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physical activity and cancer

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https://www.readbyqxmd.com/read/29340805/cardiorespiratory-fitness-and-cardiovascular-disease-prevention-an-update
#1
REVIEW
Mouaz H Al-Mallah, Sherif Sakr, Ada Al-Qunaibet
PURPOSE OF REVIEW: Cardiovascular diseases account for nearly one third of all deaths globally. Improving exercise capacity and cardiorespiratory fitness (CRF) has been an important target to reduce cardiovascular events. In addition, the American Heart Association defined decreased physical activity as the fourth risk factor for coronary artery disease. Multiple large cohort studies have evaluated the impact of CRF on outcomes. In this review, we will discuss the role of CRF in reducing cardiovascular morbidity and mortality...
January 16, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29339538/e6-protein-expressed-by-high-risk-hpv-activates-super-enhancers-of-the-egfr-and-c-met-oncogenes-by-destabilizing-the-histone-demethylase-kdm5c
#2
Xiaohua Chen, Jun Xian Loo, Xin Shi, Wenjun Xiong, Yong Guo, Haiqiang Ke, Mingkun Yang, Yanping Jiang, Siyu Xia, Min Zhao, Shan Zhong, ChunJiang He, Li Fu, Feng Li
The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradation and telomerase activation. It is also capable of stimulating expression of several oncogenes, but the molecular mechanism underlying these events are poorly understood. Here we provide evidence that HPV16 E6 physically interacts with histone H3K4 demethylase KDM5C, resulting in its degradation in an E3 ligase E6AP- and proteasome-dependent manner...
January 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29339119/targeting-of-stress-response-pathways-in-the-prevention-and-treatment-of-cancer
#3
REVIEW
Jaroslav Zelenka, Martina Koncošová, Tomáš Ruml
The hallmarks of tumor tissue are not only genetic aberrations but also the presence of metabolic and oxidative stress as a result of hypoxia and lactic acidosis. The stress activates several prosurvival pathways including metabolic remodeling, autophagy, antioxidant response, mitohormesis, and glutaminolysis, whose upregulation in tumors is associated with a poor survival of patients, while their activation in healthy tissue with statins, metformin, physical activity, and natural compounds prevents carcinogenesis...
January 12, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29338744/new-insights-in-the-relative-radiobiological-effectiveness-of-proton-irradiation
#4
REVIEW
K Ilicic, S E Combs, T E Schmid
BACKGROUND: Proton radiotherapy is a form of charged particle therapy that is preferentially applied for the treatment of tumors positioned near to critical structures due to their physical characteristics, showing an inverted depth-dose profile. The sparing of normal tissue has additional advantages in the treatment of pediatric patients, in whom the risk of secondary cancers and late morbidity is significantly higher. Up to date, a fixed relative biological effectiveness (RBE) of 1...
January 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29338722/development-and-pilot-evaluation-of-a-clinic-based-mhealth-app-referral-service-to-support-adult-cancer-survivors-increase-their-participation-in-physical-activity-using-publicly-available-mobile-apps
#5
Camille E Short, Amy Finlay, Ilea Sanders, Carol Maher
BACKGROUND: Participation in regular physical activity holds key benefits for cancer survivors, yet few cancer survivors meet physical activity recommendations. This study aimed to develop and pilot test a mHealth app referral service aimed at assisting cancer survivors to increase their physical activity. In particular, the study sought to examine feasibility and acceptability of the service and determine preliminary efficacy for physical activity behaviour change. METHODS: A systematic search identified potentially appropriate Apple (iOS) and Android mHealth apps...
January 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29337679/the-effects-of-physical-activity-on-chronic-subclinical-systemic-inflammation
#6
Alba Maria Dalbello Tir, Marina Labor, Davor Plavec
Chronic subclinical systemic inflammation (CSSI) is a pathogenic event and a common risk factor for many noncommunicable diseases like atherosclerosis, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes, cancer, and obstructive lung disease. On the other hand, regular physical activity has been found to reduce this risk. Many studies of different design were conducted to assess the association between inflammatory mediators as markers of CSSI and regular physical activity. The aim of this review was to present the current level of evidence and understanding of potential mechanisms by which physical activity reduces inflammatory mediators involved in CSSI and the types of physical activity required for the expected effect...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337398/exploring-knowledge-attitudes-and-experience-of-genitourinary-symptoms-in-women-with-early-breast-cancer-on-adjuvant-endocrine-therapy
#7
M Sousa, M Peate, C Lewis, S Jarvis, A Willis, M Hickey, M Friedlander
Clinical trials of adjuvant endocrine therapy in women with early breast cancer have consistently reported that genitourinary symptoms are common. However, little is known about women's experiences of genitourinary symptoms, their views about the symptoms and how they impact on their lives. The aim of this study was to explore knowledge, attitudes and experiences of genitourinary symptoms among women receiving adjuvant endocrine therapy for early breast cancer. Thirty-two semi-structured interviews were conducted and subjected to a rigorous qualitative analysis...
