-increasing-myopia-a-pilot-study
#5
Wendy W Harrison, Nicole M Putnam, Christine Shukis, Evelyn Nguyen, Kristen Reinard, Elizabeth Hundelt, Galina Vardanyan, Celine Gabai, Vladimir Yevseyenkov
PURPOSE: Myopia can cause many changes in the health of the eye. As it becomes more prevalent worldwide, more patients seek correction in the form of glasses, contact lenses and refractive surgery. In this study we explore the impact that high myopia has on central corneal nerve density by comparing sub basal nerve plexus density measured by confocal microscopy in a variety of refractive errors. METHODS: Seventy healthy adult subjects between the ages of 21-50 years participated in this study...
July 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#6
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28562149/in-vivo-laser-confocal-microscopy-using-the-hrt-rostock-cornea-module-diversity-and-diagnostic-implications-in-patients-with-uveitis
#7
Lyndell L Lim, Jing Xie, Chyn C Chua, Tiffany Wong, Lani T Hoang, Matthias D Becker, Eric B Suhler, James T Rosenbaum, Friederike Mackensen
PURPOSE: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. METHODS: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. RESULTS: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis...
May 31, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28548209/improved-sampling-and-analysis-of-images-in-corneal-confocal-microscopy
#8
E L Schaldemose, F I Fontain, P Karlsson, J R Nyengaard
INTRODUCTION: Corneal confocal microscopy (CCM) is a noninvasive clinical method to analyse and quantify corneal nerve fibres in vivo. Although the CCM technique is in constant progress, there are methodological limitations in terms of sampling of images and objectivity of the nerve quantification. The aim of this study was to present a randomized sampling method of the CCM images and to develop an adjusted area-dependent image analysis. Furthermore, a manual nerve fibre analysis method was compared to a fully automated method...
May 26, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28542085/quantitative-analysis-of-depth-distribution-and-density-of-cysts-in-acanthamoeba-keratitis-using-confocal-microscopy
#9
Ping Huang, Tudor Tepelus, Laura A Vickers, Elmira Baghdasaryan, Jianyan Huang, John A Irvine, Hugo Y Hsu, Srinivas Sadda, Olivia L Lee
PURPOSE: To quantify the density, distribution, and depth of invasion of cysts in the corneas of eyes with acanthamoeba keratitis (AK) by in vivo confocal microscopy (IVCM) with a novel scanning pattern. METHODS: The medical records of patients with AK evaluated at the Doheny Eye Center UCLA between September 2014 and July 2016 were reviewed retrospectively. Patients with clinically diagnosed AK underwent IVCM at various time points during their clinical course...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28528377/correlation-between-corneal-innervation-and-inflammation-evaluated-with-confocal-microscopy-and-symptomatology-in-patients-with-dry-eye-syndromes-a-preliminary-study
#10
Tudor C Tepelus, Gloria B Chiu, Jianyan Huang, Ping Huang, SriniVas R Sadda, John Irvine, Olivia L Lee
PURPOSE: To evaluate corneal innervation and inflammatory cell infiltration using in vivo confocal microscopy (IVCM) and to correlate these findings with subjective symptoms of dry eye, as measured by the Ocular Surface Disease Index (OSDI) in patients with non-Sjögren's (NSDE) and Sjögren's syndrome dry eyes (SSDE). METHODS: Central corneal images were prospectively captured from 10 age-matched healthy control eyes, 24 eyes with clinically diagnosed NSDE and 44 eyes with clinically diagnosed SSDE, using IVCM (HRT III RCM)...
