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tear osmolarity

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https://www.readbyqxmd.com/read/27913889/ocular-pharmacology-of-tear-film-dry-eye-and-allergic-conjunctivitis
#1
Shilpa Gulati, Sandeep Jain
Dry Eye Disease (DED) is "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability with potential damage to the ocular surface." DED comprises two etiologic categories: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Diagnostic workup of DED should include clinical history, symptom questionnaire, fluorescein TBUT, ocular surface staining grading, Schirmer I/II, lid and meibomian pathology, meibomian expression, followed by other available tests...
December 3, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27874148/dry-eye-disease-in-patients-with-metabolic-syndrome
#2
Kubra Serefoglu Cabuk, İlkay Cakir, Ahmet Kirgiz, Kursat Atalay, Muhittin Taskapili
OBJECTIVES: To evaluate dry eye disease (DED) in patients with metabolic syndrome (MetS) and compare with healthy individuals. METHODS: The study was conducted in the Ophthalmology and Endocrinology Department of Bagcilar Education and Research Hospital, a tertiary care center in Istanbul, Turkey, between January and December 2015. In this prospective case-controlled study, dry eye disease tests were performed on 44 patients with MetS and 43 healthy controls. TearLab Osmolarity System, which is a lab-on-a-chip technology, was used to measure tear osmolarity...
December 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27861309/pilot-study-of-corneal-sensitivity-and-its-association-in-keratoconus
#3
Preeji S Mandathara, Fiona J Stapleton, Jim Kokkinakis, Mark D P Willcox
PURPOSE: To evaluate corneal sensitivity and its association with other clinical parameters in keratoconus. METHODS: Twenty-four subjects with keratoconus aged between 18 and 65 years were recruited in this cross-sectional study. Ocular symptoms, corneal topography, tear variables such as tear osmolarity, volume and lower tear meniscus height, ocular surface staining, central sensitivity threshold (CST), and corneal subepithelial nerve mapping were obtained. Association between central CST and other clinical variables was examined using the Spearman correlation coefficient...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861308/ocular-surface-disease-parameters-after-collagen-cross-linking-for-keratoconus
#4
José I Recalde, Arantxa Acera, Iñaki Rodríguez-Agirretxe, Miguel A Sánchez-Tena, Juan San-Cristóbal, Juan A Durán
PURPOSE: To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS: This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (Ocular Surface Disease Index), tear breakup time, Schirmer test (SCH) score, tear clearance, fluorescein staining, and lissamine green staining. Variables were determined preoperatively and 3, 6, and 12 months after CXL...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861262/tear-film-osmolarity-in-response-to-long-term-orthokeratology-treatment
#5
Amelia Nieto-Bona, María Nombela-Palomo, Gema Felipe-Márquez, Miguel A Teus
PURPOSE: To compare tear film osmolarity (TFO) measurements in non-contact lens (CL) wearers and wearers of hydrogel or overnight orthokeratology (OK) CLs, and to assess possible effects of long-term OK on TFO. METHODS: Overall, 108 subjects with moderate myopia participated in 2 experiments, and TFO was measured using the TearLab osmolarity system. In experiment 1, TFO measurements were made in 77 right eyes of 23 non-CL wearers, 26 hydrogel wearers, and 28 OK wearers...
November 16, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27818317/assessment-of-dry-eye-in-a-gvhd-murine-model-approximation-through-tear-osmolarity-measurement
#6
Rafael Martínez-Carrasco, Luis Ignacio Sánchez-Abarca, Cristina Nieto-Gómez, Elisabet Martín García, Teresa L Ramos, Almudena Velasco, Fermín Sánchez-Guijo, José Aijón, Emiliano Hernández-Galilea
Dry eye disease is one of the most frequent pathological events that take place in the course of the graft versus host disease (GVHD), and is the main cause of deterioration in quality of life for patients. Thus, demonstration of dry eye signs in murine models of oGVHD is crucial for the validation of these models for the study of the disease. Given the increasing evidence that tear osmolarity is an important player of dry eye disease, our purpose in this study was to validate the use of a reliable method to assess tear osmolarity in mice: the electrical impedance method...
