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https://www.readbyqxmd.com/read/29708939/outcomes-of-thermal-pulsation-treatment-for-dry-eye-syndrome-in-patients-with-sjogren-disease
#1
Morgan R Godin, Sandra S Stinnett, Preeya K Gupta
PURPOSE: To evaluate the clinical outcomes of thermal pulsation treatment in patients with meibomian gland dysfunction (MGD) and dry eye secondary to Sjogren disease. METHODS: Twenty-four eyes from 13 patients with previously diagnosed Sjogren disease who presented to our institution with dry eye symptoms and had thermal pulsation treatment were prospectively followed up. Patients underwent comprehensive slit-lamp examination, including MGD grading, gland oil flow, corneal and conjunctival staining scores, and tear break-up time (TBUT)...
April 26, 2018: Cornea
https://www.readbyqxmd.com/read/29702077/phosphosulindac-is-efficacious-in-an-improved-concanavalin-a-based-rabbit-model-of-chronic-dry-eye-disease
#2
Robert A Honkanen, Liqun Huang, Gang Xie, Basil Rigas
Dry eye disease (DED), an inflammatory disease of the ocular surface, affects 15% of humans worldwide. No satisfactory treatment exists for DED partly because of the lack of informative animal models of this disease. We evaluated the anti-inflammatory phosphosulindac (PS) for the treatment of DED using a new rabbit model of chronic DED. In this model, based on the concanavalin A (Con A) acute DED model, we injected all lacrimal glands with Con A 3 times weekly under ultrasound guidance, which prolonged DED to >3 weeks, and used concurrently 4 parameters of efficacy: tear break-up time (TBUT), tear osmolarity, Schirmer test, and tear lactoferrin levels, making efficacy assessment robust...
April 10, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29700925/effect-of-a-punctal-plug-on-ocular-surface-disease-in-patients-using-topical-prostaglandin-analogues-a-randomised-controlled-trial
#3
Justin C Sherwin, Gokulan Ratnarajan, Babar Elahi, Anna Bilkiewicz-Pawelec, John F Salmon
IMPORTANCE: Ocular surface disease (OSD) is common and can reduce treatment compliance and quality of life. BACKGROUND: To determine whether a punctal plug improves OSD and reduces IOP in patients using prostaglandin-analogue monotherapy. DESIGN: Randomised-controlled trial PARTICIPANTS: Sixty eligible subjects aged >18 years with symptomatic OSD from glaucoma clinics were invited to participate. Lacrimal or glaucoma surgery, lid malposition and contact lens wear were exclusion criteria...
April 26, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29692601/tear-osmolarity-changes-after-use-of-hydroxypropyl-guar-based-lubricating-eye-drops
#4
Alison Ng, Adam Keech, Lyndon Jones
Purpose: To evaluate tear osmolarity after using a hydroxypropyl-guar (HP-guar)-based lubricating eye drop four times daily (QID) for 3 weeks. Methods: Thirty-one participants with dry eye disease (Ocular Surface Disease Index [OSDI] score ≥20 and tear osmolarity ≥300 mOsm/L in at least one eye) were enrolled in this prospective, dispensing, non-randomized study involving a baseline visit and 3-week follow-up. Tear osmolarity, non-invasive tear break up time (NITBUT), conjunctival hyperemia, corneal and conjunctival staining were determined at baseline...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29675272/topical-osmoprotectant-for-the-management-of-postrefractive-surgery-induced-dry-eye-symptoms-a-randomised-controlled-double-blind-trial
#5
R M Hazarbassanov, N G T Queiroz-Hazarbassanov, J N Barros, J A P Gomes
Background: Dry eye disease (DED) is one of the most common complications following refractive surgery. Purpose: Evaluate the efficacy of an osmoprotective eye drop (Optive®) for the management of induced DED in refractive surgery patients. Design: Double-masked randomised controlled trial. Methods: Twenty-two refractive surgery patients oriented to apply FreshTears (FT; n = 13) or Optive (Op; n = 9), topically, QID, for 3 months...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29669221/role-of-ion-channels-in-the-functional-response-of-conjunctival-goblet-cells-to-dry-eye
#6
Donald G Puro
Optimal vision requires an ocular surface with a stable tear film whose many critical tasks include providing >70% of the eye's refractive power. However for millions, tear film instability produces uncomfortable sight-impairing dry eye. Despite the multitude of etiologies for dry eye, a universal hallmark is hyperosmolarity of the tear film. Presently, knowledge of how the ocular surface responds to hyperosmolarity remains incomplete with little understood about the role of ion channels. This bioelectric analysis focused on conjunctival goblet cells whose release of tear-stabilizing mucin is a key adaptive response to dry eye...
