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https://www.readbyqxmd.com/read/28060062/pilot-study-of-corneal-sensitivity-and-its-association-in-keratoconus
#1
Preeji S Mandathara, Fiona J Stapleton, Jim Kokkinakis, Mark D P Willcox
PURPOSE: To evaluate corneal sensitivity and its association with other clinical parameters in keratoconus. METHODS: Twenty-four subjects with keratoconus aged between 18 and 65 years were recruited in this cross-sectional study. Ocular symptoms, corneal topography, tear variables such as tear osmolarity, volume and lower tear meniscus height, ocular surface staining, central sensitivity threshold (CST), and corneal subepithelial nerve mapping were obtained. Association between central CST and other clinical variables was examined using the Spearman correlation coefficient...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060060/ocular-surface-disease-parameters-after-collagen-cross-linking-for-keratoconus
#2
José I Recalde, Arantxa Acera, Iñaki Rodríguez-Agirretxe, Miguel A Sánchez-Tena, Juan San-Cristóbal, Juan A Durán
PURPOSE: To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS: This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (Ocular Surface Disease Index), tear breakup time, Schirmer test (SCH) score, tear clearance, fluorescein staining, and lissamine green staining. Variables were determined preoperatively and 3, 6, and 12 months after CXL...
February 2017: Cornea
https://www.readbyqxmd.com/read/28030882/ocular-response-to-environmental-variations-in-contact-lens-wearers
#3
Alberto López-de la Rosa, Vicente Martín-Montañez, Alberto López-Miguel, Itziar Fernández, Margarita Calonge, José M González-Méijome, María J González-García
PURPOSE: To assess the influence of different indoor environments simulated in an environmental chamber on soft contact lens (CL) wearers. METHODS: Fifty-four CL wearers were grouped based on their symptoms while wearing their CLs. Subjects were fitted with two different CL types, conventional hydrogel (Omafilcon A) and silicone hydrogel (comfilcon A), and exposed to two controlled indoor environmental conditions, standard [50% relative humidity (RH), 23°C, 930 mb of atmospheric pressure] and adverse (in-flight air cabin environment: 5% RH, localised air flow, 23°C, 750 mb atmospheric pressure), for 90 min in an environmental chamber, making a total of four visits...
January 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28024826/predictors-of-discordance-between-symptoms-and-signs-in-dry-eye-disease
#4
Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Simone A Nibourg, Christopher J Hammond
PURPOSE: To investigate predictors of discordance between symptoms and signs in dry eye disease (DED). DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 648 patients with dry eye from the Groningen LOngitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherlands. METHODS: Patient symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Dry eye signs were assessed by tear osmolarity, Schirmer test, tear breakup time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a composite dry eye signs severity score was calculated from these 6 tests for each patient...
December 23, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28005448/tear-film-and-ocular-surface-evaluation-in-gestational-diabetes-mellitus
#5
S Kan, U Acar, M Kizilgul, E Beyazyildiz, A B Cankaya, M Apaydin, S Beysel, M Ozbek
BACKGROUND: Dry eye syndrome is one of the complaints of diabetic patients. The aim of the present study was to evaluate the tear functions in pregnant women with gestational diabetes mellitus (GDM) using tests: Schirmer, tear break-up time (TBUT), and tear film osmolarity (TFO) tests and the Ocular Surface Disease Index score (OSDI). METHODS: Pregnant women with GDM (Group 1, n=46) and healthy pregnant women (Group 2, n=36) were enrolled. Initially, all participants were asked to answer the OSDI and then they underwent a detailed ophthalmic examination including Schirmer, TBUT, and TFO tests...
December 22, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27992482/dry-eye-after-small-incision-lenticule-extraction-smile-versus-femtosecond-laser-assisted-in-situ-keratomileusis-fs-lasik-for-myopia-a-meta-analysis
#6
Zeren Shen, Yanan Zhu, Xiaohui Song, Jie Yan, Ke Yao
PURPOSE: To compare dry eye after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (FS-LASIK) for correcting myopia. METHODS: CENTRAL, Embase and PubMed were searched in November 2016. All randomized controlled trials (RCTs) and prospective cohorts that compared dry eye after SMILE with FS-LASIK were selected. RESULTS: Five cohorts and one RCT were identified for comparing dry eye after SMILE (291 eyes) and FS-LASIK (277 eyes)...