May 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28524144/-new-approaches-to-the-treatment-of-keratoconjunctivitis-sicca
#11
T N Safonova, O V Gladkova, I A Novikov, V I Boev, A A Fedorov
A new method has been developed for the treatment of severe forms of keratoconjunctivitis sicca (KCS) that involves the use of an original cyclosporine A (CyA) saturated soft contact lens (SCL) together with preservative-free artificial tears therapy. AIM: to evaluate the effectiveness of the newly developed treatment for KCS based on the use of medical SCL saturated with 0.05% CyA. MATERIAL AND METHODS: The patients (43 men, 60 eyes) with severe KCS were divided into 2 groups...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28486719/customized-topography-guided-corneal-collagen-cross-linking-for-keratoconus
#12
Myriam Cassagne, Kévin Pierné, Stéphane D Galiacy, Marie-Pierre Asfaux-Marfaing, Pierre Fournié, François Malecaze
PURPOSE: To compare the efficacy and safety of topography-guided corneal collagen cross-linking (TG-CXL) to conventional corneal CXL (C-CXL) in progressive keratoconus. METHODS: In this prospective, nonrandomized clinical trial, 60 eyes of 60 patients were scheduled to receive either TG-CXL (30 eyes with deepithelialization focused on the cone, riboflavin application for 10 minutes, and 30 mW/cm(2) pulsed ultraviolet-A irradiance pattern according to topography) or C-CXL (30 eyes treated in accordance with the Dresden protocol)...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28480834/the-conjunctiva-associated-lymphoid-tissue-in-chronic-ocular-surface-diseases
#13
Rodolfo Mastropasqua, Luca Agnifili, Vincenzo Fasanella, Mario Nubile, Agbeanda A Gnama, Gennaro Falconio, Paolo Perri, Silvio Di Staso, Cesare Mariotti
Ocular surface diseases (OSDs) represent a widely investigated field of research given their growing incidence and the negative impact on quality of life. During OSDs, cytokines generated by damaged epithelia trigger and deregulate the lymphoid cells composing the eye-associated lymphoid tissues, inducing an immune-mediated chronic inflammation that amplifies and propagates the disease during time. The conjunctiva-associated lymphoid tissue (CALT), given its particular position that permits immune cells covering the cornea, might play a crucial role in the development of OSDs...
May 8, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28475703/cibinetide-improves-corneal-nerve-fiber-abundance-in-patients-with-sarcoidosis-associated-small-nerve-fiber-loss-and-neuropathic-pain
#14
RANDOMIZED CONTROLLED TRIAL
Daniel A Culver, Albert Dahan, Daiva Bajorunas, Maria Jeziorska, Monique van Velzen, Leon P H J Aarts, Jinny Tavee, Martijn R Tannemaat, Ann N Dunne, Rita I Kirk, Ioannis N Petropoulos, Anthony Cerami, Rayaz A Malik, Michael Brines
Purpose: Sarcoidosis frequently is complicated by small nerve fiber loss (SNFL), which can be quantified using corneal confocal microscopy (CCM). Prior studies suggest that the innate repair receptor agonist cibinetide reverses corneal nerve loss. This phase 2b, 28-day, randomized trial of 64 subjects with sarcoid-associated SNFL and neuropathic pain assessed the effect of cibinetide on corneal nerve fiber area (CNFA) and regenerating intraepidermal fibers (GAP-43+) as surrogate endpoints for disease modification, pain severity, and functional capacity (6-minute walk test [6MWT])...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28458451/characteristics-of-corneal-phospholipidosis-induced-by-topical-ocular-application-of-chloroquine-and-amiodarone-in-rabbits
#15
Yoshinori Yamagiwa, Yu Haranosono, Shingo Nemoto, Ikuyo Atsumi, Masaaki Kurata, Gakushi Kito, Hirofumi Hatakeyama, Haruko Koizumi, Hideyuki Sakaki
Several cationic-amphiphilic drugs such as chloroquine and amiodarone are known to induce phospholipidosis in the cornea by systemic administration. However, the characteristics of ophthalmological and pathological changes when phospholipidosis-inducing drugs are topically applied have not been well studied. This study was conducted to investigate the characteristics of corneal changes caused by topical application of chloroquine and amiodarone to Japanese white rabbits. The changes were evaluated by ophthalmological, histopathological, and ultrastructural examinations...
