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https://www.readbyqxmd.com/read/28081215/genome-wide-association-studies-of-multiple-keratinocyte-cancers
#1
Luba M Pardo, Wen-Qing Li, Shih-Jen Hwang, Joris A C Verkouteren, Albert Hofman, André G Uitterlinden, Peter Kraft, Constance Turman, Jiali Han, Eunyoung Cho, Joanne M Murabito, Daniel Levy, Abrar A Qureshi, Tamar Nijsten
There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly investigated. We investigated whether single nucleotide polymorphisms (SNPs) are associated with susceptibility for mKCs. A genome-wide association study (GWAS) of 1,666 cases with mKCs and 1,950 cases with single KC (sKCs; controls) from Harvard cohorts (the Nurses' Health Study [NHS], NHS II, and the Health Professionals Follow-Up Study) and the Framingham Heart Study was carried-out using over 8 million SNPs (stage-1)...
2017: PloS One
https://www.readbyqxmd.com/read/28078479/follow-up-cancer-care-perspectives-of-aboriginal-and-torres-strait-islander-cancer-survivors
#2
J A Meiklejohn, G Garvey, R Bailie, E Walpole, J Adams, D Williamson, J Martin, C M Bernardes, B Arley, B Marcusson, P C Valery
PURPOSE: The purpose of this study was to explore Indigenous Australian cancer survivors' perspectives of follow-up cancer care and management.. METHODS: This is a qualitative study employing individual interviews with 21 Indigenous cancer survivors (13 females, 8 males) recruited from a rural primary health service and large tertiary hospital in Brisbane, Queensland. Yarning methods were used to conduct semi-structured interviews. Yarning is a culturally appropriate, informal conversational process emphasising the importance of storytelling...
January 12, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28077347/translating-e-mental-health-into-practice-what-are-the-barriers-and-enablers-to-e-mental-health-implementation-by-aboriginal-and-torres-strait-islander-health-professionals
#3
James Bennett-Levy, Judy Singer, Simon DuBois, Kelly Hyde
BACKGROUND: With increasing evidence for the effectiveness of e-mental health interventions for enhancing mental health and well-being, a growing challenge is how to translate promising research findings into service delivery contexts. A 2012 e-mental health initiative by the Australian Federal Government (eMHPrac) has sought to address the issue through several strategies, one of which has been to train different health professional workforces in e-mental health (e-MH). OBJECTIVE: The aim of the study was to report on the barriers and enablers of e-MH uptake in a cohort of predominantly Aboriginal and Torres Strait Islander health professionals (21 Indigenous, 5 non-Indigenous) who occupied mainly support or case management roles within their organizations...
January 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28076543/oral-health-in-the-children-s-preventive-health-care-initiative-indicators-and-goals-in-a-primary-health-care-service
#4
Anna Schwendler, Daniel Demétrio Faustino-Silva, Cristianne Famer Rocha
The objective of this study is to assess fulfillment of the oral health goals of the Children's Preventive Health Care Initiative in 12 Health Units (HU) of a Primary Health Care Service, in Porto Alegre, in the state of Rio Grande do Sul, through a cross-sectional analytical study on the annual dental visit coverage in early childhood. The study was comprised of 660 children born in 2010. In relation to the coverage of dental visits for each year of life of children, the health units did not achieve the set targets (100%)...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28074249/protein-intake-and-risk-of-hip-fractures-in-postmenopausal-women-and-men-age-50-and-older
#5
T T Fung, H E Meyer, W C Willett, D Feskanich
: In this study, we followed postmenopausal women and men aged 50 and above for up to 32 years and found no evidence that higher protein intake increased the risk of hip fracture. Protein intake from specific sources was inversely associated with risk, but these associations appeared to differ by gender. INTRODUCTION: We examined the association between intakes of total and specific sources of protein and hip fracture risk in postmenopausal women and men over 50 years of age...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28070310/implementation-of-the-who-multimodal-hand-hygiene-improvement-strategy-in-a-university-hospital-in-central-ethiopia
