keyword
MENU ▼
Read by QxMD icon Read
search

Transmission, infection, SIngle nucleotide polymorphism

keyword
https://www.readbyqxmd.com/read/29898681/mitogen-activated-protein-kinase-eight-polymorphisms-are-associated-with-immune-responsiveness-to-hbv-vaccinations-in-infants-of-hbsag-hbeag-mothers
#1
Meng Zhuo Cao, Yan Hua Wu, Si Min Wen, Yu Chen Pan, Chong Wang, Fei Kong, Chuan Wang, Jun Qi Niu, Jie Li, Jing Jiang
BACKGROUND: Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of immune response to vaccination. We conducted this study to investigate the association between Tumor necrosis factor (TNF) and Mitogen-activated protein kinase eight (MAPK8) polymorphisms and low response to hepatitis B vaccines. METHODS: A total of 753 infants of HBsAg positive and hepatitis Be antigen (HBeAg) negative mothers from the prevention of mother-to-infant transmission of HBV cohort were included...
June 14, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29859292/genetic-modifications-of-cytokine-genes-and-toxoplasma-gondii-infections-in-pregnant-women
#2
Wioletta Wujcicka, Jan Wilczyński, Ewa Śpiewak, Dorota Nowakowska
PURPOSE: Toxoplasma gondii causes one of the most common intrauterine infections worldwide, thus being a severe threat during pregnancy. IL1, IL6, IL10, IL12, and TNF-α cytokines were reported to be involved in immune responses to infections with T. gondii. The research was aimed to reveal relationships between genetic changes within the polymorphisms of these cytokine genes and the incidence of T. gondii infection among pregnant women, as well as congenital transmission of the parasite to the foetuses of their infected mothers...
May 30, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29842979/spatio-temporal-distribution-of-pfmdr1-polymorphism-among-uncomplicated-plasmodium-falciparum-malaria-cases-along-international-border-of-north-east-india
#3
Shelly Goomber, Neelima Mishra, Anup Anvikar, ChanderPrakash Yadav, Neena Valecha
PfMDR1 single nucleotide polymorphisms (SNP) are good correlate markers for antimalarial drug resistance worldwide. Present study is a comprehensive view of screening of PfMDR1 polymorphism to antimalarials practiced with geography and time. Study sites Mizoram, Tripura, Meghalaya chosen are at multivariate drug pressure due to cross border migration and transmission. Mizoram is gateway to south east Asia through Myanmar whereas Tripura, Meghalaya share porous border with Bangladesh. Baseline finger pricked blood stained filter paper for confirmed uncomplicated Plasmodium falciparum infected patients (year 2015) were obtained from National Institute of Malaria Research, New Delhi, India...
May 26, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29755435/analysis-of-phylogenetic-variation-of-stenotrophomonas-maltophilia-reveals-human-specific-branches
#4
Joerg Steinmann, Uwe Mamat, Ebrahim M Abda, Lisa Kirchhoff, Wolfgang R Streit, Ulrich E Schaible, Stefan Niemann, Thomas A Kohl
Stenotrophomonas maltophilia is a non-fermenting Gram-negative bacterium that is ubiquitous in the environment. In humans, this opportunistic multi-drug-resistant pathogen is responsible for a plethora of healthcare-associated infections. Here, we utilized a whole genome sequencing (WGS)-based phylogenomic core single nucleotide polymorphism (SNP) approach to characterize S. maltophilia subgroups, their potential association with human infection, and to detect any possible transmission events. In total, 89 isolates (67 clinical and 22 environmental) from Germany were sequenced...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29739475/an-outbreak-of-streptococcus-pyogenes-in-a-mental-health-facility-advantage-of-well-timed-whole-genome-sequencing-over-emm-typing
#5
Sarah M Bergin, Balamurugan Periaswamy, Timothy Barkham, Hong Choon Chua, Yee Ming Mok, Daniel Shuen Sheng Fung, Alex Hsin Chuan Su, Yen Ling Lee, Ming Lai Ivan Chua, Poh Yong Ng, Wei Jia Wendy Soon, Collins Wenhan Chu, Siyun Lucinda Tan, Mary Meehan, Brenda Sze Peng Ang, Yee Sin Leo, Matthew T G Holden, Partha De, Li Yang Hsu, Swaine L Chen, Paola Florez de Sessions, Kalisvar Marimuthu
OBJECTIVEWe report the utility of whole-genome sequencing (WGS) conducted in a clinically relevant time frame (ie, sufficient for guiding management decision), in managing a Streptococcus pyogenes outbreak, and present a comparison of its performance with emm typing.SETTINGA 2,000-bed tertiary-care psychiatric hospital.METHODSActive surveillance was conducted to identify new cases of S. pyogenes. WGS guided targeted epidemiological investigations, and infection control measures were implemented. Single-nucleotide polymorphism (SNP)-based genome phylogeny, emm typing, and multilocus sequence typing (MLST) were performed...
