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https://www.readbyqxmd.com/read/28633808/impact-of-mr-guided-boiling-histotripsy-in-distinct-murine-tumor-models
#1
Martijn Hoogenboom, Dylan C Eikelenboom, Renske J E van den Bijgaart, Arend Heerschap, Pieter Wesseling, Martijn H den Brok, Jurgen J Fütterer, Gosse J Adema
Interest in mechanical high intensity focused ultrasound (HIFU) ablation is rapidly growing. Boiling histotripsy (BH) is applied for mechanical fragmentation of soft tissue into submicron fragments with limited temperature increase using the shock wave and cavitation effects of HIFU. Research on BH has been largely limited to ex vivo experiments. As a consequence, the in vivo pathology after BH treatment and the relation to preexistent tissue characteristics are not well understood. This study reports on in vivo MR guided BH treatment, either with 100 or 200 pulses per focal spot, in three different subcutaneous mouse tumor models: a soft-tissue melanoma (B16OVA), a compact growing thymoma (EL4), and a highly vascularized neuroblastoma (9464D)...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28626767/closer-to-a-uniform-language-in-colposcopy-study-on-the-potential-application-of-2011-international-federation-for-cervical-pathology-and-colposcopy-terminology-in-clinical-practice
#2
Yanyun Li, Xiaoling Duan, Long Sui, Fengying Xu, Shuifang Xu, Hongwei Zhang, Congjian Xu
As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011 IFCPC classification in 525 patients, reviewed by 13 trained colposcopists. Results show that colposcopic diagnoses are in 64.95% perfect agreement with cervical pathology, with 63.64% sensitivity and 96...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28623231/cry6aa1-a-bacillus-thuringiensis-nematocidal-and-insecticidal-toxin-forms-pores-in-planar-lipid-bilayers-at-extremely-low-concentrations-and-without-the-need-of-proteolytic-processing
#3
Eva Fortea, Vincent Lemieux, Léna Potvin, Vimbai Chikwana, Samantha Griffin, Thimothy Hey, David McCaskill, Kenneth Narva, Sek Yee Tan, Xiaoping Xu, Vincent Vachon, Jean-Louis Schwartz
Cry6Aa1 is a Bacillus thuringiensis (Bt) toxin active against nematodes and corn rootworm insects. Its 3-D molecular structure, which has been recently elucidated, is unique among those known for other Bt toxins. Typical three-domain Bt toxins permeabilise receptor-free planar lipid bilayers (PLBs) by forming pores at doses in the 1-50 μg/ml range. Solubilisation and proteolytic activation are necessary steps for PLB permeabilisation. In contrast to other Bt toxins, Cry6Aa1 formed pores in receptor-free bilayers at doses as low as 200 pg/ml in a wide range of pH (5...
June 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28619060/incidence-disease-onset-and-short-term-outcome-in-urea-cycle-disorders-cross-border-surveillance-in-germany-austria-and-switzerland
#4
Susanne Nettesheim, Stefan Kölker, Daniela Karall, Johannes Häberle, Roland Posset, Georg F Hoffmann, Beate Heinrich, Florian Gleich, Sven F Garbade
BACKGROUND: Urea cycle disorders (UCDs) are a group of rare inherited metabolic disorders. Affected individuals often present with hyperammonemic encephalopathy (HE) and have an increased risk of severe neurologic disease and early death. The study aims to provide epidemiologic data and to describe the disease manifestation and short-term outcome. METHOD: Cross-border surveillance of newly diagnosed patients with UCDs - below 16 years of age - was performed from July 2012 to June 2015 in Germany and Austria and from January 2012 to December 2015 in Switzerland...
June 15, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28615060/outcome-of-proximal-esophageal-cancer-after-definitive-combined-chemo-radiation-a-swiss-multicenter-retrospective-study
#5
Evelyn Herrmann, Nando Mertineit, Berardino De Bari, Laura Hoeng, Francesca Caparotti, Dominic Leiser, Raphael Jumeau, Nikola Cihoric, Alexandra D Jensen, Daniel M Aebersold, Mahmut Ozsahin
OBJECTIVE: To report oncological outcomes and toxicity rates, of definitive platin-based chemoradiadiationtherapy (CRT) in the management of proximal esophageal cancer. METHODS: We retrospectively reviewed the medical records of patients with cT1-4 cN0-3 cM0 cervical esophageal cancer (CEC) (defined as tumors located below the inferior border of the cricoid cartilage, down to 22 cm from the incisors) treated between 2004 and 2013 with platin-based definitive CRT in four Swiss institutions...