#6
Frieder Pfäfflin, Tafese Beyene Tufa, Million Getachew, Tsehaynesh Nigussie, Andreas Schönfeld, Dieter Häussinger, Torsten Feldt, Nicole Schmidt
BACKGROUND: The burden of health-care associated infections in low-income countries is high. Adequate hand hygiene is considered the most effective measure to reduce the transmission of nosocomial pathogens. We aimed to assess compliance with hand hygiene and perception and knowledge about hand hygiene before and after the implementation of a multimodal hand hygiene campaign designed by the World Health Organization. METHODS: The study was carried out at Asella Teaching Hospital, a university hospital and referral centre for a population of about 3...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28069830/meat-intake-and-risk-of-diverticulitis-among-men
#7
Yin Cao, Lisa L Strate, Brieze R Keeley, Idy Tam, Kana Wu, Edward L Giovannucci, Andrew T Chan
OBJECTIVE: Diverticulitis is a common disease with a substantial clinical and economic burden. Besides dietary fibre, the role of other foods in the prevention of diverticulitis is underexplored. DESIGN: We prospectively examined the association between consumption of meat (total red meat, red unprocessed meat, red processed meat, poultry and fish) with risk of incident diverticulitis among 46 461 men enrolled in the Health Professionals Follow-Up Study (1986-2012)...
January 9, 2017: Gut
https://www.readbyqxmd.com/read/28067961/quality-of-life-in-relation-to-neuropsychiatric-symptoms-in-alzheimer-s-disease-5-year-prospective-alsova-cohort-study
#8
Kristiina Hongisto, Ilona Hallikainen, Tuomas Selander, Soili Törmälehto, Saku Väätäinen, Janne Martikainen, Tarja Välimäki, Sirpa Hartikainen, Jaana Suhonen, Anne M Koivisto
OBJECTIVE: To examine the association between neuropsychiatric symptoms (NPS) with self- and caregiver-rated Quality of Life (QoL) for patients with Alzheimer's disease (AD) during a 5-year follow-up. METHODS: The ALSOVA 5-year follow-up study included, at baseline, 236 patients with either very mild (Clinical Dementia Rating Scale (CDR) 0.5), or mild (CDR 1) AD, together with their caregivers from three Finnish hospital districts. QoL was evaluated using patient self-reported, and caregiver-rated, QoL in AD (QoL-AD) scores...
January 9, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28065788/western-dietary-pattern-increases-whereas-prudent-dietary-pattern-decreases-risk-of-incident-diverticulitis-in-a-prospective-cohort-study
#9
Lisa L Strate, Brieze R Keeley, Yin Cao, Kana Wu, Edward L Giovannucci, Andrew T Chan
BACKGROUND & AIMS: Dietary fiber is implicated as a risk factor for diverticulitis. Analyses of dietary patterns may provide information on risk beyond those of individual foods or nutrients. We examined whether major dietary patterns are associated with risk of incident diverticulitis. METHODS: We performed a prospective cohort study of 46,295 men who were free of diverticulitis and known diverticulosis in 1986 (baseline) using data from the Health Professionals Follow-up Study...
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28062398/perineural-invasion-and-risk-of-lethal-prostate-cancer
#10
Piotr Zareba, Richard Flavin, Masis Isikbay, Jennifer R Rider, Travis A Gerke, Stephen Finn, Andreas Pettersson, Francesca Giunchi, Robert H Unger, Alex M Tinianow, Swen-Olof Andersson, Ove Andrén, Katja Fall, Michelangelo Fiorentino, Lorelei A Mucci
BACKGROUND: Prostate cancer has a propensity to invade and grow along nerves, a phenomenon called perineural invasion (PNI). Recent studies suggest that presence of PNI in prostate cancer has been associated with cancer aggressiveness. METHODS: We investigated the association between PNI and lethal prostate cancer in untreated and treated prostate cancer cohorts: the Swedish Watchful Waiting Cohort of 615 men who underwent watchful waiting, and the U.S. Health Professionals Follow-Up Study of 849 men treated with radical prostatectomy...
