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https://www.readbyqxmd.com/read/27926543/effects-of-exercise-interventions-and-physical-activity-behavior-on-cancer-related-cognitive-impairments-an-update
#1
Nils Schaffrath, Max Oberste, Philipp Zimmer
PURPOSE OF REVIEW: The purpose of this review is to give an update on studies investigating the influence of physical activity behavior and exercise interventions on cancer-related cognitive impairments. RECENT FINDINGS: Cross-sectional and observational studies underline previous findings, revealing an association of cancer patients' fitness and their cognitive functions. Results from interventional studies are sparse. Only one study investigated self-perceived cognitive function in breast cancer patients as a secondary outcome, indicating no effects...
December 6, 2016: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27925359/effect-of-aerobic-exercise-intervention-on-markers-of-insulin-resistance-in-breast-cancer-women
#2
E Bruno, E Roveda, J Vitale, A Montaruli, F Berrino, A Villarini, E Venturelli, G Gargano, L Galasso, A Caumo, F Carandente, P Pasanisi
Insulin may affect breast cancer (BC) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention (AEI) on insulin parameters and body composition in non-obese BC women without insulin resistance. Thirty-eight BC women were randomised into an intervention group (IG = 18) or control group (CG = 20). IG participated in a structured AEI for 3 months, while CG received only the Word Cancer Research Fund/American Institute Cancer Research (WCRF/AICR) recommendation to be physically active...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27925326/navigating-physical-activity-engagement-following-a-diagnosis-of-cancer-a-qualitative-exploration
#3
C Cummins, N M Kayes, J Reeve, G Smith, R MacLeod, K M McPherson
This qualitative descriptive study explored cancer survivors' experiences of barriers and facilitators to undertaking physical activity to inform how services and professionals might offer better support. Purposive and theoretical sampling was used to recruit 25 people who were up to 5 years post-cancer diagnosis. Participants took part in face to face, semi-structured interviews, and transcripts were analysed using thematic analysis. The analysis identified five interrelated themes which represented cancer survivors' views: 1) You're on your own-a sense of abandonment post-treatment, and lack of sufficient and tailored information; 2) Dis-ease-disruption to self and identity, and a heightened awareness of physical self and fragility; 3) Becoming acclimatised-physical activity in the face of treatment-related side effects and residual impairment; 4) Importance of others-encouragement and support from health professionals, family and friends, and cancer-specific exercise groups; 5) Meanings people ascribed to physical activity-these were central and could help or hinder engagement...
December 7, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27923793/aerobic-exercise-in-anthracycline-induced-cardiotoxicity-a-systematic-review-of-current-evidence-and-future-directions
#4
Joseph J Chen, Pei T Wu, Holly R Middlekauff, Kim-Lien Nguyen
Cancer and cardiovascular disease are major causes of morbidity and mortality worldwide. Older cancer patients often wrestle with underlying heart disease during cancer therapy while childhood cancer survivors are living long enough to face long-term unintended cardiac consequences of cancer therapies, including anthracyclines. Although effective and widely used, particularly in the pediatric population, side effects including dose-dependent association with cardiac dysfunction limits its usage. Unfortunately, there is only one US FDA-approved drug (dexrazoxane) available for the prevention and mitigation of cardiotoxicity related to anthracycline therapy...
December 6, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27917414/receptivity-and-preferences-for-lifestyle-programs-to-reduce-cancer-risk-among-lung-cancer-family-members
#5
Lisa A Howell, Tabetha A Brockman, Pamela S Sinicrope, Christi A Patten, Paul A Decker, Allan Busta, Shawn Stoddard, Sheila R McNallan, Ping Yang
BACKGROUND: Lifestyle factors and genetic information has been found to contribute to the occurrence of lung cancer. This study assessed receptivity to participating in lifestyle programs to reduce cancer risk among unaffected lung cancer family members. We also explored demographic, medical, and psychosocial correlates of willingness to participate in lifestyle programs. METHODS: Family members who are part of a lung Cancer Family Registry were asked to fill out a survey assessing their receptivity to cancer risk reduction programs including preferences for an individual or family-based program...
September 2016: Adv Cancer Prev
https://www.readbyqxmd.com/read/27913448/targeting-inflammation-in-cancer-prevention-and-therapy
#6
REVIEW
Jelena Todoric, Laura Antonucci, Michael Karin
Inflammation is associated with the development and malignant progression of most cancers. As most of the cell types involved in cancer-associated inflammation are genetically stable and thus are not subjected to rapid emergence of drug resistance, the targeting of inflammation represents an attractive strategy both for cancer prevention and for cancer therapy. Tumor-extrinsic inflammation is caused by many factors, including bacterial and viral infections, autoimmune diseases, obesity, tobacco smoking, asbestos exposure, and excessive alcohol consumption, all of which increase cancer risk and stimulate malignant progression...