May 9, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29681517/internal-migration-and-transmission-dynamics-of-tuberculosis-in-shanghai-china-an-epidemiological-spatial-genomic-analysis
#6
Chongguang Yang, Liping Lu, Joshua L Warren, Jie Wu, Qi Jiang, Tianyu Zuo, Mingyu Gan, Mei Liu, Qingyun Liu, Kathryn DeRiemer, Jianjun Hong, Xin Shen, Caroline Colijn, Xiaoqin Guo, Qian Gao, Ted Cohen
BACKGROUND: Massive internal migration from rural to urban areas poses new challenges for tuberculosis control in China. We aimed to combine genomic, spatial, and epidemiological data to describe the dynamics of tuberculosis in an urban setting with large numbers of migrants. METHODS: We did a population-based study of culture-positive Mycobacterium tuberculosis isolates in Songjiang, Shanghai. We used whole-genome sequencing to discriminate apparent genetic clusters of M tuberculosis sharing identical variable-number-tandem-repeat (VNTR) patterns, and analysed the relations between proximity of residence and the risk of genomically clustered M tuberculosis...
April 19, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29674657/emergence-of-vancomycin-resistant-enterococcus-faecium-at-an-australian-hospital-a-whole-genome-sequencing-analysis
#7
Kelvin W C Leong, Louise A Cooley, Tara L Anderson, Sanjay S Gautam, Belinda McEwan, Anne Wells, Fiona Wilson, Lucy Hughson, Ronan F O'Toole
In 2015, a marked increase in vancomycin-resistant Enterococcus faecium (VREfm) isolation was detected at the Royal Hobart Hospital, Australia. The primary objective of this work was to examine the dynamics of VREfm transmission using whole genome data mapped to public health surveillance information. Screening and clinical isolates of VREfm from patients were typed for the specific vancomycin-resistance locus present. Of total isolates collected from 2014-2016 (n = 222), 15.3% and 84.7% harboured either the vanA or the vanB vancomycin-resistance locus, respectively...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29616014/routine-whole-genome-sequencing-for-outbreak-investigations-of-staphylococcus-aureus-in-a-national-reference-center
#8
Geraldine Durand, Fabien Javerliat, Michèle Bes, Jean-Baptiste Veyrieras, Ghislaine Guigon, Nathalie Mugnier, Stéphane Schicklin, Gaël Kaneko, Emmanuelle Santiago-Allexant, Coralie Bouchiat, Patrícia Martins-Simões, Frederic Laurent, Alex Van Belkum, François Vandenesch, Anne Tristan
The French National Reference Center for Staphylococci currently uses DNA arrays and spa typing for the initial epidemiological characterization of Staphylococcus aureus strains. We here describe the use of whole-genome sequencing (WGS) to investigate retrospectively four distinct and virulent S. aureus lineages [clonal complexes (CCs): CC1, CC5, CC8, CC30] involved in hospital and community outbreaks or sporadic infections in France. We used a WGS bioinformatics pipeline based on de novo assembly (reference-free approach), single nucleotide polymorphism analysis, and on the inclusion of epidemiological markers...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29577990/whole-genome-sequencing-in-the-investigation-of-recurrent-invasive-group-a-streptococcus-outbreaks-in-a-maternity-unit
#9
Harriet Dickinson, Mark Reacher, Bernadette Nazareth, Heidi Eagle, Deirdre Fowler, Anthony Underwood, Meera Chand, Victoria Chalker, Juliana Coelho, Roger Daniel, Georgia Kapatai, Ali Al-Shabib, Richard Puleston
BACKGROUND: The clinical manifestations of Group A streptococcus (GAS) - (Streptococcus pyogenes) are diverse, ranging from asymptomatic colonisation to devastating invasive disease. Maternity related clusters of invasive Group A streptococcus (iGAS) infection are complex to investigate and control, especially if recurrent. AIM: We report on the investigation into three episodes of emm 75 GAS/iGAS infection in maternity patients at one hospital site over a 4 year period, two with monophyletic ancestry...
March 22, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29527064/population-structure-of-the-ash-dieback-pathogen-hymenoscyphus-fraxineus-in-relation-to-its-mode-of-arrival-in-the-uk
#10
E S Orton, C M Brasier, L J Bilham, A Bansal, J F Webber, J K M Brown
The ash dieback fungus, Hymenoscyphus fraxineus , a destructive, alien pathogen of common ash ( Fraxinus excelsior ), has spread across Europe over the past 25 years and was first observed in the UK in 2012. To investigate the relationship of the pathogen's population structure to its mode of arrival, isolates were obtained from locations in England and Wales, either where established natural populations of ash had been infected by wind-dispersed ascospores or where the fungus had been introduced on imported planting stock...