January 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28052841/preventing-depression-in-adults-with-subthreshold-depression-health-economic-evaluation-alongside-a-pragmatic-randomized-controlled-trial-of-a-web-based-intervention
#11
Claudia Buntrock, Matthias Berking, Filip Smit, Dirk Lehr, Stephanie Nobis, Heleen Riper, Pim Cuijpers, David Ebert
BACKGROUND: Psychological interventions for the prevention of depression might be a cost-effective way to reduce the burden associated with depressive disorders. OBJECTIVE: To evaluate the cost-effectiveness of a Web-based guided self-help intervention to prevent major depressive disorder (MDD) in people with subthreshold depression (sD). METHODS: A pragmatic randomized controlled trial was conducted with follow-up at 12 months. Participants were recruited from the general population via a large statutory health insurance company and an open access website...
January 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28049663/reproducibility-of-urinary-biomarkers-in-multiple-24-h-urine-samples
#12
Qi Sun, Kimberly A Bertrand, Adrian A Franke, Bernard Rosner, Gary C Curhan, Walter C Willett
BACKGROUND: Limited knowledge regarding the reproducibility of biomarkers in 24-h urine samples has hindered the collection and use of the samples in epidemiologic studies. OBJECTIVE: We aimed to evaluate the reproducibility of various markers in repeat 24-h urine samples. DESIGN: We calculated intraclass correlation coefficients (ICCs) of biomarkers measured in 24-h urine samples that were collected in 3168 participants in the NHS (Nurses' Health Study), NHSII (Nurses' Health Study II), and Health Professionals Follow-Up Study...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28040988/how-will-cancer-survivors-use-survivorship-care-plans
#13
Nicole A Kinnane, Amanda J Piper, Michael Jefford
BACKGROUND: Survivorship care plans (SCPs) are internationally endorsed as an important tool to enhance post-treatment survivorship care. To support broad implementation of SCPs, we investigated survivors' preferences regarding SCPs. MATERIAL AND METHODS: The study was conducted at a comprehensive cancer center. Eligible patients from 10 clinical services, generally up to 12 months following end of treatment (EOT) were approached in clinics or via telephone. A purpose-designed survey assessed survivors' intended use of a SCP and preferences regarding format and content...
December 31, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/28038889/periodontitis-in-oral-pemphigus-and-pemphigoid-a-systematic-review-of-published-studies
#14
REVIEW
Isabella Jascholt, Olivia Lai, Detlef Zillikens, Michael Kasperkiewicz
Periodontitis and autoimmune bullous diseases, including pemphigus vulgaris and mucous membrane pemphigoid, are immunoinflammatory disorders leading to microbial plaque- and autoantibody-elicited tissue injury of the oral cavity, respectively. Evidence indicates that these autoimmune conditions may represent a risk factor for periodontitis, but no systematic evaluation exists to corroborate this assumption. A systematic literature review of periodontal status in pemphigus and pemphigoid was conducted. Electronic searches using PubMed from inception to July 2016 identified 10 studies meeting predetermined inclusion and exclusion criteria...
December 28, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28027484/alcohol-use-screening-and-intervention-by-american-primary-care-providers
#15
Ethan Sahker, Stephan Arndt
BACKGROUND: Regular/chronic drinking, defined by five or more drinks in one sitting on each of five or more occasions in the past 30 days, is a significant problem contributing to negative health outcomes, morbidity, and mortality. Regular/chronic and heavy episodic drinking largely goes undetected by primary care providers due to a lack of screening and intervention. The present study explores the extent to which healthcare practitioners screen for alcohol use, provide interventions, and refer to treatment across different types of drinkers...