December 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27913051/erg-expression-in-multiple-myeloma-a-potential-diagnostic-pitfall
#7
Juliana Knief, Katharina Reddemann, Jan Gliemroth, Swantje Brede, Tobias Bartscht, Christoph Thorns
INTRODUCTION: ERG expression has been described as a frequent event in prostate cancer indicating poor prognosis and promoting oncogenesis. It has also been demonstrated in Ewing's sarcoma, acute myeloid leukemia and acute T-lymphoblastic leukemia but could not be found in other epithelial tumors, Hodgkin's or Non-Hodgkin's lymphoma. We aimed to analyze ERG expression in multiple myeloma, following an index case of a patient with metastases of unknown origin in the spine strongly expressing ERG, which were thought to be of prostatic origin but turned out to be plasmacytic lesions...
November 3, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27913001/cancer-related-fatigue-persistent-pervasive-and-problematic
#8
REVIEW
Lynn H Gerber
Cancer-related fatigue (CRF) is commonly reported by patients with cancer before, during, and after treatment. It is a persistent sense of tiredness that interferes with function, is distressing, and requires monitoring and, possibly, treatment. Fatigue assessment requires objective measures and self-reports, such as Functional Assessment of Cancer Therapy-Fatigue. Significant contributors to CRF include anemia, pain, insomnia, depressive symptoms, and elevated BMI. Elevated inflammatory cytokines, diabetes mellitus, cortisol, and cellular dysregulation have been associated with CRF...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27912996/alternative-exercise-traditions-in-cancer-rehabilitation
#9
REVIEW
Kathryn J Ruddy, Daniela L Stan, Anjali Bhagra, Mary Jurisson, Andrea L Cheville
Alternative exercise traditions (AETs) such as Pilates, yoga, Tai Chi Chuan, Qigong, and various forms of dance offer the potential to improve diverse outcomes among cancer survivors by reducing adverse symptoms and mood disorders, and by enhancing function. Additionally AETs have emerged as a potential means to address deficits in current disease-focused care delivery models which are marked by prevalent under-treatment of symptoms and physical impairments. Relative to therapeutic exercise in allopathic models, many AETs are comparatively affordable and accessible...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27912947/exploratory-outcome-assessment-of-qigong-tai-chi-easy-on-breast-cancer-survivors
#10
Linda K Larkey, Denise J Roe, Lisa Smith, Denise Millstine
OBJECTIVE: Breast cancer survivors (BCSs) experience symptoms affecting overall quality of life (QOL), often for a prolonged period post-treatment. Meditative Movement (MM), including Qigong and Tai Chi Easy (QG/TCE), has demonstrated benefit for improving QOL issues such as fatigue and sleep, but there is limited evidence of its impact on cognitive function, overall physical activity, and body weight for BCSs. DESIGN: This double-blind, randomized controlled pilot study with 87 female BCSs explored effects of QG/TCE on mental and physical QOL (Medical Outcomes Survey, Short Form), cognitive function (Functional Assessment of Cancer Therapy-Cognitive Function and two cognitive performance tests from the WAIS III), overall levels of physical activity (PA)(Brief Physical Activity Questionnaire) and body mass index (BMI)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27911710/eml-proteins-in-microtubule-regulation-and-human-disease
#11
REVIEW
Andrew M Fry, Laura O'Regan, Jessica Montgomery, Rozita Adib, Richard Bayliss
The EMLs are a conserved family of microtubule-associated proteins (MAPs). The founding member was discovered in sea urchins as a 77-kDa polypeptide that co-purified with microtubules. This protein, termed EMAP for echinoderm MAP, was the major non-tubulin component present in purified microtubule preparations made from unfertilized sea urchin eggs [J. Cell Sci. (1993) 104: , 445-450; J. Cell Sci. (1987) 87: (Pt 1), 71-84]. Orthologues of EMAP were subsequently identified in other echinoderms, such as starfish and sand dollar, and then in more distant eukaryotes, including flies, worms and vertebrates, where the name of ELP or EML (both for EMAP-like protein) has been adopted [BMC Dev...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27910284/resting-heart-rate-is-an-independent-predictor-of-death-in-patients-with-colorectal-pancreatic-and-non-small-cell-lung-cancer-results-of-a-prospective-cardiovascular-long-term-study
#12
Markus S Anker, Nicole Ebner, Bert Hildebrandt, Jochen Springer, Marianne Sinn, Hanno Riess, Stefan D Anker, Ulf Landmesser, Wilhelm Haverkamp, Stephan von Haehling
AIMS: Patients with advanced cancer have been shown to suffer from abnormal cardiac function and impaired exercise capacity that may contribute to their impaired quality of life. As tachycardia is considered as a sign of potential early cardiac damage, we sought to determine whether resting heart rate and other ECG-derived variables have prognostic value. METHODS AND RESULTS: From 2005 to 2010, we enrolled 145 patients with histologically confirmed cancer (36 colorectal, 72 pancreatic, and 37 non-small cell lung cancer patients) and 59 healthy controls...
