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https://www.readbyqxmd.com/read/28720151/supplementation-with-lactobacillus-paracasei-or-pediococcus-pentosaceus-does-not-prevent-diarrhoea-in-neonatal-pigs-infected-with-escherichia-coli-f18
#1
Anders D Andersen, Malene S Cilieborg, Charlotte Lauridsen, Anne Louise Mørkbak, Per Torp Sangild
Infectious diarrhoea is a worldwide problem in newborns. Optimal bacterial colonisation may enhance gut maturation and protect against pathogenic bacteria after birth. We hypothesised that lactic acid bacteria (LAB) administration prevents pathogen-induced diarrhoea in formula-fed newborns. Newborn caesarean-delivered, colostrum-deprived term piglets on parenteral nutrition for the first 15 h, were used as models for sensitive newborn infants. A commercially available probiotic strain, Lactobacillus paracasei F19 (LAP, 2·6×108 colony-forming units (CFU)/kg per d) and a novel LAB isolate, Pediococcus pentosaceus (PEP, 1·3×1010 CFU/kg per d), were administered for 5 d with or without inoculation of the porcine pathogen, Escherichia coli F18 (F18, 1010 CFU/d)...
July 19, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28720083/a-prolonged-community-wide-cholera-outbreak-associated-with-drinking-water-contaminated-by-sewage-in-kasese-district-western-uganda
#2
Benon Kwesiga, Gerald Pande, Alex Riolexus Ario, Nazarius Mbona Tumwesigye, Joseph K B Matovu, Bao-Ping Zhu
BACKGROUND: In May 2015, a cholera outbreak that had lasted 3 months and infected over 100 people was reported in Kasese District, Uganda, where multiple cholera outbreaks had occurred previously. We conducted an investigation to identify the mode of transmission to guide control measures. METHODS: We defined a suspected case as onset of acute watery diarrhoea from 1 February 2015 onwards in a Kasese resident. A confirmed case was a suspected case with Vibrio cholerae O1 El Tor, serotype Inaba cultured from a stool sample...
July 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28719561/arterial-topographic-anatomy-near-the-femoral-head-neck-perforation-with-surgical-relevance
#3
Paulo Rego, Vasco Mascarenhas, Diego Collado, Ana Coelho, Luis Barbosa, Reinhold Ganz
BACKGROUND: Knowledge of the vascular supply of the femoral head is crucial for hip-preserving surgical procedures. The critical area for reshaping cam deformity is at the retinacular vessel penetration, an area with ill-defined topographic anatomy. We performed a cadaver study of the extension of the lateral retinaculum near the head-neck junction, distribution of the arterial vascular foramina, and initial intracapital course of these vessels. METHODS: In 16 fresh proximal parts of the femur without head-neck deformities, the deep branch of the medial femoral circumflex artery was injected with gadolinium for magnetic resonance imaging (MRI) sequences to identify arterial structures...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28716150/swedish-norwegian-co-operation-in-the-treatment-of-three-hypothermia-victims-a-case-report
#4
Anders Wetting Carlsen, Nils K Skjaervold, Nils Johan Berg, Øystein Karlsen, Eli Gunnarson, Alexander Wahba
BACKGROUND: Accidental hypothermia with cardiac arrest represents a challenge for pre-hospital rescuers as well as in-hospital staff. For pre-hospital personnel, the main focus is to get the patient to the correct destination without unnecessary delay. For in-hospital personnel early information is vital to assess the possibility for resuscitation with extracorporeal re-warming. The challenge is augmented when rescuers must cross national borders to reach and/or deliver the patients. We present a case where three adolescent boys suffered severe hypothermia after a canoeing accident in Sweden...
July 17, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28711737/subthalamic-deep-brain-stimulation-sweet-spots-and-hyperdirect-cortical-connectivity-in-parkinson-s-disease
#5
Harith Akram, Stamatios N Sotiropoulos, Saad Jbabdi, Dejan Georgiev, Philipp Mahlknecht, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Marjan Jahanshahi, Marwan Hariz, John Ashburner, Tim Behrens, Ludvic Zrinzo
OBJECTIVES: Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdirect pathways which predict maximum efficacy. METHODS: High angular resolution diffusion imaging in twenty patients with advanced Parkinson's disease was acquired prior to bilateral subthalamic nucleus deep brain stimulation...