December 24, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28013256/from-training-to-practice-the-impact-of-engage-ireland-s-national-men-s-health-training-programme
#16
Aoife Osborne, Paula Carroll, Noel Richardson, Martin Doheny, Lorcan Brennan, Barry Lambe
Ireland's National Men's Health Policy recommended developing training programmes tailored to the needs of those working in health and allied health professionals and ENGAGE was developed to meet that recommendation. This study evaluated the impact of ENGAGE on frontline service providers' self-reported knowledge, skills, capacity and practice up to 5-months post training. Between 2012 and 2015, ENGAGE Trainers (n = 57) delivered 62 1-day training programmes to 810 participants. This study was conducted on a subset of those training days (n = 26) and participants...
December 24, 2016: Health Promotion International
https://www.readbyqxmd.com/read/28007445/functional-goals-and-predictors-of-their-attainment-in-low-income-community-dwelling-older-adults
#17
Brian W Waldersen, Jennifer L Wolff, Laken Roberts, Allysin E Bridges, Laura N Gitlin, Sarah L Szanton
OBJECTIVE: To describe functional goals and factors associated with goal attainment among low-income older adults with disabilities living in the community. DESIGN: Secondary analysis from two studies of CAPABLE. Functional goals were coded using the International Classification of Functioning, Disability, and Health (ICF) framework. The percentage of goals attained at five months follow-up was computed within each ICF domain. Multivariate logistic regression was used to identify factors associated with goal attainment...
December 19, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28004296/orthopedic-surgeons-attitudes-to-osteoporosis-investigation-and-management-after-minimal-trauma-fracture-mtf
#18
Jane Anderson-Wurf, Joe McGirr, Alexa Seal, Catherine Harding
: A study of orthopedic surgeons in rural and regional Southeast Australia to determine attitudes to investigation and management of osteoporosis found they believe follow-up in regard to osteoporosis after MTF is important; responsibility for follow-up diagnosis and management lies with primary health care and current communication systems are poor. PURPOSE/INTRODUCTION: The investigation and treatment of osteoporosis after minimal trauma fracture (MTF) is regarded as sub-optimal...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28000212/interventions-to-improve-adherence-to-lipid-lowering-medication
#19
REVIEW
Mieke L van Driel, Michael D Morledge, Robin Ulep, Johnathon P Shaffer, Philippa Davies, Richard Deichmann
BACKGROUND: Lipid-lowering drugs are widely underused, despite strong evidence indicating they improve cardiovascular end points. Poor patient adherence to a medication regimen can affect the success of lipid-lowering treatment. OBJECTIVES: To assess the effects of interventions aimed at improving adherence to lipid-lowering drugs, focusing on measures of adherence and clinical outcomes. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, PsycINFO and CINAHL up to 3 February 2016, and clinical trials registers (ANZCTR and ClinicalTrials...
December 21, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27998235/cancer-related-fatigue-in-patients-with-and-survivors-of-hodgkin-lymphoma-the-impact-on-treatment-outcome-and-social-reintegration
#20
Karolin Behringer, Helen Goergen, Horst Müller, Indra Thielen, Corinne Brillant, Stefanie Kreissl, Teresa Veronika Halbsguth, Julia Meissner, Richard Greil, Peter Moosmann, Oluwatoyin Shonukan, Jens Ulrich Rueffer, Hans-Henning Flechtner, Michael Fuchs, Volker Diehl, Andreas Engert, Peter Borchmann
Purpose Cancer-related fatigue occurs frequently in patients with Hodgkin lymphoma (HL) and has a major impact on their quality of life. We hypothesized that severe fatigue (sFA) might have an impact on patients' treatment outcome and social reintegration. Methods Of 5,306 patients enrolled in the German Hodgkin Study Group's fifth generation of clinical trials in HL (HD13, HD14, and HD15; nonqualified and older [> 60 years] patients excluded), 4,529 provided data on health-related quality of life. We describe sFA (defined as a score ≥ 50 on the 0 to 100 scale from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) before and up to 9 years after therapy and analyze its impact on treatment outcome and social reintegration...
December 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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