January 16, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29336644/evidence-education-and-multi-disciplinary-integration-are-needed-to-embed-exercise-into-lung-cancer-clinical-care-a-qualitative-study-involving-physiotherapists
#8
Catherine L Granger, Selina M Parry, Linda Denehy, Louisa Remedios
AIMS: To explore physiotherapists perceptions regarding barriers and enablers to embedding exercise into routine lung cancer clinical care. DESIGN: Qualitative study (content analysis). Eight physiotherapists working in the area of lung cancer at five hospitals participated. The focus group was conducted, transcribed verbatim and independently crosschecked. Thematic analysis was utilized. RESULTS: The data generated four major themes: evidence justifying exercise; staffing and services; maximising the efficacy of interventions; and hospital culture...
January 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29334983/an-individually-tailored-family-centered-intervention-for-pediatric-obesity-in-primary-care-study-protocol-of-a-randomized-type-ii-hybrid-effectiveness-implementation-trial-raising-healthy-children-study
#9
Justin D Smith, Cady Berkel, Neil Jordan, David C Atkins, Shrikanth S Narayanan, Carlos Gallo, Kevin J Grimm, Thomas J Dishion, Anne M Mauricio, Jenna Rudo-Stern, Mariah K Meachum, Emily Winslow, Meg M Bruening
BACKGROUND: Pediatric obesity is a multi-faceted public health concern that can lead to cardiovascular diseases, cancers, and early mortality. Small changes in diet, physical activity, or BMI can significantly reduce the possibility of developing cardiometabolic risk factors. Family-based behavioral interventions are an underutilized, evidence-based approach that have been found to significantly prevent excess weight gain and obesity in children and adolescents. Poor program availability, low participation rates, and non-adherence are noted barriers to positive outcomes...
January 15, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29331901/an-ultrasensitive-detection-of-mirna-155-in-breast-cancer-via-direct-hybridization-assay-using-two-dimensional-molybdenum-disulfide-field-effect-transistor-biosensor
#10
Samira Mansouri Majd, Abdollah Salimi, Foad Ghasemi
MicroRNAs (miRNAs), critical biomarkers of acute and chronic diseases, play key regulatory roles in many biological processes. As a result, robust assay platforms to enable an accurate and efficient detection of low-level miRNAs in complex biological samples are of great significance. In this work, a label-free and direct hybridization assay using molybdenum disulfide (MoS2) field-effect transistor (FET) biosensor has been developed for ultrasensitive detection of miRNA-155 as a breast cancer biomarker in human serum and cell-line samples...
January 6, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29330806/fluorescence-activated-cell-sorting-of-murine-mammary-cancer-stem-like-cell-subpopulations-with-hif-activity
#11
Danielle L Brooks, Tiffany N Seagroves
Fluorescence-activated cell sorting (FACS) is a common method to identify and to isolate subpopulations within a complex mixture of cells based on their light scatter and fluorescent staining profiles. FACS is widely used to enrich for normal tissue and tumor cells that have stem cell potential. Whereas FACS protocols using conventional breast cancer cell lines are relatively routine, additional technical challenges are encountered when sorting for cell populations from freshly digested solid tumors, particularly for use in downstream cancer stem cell (CSC) assays...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29330081/optimization-of-a-technology-supported-physical-activity-intervention-for-breast-cancer-survivors-fit2thrive-study-protocol
#12
Siobhan M Phillips, Linda M Collins, Frank J Penedo, Kerry S Courneya, Whitney Welch, Alison Cottrell, Gillian R Lloyd, Kara Gavin, David Cella, Ronald T Ackermann, Juned Siddique, Bonnie Spring
Fit2Thrive is a theory-guided physical activity promotion trial using the Multiphase Optimization Strategy (MOST) to test efficacy for improving physical activity of five technology-supported physical activity promotion intervention components among breast cancer survivors. This trial will recruit 256 inactive breast cancer survivors nationwide. All participants will receive the core intervention which includes a Fitbit and standard self-monitoring Fit2Thrive smartphone application which will be downloaded to their personal phone...
January 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29327644/evaluation-of-supervised-multimodal-prehabilitation-programme-in-cancer-patients-undergoing-colorectal-resection-a-randomized-control-trial
#13
Guillaume Bousquet-Dion, Rashami Awasthi, Sarah-Ève Loiselle, Enrico M Minnella, Ramanakumar V Agnihotram, Andreas Bergdahl, Francesco Carli, Celena Scheede-Bergdahl
BACKGROUND: Prehabilitation has been previously shown to be more effective in enhancing postoperative functional capacity than rehabilitation alone. The purpose of this study was to determine whether a weekly supervised exercise session could provide further benefit to our current prehabilition program, when comparing to standard post-surgical rehabilitation. METHODS: A parallel-arm single-blind randomized control trial was conducted in patients scheduled for non-metastatic colorectal cancer resection...