November 3, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27817918/a-randomized-double-masked-placebo-controlled-clinical-trial-of-two-forms-of-omega-3-supplements-for-treating-dry-eye-disease
#7
Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie
PURPOSE: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). DESIGN: Randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27811278/the-effects-of-transdermal-testosterone-and-oestrogen-therapy-on-dry-eye-in-postmenopausal-women-a-randomised-placebo-controlled-pilot-study
#8
Blanka Golebiowski, Noor Badarudin, John Eden, Leanne Gerrand, Jennifer Robinson, Jinzhu Liu, Ulrike Hampel, Jingjing You, Fiona Stapleton
AIMS: Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. METHODS: A randomised double-blind placebo-controlled pilot study was conducted involving 40 women with dry eye (age 63.9±5.1 years, 13.2±6.3 years post menopause). Ten women were assigned to each of four treatment groups: transdermal testosterone, oestradiol, testosterone/oestradiol combination and placebo...
November 3, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27798494/in-response-tear-osmolarity-and-tear-film-parameters-in-patients-with-ocular-rosacea
#9
Sevil Karaman Erdur
No abstract text is available yet for this article.
November 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27798493/tear-osmolarity-and-tear-film-parameters-in-patients-with-ocular-rosacea
#10
Melis Palamar, Cumali Degirmenci, Ilgen Ertam, Ayse Yagci
No abstract text is available yet for this article.
November 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27761982/assessment-of-tear-film-osmolarity-using-the-tearlab-%C3%A2-osmometer-in-normal-dogs-and-dogs-with-keratoconjunctivitis-sicca
#11
Lionel Sebbag, Shin Ae Park, Philip H Kass, David J Maggs, Mayssa Attar, Christopher J Murphy
OBJECTIVE: To evaluate repeatability and reproducibility of tear osmolarity measured using the TearLab(™) osmometer in normal dogs and to assess its diagnostic potential in dogs with keratoconjunctivitis sicca (KCS). ANIMALS STUDIED: Beagle dogs; six normal and five with KCS. PROCEDURES: Tear osmolarity and Schirmer tear test-1 (STT-1) values were obtained at various times. Normal dogs were assessed for diurnal variation and repeatability and reproducibility of measurements...
October 20, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27660921/dry-eye-assessment-in-patients-with-vitamin-d-deficiency
#12
Goktug Demirci, Sevil Karaman Erdur, Mustafa Ozsutcu, Mustafa Eliacik, Oktay Olmuscelik, Rukiye Aydin, Mehmet Selim Kocabora
OBJECTIVES: The aim of this study was to evaluate tear film function in patients with vitamin D deficiency. METHODS: In a single center, 60 eyes of 30 patients with vitamin D deficiency (group 1), and 60 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear break-up time (TBUT), scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity. RESULTS: Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (309±9 mOsm/L, 35...
September 22, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27641535/response-to-comment-on-the-effects-of-hemodialysis-on-tear-osmolarity
#13
COMMENT
Muhittin Taskapili, Kubra Serefoglu Cabuk, Rukiye Aydin, Kursat Atalay, Ahmet Kirgiz, Dede Sit, Hasan Kayabasi
No abstract text is available yet for this article.
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27585060/tear-film-assessments-for-the-diagnosis-of-dry-eye
#14
Thomas H Dohlman, Jessica B Ciralsky, Edward C Lai
PURPOSE OF REVIEW: Dry eye disease (DED) is a complex, multifactorial condition that is challenging to diagnose and monitor clinically. To date, diagnosis has consisted largely of self-reported symptom questionnaires and a collection of clinical tests including vital dye staining, estimation of tear breakup time and Schirmer's testing, as no gold standard exists. As the dry eye field has made progress in understanding disease pathogenesis, new methods for assessment of this condition have been developed...
October 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27560032/dry-eye-after-small-incision-lenticule-extraction-and-femtosecond-laser-assisted-lasik-meta-analysis
#15
Hidenaga Kobashi, Kazutaka Kamiya, Kimiya Shimizu
PURPOSE: To compare postoperative ocular surface integrity and innervation between small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). METHODS: The Cochrane Central Register of Controlled Trials, PubMED, and EMBASE were searched for prospective comparative studies. Trials meeting the selection criteria were quality appraised, and the data were extracted by 2 independent authors. The weighted mean differences (WMDs) and 95% confidence intervals (CIs) were used to compare dry eye examinations and corneal subbasal nerve density (SMILE-FS-LASIK)...
