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physical activity and cancer

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https://www.readbyqxmd.com/read/28227910/development-of-a-three-dimensional-lattice-free-multiscale-model-of-the-mammary-terminal-end-bud
#1
Joseph D Butner, Vittorio Cristini, Zhihui Wang, Joseph D Butner, Vittorio Cristini, Zhihui Wang, Vittorio Cristini, Joseph D Butner, Zhihui Wang
The terminal end bud (TEB) is a bulbous structure composed of highly proliferative cells that is responsible for mammary gland development during the pubertal stage. This is a highly organized process, involving cellular differentiation hierarchies regulated by endocrine and paracrine signaling. Here, we present development of a lattice-free, three dimensional multiscale agent based model of the TEB to study the effects of cellular phenotypic hierarchies, endocrine and paracrine signaling, and proliferation demographics on pubertal mammary gland development...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226219/dietary-inflammatory-index-and-odds-of-colorectal-cancer-in-a-case-control-study-from-jordan
#2
Nitin Shivappa, James R Hébert, Susan E Steck, Lorne J Hofseth, Ihab Shehadah, Kamal E Bani-Hani, Tareq Al-Jaberi, Majed Al-Nusairr, Dennis Heath, Reema Tayyem
BACKGROUND: Dietary components that promote inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet and CRC has been investigated in several developed or Western countries. Despite the fact that dietary choices in the Middle East differ markedly from those in the West, results have not been reported from any study conducted in a Middle-Eastern population. We examined the association between dietary inflammatory index (DII)TM scores and CRC in a case-control study conducted in Jordan...
February 22, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28225043/prevention-of-tumorigenesis-in-mice-by-exercise-is-dependent-on-strain-background-and-timing-relative-to-carcinogen-exposure
#3
Scott A Kelly, Liyang Zhao, Kuo-Chen Jung, Kunjie Hua, David W Threadgill, Yunjung Kim, Fernando Pardo Manuel de Villena, Daniel Pomp
Among cancer diagnoses, colorectal cancer (CRC) is prevalent, with a lifetime risk of developing CRC being approximately 5%. Population variation surrounding the mean risk of developing CRCs has been associated with both inter-individual differences in genomic architecture and environmental exposures. Decreased risk of CRC has been associated with physical activity, but protective responses are variable. Here, we utilized a series of experiments to examine the effects of genetic background (strain), voluntary exercise (wheel running), and their interaction on azoxymethane (AOM)-induced intestinal tumor number and size in mice...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28222775/modification-of-the-association-between-recreational-physical-activity-and-survival-after-breast-cancer-by-promoter-methylation-in-breast-cancer-related-genes
#4
Lauren E McCullough, Jia Chen, Yoon Hee Cho, Nikhil K Khankari, Patrick T Bradshaw, Alexandra J White, Susan L Teitelbaum, Mary Beth Terry, Alfred I Neugut, Hanina Hibshoosh, Regina M Santella, Marilie D Gammon
BACKGROUND: Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast cancer-related genes, as well as global methylation, may modify the association between prediagnostic recreational physical activity (RPA) and breast cancer mortality. METHODS: Using a population-based sample of 1254 women diagnosed with first primary breast cancer, we examined modification of the RPA-mortality association by gene-specific promoter methylation and global methylation...
February 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28222085/physical-activity-promotion-beliefs-and-barriers-among-australasian-oncology-nurses
#5
Justin W L Keogh, Petra Pühringer, Alicia Olsen, Sally Sargeant, Lynnette M Jones, Mike Climstein
PURPOSE/OBJECTIVES: To describe the physical activity (PA) promotion practices, beliefs, and barriers of Australasian oncology nurses and gain preliminary insight into how PA promotion practices may be affected by the demographics of the nurses.
. DESIGN: Cross-sectional survey.
. SETTING: Australia and New Zealand.
. SAMPLE: 119 registered oncology nurses.