2016: PloS One
https://www.readbyqxmd.com/read/27935235/bilateral-tear-film-alterations-in-patients-with-unilateral-quiescent-herpes-simplex-keratitis
#7
Xiao Ma, Yan Lu
PURPOSE: To evaluate bilateral tear function and corneal sensitivity in patients with unilateral quiescent herpes simplex keratitis (HSK) and determine the correlation between corneal sensitivity and tear secretion in both eyes. METHODS: Thirty-five patients diagnosed with unilateral quiescent HSK and 35 heathy controls were included in this study. Bilateral tear osmolarity, Schirmer's test, the tear break-up time (TBUT) and corneal sensitivity were measured in all participants...
December 9, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27913889/ocular-pharmacology-of-tear-film-dry-eye-and-allergic-conjunctivitis
#8
Shilpa Gulati, Sandeep Jain
Dry Eye Disease (DED) is "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability with potential damage to the ocular surface." DED comprises two etiologic categories: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Diagnostic workup of DED should include clinical history, symptom questionnaire, fluorescein TBUT, ocular surface staining grading, Schirmer I/II, lid and meibomian pathology, meibomian expression, followed by other available tests...
December 3, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27874148/dry-eye-disease-in-patients-with-metabolic-syndrome
#9
Kubra Serefoglu Cabuk, İlkay Cakir, Ahmet Kirgiz, Kursat Atalay, Muhittin Taskapili
OBJECTIVES: To evaluate dry eye disease (DED) in patients with metabolic syndrome (MetS) and compare with healthy individuals. METHODS: The study was conducted in the Ophthalmology and Endocrinology Department of Bagcilar Education and Research Hospital, a tertiary care center in Istanbul, Turkey, between January and December 2015. In this prospective case-controlled study, dry eye disease tests were performed on 44 patients with MetS and 43 healthy controls. TearLab Osmolarity System, which is a lab-on-a-chip technology, was used to measure tear osmolarity...
December 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27861309/pilot-study-of-corneal-sensitivity-and-its-association-in-keratoconus
#10
Preeji S Mandathara, Fiona J Stapleton, Jim Kokkinakis, Mark D P Willcox
PURPOSE: To evaluate corneal sensitivity and its association with other clinical parameters in keratoconus. METHODS: Twenty-four subjects with keratoconus aged between 18 and 65 years were recruited in this cross-sectional study. Ocular symptoms, corneal topography, tear variables such as tear osmolarity, volume and lower tear meniscus height, ocular surface staining, central sensitivity threshold (CST), and corneal subepithelial nerve mapping were obtained. Association between central CST and other clinical variables was examined using the Spearman correlation coefficient...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861308/ocular-surface-disease-parameters-after-collagen-cross-linking-for-keratoconus
#11
José I Recalde, Arantxa Acera, Iñaki Rodríguez-Agirretxe, Miguel A Sánchez-Tena, Juan San-Cristóbal, Juan A Durán
PURPOSE: To analyze the variations in tear quantity and quality after corneal collagen cross-linking (CXL) in patients with keratoconus. METHODS: This is a prospective observational study of 24 eyes with keratoconus that underwent epithelium-off CXL. The variables studied were tear film osmolarity, subjective symptoms (Ocular Surface Disease Index), tear breakup time, Schirmer test (SCH) score, tear clearance, fluorescein staining, and lissamine green staining. Variables were determined preoperatively and 3, 6, and 12 months after CXL...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27861262/tear-film-osmolarity-in-response-to-long-term-orthokeratology-treatment
#12
Amelia Nieto-Bona, María Nombela-Palomo, Gema Felipe-Márquez, Miguel A Teus
PURPOSE: To compare tear film osmolarity (TFO) measurements in non-contact lens (CL) wearers and wearers of hydrogel or overnight orthokeratology (OK) CLs, and to assess possible effects of long-term OK on TFO. METHODS: Overall, 108 subjects with moderate myopia participated in 2 experiments, and TFO was measured using the TearLab osmolarity system. In experiment 1, TFO measurements were made in 77 right eyes of 23 non-CL wearers, 26 hydrogel wearers, and 28 OK wearers...