January 2017: Cornea
https://www.readbyqxmd.com/read/27521606/role-of-tear-osmolarity-in-dry-eye-symptoms-after-cataract-surgery
#16
Ana González-Mesa, Javier Paz Moreno-Arrones, Daniele Ferrari, Miguel A Teus
PURPOSE: To analyze changes in tear osmolarity and the Ocular Surface Disease Index (OSDI) in patients after cataract surgery. DESIGN: Prospective, observational cohort study. METHODS: setting: Institutional. PATIENT POPULATION: Fifty-two patients with a unilateral cataract (study eye) scheduled for surgery and good visual function in the fellow (control eye). Patients were excluded who were receiving chronic topical therapy, such as glaucoma medications, or had a history of previous ocular surgery...
October 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27490319/functional-and-morphologic-changes-of-meibomian-glands-in-an-asymptomatic-adult-population
#17
Nisha S Yeotikar, Hua Zhu, Maria Markoulli, Kelly K Nichols, Thomas Naduvilath, Eric B Papas
PURPOSE: The aim of the study was to understand natural changes of meibomian glands (MG) that occur with aging in the absence of any ocular pathology or ocular discomfort symptoms, to differentiate between "age normal" and pathologic or dysfunctional changes of the MG. METHODS: A total of 185 subjects (109 females) with no pre-existing ocular and systemic abnormalities were recruited and divided into four age groups: 25 to 34, 35 to 44, 45 to 54, and 55 to 66 years...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27442314/effect-of-oral-re-esterified-omega-3-nutritional-supplementation-on-dry-eyes
#18
Alice T Epitropoulos, Eric D Donnenfeld, Zubin A Shah, Edward J Holland, Michael Gross, William J Faulkner, Cynthia Matossian, Stephen S Lane, Melissa Toyos, Frank A Bucci, Henry D Perry
PURPOSE: To assess the effect of oral re-esterified omega-3 fatty acids on tear osmolarity, matrix metalloproteinase-9 (MMP-9), tear break-up time (TBUT), Ocular Surface Disease Index (OSDI), fluorescein corneal staining, Schirmer score, meibomian gland dysfunction (MGD) stage and omega-3 index in subjects with dry eyes and confirmed MGD. METHODS: This was a multicenter, prospective, interventional, placebo-controlled, double-masked study. Subjects were randomized to receive 4 softgels containing a total of 1680 mg of eicosapentaenoic acid/560 mg of docosahexaenoic acid or a control of 3136 mg of linoleic acid, daily for 12 weeks...
September 2016: Cornea
https://www.readbyqxmd.com/read/27425263/the-relief-of-dry-eye-signs-and-symptoms-using-a-combination-of-lubricants-lid-hygiene-and-ocular-nutraceuticals
#19
William Ngo, Sruthi Srinivasan, Diane Houtman, Lyndon Jones
PURPOSE: To determine the combined effect of TheraTears(®) Lubricant Eye Drops, TheraTears(®) SteriLid Eyelid Cleanser, and TheraTears(®) Nutrition on dry eye signs and symptoms. METHODS: This prospective study enrolled 28 dry eye participants. Participants were instructed to use the Lubricant Eye Drops at least 2-4× a day, SteriLid 1-2× a day, and Nutrition 3 gel caps once a day. Participants were followed up at baseline, 1 month and 3 months. Outcome variables were the Ocular Surface Disease Index (OSDI), Symptom Assessment iN Dry Eye (SANDE) questionnaire, non-invasive tear break-up time (NIBUT), osmolarity, number of meibomian glands blocked (#MG blocked), meibum quality, eyelid margin features, Schirmer's test, tear film lipid layer thickness (LLT), meniscus height, corneal and conjunctival staining...
July 11, 2016: Journal of Optometry
https://www.readbyqxmd.com/read/27422575/effects-of-topical-acne-treatment-on-the-ocular-surface-in-patients-with-acne-vulgaris
#20
Seray Aslan Bayhan, Hasan Ali Bayhan, Emine Çölgeçen, Canan Gürdal
PURPOSE: To assess the ocular side effects during topical retinoid-antibiotic combination treatment in patients with facial acne vulgaris. METHODS: Forty-three patients applying topical isotretinoin+erythromycin combination (isotrexin gel, GlaxoSmithKline) once daily for the treatment of acne vulgaris were enrolled. Full ophthalmologic examination, Schirmer test (with topical anesthesia), fluorescein break-up time (BUT), corneal fluorescein staining and tear osmolarity measurement with the TearLab system (TearLab Corporation) were carried out before and at the end of the first month of the treatment...
July 12, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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