July 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28709866/mesenchymal-stem-cell-transplantation-carried-in-svvyglr-modified-self-assembling-peptide-promoted-cardiac-repair-and-angiogenesis-after-myocardial-infarction
#6
Xi-Ren Gao, Hai-Jun Xu, Li-Fang Wang, Chong-Bin Liu, Feng Yu
The efficiency of stem cell therapy for myocardial infarction (MI) was very low due to the hostile microenvironment and poor blood perfusion. In this study, we designed a new self-assembling peptide through adding angiogenic polypeptide SVVYGLR to the carboxyl terminal of RADA16, and evaluated the therapeutic potential of mesenchymal stem cell (MSC) transplantation carried in this designer self-assembling peptide (DSP) on MI. After the model of cell ischemia and hypoxia was established in vitro, cytoprotective effect of DSP on MSC was detected by AO/EB staining...
July 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28709857/remodeling-of-the-transverse-tubular-system-after-myocardial-infarction-in-rabbit-correlates-with-local-fibrosis-a-potential-role-of-biomechanics
#7
REVIEW
T Seidel, A C Sankarankutty, F B Sachse
The transverse tubular system (t-system) of ventricular cardiomyocytes is essential for efficient excitation-contraction coupling. In cardiac diseases, such as heart failure, remodeling of the t-system contributes to reduced cardiac contractility. However, mechanisms of t-system remodeling are incompletely understood. Prior studies suggested an association with altered cardiac biomechanics and gene expression in disease. Since fibrosis may alter tissue biomechanics, we investigated the local microscopic association of t-system remodeling with fibrosis in a rabbit model of myocardial infarction (MI)...
July 11, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28708475/prevalence-and-length-of-the-anterior-loop-of-the-inferior-alveolar-nerve-in-iranians
#8
Mahsa Shariati, Maryam Rastegar Moghddam, Zeinab Davoudmanesh, Nasim Azizi, Vahid Rakhshan
The anterior loop of the inferior alveolar nerve is a sensitive anatomical feature which should be taken into account during installing dental implants anterior to the mental foramen. Since results regarding its prevalence and length are controversial, this study was conducted. A total of 452 mandible quadrants of 234 patients (age: 50.1±13.3 years, 113 males, 121 females) were studied using cone-beam computerized tomography (CBCT). After reconstructing axial, frontal, and sagittal slices, the region between the most anterior point on the mental foramen and the most anterior part of the mandibular nerve was inspected for signs of anterior loop presence...
July 14, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28706039/when-an-emerging-disease-becomes-endemic
#9
REVIEW
Graham F Medley, Anna Vassall
Epidemics, such as HIV in the early 1980s and Ebola in 2014, inspire decisive government investment and action, and individual and societal concern, sometimes bordering on panic. By contrast, endemic diseases, such as HIV in 2017 and tuberculosis, struggle to maintain the same attention. For many, the paradox is that endemic disease, in its totality, continues to impose a far higher public health burden than epidemic disease. Overall, the swift political response to epidemics has resulted in success. It has proven possible to eradicate epidemic diseases, often without the availability of vaccines and other biomedical technologies...
July 14, 2017: Science
https://www.readbyqxmd.com/read/28705091/molecular-approaches-to-potentiate-cisplatin-responsiveness-in-carcinoma-therapeutics
#10
Aayushi Jain, Devashree Jahagirdar, Pritish Nilendu, Nilesh Kumar Sharma
Cisplatin has been considered as the crucial regimen of widely prescribed chemotherapy treatment for cancer. The advancing treatment of cancers has reached the border line, where tumors show resistance to cisplatin and may thwart its use. Other than issues of drug resistance, cisplatin has been reported to evince side effects such as nephrotoxicity and ototoxicity. Therefore, there is a compelling need to untangle the problems associated with cisplatin treatment in carcinoma. Areas covered: In this review, we summarize the current status of combinatorial options to bring about better pre-clinical and clinical cisplatin drug responses in carcinoma...