. METHODS: Self-reported online survey completed once per participant...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28221215/experiences-of-patients-with-breast-cancer-of-participating-in-a-lifestyle-intervention-study-while-receiving-adjuvant-chemotherapy
#6
Karianne Vassbakk-Brovold, Anne J Antonsen, Sveinung Berntsen, Christian Kersten, Liv Fegran
BACKGROUND: Lifestyle interventions are suggested to reduce the symptom burden and comorbidities in patients with breast cancer and as an empowerment tool. However, undergoing chemotherapy is associated with low compliance to lifestyle recommendations. Importantly, few studies have documented the experiences of patients with breast cancer of participating in a comprehensive lifestyle intervention study while undergoing curative chemotherapy. OBJECTIVE: The aim of this study was to explore the experiences of patients with breast cancer of participating in an individualized comprehensive lifestyle intervention study focusing on diet, physical activity, mental stress management, and smoking cessation while undergoing curative chemotherapy...
February 17, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28220911/national-survey-of-health-in-the-tattoo-industry-observational-study-of-448-french-tattooists
#7
Nicolas Kluger
OBJECTIVES: The data regarding the health of professional tattooists is inexistent. Tattooists are usually heavily tattooed and exposed daily to body fluids and skin-to-skin contacts with customers, tattoo inks, solvents, allergens, irritants, and work for hours often in inadequate positions using vibrating tattoo machines. We analyzed the health status of active French professional tattooists. MATERIAL AND METHODS: An observational self-reported Internet survey was performed among 448 tattooists who were members of the French Tattoo Union in November 2013...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220328/the-provision-of-dietary-and-physical-activity-advice-for-men-diagnosed-with-prostate-cancer-a-qualitative-study-of-the-experiences-and-views-of-health-care-professionals-patients-and-partners
#8
Eileen Sutton, Lucy E Hackshaw-McGeagh, Jonathan Aning, Amit Bahl, Anthony Koupparis, Raj Persad, Richard M Martin, J Athene Lane
PURPOSE: To explore the views and experiences of health care professionals (HCPs), men diagnosed with localised prostate cancer and their partners about the provision of advice on diet and physical activity after diagnosis and treatment for localised prostate cancer. METHODS: Semi-structured in-depth interviews with ten HCPs (Consultant Urological Surgeons, Uro-Oncology Clinical Nurse Specialists and Allied Health Professionals: see Table 1) and sixteen men diagnosed with localised prostate cancer and seven of their partners...
February 20, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28218910/a-mechanically-active-heterotypic-e-cadherin-n-cadherin-adhesion-enables-fibroblasts-to%C3%A2-drive-cancer-cell-invasion
#9
Anna Labernadie, Takuya Kato, Agustí Brugués, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor González-Tarragó, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai, Xavier Trepat
Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. This adhesion is mechanically active; when subjected to force it triggers β-catenin recruitment and adhesion reinforcement dependent on α-catenin/vinculin interaction. Impairment of E-cadherin/N-cadherin adhesion abrogates the ability of CAFs to guide collective cell migration and blocks cancer cell invasion...
February 20, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28218585/systematic-review-of-occupational-therapy-and-adult-cancer-rehabilitation-part-1-impact-of-physical-activity-and-symptom-management-interventions
#10
Elizabeth G Hunter, Robert W Gibson, Marian Arbesman, Mariana D'Amico
This article is the first part of a systematic review of evidence for the effectiveness of cancer rehabilitation interventions within the scope of occupational therapy that address the activity and participation needs of adult cancer survivors. This article focuses on the importance of physical activity and symptom management. Strong evidence supports the use of exercise for cancer-related fatigue and indicates that lymphedema is not exacerbated by exercise. Moderate evidence supports the use of yoga to relieve anxiety and depression and indicates that exercise as a whole may contribute to a return to precancer levels of sexual activity...
