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https://www.readbyqxmd.com/read/29786776/a-framework-for-image-based-modeling-of-acute-myocardial-ischemia-using-intramurally-recorded-extracellular-potentials
#1
Brett M Burton, Kedar K Aras, Wilson W Good, Jess D Tate, Brian Zenger, Rob S MacLeod
The biophysical basis for electrocardiographic evaluation of myocardial ischemia stems from the notion that ischemic tissues develop, with relative uniformity, along the endocardial aspects of the heart. These injured regions of subendocardial tissue give rise to intramural currents that lead to ST segment deflections within electrocardiogram (ECG) recordings. The concept of subendocardial ischemic regions is often used in clinical practice, providing a simple and intuitive description of ischemic injury; however, such a model grossly oversimplifies the presentation of ischemic disease-inadvertently leading to errors in ECG-based diagnoses...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786527/retrospective-analysis-of-bluetongue-farm-risk-profile-definition-based-on-biology-farm-management-practices-and-climatic-data
#2
Stefano Cappai, Federica Loi, Annamaria Coccollone, Marino Contu, Paolo Capece, Michele Fiori, Simona Canu, Cipriano Foxi, Sandro Rolesu
Bluetongue (BT) is a vector-borne disease transmitted by species of Culicoides midges (Diptera: Ceratopogonidae). Many studies have contributed to clarifying various aspects of its aetiology, epidemiology and vector dynamic; however, BT remains a disease of epidemiological and economic importance that affects ruminants worldwide. Since 2000, the Sardinia region has been the most affected area of the Mediterranean basin. The region is characterised by wide pastoral areas for sheep and represents the most likely candidate region for the study of Bluetongue virus (BTV) distribution and prevalence in Italy...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786522/a-survey-of-experiences-of-uk-cattle-and-sheep-farmers-with-anthelmintic-prescribers-are-best-practice-principles-being-deployed-at-farm-level
#3
Easton Stephanie, L Pinchbeck Gina, J Bartley David, E Hodgkinson Jane, B Matthews Jacqueline
Helminths are common pathogens of ruminants. These are controlled by anthelmintics; however, resistance is a major issue. More sustainable practices need to be deployed to protect anthelmintic efficacy. There is no published information on how farmer/prescriber interactions at anthelmintic purchase shape application of best practice on-farm. To determine experiences of UK ruminant farmers as they relate to anthelmintic purchasing/provision of best practice advice at the point-of-sale, an online survey was distributed...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29785802/bayesian-measurement-error-driven-hidden-markov-regression-model-for-calibrating-the-effect-of-covariates-on-multistate-outcomes-application-to-androgenetic-alopecia
#4
Amy Ming-Fang Yen, Hsiu-Hsi Chen
Multistate Markov regression models used for quantifying the effect size of state-specific covariates pertaining to the dynamics of multistate outcomes have gained popularity. However, the measurements of multistate outcome are prone to the errors of classification, particularly when a population-based survey/research is involved with proxy measurements of outcome due to cost consideration. Such a misclassification may affect the effect size of relevant covariates such as odds ratio used in the field of epidemiology...
May 21, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29784805/direct-evidence-of-a-large-northern-european-roman-period-martial-event-and-post-battle-corpse-manipulation
#5
Mads Kähler Holst, Jan Heinemeier, Ejvind Hertz, Peter Jensen, Mette Løvschal, Lene Mollerup, Bent Vad Odgaard, Jesper Olsen, Niels Emil Søe, Søren Munch Kristiansen
New archaeological excavations at Alken Enge, Jutland, Denmark, have revealed a comprehensive assemblage of disarticulated human remains within a 75-ha wetland area. A minimum of 82 individuals have been uncovered. Based on the distribution, the total population is estimated to be greater than 380 individuals, exclusively male and predominantly adult. The chronological radiocarbon evidence of the human bones indicates that they belong to a single, large event in the early first century AD. The bones show a high frequency of unhealed trauma from sharp-edged weapons, which, together with finds of military equipment, suggests that the find is of martial character...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29784605/code-seq-an-augmented-whole-exome-sequencing-enables-the-accurate-detection-of-cnvs-and-mutations-in-mendelian-obesity-and-intellectual-disability
#6
Louise Montagne, Mehdi Derhourhi, Amélie Piton, Bénédicte Toussaint, Emmanuelle Durand, Emmanuel Vaillant, Dorothée Thuillier, Stefan Gaget, Franck De Graeve, Iandry Rabearivelo, Amélie Lansiaux, Bruno Lenne, Sylvie Sukno, Rachel Desailloud, Miriam Cnop, Ramona Nicolescu, Lior Cohen, Jean-François Zagury, Mélanie Amouyal, Jacques Weill, Jean Muller, Olivier Sand, Bruno Delobel, Philippe Froguel, Amélie Bonnefond
OBJECTIVE: The molecular diagnosis of extreme forms of obesity, in which accurate detection of both copy number variations (CNVs) and point mutations, is crucial for an optimal care of the patients and genetic counseling for their families. Whole-exome sequencing (WES) has benefited considerably this molecular diagnosis, but its poor ability to detect CNVs remains a major limitation. We aimed to develop a method (CoDE-seq) enabling the accurate detection of both CNVs and point mutations in one step...