December 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27909546/reducing-the-risk-of-breast-cancer-recurrence-an-evaluation-of-the-effects-and-mechanisms-of-diet-and-exercise
#13
REVIEW
Christina M Dieli-Conwright, Kyuwan Lee, Jacqueline L Kiwata
With recent medical advances in diagnosis and treatment, the increasing numbers of long-term survivors of breast cancer is considerable and has resulted in the expansion of scientific research to include examination of lifestyle modifications as means of prevention of recurrence, new breast cancer events, and mortality. The objective of this report is to review randomized controlled trials (RCTs) including diet and/or exercise interventions on breast cancer recurrence in women with a history of breast cancer as well as pertinent recent epidemiologic evidence...
2016: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/27908923/aerobic-exercise-and-cancer-related-fatigue-in-adults-a-re-examination-using-the-ivhet-model-for-meta-analysis
#14
George A Kelley, Kristi S Kelley
BACKGROUND: While the results of a recent meta-analysis using the traditional random-effects model yielded a statistically significant standardized mean difference (SMD) reduction in cancer-related fatigue (CRF) as a result of aerobic exercise, a recently developed inverse heterogeneity (IVhet) model has been shown to be more valid than the traditional random-effects model. The purpose of this study was to compare these previous meta-analytic results using the IVhet model. METHODS: Using data from a previous meta-analysis that included 36 SMD effect sizes (ES's) representing 2,830 adults (1,426 exercise, 1,404 control), results were pooled using the IVhet model...
December 1, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27904656/the-berlin-treatment-algorithm-recommendations-for-tailored-innovative-therapeutic-strategies-for-multiple-sclerosis-related-fatigue
#15
REVIEW
Christian Veauthier, Helge Hasselmann, Stefan M Gold, Friedemann Paul
More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed...
2016: EPMA Journal
https://www.readbyqxmd.com/read/27904241/what-does-the-cochrane-collaboration-say-about-exercise-after-breast-cancer
#16
(no author information available yet)
No abstract text is available yet for this article.
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27904238/physical-activity-and-breast-cancer-a-qualitative-study-on-the-barriers-to-and-facilitators-of-exercise-promotion-from-the-perspective-of-health-care-professionals
#17
Jenna Smith-Turchyn, Julie Richardson, Richard Tozer, Margaret McNeely, Lehana Thabane
Purpose: We determined the barriers to and facilitators of exercise promotion by health care professionals (HCPs) for women with breast cancer (BC). Methods: The study was a qualitative descriptive study. Semi-structured interviews were conducted with HCPs who treat individuals with BC in Ontario. The interviews were recorded and transcribed. Two reviewers independently used content analysis to determine codes and themes developed in the interviews. NVivo 10 was used during the coding process. Results: A total of 24 HCPs participated in this study...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27903842/a-comprehensive-lifestyle-randomized-clinical-trial-design-and-initial-patient-experience
#18
Banu Arun, Taylor Austin, Gildy V Babiera, Karen Basen-Engquist, Cindy L Carmack, Alejandro Chaoul, Lorenzo Cohen, Lisa Connelly, Robin Haddad, Carol Harrison, Yisheng Li, Smitha Mallaiah, Raghuram Nagarathna, Patricia A Parker, George H Perkins, James M Reuben, Ya-Chen Tina Shih, Amy Spelman, Anil Sood, Peiying Yang, Sai-Ching J Yeung
BACKGROUND: Although epidemiological research demonstrates that there is an association between lifestyle factors and risk of breast cancer recurrence, progression of disease, and mortality, no comprehensive lifestyle change clinical trials have been conducted to determine if changing multiple risk factors leads to changes in biobehavioral processes and clinical outcomes in women with breast cancer. This article describes the design, feasibility, adherence to the intervention and data collection, and patient experience of a comprehensive lifestyle change clinical trial (CompLife)...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903841/influence-of-a-moderate-intensity-exercise-program-on-early-nk-cell-immune-recovery-in-pediatric-patients-after-reduced-intensity-hematopoietic-stem-cell-transplantation
#19
Carolina Chamorro-Viña, Jaime Valentín, Lucía Fernández, Marta González-Vicent, Margarita Pérez-Ruiz, Alejandro Lucía, S Nicole Culos-Reed, Miguel Ángel Díaz, Antonio Pérez-Martínez
INTRODUCTION: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56(bright) subset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer. PURPOSE: To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903152/obesity-and-cancer-mechanisms-cancer-metabolism
#20
Benjamin D Hopkins, Marcus D Goncalves, Lewis C Cantley
Obesity is a risk factor for cancer development and is associated with poor prognosis in multiple tumor types. The positive energy balance linked with obesity induces a variety of systemic changes including altered levels of insulin, insulin-like growth factor-1, leptin, adiponectin, steroid hormones, and cytokines. Each of these factors alters the nutritional milieu and has the potential to create an environment that favors tumor initiation and progression. Although the complete ramifications of obesity as it relates to cancer are still unclear, there is convincing evidence that reducing the magnitude of the systemic hormonal and inflammatory changes has significant clinical benefits...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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