March 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28216379/association-between-muscle-strengthening-physical-activities-and-mortality-among-american-adults-with-mobility-limitations
#11
Paul D Loprinzi, Ovuokerie Addoh, Joshua R Mann
Compared to aerobic-based physical activity, less research has evaluated the effects of muscle-strengthening physical activity (MSPA) on mortality. Additionally, limited research has evaluated this among adults with mobility limitations, which was this study's purpose. Data from the 2003-2006 NHANES, with follow-up through 2011, were used (analyzed in 2016). MSPA was assessed via self-report, with all-cause, CVD-specific, and cancer-specific mortality assessed as the outcome variables. Analyses were limited to adults with mobility limitations (N=1411), assessed via a validated questionnaire...
February 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28216377/neighborhood-walkability-and-hospital-treatment-costs-a-first-assessment
#12
Yan Yu, Rachel Davey, Tom Cochrane, Vincent Learnihan, Ivan C Hanigan, Nasser Bagheri
Health system expenditure is a global concern, with hospital cost a major component. Built environment has been found to affect physical activity and health outcomes. The purpose of the study was a first assessment of the relationship between neighborhood walkability and hospital treatment costs. For 88 neighborhoods in the Australian Capital Territory (ACT), 2011-2013, a total of 30,690 hospital admissions for the treatment of four diagnostic groups (cancers, endocrine, nutritional and metabolic diseases, circulatory diseases and respiratory diseases) were extracted from the ACT admitted patient care database and analyzed in relation to the Walk Score® index as a measure of walkability...
February 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28216110/the-current-global-state-of-key-lifestyle-characteristics-health-and-economic-implications
#13
REVIEW
Ross Arena, Amy McNeil, Michael Sagner, Andrew P Hills
The chronic disease crisis we currently face must be addressed in rapid fashion. Cardiovascular (CV) and pulmonary diseases, diabetes as well as several forms of cancer are leading causes of morbidity and mortality globally. Collectively, these conditions have a significant impact on the quality of life of individuals, families and communities, placing an unsustainable burden on health systems. There is hope for the chronic disease crisis in that these conditions are largely preventable or can be delayed to much later in life through a timeless medicine, healthy living...
February 16, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28214933/findings-from-american-indian-needs-assessments
#14
Linda Burhansstipanov, Linda U Krebs, Lisa Harjo, Kathleen Ragan, Judith Salmon Kaur, Vickie Marsh, Dewey Painter
Because of decreased access and dismal survival rates, strategies need to be developed to increase cancer awareness and facilitate cancer prevention, early detection, and screening activities within American Indian (AI) populations. The purpose of this study was to develop a locally tailored needs assessment to collect cancer prevention, control, and risk factor information and knowledge, attitude, and perceived behavior (hereafter referred to as "needs assessment") data from 500 community members living in 3 geographically diverse settings: the Southeastern USA, the Rocky Mountain region, and the Northern Plains...
February 18, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28210916/a-multiscale-mathematical-model-of-tumour-invasive-growth
#15
Lu Peng, Dumitru Trucu, Ping Lin, Alastair Thompson, Mark A J Chaplain
Known as one of the hallmarks of cancer (Hanahan and Weinberg in Cell 100:57-70, 2000) cancer cell invasion of human body tissue is a complicated spatio-temporal multiscale process which enables a localised solid tumour to transform into a systemic, metastatic and fatal disease. This process explores and takes advantage of the reciprocal relation that solid tumours establish with the extracellular matrix (ECM) components and other multiple distinct cell types from the surrounding microenvironment. Through the secretion of various proteolytic enzymes such as matrix metalloproteinases or the urokinase plasminogen activator (uPA), the cancer cell population alters the configuration of the surrounding ECM composition and overcomes the physical barriers to ultimately achieve local cancer spread into the surrounding tissue...
