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https://www.readbyqxmd.com/read/28627956/evaluating-the-effects-of-botulinum-toxin-a-on-tear-metrics-in-patients-with-hemifacial-spasm
#1
Yasmin Poustchi Mali, Robert L Schultze, Edward J Wladis
Hemifacial spasm has been previously shown to result in dry eye and ocular surface diseases. This study was performed to assess the impact of chemodenervation with botulinum toxin on clinically-relevant metrics of tears. Tear osmolarity and lipid layer thickness were measured in patients with hemifacial spasm after they achieved relief from hemifacial spasm via botulinum toxin injections. Twelve eyes of 6 patients with hemifacial spasm (2 men and 4 women; mean age 55.5 years) were assessed in accordance with the Declaration of Helsinki and IRB approval...
June 19, 2017: Orbit
https://www.readbyqxmd.com/read/28585267/intense-pulsed-light-treatment-and-meibomian-gland-expression-for-moderate-to-advanced-meibomian-gland-dysfunction
#2
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin, Paris, France) combined with therapeutic meibomian gland expression at baseline, Week 2 and Week 6...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28585260/randomised-controlled-trial-of-topical-antibacterial-manuka-leptospermum-species-honey-for-evaporative-dry-eye-due-to-meibomian-gland-dysfunction
#3
Julie M Albietz, Katrina L Schmid
BACKGROUND: The aim was to evaluate the efficacy of standardised Manuka (Leptospermum species) antibacterial honey as adjunctive twice daily treatment to conventional therapy (warm compresses, lid massage and preservative-free lubricant), in participants with evaporative dry eye due to moderate to advanced meibomian gland dysfunction. METHODS: This prospective, open-label study involved 114 participants. After two weeks of conventional therapy participants were randomised to one of three treatment groups: Optimel Antibacterial Manuka Eye Gel (98 per cent Leptospermum species honey) plus conventional therapy (n = 37), Optimel Manuka plus Lubricant Eye Drops (16 per cent Leptospermum species honey) plus conventional therapy (n = 37) and a control (conventional therapy) (n = 40)...
June 6, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28579744/randomized-comparison-of-in-vivo-performance-of-two-point-of-care-tear-film-osmometers
#4
Jerry Nolfi, Barbara Caffery
PURPOSE: To compare the in vivo precision of two commercially available point-of-care osmometers among normal subjects with no dry eye disease. METHODS: Twenty healthy adults with healthy ocular surfaces were evaluated by licensed eye care practitioners. All subjects had low Ocular Surface Disease Index score (<5), normal tear breakup time (>10 seconds), and no evidence of corneal fluorescein staining. Five consecutive measurements of tear osmolarity were measured on each eye using each of the two osmometers: the TearLab Osmolarity System (TearLab) and the I-Med i-Pen (i-Pen), for a total of 200 measurements per device...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28553560/optical-coherence-tomography-reveals-changes-to-corneal-reflectivity-and-thickness-in-individuals-with-tear-hyperosmolarity
#5
Laura Adelaide Deinema, Algis Jonas Vingrys, Holly Rose Chinnery, Laura Elizabeth Downie
PURPOSE: To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS: This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-osmolar tears). Symptoms and signs of DED (tear osmolarity, sodium fluorescein tear break-up time, ocular surface staining, Schirmer test) were assessed...
May 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28547534/a-cross-sectional-comparative-study-on-chronic-ocular-manifestations-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-chinese-eyes-a-15-year-case-series
#6
Loraine L W Chow, Alex L K Ng, Sharon S W Chow, Bonnie N K Choy, Kendrick C Shih, Ian Y H Wong, Johnny C Y Chan, Jimmy S M Lai
PURPOSE: To compare the chronic ocular manifestations in Stevens-Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort. METHODS: All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Tear osmolarity was also measured...