January 12, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29327178/clinical-impact-and-risk-factors-for-skeletal-muscle-loss-after-complete-resection-of-early-non-small-cell-lung-cancer
#14
Shinkichi Takamori, Gouji Toyokawa, Tatsuro Okamoto, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiko Hirai, Fumihiro Shoji, Tetsuzo Tagawa, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara
BACKGROUND: A relationship between sarcopenia diagnosed by skeletal muscle area (SMA) and poor prognosis in cancer patients has recently been reported. This study aimed to clarify the clinical significance of postoperatively decreased SMA in patients with early non-small cell lung cancer (NSCLC). METHODS: This study selected 101 patients with pathologic stage 1 NSCLC who had undergone pre- and postoperative (~ 1 year) computed tomography scans and lobectomy between 2005 and 2010 at Kyushu University Hospital...
January 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29325658/tele-motivational-interviewing-for-cancer-survivors-feasibility-preliminary-efficacy-and%C3%A2-lessons-learned
#15
Ashlea Braun, James Portner, Elizabeth M Grainger, Emily B Hill, Gregory S Young, Steven K Clinton, Colleen K Spees
OBJECTIVE: Determine the feasibility, acceptability, and efficacy of tele-Motivational Interviewing (MI) for overweight cancer survivors. DESIGN: Six-month nonrandomized phase 2 clinical trial. SETTING: Urban garden and remote platforms. PARTICIPANTS: Overweight and obese cancer survivors post active treatment. INTERVENTION: Remote tele-MI from a trained registered dietitian nutritionist (RDN)...
January 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29325535/effects-of-physical-activity-on-colorectal-cancer-risk-among-family-history-and-body-mass-index-subgroups-a-systematic-review-and-meta-analysis
#16
Eileen Shaw, Megan S Farris, Chelsea R Stone, Jeroen W G Derksen, Rhys Johnson, Robert J Hilsden, Christine M Friedenreich, Darren R Brenner
BACKGROUND: Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of colorectal cancer or high body mass index remains unclear. METHODS: We searched MEDLINE for studies examining physical activity and colorectal cancer risk among higher risk subgroups through July 11, 2017. Fifteen and three studies were eligible for inclusion for body mass index and first-degree family history of colorectal cancer subgroups, respectively...
January 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29320689/collective-cell-migration-in-embryogenesis-follows-the-laws-of-wetting
#17
Bernhard Wallmeyer, Sarah Trinschek, Sargon Yigit, Uwe Thiele, Timo Betz
Collective cell migration is a fundamental process during embryogenesis and its initial occurrence, called epiboly, is an excellent in vivo model to study the physical processes involved in collective cell movements that are key to understanding organ formation, cancer invasion, and wound healing. In zebrafish, epiboly starts with a cluster of cells at one pole of the spherical embryo. These cells are actively spreading in a continuous movement toward its other pole until they fully cover the yolk. Inspired by the physics of wetting, we determine the contact angle between the cells and the yolk during epiboly...
January 9, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29320342/factors-associated-with-sunbed-use-in-women-the-e3n-sunexp-study
#18
Isabelle Savoye, Iris Cervenka, Yahya Mahamat Saleh, Marie-Christine Boutron-Ruault, Marina Kvaskoff
OBJECTIVES: In this study, we attempt to describe the profile of sunbed users among cancer-free French women. METHODS: E3N is a prospective cohort including 98,995 French women aged 40- 65 years in 1990. In 2008, a specific UV questionnaire was sent to all reported skin cancer cases and 3 controls per case, matched on age, county of birth, and education. We used logistic regression models adjusted for pigmentary traits. RESULTS: Compared with non-users, ever-users of sunbeds were younger (ptrend < ...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29319387/relationship-between-physical-activity-disability-and-physical-fitness-profile-in-sedentary-latina-breast-cancer-survivors
#19
Alexis Ortiz, Maribel Tirado, Daniel C Hughes, Velda Gonzalez, JaeJoon Song, Scherezade K Mama, Karen Basen-Engquist
OBJECTIVE: To report baseline data from a physical activity (PA) intervention for Latina breast cancer survivors, and assess the relationship between PA, fitness, and disability. METHODS: Eighty-nine Latina breast cancer survivors from San Juan, PR and Houston, TX (age: 55.4 ± 9.9 years; BMI: 29.87 ± 5.62 kg/m2; ≥ 3 months post-treatment) participated in this study. At baseline participants completed fitness testing (six-minute walk test [6MWT], 30-second sit-stand; grip strength, lower and upper extremity and low back strength, shoulder range of motion, balance testing), and assessment of physical activity (PA) and disability...
January 10, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29318117/risk-factors-for-breast-cancer-among-jordanian-women-a-case-control-study
#20
Mohammad Al Qadire, Murad Alkhalaileh, Hedaya Hina
Background: The interaction between inherited mutated genes and environmental factors is believed to play a crucial role in cancer development. The main aim was to identify lifestyle-related risk factors for breast cancer among Jordanian women. Methods: A hospital-based multicenter case-control study was conducted in Jordan in 2016. Overall, 405 cases and 418 controls, in 3 large hospitals where cancer patients are treated, participated. The prevalence of individual and groups of cancer-related risk factors was estimated descriptively using percentages and odd ratios with their correlated 95% Confidence interval (CI)...
January 2018: Iranian Journal of Public Health
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