February 16, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28210884/energy-balance-and-obesity-what-are-the-main-drivers
#16
Isabelle Romieu, Laure Dossus, Simón Barquera, Hervé M Blottière, Paul W Franks, Marc Gunter, Nahla Hwalla, Stephen D Hursting, Michael Leitzmann, Barrie Margetts, Chizuru Nishida, Nancy Potischman, Jacob Seidell, Magdalena Stepien, Youfa Wang, Klaas Westerterp, Pattanee Winichagoon, Martin Wiseman, Walter C Willett
PURPOSE: The aim of this paper is to review the evidence of the association between energy balance and obesity. METHODS: In December 2015, the International Agency for Research on Cancer (IARC), Lyon, France convened a Working Group of international experts to review the evidence regarding energy balance and obesity, with a focus on Low and Middle Income Countries (LMIC). RESULTS: The global epidemic of obesity and the double burden, in LMICs, of malnutrition (coexistence of undernutrition and overnutrition) are both related to poor quality diet and unbalanced energy intake...
February 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28210862/physical-activity-related-differences-in-body-mass-index-and-patient-reported-quality-of-life-in-socioculturally-diverse-endometrial-cancer-survivors
#17
Amerigo Rossi, Carol Ewing Garber, Gurpreet Kaur, Xiaonan Xue, Gary L Goldberg, Nicole S Nevadunsky
PURPOSE: The purpose of this study was to describe physical activity-related differences in body composition, quality of life, and behavioral variables among a socioculturally diverse sample of endometrial cancer survivors. METHODS: Ambulatory, English-speaking endometrial cancer survivors (6 months to 5 years post-treatment), who were residents of Bronx, NY, were recruited to complete questionnaires about physical activity (PA), quality of life (QoL), and psychosocial characteristics...
February 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28209923/novel-involvement-of-rhebl1-in-sphingosylphosphorylcholine-induced-keratin-phosphorylation-and-reorganization-binding-to-and-activation-of-akt1
#18
Hyun Ji Kim, Hyun Jung Byun, Mi Kyung Park, Eun Ji Kim, Gyeoung Jin Kang, Chang Hoon Lee
Sphingosylphosphorylcholine induces keratin phosphorylation and reorganization, and increases viscoelasticity of metastatic cancer cells such as PANC-1 cells. However, the mechanism involved in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization is largely unknown. Sphingosylphosphorylcholine dose- and time-dependently induces the expression of RhebL1. The involvement of RhebL1 in sphingosylphosphorylcholine-induced events including keratin 8 (K8) phosphorylation, reorganization, migration and invasion was examined...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28208044/daily-step-count-and-the-need-for-hospital-care-in-subsequent-years-in-a-community-based-sample-of-older-australians
#19
Ben D Ewald, Christopher Oldmeadow, John R Attia
OBJECTIVES: To determine the extent to which physical activity reduces the number of hospital bed-days for Australians over 55, using an objective measure of activity. DESIGN, SETTING AND PARTICIPANTS: 9784 Newcastle residents aged 55 years or more were invited to participate. 3253 responders were eligible and wore pedometers for one week during 2005-2007; their hospital data from recruitment to 31 March 2015 were analysed (mean follow-up time: 8.2 years). Complete data for 2110 people were available for analysis...
February 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28207820/objectively-measured-versus-self-reported-physical-activity-in-children-and-adolescents-with-cancer
#20
Miriam Götte, Corinna Caroline Seidel, Sabine Verena Kesting, Dieter Rosenbaum, Joachim Boos
OBJECTIVE: Existing research recognizes low levels of physical activity in pediatric patients with cancer, but much uncertainty exists about their capability to self-reflect physical activity levels. The objective of this study was to compare results of subjective self-reports and objective accelerometers regarding levels of daily walking as well as moderate-to-vigorous physical activities. METHODS: Results of the objective assessment tool StepWatchTM Activity Monitor and self-reporting with a standardized questionnaire were compared in 28 children and adolescents during cancer treatment...
2017: PloS One
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