April 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28445703/sensitivity-and-specificity-of-laser-scanning-in%C3%A2-vivo-confocal-microscopy-for-filamentous-fungal-keratitis-role-of-observer-experience
#16
Ahmad Kheirkhah, Zeba A Syed, Vannarut Satitpitakul, Sunali Goyal, Rodrigo Müller, Elmer Y Tu, Reza Dana
PURPOSE: To determine sensitivity and specificity of laser-scanning in vivo confocal microscopy (LS-IVCM) for detection of filamentous fungi in patients with microbial keratitis and to evaluate the effect of observer's imaging experience on these parameters. DESIGN: Retrospective reliability study. METHODS: This study included 21 patients with filamentous fungal keratitis and 24 patients with bacterial keratitis (as controls). The etiology of infection was confirmed based on the response to specific therapy regardless of culture results...
July 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28410280/long-term-impacts-of-orthokeratology-treatment-on-sub-basal-nerve-plexus-and-corneal-sensitivity-responses-and-their-reversibility
#17
María Nombela-Palomo, Gema Felipe-Marquez, Miguel Angel Teus, Jose Luis Hernandez-Verdejo, Amelia Nieto-Bona
PURPOSE: To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption. METHODS: Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet-Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy...
April 13, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28399039/characterization-of-corneal-involvement-in-eyes-with-mucous-membrane-pemphigoid-by-in-vivo-confocal-microscopy
#18
Tudor C Tepelus, Jianyan Huang, SriniVas R Sadda, Olivia L Lee
PURPOSE: To describe the morphological features of the corneal epithelial layers, subbasal nerve plexus, stroma, and endothelium in patients with mucous membrane pemphigoid (MMP) as shown by in vivo confocal microscopy (IVCM). METHODS: Central corneal images were captured from 10 healthy age-matched control eyes and 30 eyes with clinically diagnosed MMP by in vivo laser scanning confocal microscopy (HRT III RCM). Morphological changes of the corneal epithelial layers, stroma, and endothelium, characteristics of corneal nerves, and presence of inflammatory dendritic cells (DCs) were evaluated...
April 10, 2017: Cornea
https://www.readbyqxmd.com/read/28393028/analysis-of-corneal-morphologic-and-pathologic-changes-in-early-stage-congenital-aniridic-keratopathy
#19
Juan Du, Rong-Qiang Liu, Lei Ye, Zhi-Hui Li, Feng-Tu Zhao, Nan Jiang, Lin-Hong Ye, Yi Shao
AIM: To determine typical corneal changes of congenital aniridic keratopathy (CAK) using corneal topography and confocal systems, and to identify characteristics that might assist in early diagnosis. METHODS: Patients with CAK and healthy control subjects underwent detailed ophthalmic examinations including axial length, corneal thickness, tear film condition, corneal topography, and laser-scanning in vivo confocal microscopy (IVCM). RESULTS: In early stage aniridic keratopathy, Schirmer I test (SIT), break-up time (BUT), mean keratometry (mean K) and simulated keratometry (sim K) were reduced relative to controls (P<0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28378047/-confocal-microscope-examination-of-the-corneal-nerve-plexus-as-biomarker-for-systemic-diseases-view-from-the-corneal-nerve-plexus-on-diabetes-mellitus-disease
#20
S Baltrusch
It is estimated that approximately 50% of patients with diabetes mellitus suffer from polyneuropathy, which is frequently diagnosed too late. Consequently, the question arises whether imaging procedures of the eye, namely optical coherence tomography of the retina and confocal microscopy of the cornea are suitable for the diagnostics and follow-up control of neurodegenerative changes in patients with diabetes mellitus. De Clerck and co-workers could demonstrate this by a systematic review of studies. Of these studies 11 were further evaluated with respect to corneal confocal microscopy...
July 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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