April 18, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29664111/morphological-and-functional-changes-in-trpm8-expressing-corneal-cold-thermoreceptor-neurons-during-aging-and-their-impact-on-tearing-in-mice
#7
Ignacio Alcalde, Almudena Íñigo-Portugués, Omar González-González, Laura Almaraz, Enol Artime, Cruz Morenilla-Palao, Juana Gallar, Félix Viana, Jesús Merayo-Lloves, Carlos Belmonte
Morphological and functional alterations of peripheral somatosensory neurons during the aging process lead to a decline of somatosensory perception. Here, we analyze the changes occurring with aging in trigeminal ganglion (TG), TRPM8-expressing cold thermoreceptor neurons innervating the mouse cornea, which participate in the regulation of basal tearing and blinking and have been implicated in the pathogenesis of dry eye disease (DED). TG cell bodies and axonal branches were examined in a mouse line (TRPM8BAC -EYFP) expressing a fluorescent reporter...
April 17, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29620566/variability-of-tear-osmolarity-measurements-with-a-point-of-care-system-in-healthy-subjects-systematic-review
#8
Philipp B Baenninger, Susanne Voegeli, Lucas M Bachmann, Livia Faes, Katja Iselin, Claude Kaufmann, Michael A Thiel
PURPOSE: To assess the variability of osmolarity measured by the point-of-care TearLab system in healthy eyes. METHODS: A systematic review was performed by searching MEDLINE, Scopus, and the Web of Science Databases until November 2016 and checking reference lists of included articles and reviews. The requirements for inclusion were the availability of TearLab results in healthy subjects and a minimum study sample of 20 eyes. Two reviewers assessed articles against the inclusion criteria, extracted relevant data, and examined the methodological quality...
April 4, 2018: Cornea
https://www.readbyqxmd.com/read/29547469/quantitative-assessment-of-dry-eye-parameters-after-muller-s-muscle-conjunctival-resection
#9
Sana Ali Bautista, Edward J Wladis, Robert L Schultze
PURPOSE: Muller's muscle-conjunctival resection (MMCR) is a highly effective technique to correct upper eyelid ptosis. However, several authorities have raised concerns about the possibility of postoperative ocular surface dryness. This study was performed to assess the impact of MMCR on clinically meaningful parameters of the ocular surface. METHODS: In adult patients, tear break-up time, lipid layer thickness, and osmolarity were measured via direct observation, interferometry, and impedance measurements before surgery and 3 months after surgery in patients who underwent MMCR...
March 14, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29533687/assessment-of-tear-functions-in-patients-with-acne-rosacea-without-meibomian-gland-dysfunction
#10
Dilay Ozek, Özlem Evren Kemer, Ferda Artüz
PURPOSE: To evaluate the results of tear functions in acne rosacea. METHODS: This prospective study includes 64 eyes of 32 acne rosacea patients without blepharitis and meibomian gland dysfunction and 90 eyes of 45 patients as control group. Tear functions of all were evaluated with ocular surface disease index (OSDI) questionnaire, and measurements of tear osmolarity were performed by using TearLab, Schirmer I tests without anesthesia and fluorescein tear break-up time (TBUT)...
March 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29519880/meibomian-gland-dysfunction-and-keratopathy-are-associated-with-dry-eye-disease-in-aniridia
#11
Erlend Christoffer Sommer Landsend, Hilde Røgeberg Pedersen, Øygunn Aass Utheim, Jiaxin Xiao, Muhammed Yasin Adil, Behzod Tashbayev, Neil Lagali, Darlene Ann Dartt, Rigmor C Baraas, Tor Paaske Utheim
AIMS: To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. METHODS: Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 healthy controls were examined. All subjects underwent an extensive dry eye examination, including evaluation of meibomian glands (MGs) by meibography, measurement of tear production and tear film osmolarity and grading of vital staining of the ocular surface...
March 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29510226/exploring-topical-anti-glaucoma-medication-effects-on-the-ocular-surface-in-the-context-of-the-current-understanding-of-dry-eye
#12
Aaron B C Wong, Michael T M Wang, Kevin Liu, Zak J Prime, Helen V Danesh-Meyer, Jennifer P Craig
PURPOSE: To assess tear film parameters, ocular surface characteristics, and dry eye symptomology in patients receiving topical anti-glaucoma medications. METHODS: Thirty-three patients with a diagnosis of open angle glaucoma or ocular hypertension, receiving unilateral topical anti-glaucoma medication for at least 6 months, were recruited in a cross-sectional, investigator-masked, paired-eye comparison study. Tear film parameters, ocular surface characteristics, and dry eye symptomology of treated and fellow eyes were evaluated and compared...
March 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29476817/basal-tear-osmolarity-as-a-metric-to-estimate-body-hydration-and-dry-eye-severity
#13
REVIEW
C Willshire, A J Bron, E A Gaffney, E Ian Pearce
The osmolarities of various bodily fluids, including tears, saliva and urine, have been used as indices of plasma osmolality, a measure of body hydration, while tear osmolarity is used routinely in dry eye diagnosis, the degree of tear hyperosmolarity providing an index of disease severity. Systemic dehydration, due to inadequate water intake or excessive water loss is common in the elderly population, has a high morbidity and may cause loss of life. Its diagnosis is often overlooked and there is a need to develop a simple, bedside test to detect dehydration in this population...