February 2018: Plant Pathology
https://www.readbyqxmd.com/read/29488865/farm-to-fork-investigation-of-an-outbreak-of-shiga-toxin-producing-escherichia-coli-o157
#11
Deborah Wilson, Gayle Dolan, Heather Aird, Shirley Sorrell, Timothy J Dallman, Claire Jenkins, Lucy Robertson, Russell Gorton
Fifteen cases of Shiga toxin-producing Escherichia coli (STEC) O157 infection were associated with the consumption of contaminated food from two related butchers' premises in the north-east of England. Ten cases were admitted to hospital and seven cases developed haemolytic uraemic syndrome. A case control study found a statistically significant association with the purchase of raw and/or ready-to-eat (RTE) food supplied by the implicated butchers' shops. Isolates of STEC O157 were detected in two raw lamb burgers taken from one of the butchers' premises...
February 28, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29482619/population-based-analysis-of-ocular-chlamydia-trachomatis-in-trachoma-endemic-west-african-communities-identifies-genomic-markers-of-disease-severity
#12
A R Last, H Pickering, C H Roberts, F Coll, J Phelan, S E Burr, E Cassama, M Nabicassa, H M B Seth-Smith, J Hadfield, L T Cutcliffe, I N Clarke, D C W Mabey, R L Bailey, T G Clark, N R Thomson, M J Holland
BACKGROUND: Chlamydia trachomatis (Ct) is the most common infectious cause of blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to the observed variability in severity of clinical disease. METHODS: Using Ct whole genome sequences obtained directly from conjunctival swabs, we studied Ct genomic diversity and associations between Ct genetic polymorphisms with ocular localization and disease severity in a treatment-naïve trachoma-endemic population in Guinea-Bissau, West Africa...
February 26, 2018: Genome Medicine
https://www.readbyqxmd.com/read/29367612/use-of-whole-genome-sequencing-to-investigate-an-increase-in-neisseria-gonorrhoeae-infection-among-women-in-urban-areas-of-australia
#13
Cameron Buckley, Brian M Forde, Ella Trembizki, Monica M Lahra, Scott A Beatson, David M Whiley
Increasing rates of gonorrhoea have been observed among women within the Australian state of New South Wales. Here, we applied whole genome sequencing (WGS) to better understand the associated networks and transmission dynamics. Ninety-four isolates of a particular N. gonorrhoeae genotype (G122) associated with women (years 2012 to 2014) underwent phylogenetic analysis using core single nucleotide polymorphisms. WGS data revealed five main clusters, all of which were heterogeneous in terms of patient age and site of infection...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29366468/evaluation-of-wgs-based-approaches-for-investigating-a-food-borne-outbreak-caused-by-salmonella-enterica-serovar-derby-in-germany
#14
Sandra Simon, Eva Trost, Jennifer Bender, Stephan Fuchs, Burkhard Malorny, Wolfgang Rabsch, Rita Prager, Erhard Tietze, Antje Flieger
In Germany salmonellosis still represents the 2nd most common bacterial foodborne disease. The majority of infections are caused by Salmonella (S.) Typhimurium and S. Enteritidis followed by a variety of other broad host-range serovars. Salmonella Derby is one of the five top-ranked serovars isolated from humans and it represents one of the most prevalent serovars in pigs, thus bearing the potential risk for transmission to humans upon consumption of pig meat and products thereof. From November 2013 to January 2014 S...
May 2018: Food Microbiology
https://www.readbyqxmd.com/read/29362238/adaptive-evolution-of-rh5-in-ape-plasmodium-species-of-the-laverania-subgenus
#15
Lindsey J Plenderleith, Weimin Liu, Oscar A MacLean, Yingying Li, Dorothy E Loy, Sesh A Sundararaman, Frederic Bibollet-Ruche, Gerald H Learn, Beatrice H Hahn, Paul M Sharp
Plasmodium falciparum , the major cause of malaria morbidity and mortality in humans, has been shown to have emerged after cross-species transmission of one of six host-specific parasites (subgenus Laverania ) infecting wild chimpanzees ( Pan troglodytes ) and western gorillas ( Gorilla gorilla ). Binding of the parasite-encoded ligand RH5 to the host protein basigin is essential for erythrocyte invasion and has been implicated in host specificity. A recent study claimed to have found two amino acid changes in RH5 that "drove the host shift leading to the emergence of P...