May 16, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29783028/thoracic-duct-embolization-a-survey-of-practice-patterns
#7
Samantha A Jayasinghe, Ravi N Srinivasa, Anthony N Hage, Joseph J Gemmete, Bill S Majdalany, Jeffrey Forris Beecham Chick
PURPOSE: To determine training, treatment techniques, outcomes, and practice patterns of practitioners performing thoracic duct embolization (TDE). MATERIALS AND METHODS: From September to October of 2017, a 34-question survey focusing on training, treatment techniques, outcomes, and practice patterns of TDE was distributed through the Open Forum using the Society of Interventional Radiology Connect website. 54 practitioners completed the entire survey. Percentages were calculated for answers to the questions...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29783009/antiplatelet-medication-reversal-strategies-in-operative-intracranial-hemorrhage-a-survey-of-practicing-neurosurgeons
#8
Paul M Foreman, Adeel Ilyas, James Mooney, Philip G R Schmalz, Beverly C Walters, Christoph J Griessenauer
OBJECTIVE: Antiplatelet therapy is common and complicates the operative management of acute intracranial hemorrhage. Little data exist to guide antiplatelet reversal strategies. METHODS: An online survey detailing antiplatelet reversal strategies in patients presenting with acute operative intracranial hemorrhage (subdural hematoma (SDH), epidural hematoma (EDH), and intracerebral hemorrhage (ICH) was distributed to board certified neurosurgeons in the North America...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#9
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29781610/sulfur-speciation-in-biochars-by-very-high-resolution-benchtop-k%C3%AE-x-ray-emission-spectroscopy
#10
William Holden, Gerald T Seidler, Singfoong Cheah
The analytical chemistry of sulfur-containing materials poses substantial technical challenges, especially due to the limitations of 33S NMR and the time-intensive preparations required for wet-chemistry analyses. A number of prior studies have found that synchrotron-based x-ray absorption near edge structure (XANES) measurements can give detailed speciation of sulfur chemistry in such cases. However, due to the obvious access limitations, synchrotron XANES of sulfur cannot be part of routine analytical practice across the chemical sciences community...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29780980/charge-and-hydration-structure-of-dendritic-polyelectrolytes-molecular-simulations-of-polyglycerol-sulphate
#11
Rohit Nikam, Xiao Xu, Matthias Ballauff, Matej Kanduč, Joachim Dzubiella
Macromolecules based on dendritic or hyperbranched polyelectrolytes have been emerging as high potential candidates for biomedical applications. Here we study the charge and solvation structure of dendritic polyglycerol sulphate (dPGS) of generations 0 to 3 in aqueous sodium chloride solution by explicit-solvent molecular dynamics computer simulations. We characterize dPGS by calculating several important properties such as relevant dPGS radii, molecular distributions, the solvent accessible surface area, and the partial molecular volume...
May 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29780836/defining-platelet-rich-plasma-usage-by-team-physicians-in-elite-athletes
#12
David E Kantrowitz, Ajay S Padaki, Christopher S Ahmad, T Sean Lynch
Background: The indications for the use of platelet-rich plasma (PRP) are vaguely defined despite the frequency of its use as a treatment for athletes. While select studies have advocated for its efficacy, the majority of orthopaedic research conducted on the topic has been equivocal. Purpose: To define the use of PRP in elite athletes by team physicians from professional sports leagues. Study Design: Cross-sectional study. Methods: A survey assessing treatment timing, usage patterns, indications, and complications was generated by fellowship-trained sports medicine orthopaedic surgeons...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29780810/factors-associated-with-bites-to-a-child-from-a-dog-living-in-the-same-home-a-bi-national-comparison
#13
Locksley L McV Messam, Philip H Kass, Bruno B Chomel, Lynette A Hart
We conducted a veterinary clinic-based retrospective cohort study aimed at identifying child-, dog-, and home-environment factors associated with dog bites to children aged 5-15 years old living in the same home as a dog in Kingston, Jamaica (236) and San Francisco, USA (61). Secondarily, we wished to compare these factors to risk factors for dog bites to the general public. Participant information was collected via interviewer-administered questionnaire using proxy respondents. Data were analyzed using log-binomial regression to estimate relative risks and associated 95% confidence intervals (CIs) for each exposure-dog bite relationship...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29780578/towards-the-development-of-day-one-competences-in-veterinary-behaviour-medicine-survey-of-veterinary-professionals-experience-in-companion-animal-practice-in-ireland
#14
Olwen Golden, Alison J Hanlon
Background: Veterinary behaviour medicine should be a foundation subject of the veterinary curriculum because of its wide scope of applications to veterinary practice. Private practitioners are likely to be the primary source of information on animal behaviour for most pet owners, however studies indicate that behavioural issues are not frequently discussed during companion animal consultations and many practitioners lack confidence in dealing with behavioural problems, likely due to poor coverage of this subject in veterinary education...