November 16, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27818317/assessment-of-dry-eye-in-a-gvhd-murine-model-approximation-through-tear-osmolarity-measurement
#13
Rafael Martínez-Carrasco, Luis Ignacio Sánchez-Abarca, Cristina Nieto-Gómez, Elisabet Martín García, Teresa L Ramos, Almudena Velasco, Fermín Sánchez-Guijo, José Aijón, Emiliano Hernández-Galilea
Dry eye disease is one of the most frequent pathological events that take place in the course of the graft versus host disease (GVHD), and is the main cause of deterioration in quality of life for patients. Thus, demonstration of dry eye signs in murine models of oGVHD is crucial for the validation of these models for the study of the disease. Given the increasing evidence that tear osmolarity is an important player of dry eye disease, our purpose in this study was to validate the use of a reliable method to assess tear osmolarity in mice: the electrical impedance method...
November 3, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27817918/a-randomized-double-masked-placebo-controlled-clinical-trial-of-two-forms-of-omega-3-supplements-for-treating-dry-eye-disease
#14
Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie
PURPOSE: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). DESIGN: Randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/27811278/the-effects-of-transdermal-testosterone-and-oestrogen-therapy-on-dry-eye-in-postmenopausal-women-a-randomised-placebo-controlled-pilot-study
#15
Blanka Golebiowski, Noor Badarudin, John Eden, Leanne Gerrand, Jennifer Robinson, Jinzhu Liu, Ulrike Hampel, Jingjing You, Fiona Stapleton
AIMS: Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. METHODS: A randomised double-blind placebo-controlled pilot study was conducted involving 40 women with dry eye (age 63.9±5.1 years, 13.2±6.3 years post menopause). Ten women were assigned to each of four treatment groups: transdermal testosterone, oestradiol, testosterone/oestradiol combination and placebo...
November 3, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27798494/in-response-tear-osmolarity-and-tear-film-parameters-in-patients-with-ocular-rosacea
#16
Sevil Karaman Erdur
No abstract text is available yet for this article.
November 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27798493/tear-osmolarity-and-tear-film-parameters-in-patients-with-ocular-rosacea
#17
Melis Palamar, Cumali Degirmenci, Ilgen Ertam, Ayse Yagci
No abstract text is available yet for this article.
November 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27761982/assessment-of-tear-film-osmolarity-using-the-tearlab-%C3%A2-osmometer-in-normal-dogs-and-dogs-with-keratoconjunctivitis-sicca
#18
Lionel Sebbag, Shin Ae Park, Philip H Kass, David J Maggs, Mayssa Attar, Christopher J Murphy
OBJECTIVE: To evaluate repeatability and reproducibility of tear osmolarity measured using the TearLab(™) osmometer in normal dogs and to assess its diagnostic potential in dogs with keratoconjunctivitis sicca (KCS). ANIMALS STUDIED: Beagle dogs; six normal and five with KCS. PROCEDURES: Tear osmolarity and Schirmer tear test-1 (STT-1) values were obtained at various times. Normal dogs were assessed for diurnal variation and repeatability and reproducibility of measurements...
October 20, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27660921/dry-eye-assessment-in-patients-with-vitamin-d-deficiency
#19
Goktug Demirci, Sevil Karaman Erdur, Mustafa Ozsutcu, Mustafa Eliacik, Oktay Olmuscelik, Rukiye Aydin, Mehmet Selim Kocabora
OBJECTIVES: The aim of this study was to evaluate tear film function in patients with vitamin D deficiency. METHODS: In a single center, 60 eyes of 30 patients with vitamin D deficiency (group 1), and 60 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear break-up time (TBUT), scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity. RESULTS: Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (309±9 mOsm/L, 35...
September 22, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27641535/response-to-comment-on-the-effects-of-hemodialysis-on-tear-osmolarity
#20
COMMENT
Muhittin Taskapili, Kubra Serefoglu Cabuk, Rukiye Aydin, Kursat Atalay, Ahmet Kirgiz, Dede Sit, Hasan Kayabasi
No abstract text is available yet for this article.
2016: Journal of Ophthalmology
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