June 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28614377/spatial-distribution-of-child-pedestrian-injuries-along-census-tract-boundaries-implications-for-identifying-area-based-correlates
#6
Jacqueline W Curtis
Census tracts are often used to investigate area-based correlates of a variety of health outcomes. This approach has been shown to be valuable in understanding the ways that health is shaped by place and to design appropriate interventions that account for community-level processes. Following this line of inquiry, it is common in the study of pedestrian injuries to aggregate the point level locations of these injuries to the census tracts in which they occur. Such aggregation enables investigation of the relationships between a range of socioeconomic variables and areas of notably high or low incidence...
2017: PloS One
https://www.readbyqxmd.com/read/28613054/-quantitative-evaluation-of-printing-accuracy-and-tissue-surface-adaptation-of-mandibular-complete-denture-polylactic-acid-pattern-fabricated-by-fused-deposition-modeling-technology
#7
K H Deng, Y Wang, H Chen, Y J Zhao, Y S Zhou, Y C Sun
Objective: To quantitatively evaluate the adaptation of polylactic acid (PLA) pattern of mandibular complete denture fabricated by fused deposition modeling (FDM) technology. Methods: A mandibular complete denture digital model was designed through a complete denture design software based on a pair of standard maxillomandibular edentulous plaster model and their occlusion bases. Ten PLA mandibular complete dentures were printed with a FDM machine. The dentures were scanned with and without the plaster model using a three-dimensional (3D) scanner...
June 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28610122/a-new-species-of-i-otothyropsis-i-siluriformes-loricariidae-from-the-upper-r%C3%A3-o-paran%C3%A3-basin-paraguay-with-a-discussion-of-the-limits-between-i-otothyropsis-i-and-hisonotus
#8
Bárbara B Calegari, Walter Gill Morlis, Roberto E Reis
Otothyropsis dialeukos is described from Itá creek, tributary to the upper Río Paraná basin, Paraguay. The new species is distinguished from its congeners by having a unique caudal-fin coloration pattern composed of a brown to almost black background with roundish hyaline blotches in the middle of the outermost branched rays and a hyaline posterior border interrupted in middle rays; abdomen entirely covered by enlarged plates, without naked areas; longer pectoral- and dorsal-fin spines; absence of a raised crest of enlarged odontodes on the posterior portion of the parieto-supraoccipital, and other morphometric and meristic features...
March 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609125/minimum-2-year-outcomes-of-hip-arthroscopic-surgery-in-patients-with-acetabular-overcoverage-and-profunda-acetabulae-compared-with-matched-controls-with-normal-acetabular-coverage
#9
Sivashankar Chandrasekaran, Nader Darwish, Edwin O Chaharbakhshi, Carlos Suarez-Ahedo, Parth Lodhia, Benjamin G Domb
BACKGROUND: Advancements in instrumentation and techniques have extended the scope of hip arthroscopic surgery to treat complex osseous deformities that were previously best addressed with an open approach. Global pincer-type femoroacetabular impingement is an example of an abnormality requiring osseous correction with a technically challenging access point. PURPOSE: To report on the patterns of clinical presentation and intra-articular derangements, radiological associations, and minimum 2-year outcomes after hip arthroscopic surgery in patients with a lateral center edge angle (LCEA) >40° and profunda acetabulae in comparison with matched controls with normal acetabular coverage...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28603839/evaluation-of-the-effects-of-sweet-potato-ipomoea-batatas-l-lam-in-broiler-diets
#10
J Pandi, P Glatz, R Forder, B Komolong, K Chousalkar
Cereal grains such as maize and wheat are used extensively in feed formulations for poultry as the primary source of carbohydrates. High cost of these grains in many developing countries necessitates the evaluation of other ingredients that are grown locally. Sweet potato is one such crop. The study was conducted as a proof of concept experiment to test the hypothesis that in the presence and absence of enzyme, sweet potato roots when included in diets of broiler chickens may affect the total metabolisable energy content of the diets which may exert certain influences on dry matter digestibility of these diets as well as impacting on production and certain gut parameters...