2018: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29780369/identification-and-removal-of-contaminant-sequences-from-ribosomal-gene-databases-lessons-from-the-census-of-deep-life
#15
Cody S Sheik, Brandi Kiel Reese, Katrina I Twing, Jason B Sylvan, Sharon L Grim, Matthew O Schrenk, Mitchell L Sogin, Frederick S Colwell
Earth's subsurface environment is one of the largest, yet least studied, biomes on Earth, and many questions remain regarding what microorganisms are indigenous to the subsurface. Through the activity of the Census of Deep Life (CoDL) and the Deep Carbon Observatory, an open access 16S ribosomal RNA gene sequence database from diverse subsurface environments has been compiled. However, due to low quantities of biomass in the deep subsurface, the potential for incorporation of contaminants from reagents used during sample collection, processing, and/or sequencing is high...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29780006/investigation-of-the-applicability-of-a-rapid-diagnosis-test-in-the-diagnosis-of-cystic-echinococcosis
#16
Sema Ertuğ, Serçin Özlem Çalışkan, Erdoğan Malatyalı, Hatice Ertabaklar
OBJECTIVE: Echinococcus granulosus, the etiological agent of cystic echinococcosis (CE) in humans and livestock, is a widely distributed zoonotic pathogen tapeworm. The infection is transmitted to humans by the ingestion of E. granulosus eggs released in the feces of definitive hosts such as dogs. The larval stage of the parasite develops a slowly enlarging cyst in the visceral organs, particularly in the liver and/or lung. The aim of the present study was to evaluate the diagnostic value of an immunochromatographic test (ICT) for CE...
May 21, 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29779982/statistical-control-of-the-production-of-blood-components-by-control-charts-of-attribute-to-improve-quality-characteristics-and-to-comply-with-current-specifications
#17
REVIEW
Paulo Pereira, Jerard Seghatchian, Beatriz Caldeira, Sandra Xavier, Gracinda de Sousa
Statistical process control (SPC) is closely related to good quality control practices in the manufacturing process. One of the primary goals is to detect unnatural patterns, allowing the production service to control the conformity of the blood components produced. Despite being recommended by national and international standards, its exercise is not uniform, and sometimes the methodology used is misinterpreted as SPC. When the input data has a Gaussian distribution, control charts for variables are proposed...
May 8, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29779543/geographic-variation-in-the-supply-of-selected-behavioral-health-providers
#18
C Holly A Andrilla, Davis G Patterson, Lisa A Garberson, Cynthia Coulthard, Eric H Larson
INTRODUCTION: In 2015, an estimated 43.4 million Americans aged 18 and older suffered from a behavioral health issue. Accurate estimates of the number of psychiatrists, psychologists, and psychiatric nurse practitioners are needed as demand for behavioral health care grows. METHODS: The National Plan and Provider Enumeration System National Provider Identifier data (October 2015) was used to examine the supply of psychiatrists, psychologists, and psychiatric nurse practitioners...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29778497/food-groups-for-allergen-risk-assessment-combining-food-consumption-data-from-different-countries-in-europe
#19
Sophie Birot, Charlotte B Madsen, Astrid G Kruizinga, Amélie Crépet, Tue Christensen, Per B Brockhoff
To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan-European food data suitable for food allergy risk assessment. The aim of this paper is to investigate if consumption data, at a meal level, from National Food Consumption Surveys, can be combined to form a common Food Consumption database...
May 17, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29777167/bending-loss-independent-operation-of-slope-assisted-brillouin-optical-correlation-domain-reflectometry
#20
Heeyoung Lee, Tianyi Ma, Yosuke Mizuno, Kentaro Nakamura
We demonstrate loss-insensitive operation of slope-assisted Brillouin optical correlation-domain reflectometry by employing a special silica fiber with low bending loss. As fundamental characterization, we measure the coefficients of the power-change dependencies on strain and temperature to be 1.42 × 10-4 dB/µε and 3.28 × 10-3 dB/K, respectively. Subsequently, by comparing the distributed strain and temperature measurement results using a standard silica fiber and the special fiber, we show that this configuration offers highly stable loss-insensitive operation for practical use in the future...
May 18, 2018: Scientific Reports
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