July 20, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28702085/electricity-assisted-production-of-caproic-acid-from-grass
#11
Way Cern Khor, Stephen Andersen, Han Vervaeren, Korneel Rabaey
BACKGROUND: Medium chain carboxylic acids, such as caproic acid, are conventionally produced from food materials. Caproic acid can be produced through fermentation by the reverse β-oxidation of lactic acid, generated from low value lignocellulosic biomass. In situ extraction of caproic acid can be achieved by membrane electrolysis coupled to the fermentation process, allowing recovery by phase separation. RESULTS: Grass was fermented to lactic acid in a leach-bed-type reactor, which was then further converted to caproic acid in a secondary fermenter...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28700068/implication-of-tityus-apiacas-lourenco-2002-in-scorpion-envenomations-in-the-southern-amazon-border-brazil
#12
Bruna Andressa Jung da Silva, Nelson Ferreira Fé, André Alexandre Dos Santos Gomes, Anderson da Silva Souza, Jacqueline de Almeida Gonçalves Sachett, Hui Wen Fan, Gisely Cardoso de Melo, Wuelton Marcelo Monteiro
Herein, four cases of scorpion stings caused by Tityus apiacas recorded from the municipality of Apuí, in the southern region of the Brazilian Amazon, are described. Patients showed systemic clinical manifestations, described as unusual, involuntary, and generalized tingling and numbness, reported by patients as an electric shock sensation, lasting up to 24 hours after the sting. All patients described local pain and sensation, along with other clinical symptoms including local edema and erythema. Systemic manifestations were not life threatening...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28690806/world-without-borders-genetic-population-structure-of-a-highly-migratory-marine-predator-the-blue-shark-prionace-glauca
#13
Ana Veríssimo, Íris Sampaio, Jan R McDowell, Paulo Alexandrino, Gonzalo Mucientes, Nuno Queiroz, Charlene da Silva, Catherine S Jones, Leslie R Noble
Highly migratory, cosmopolitan oceanic sharks often exhibit complex movement patterns influenced by ontogeny, reproduction, and feeding. These elusive species are particularly challenging to population genetic studies, as representative samples suitable for inferring genetic structure are difficult to obtain. Our study provides insights into the genetic population structure one of the most abundant and wide-ranging oceanic shark species, the blue shark Prionace glauca, by sampling the least mobile component of the populations, i...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28688857/three-dimensional-echocardiographic-automated-quantification-of-left-heart-chamber-volumes-using-an-adaptive-analytics-algorithm-feasibility-and-impact-of-image-quality-in-nonselected-patients
#14
Diego Medvedofsky, Victor Mor-Avi, Isida Byku, Amita Singh, Lynn Weinert, Megan Yamat, Eric Kruse, Boguslawa Ciszek, Alma Nelson, Kyoko Otani, Masaaki Takeuchi, Roberto M Lang
BACKGROUND: Although 3D echocardiography (3DE) allows accurate and reproducible quantification of cardiac chambers, it has not been integrated into clinical practice because it relies on manual input, which interferes with workflow. A recently developed automated adaptive analytics algorithm for simultaneous quantification of left ventricular and atrial (LV, LA) volumes was found to be accurate and reproducible in patients with good images. We sought to prospectively test its feasibility and accuracy in consecutive patients in relationship with image quality and reader experience...
July 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28688332/regenerative-capacity-of-allogenic-gingival-margin-derived-stem-cells-with-fibrin-glue-on-albino-rats-partially-dissected-submandibular-salivary-glands
#15
Noura Abd El-Latif, Mohamed Abdulrahman, Mohamad Helal, Mohammed E Grawish
OBJECTIVE: To evaluate the possible regenerative effect of allogenic gingival margin-derived stem cells (GMSCs) with or without autologous fibrin glue on partially dissected submandibular salivary glands of albino rats. METHODS: Forty rats were randomly divided into four equal groups. Group I, where no operation was performed, was considered the negative control. Group II rats were considered the positive control and were subjected to a rectangular cut on the outer surface of the center right of the submandibular salivary gland and received no other treatment...