June 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28603568/current-concepts-in-radial-club-hand
#11
Takehiko Takagi, Atsuhito Seki, Shinichiro Takayama, Masahiko Watanabe
Radial club hand is a complex congenital abnormality of the radial or pre-axial border of the upper extremity. It has a wide range of phenotypes from hypoplasia of the thumb to complete absence of the radius and the first ray. Centralization with tendon transfer is a popular method for maintaining the correct position of radial club hand. On the other hand, various corrections were devised, e.g. radialization after distraction to emphasize the fact that the head of the ulna is positioned under the radial carpal bones and is no longer placed in a slot in the center of the carpus, microvascular epiphysis transfer, gradual correction using Ilizarov method, for Bayne Type III or Type IV...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28600727/evaluation-of-acidity-in-late-permian-outcrop-coals-and-its-association-with-endemic-fluorosis-in-the-border-area-of-yunnan-guizhou-and-sichuan-in-china
#12
Xiuping Hong, Handong Liang, Yufa Zhang
The junction area of Yunnan, Guizhou, and Sichuan provinces is the heaviest coal-burning endemic fluorosis zones in China. To better understand the pathogenicity of endemic fluorosis in this area, 87 coal samples from the late Permian outcrop or semi-outcrop coal seams were collected in eight counties of the junction area of Yunnan, Guizhou, and Sichuan provinces. The total fluorine and sulfate content, etc. in the coal was determined using combustion-hydrolysis/fluoride-ion-selective electrode method and ion chromatography, respectively...
June 9, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28587601/cavalier-king-charles-spaniels-with-chiari-like-malformation-and-syringomyelia-have-increased-variability-of-spatio-temporal-gait-characteristics
#13
Emil Olsen, Emma Jane Suiter, Thilo Pfau, Imelda M McGonnell, Kaspar Matiasek, Anna Giejda, Holger Andreas Volk
BACKGROUND: Chiari-like malformation in the Cavalier King Charles Spaniel is a herniation of the cerebellum and brainstem into or through the foramen magnum. This condition predisposes to Syringomyelia; fluid filled syrinxes within the spinal cord. The resulting pathology in spinal cord and cerebellum create neuropathic pain and changes in gait. This study aims to quantify the changes in gait for Cavalier King Charles Spaniel with Chiari-like malformation and Syringomyelia. METHODS: We compared Cavalier King Charles Spaniel with Chiari-like malformation with (n = 9) and without (n = 8) Syringomyelia to Border Terriers (n = 8)...
June 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28573716/painful-decisions-how-classifying-sensations-can-change-the-experience-of-pain
#14
M A van der Meulen, F Anton, S Petersen
BACKGROUND: Categorizing perceptual stimuli is a mechanism for facilitating the processing of sensory input from our environment. This facilitation of perception is achieved through generalization (assimilation) of stimulus characteristics within categories and accentuation between categories. These categorization processes have been demonstrated in visual, auditory, tactile and social perception, but never in pain perception. METHOD: We presented participants with six thermal noxious stimuli, increasing in steps of 0...