May 25, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28533678/effect-of-thermal-pulsation-treatment-on-tear-film-parameters-in-dry-eye-disease-patients
#7
Michelle J Kim, Sandra S Stinnett, Preeya K Gupta
PURPOSE: The goal of this study was to evaluate the effect of thermal pulsation treatment on tear film parameters, specifically osmolarity and matrix metalloproteinase-9 (MMP-9), in patients with meibomian gland dysfunction (MGD) and dry eye disease (DED). METHODS: A single-center review of 189 eyes that underwent thermal pulsation treatment was performed. Data were collected on pre and posttreatment osmolarity, MMP-9, tear break-up time (TBUT), and ocular surface disease index (OSDI) score...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28514245/comparison-of-ocular-lubricant-osmolalities
#8
Etty Bitton, Carolyn Perugino, Stéphanie Charette
PURPOSE: The aim of this study was to evaluate the osmolality of commercially available ocular tear lubricants. METHODS: Thirty-seven (n = 37) ocular lubricants, measured three times each, were evaluated for osmolality using a vapor pressure osmometer (Wescor VAPRO 5520). The osmometer was calibrated before each use, and the order of the lubricants was randomized. Ambient temperature and humidity were monitored for stability. RESULTS: Of the 37 ocular lubricants tested, 35 (94...
June 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28502385/the-effects-of-blood-glucose-regulation-on-tear-function-tests-in-diabetic-patients
#9
S Kan, U Acar, M Kizilgul, E Beyazyildiz, A B Cankaya, O Ozcelik, M Ozbek
PURPOSE: To investigate whether blood glucose regulation in patients with diabetes mellitus (DM) has an influence on the ocular surface disease index (OSDI) score and tear function tests such as tear film osmolarity (TFO), tear break-up time (TBUT) and Schirmer tests. METHODS: Fifty diabetic patients with a fasting blood glucose (FBG) level greater than 200mg/dL and HbA1c level greater than 10% were recruited for this prospective study. All of the patients underwent a detailed ophthalmic examination including OSDI questionnaire, TFO test, TBUT test and Schirmer test initially...
May 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28496300/prospective-evaluation-of-intense-pulsed-light-and-meibomian-gland-expression-efficacy-on-relieving-signs-and-symptoms-of-dry-eye-disease-due-to-meibomian-gland-dysfunction
#10
Steven J Dell, Ronald N Gaster, Sheila C Barbarino, Derek N Cunningham
PURPOSE: The aim of this study was to estimate the efficacy of intense pulsed light (IPL), followed by meibomian gland expression (MGX), for reducing the number and severity of signs and symptoms of dry eye disease (DED) secondary to meibomian gland dysfunction (MGD). PATIENTS AND METHODS: In a prospective study conducted in two sites, 40 subjects (80 eyes) with moderate to severe MGD were enrolled. Major inclusion criteria consisted of at least two of the following measures being compatible with DED in both eyes: tear breakup time (TBUT), meibomian gland score (MGS), corneal fluorescein staining (CFS), Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and tear film osmolarity (TFO)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28486313/comparison-of-tear-osmolarity-in-rheumatoid-arthritis-patients-with-and-without-secondary-sjogren-syndrome
#11
Alex L K Ng, Bonnie N K Choy, Tommy C Y Chan, Ian Y H Wong, Jimmy S M Lai, Mo Yin Mok
PURPOSE: To compare tear osmolarity (TO) and other dry eye parameters in rheumatoid arthritis (RA) patients with or without secondary Sjogren syndrome (sSS). METHODS: Consecutive patients with RA were divided into a sSS group and no-sSS group using conventional diagnostic criteria by rheumatologists using symptomatology, Schirmer test score, and anti-Ro or anti-La autoantibody status. The TO, Ocular Surface Disease Index, dry eye disease (DED) parameters [such as tear breakup time (TBUT) and corneal staining score] and the systemic inflammatory markers [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] were compared...