June 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28686126/impact-of-magnetic-resonance-imaging-and-urodynamic-studies-on-the-management-of-sacrococcygeal-dimples
#16
Goichiro Tamura, Nobuhito Morota, Satoshi Ihara
OBJECTIVE Sacrococcygeal dimples in neonates and infants are of uncertain pathological import. Previously they were believed to be rarely associated with intraspinal anomalies. Recent studies using MRI, however, revealed that 6%-7% of pediatric cases of sacrococcygeal dimples were associated with anatomical tethered spinal cord (TSC). Because the prevalence of tethered cord syndrome is still unclear, there is no consensus among pediatric neurosurgeons on the management of children with sacrococcygeal dimples...
July 7, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28680845/dilemma-of-gonial-angle-measurement-panoramic-radiograph-or-lateral-cephalogram
#17
Pillai Devu Radhakrishnan, Nilambur Kovilakam Sapna Varma, Vallikat Velath Ajith
PURPOSE: The purpose of this study was to evaluate the accuracy of panoramic imaging in measuring the right and left gonial angles by comparing the measured angles with the angles determined using a lateral cephalogram of adult patients with class I malocclusion. MATERIALS AND METHODS: The gonial angles of 50 class I malocclusion patients (25 males and 25 females; mean age: 23 years) were measured using both a lateral cephalogram and a panoramic radiograph. In the lateral cephalograms, the gonial angle was measured at the point of intersection of the ramus plane and the mandibular plane...
June 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28674269/detection-of-ceramide-a-risk-factor-for-coronary-artery-disease-in-human-coronary-plaques-by-fluorescent-angioscopy
#18
Yasumi Uchida, Yasuto Uchida, Takanobu Kobayashi, Seiichiro Shirai, Nobuyuki Hiruta, Ei Shimoyama, Tsuyoshi Tabata
BACKGROUND: The presence of ceramide in human coronary plaques is a risk factor for ischemic heart disease, but its visualization in the human vessel wall is currently beyond the scope of any available imaging techniques.Methods and Results:Deposition of ceramide was examined by fluorescent angioscopy (FA) and microscopy (FM) using golden fluorescence (Go) as a specific marker of ceramide in yellow plaques, which were obtained from 23 autopsy subjects and classified by conventional angioscopy and histology...
June 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28667767/equine-meniscal-degeneration-is-associated-with-medial-femorotibial-osteoarthritis
#19
J Dubuc, C Girard, H Richard, J De Lasalle, S Laverty
BACKGROUND: There is limited information available concerning normal equine meniscal morphology, its degeneration and role in osteoarthritis (OA). OBJECTIVES: To characterise normal equine meniscal morphology and lesions and to explore the relationship between equine meniscal degeneration and femorotibial OA. STUDY DESIGN: Ex vivo cadaveric study. METHODS: Menisci were harvested from 7 normal joints (n = 14 menisci) and 15 joints with OA (n = 30 menisci)...
July 1, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28666560/worldwide-population-variation-in-pelvic-sexual-dimorphism-a-validation-and-recalibration-of-the-klales-et-al-method
#20
Michael W Kenyhercz, Alexandra R Klales, Kyra E Stull, Kyle A McCormick, Stephanie J Cole
Sex estimation is an integral aspect of biological anthropology. Correctly estimating sex is the first step to many subsequent analyses, such as estimating living stature or age-at-death. Klales et al. (2012) [6] provided a revised version of the Phenice (1969) [3] method that expanded the original three traits (ventral arc, subpubic concavity/contour, and medial aspect of the ischio-pubic ramus) into five character states to capture varying degrees of expression within each trait. The Klales et al. (2012) [6] method also provided associated probabilities with each sex classification, which is of particular importance in forensic anthropology...
May 8, 2017: Forensic Science International
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