June 2, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28570455/anatomical-reconstruction-of-the-nasal-floor-in-complete-unilateral-cleft-lip-repair
#15
Lan Sook Chang, Yoosung Son, Rong-Min Baek, Baek-Kyu Kim
BACKGROUND: Numerous methods exist for repairing unilateral cleft lips and mainly focus on cutaneous design to achieve sufficient rotation of the medial (M) cleft lip and produce a natural Cupid's bow and philtrum. However, precise nasal floor reconstruction has not been described in detail. This is the first study to introduce a technique for repairing complete unilateral cleft lips with a focus on nasal floor reconstruction. METHODS: In our technique, "Straight-Line Advanced Release Technique (StART)," the nasal floor is considered a 3-dimensional cuboid structure; the M mucosal and lateral (L) mucosal flaps constituted the posterior surface...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28561675/gastric-cancer-in-asia-unique-features-and-management
#16
Tomoyuki Irino, Hiroya Takeuchi, Masanori Terashima, Toshifumi Wakai, Yuko Kitagawa
Gastric cancer (GC) poses a burden to patients across the globe as the third leading cause of cancer deaths worldwide. Incidence of GC is particularly high in Asian countries, which is attributed to the prevalence of Helicobacter pylori (H. pylori) infection and has prompted the establishment of unique treatment strategies. D2 gastrectomy, which was established in the 1950s in Japan, has served as a gold standard for locally advanced GC for over half a century. Since the beginning of the 21st century, endoscopic resection (ER) techniques and minimally invasive laparoscopic surgery have greatly changed the treatment of patients with early GC...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28552884/ranolazine-facilitates-termination-of-ventricular-tachyarrhythmia-associated-with-acute-myocardial-ischemia-through-suppression-of-late-ina-mediated-focal-activity
#17
Takashi Ogawa, Haruo Honjo, Masatoshi Yamazaki, Yasunori Kushiyama, Ichiro Sakuma, Itsuo Kodama, Kaichiro Kamiya
BACKGROUND: Ventricular tachycardia/fibrillation (VT/VF) associated with acute myocardial ischemia is the most common cause of sudden cardiac death, but its underlying mechanisms are incompletely understood. It is hypothesized that late Na(+)current (INa) contributes to arrhythmogenic activity in ischemic myocardium.Methods and Results:Langendorff-perfused rabbit hearts with regional ischemia in ventricles were optically mapped. Perfusion with ranolazine (10 μmol/L), a selective inhibitor of lateINa, significantly reduced excitation frequency and facilitated termination of VT/VF induced after occlusion of the left main coronary trunk...
May 26, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28552438/high-prevalence-of-demodex-spp-infestation-among-patients-with-posterior-blepharitis-correlation-with-age-and-cylindrical-dandruff
#18
D López-Ponce, F Zuazo, C Cartes, D Salinas-Toro, C Pérez-Valenzuela, F Valenzuela, L Traipe-Castro, R O López-Solís
OBJECTIVE: To determine prevalence of Demodex spp. and infestation index (II) by the parasite among patients of different ages with blepharitis and to assess association with occurrence of cylindrical dandruff (CC). MATERIALS AND METHODS: Prospective study including patients diagnosed with posterior blepharitis between 2013 and 2015, without previous acaricide treatment, was conducted by Fundación Oftalmológica Los Andes (Chile). Four eyelashes were randomly extracted from each eyelid for parasite detection...
May 25, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28551912/-bacteria-without-borders-a-high-carriage-rate-of-antibiotic-resistant-bacteria-among-syrian-children-hospitalized-in-galilee-medical-center
#19
Diana Faour Kassem, Naama Shahar, Smadar Ocampo, Tarif Bader, Zeev Zonis, Daniel Glikman
INTRODUCTION: As the civil war in Syria enters its fifth year, the Israeli government continues to provide humanitarian aid to Syrian civilians in Israeli hospitals. Many wounded Syrian children are treated at the Galilee Medical Center (GMC). Due to the patients' incomplete medical history and increasing infection rates in Syria, contact isolation and screening cultures for multi-drug resistant bacteria (MDR's) are conducted upon admission for all Syrian children. AIMS: To describe the rate of MDR carriage in Syrian children and compare it to hospitalized Israeli children...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28546692/age-related-changes-in-the-foveal-bulge-in-healthy-eyes
#20
Kumar Saurabh, Rupak Roy, Preeti Sharma, Dhileesh P Chandrasekharan, Kaustubh Deshmukh, Chinmayi Vyas
BACKGROUND: Intact foveal bulge has been associated with good visual outcome in retinal diseases. The aim of this study was to study the variation in foveal bulge with age. METHODS: It was an observational cross-sectional study conducted between October 2014 and December 2015. Totally, 101 eyes of 101 healthy volunteers were studied in a tertiary care center. All individuals had best corrected visual acuity of 20/20 or better. High myopia (>6 D), high hyperopia (>4 D), unstable fixation, media opacities and retinal disorder like diabetic retinopathy, retinal vein occlusion were the exclusion criteria...
January 2017: Middle East African Journal of Ophthalmology
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