January 23, 2018: MBio
https://www.readbyqxmd.com/read/29358725/fine-scale-landscape-genomics-helps-explain-the-slow-spatial-spread-of-wolbachia-through-the-aedes-aegypti-population-in-cairns-australia
#16
Thomas L Schmidt, Igor Filipović, Ary A Hoffmann, Gordana Rašić
The endosymbiotic bacterium Wolbachia suppresses the capacity for arbovirus transmission in the mosquito Aedes aegypti, and can spread spatially through wild mosquito populations following local introductions. Recent introductions in Cairns, Australia have demonstrated slower than expected spatial spread. Potential reasons for this include: (i) barriers to Ae. aegypti dispersal; (ii) higher incidence of long-range dispersal; and (iii) intergenerational loss of Wolbachia. We investigated these three potential factors using genome-wide single-nucleotide polymorphisms (SNPs) and an assay for the Wolbachia infection wMel in 161 Ae...
May 2018: Heredity
https://www.readbyqxmd.com/read/29326013/a-cluster-of-multidrug-resistant-mycobacterium-tuberculosis-among-patients-arriving-in-europe-from-the-horn-of-africa-a-molecular-epidemiological-study
#17
Timothy M Walker, Matthias Merker, Astrid M Knoblauch, Peter Helbling, Otto D Schoch, Marieke J van der Werf, Katharina Kranzer, Lena Fiebig, Stefan Kröger, Walter Haas, Harald Hoffmann, Alexander Indra, Adrian Egli, Daniela M Cirillo, Jérôme Robert, Thomas R Rogers, Ramona Groenheit, Anne T Mengshoel, Vanessa Mathys, Marjo Haanperä, Dick van Soolingen, Stefan Niemann, Erik C Böttger, Peter M Keller
BACKGROUND: The risk of tuberculosis outbreaks among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among patients from the Horn of Africa and Sudan. METHODS: On April 29 and May 30, 2016, the Swiss and German National Mycobacterial Reference Laboratories independently triggered an outbreak investigation after four patients were diagnosed with multidrug-resistant tuberculosis...
April 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29259599/epidemiology-of-danish-aeromonas-salmonicida-subsp-salmonicida-in-fish-farms-using-whole-genome-sequencing
#18
Simona Bartkova, Pimlapas Leekitcharoenphon, Frank M Aarestrup, Inger Dalsgaard
Furunculosis, a serious infection caused by the bacterium Aeromonas salmonicida subsp. salmonicida is common in sea-reared rainbow trout production in Denmark. Developing an effective control strategy requires knowledge of the epidemiology, as well as the genomic and virulent variability of the Danish A. salmonicida subsp. salmonicida isolates. To obtain this, the genomes of 101 A. salmonicida subsp. salmonicida , including 99 Danish isolates, one Scottish strain and the type strain NCIMB 1102, were sequenced using the Illumina HiSeq platform...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29247013/whole-genome-sequencing-reveals-transmission-of-gonococcal-antibiotic-resistance-among-men-who-have-sex-with-men-an-observational-study
#19
Jason C Kwong, Eric P F Chow, Kerrie Stevens, Timothy P Stinear, Torsten Seemann, Christopher K Fairley, Marcus Y Chen, Benjamin P Howden
OBJECTIVES: Drug-resistant Neisseria gonorrhoeae are now a global public health threat. Direct transmission of antibiotic-resistant gonococci between individuals has been proposed as a driver for the increased transmission of resistance, but direct evidence of such transmission is limited. Whole-genome sequencing (WGS) has superior resolution to investigate outbreaks and disease transmission compared with traditional molecular typing methods such as multilocus sequence typing (MLST) and N...
March 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29208056/importation-mitigation-and-genomic-epidemiology-of-candida-auris-at-a-large-teaching-hospital
#20
Emil P Lesho, Melissa Z Bronstein, Patrick McGann, Jason Stam, Yoon Kwak, Rosslyn Maybank, Jodi McNamara, Megan Callahan, Jean Campbell, Mary K Hinkle, Edward E Walsh
OBJECTIVE Candida auris (CA) is an emerging multidrug-resistant pathogen associated with increased mortality. The environment may play a role, but transmission dynamics remain poorly understood. We sought to limit environmental and patient CA contamination following a sustained unsuspected exposure. DESIGN Quasi-experimental observation. SETTING A 528-bed teaching hospital. PATIENTS The index case patient and 17 collocated ward mates. INTERVENTION Immediately after confirmation of CA in the bloodstream and urine of a patient admitted 6 days previously, active surveillance, enhanced transmission-based precautions, environmental cleaning with peracetic acid-hydrogen peroxide and ultraviolet light, and patient relocation were undertaken...
January 2018: Infection Control and Hospital Epidemiology
keyword
keyword
68511
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"