February 21, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29475928/tear-film-osmolarity-in-subjects-with-acute-allergic-rhinoconjunctivitis
#14
Eirini Nitoda, Anastasios Lavaris, Konstantinos Laios, Sophia Androudi, Chris D Kalogeropoulos, Michael Tsatsos, Christos Damaskos, Nikolaos Garmpis, Marilita M Moschos
BACKGROUND/AIM: Acute allergic rhinoconjuctivitis is the most common form of ocular allergies. The pathogenetic mechanisms are based on an immunoglobulin E (IgE)-mediated hypersensitivity reaction. On the other hand, tear osmolarity has been suggested to be an index of ocular surface damage and inflammation. These data were the motive to investigate the levels of tear osmolarity in subjects with acute allergic rhinoconjuctivitis, before and after administration of artificial tears. PATIENTS AND METHODS: Forty-five subjects with acute allergic rhinoconjuctivitis were randomly divided into three groups, based on the type of artificial tears that they received: Group A (Thera tears), Group B (Wet therapy) and Group C (Tears Naturale free)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29470972/influence-of-nasal-tear-osmolarity-on-ocular-symptoms-related-to-dry-eye-disease
#15
Ho Chul Yi, Yoon Pyo Lee, Young Joo Shin
PURPOSE: To investigate relationships between local tear osmolarity and tear film characteristics and dry eye disease (DED) symptoms. DESIGN: Prospective, cross-sectional, observational study. METHODS: Nasal and temporal tear osmolarity were measured in subjects with DED. The difference between nasal and temporal tears (OSM difference) was then calculated. Ocular symptoms were evaluated and tear break-up time (TBUT), corneal fluorescein staining score (CFSS), eyelid hyperemia, and tear production were measured...
May 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29457271/does-the-temperature-of-an-artificial-tear-affect-its-comfort
#16
Etty Bitton, Vanessa Crncich, Noemie Brunet
BACKGROUND: Refrigerated eye-drops have been advocated in cases of ocular allergies to provide a soothing effect upon instillation. This notion continues to be promoted by practitioners for artificial tears (AT) in the management of dry eye (DE) with little support in the literature. To further substantiate claims of a soothing effect of cold eye-drops, the aim of this study was to determine if refrigeration of an AT enhanced the subjective comfort upon instillation. METHODS: Participants with mild to moderate DE participated in an open label contralateral study of two weeks duration...
February 18, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29452970/effect-of-tear-supplements-on-signs-symptoms-and-inflammatory-markers-in-dry-eye
#17
Eilidh Martin, Katherine M Oliver, E Ian Pearce, Alan Tomlinson, Peter Simmons, Suzanne Hagan
PURPOSE: Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS: In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At each visit, symptoms, tear evaporation rate, stability and osmolarity were measured and tear samples were analyzed for 7 inflammatory markers, using multiplex immunoassays...
May 2018: Cytokine
https://www.readbyqxmd.com/read/29438120/misight-assessment-study-spain-adverse-events-tear-film-osmolarity-and-discontinuations
#18
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Francisco L Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: To assess the relative clinical success of MiSight contact lenses (CLs) (study group) and distance single-vision (SV) spectacles (control group) in children in terms of adverse events (AEs), discontinuations, and tear film osmolarity over a 2-year period. METHODS: Seventy-four subjects aged 8 to 12 with myopia of -0.75 to -4.00 D and astigmatism less than 1.00 D were randomly assigned to MiSight CLs or SV groups. Subjects were monitored at 6-month intervals over the course of 24 months and advised to report to the clinic immediately should AEs occur...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29388864/the-effect-of-low-dose-aspirin-on-dry-eye-parameters-and-ocular-surface-disease-index-questionnaire
#19
Alper Yazıcı, Esin Sarı, Erkan Ayhan, Gözde Şahin, Nesime Setge Tıskaoğlu, Taha Gürbüzer, Hüseyin Kurt, Sıtkı Samet Ermiş
PURPOSE: To evaluate the effects of acetylsalicylic acid (aspirin) on tear film parameters and dry eye disease. METHODS: Fifty-seven patients using low-dose aspirin regularly for antiaggregant purposes as well as 49 controls, who required antiaggregant treatment but who had not yet started, were included in the study. Tear osmolarity, tear break-up time (TBUT), Schirmer and Oxford grading of ocular surface staining were performed on all patients and dry eye symptomatology was assessed using the ocular surface disease index questionnaire (OSDI)...
April 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29382955/ocular-findings-and-ocular-graft-versus-host-disease-after-allogeneic-stem-cell-transplantation-without-total-body-irradiation
#20
Meeta Pathak, Phoi Phoi Diep, Xiaoran Lai, Lorentz Brinch, Ellen Ruud, Liv Drolsum
Patients treated with allogeneic stem cell transplantation (allo-SCT) often develop ocular complications. To investigate the ocular findings in young long-term survivors after allo-SCT without TBI, we examined 96 patients more than 5 years after transplantation. All patients were under 30 years of age at transplantation. The mean follow-up time was 16.8 years (range 6.0-26.1 years). The study was a part of the Norwegian Allo Survivorship Study investigating health impairments in young survivors after allo-SCT...
January 30, 2018: Bone Marrow Transplantation
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