July 2017: Cornea
https://www.readbyqxmd.com/read/28476958/res-loaded-pegylated-cs-nps-for-efficient-ocular-delivery
#12
Saravanakumar Pandian, Vinoth Jeevanesan, Chandrasekar Ponnusamy, Subramanian Natesan
The objective of this study is to develop resveratrol (RES) loaded polyethylene glycols (PEGs) modified chitosan (CS) nanoparticles (NPs) by ionic gelation method for the treatment of glaucoma. While increasing the concentration of PEG, the particle size and polydispersity index of the formulations increased. Entrapment efficiency and RES loading (RL) of NPs decreased while increasing PEG concentration. The in vitro release of NPs showed an initial burst release of RES (45%) followed by controlled release. Osmolality of formulations revealed that the prepared NPs were iso-osmolar with the tear...
February 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28431436/enhanced-tearing-by-electrical-stimulation-of-the-anterior-ethmoid-nerve
#13
Mark Brinton, Andrea L Kossler, Zara M Patel, James Loudin, Manfred Franke, Christopher N Ta, Daniel Palanker
Purpose: Electrical neurostimulation enhances tear secretion, and can be applied to treatment of dry eye disease. Using a chronic implant, we evaluate the effects of stimulating the anterior ethmoid nerve on the aqueous, lipid, and protein content of secreted tears. Methods: Neurostimulators were implanted beneath the nasal mucosa in 13 New Zealand white rabbits. Stimulations (2.3-2.8 mA pulses of 75-875 μs in duration repeated at 30-100 Hz for 3 minutes) were performed daily, for 3 weeks to measure changes in tear volume (Schirmer test), osmolarity (TearLab osmometer), lipid (Oil-Red-O staining), and protein (BCA assay, mass spectrometry)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28380091/tear-osmolarity-and-ocular-surface-parameters-in-patients-with-psoriasis
#14
Goktug Demirci, Sevil Karaman Erdur, Rukiye Aydin, Ali Balevi, Mustafa Eliacik, Mustafa Ozsutcu, Oktay Olmuscelik
Purpose: The aim of this study was to evaluate tear osmolarity, tear film function, and ocular surface changes in patients with psoriasis. Methods: At a single center, 30 eyes of 30 patients with psoriasis (group 1) and 30 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT) test, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity measurement...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28368991/ocular-surface-parameters-predicting-patient-satisfaction-after-a-single-vectored-thermal-pulsation-procedure-for-management-of-symptomatic-meibomian-gland-dysfunction
#15
Allister Gibbons, Daniel Waren, Nilufer Yesilirmak, Kendra Davis, Felipe Valenzuela, Juan C Murillo, Victor L Perez
PURPOSE: To evaluate the ocular surface parameters that could predict patient satisfaction after single application of vectored thermal pulsation (VTP). METHODS: This is a retrospective interventional case series; it included consecutive patients who underwent bilateral VTP for management of symptomatic meibomian gland dysfunction (MGD). Patients received a full ocular surface evaluation. The outcome was patient subjective improvement during the first 3-4 months after 3 follow-up visits...
June 2017: Cornea
https://www.readbyqxmd.com/read/28367524/effects-of-adjuvant-omega-3-fatty-acid-supplementation-on-dry-eye-syndrome-following-cataract-surgery-a-randomized-clinical-trial
#16
Mehrdad Mohammadpour, Shima Mehrabi, Narges Hassanpoor, Reza Mirshahi
PURPOSE: To investigate the effect of omega-3 polyunsaturated fatty acid supplement on qualitative and quantitative subjective (ocular surface disease index [OSDI]) and objective (Schirmer's test, tear break up time [TBUT], and tear osmolarity) dry eye indices after cataract surgery. METHODS: In this randomized clinical study, 61 eyes of 48 patients complaining of new onset dry eye symptoms after phacoemulsification were enrolled. Subjects were randomly allocated into two groups using urn randomization...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28366362/femtosecond-laser-assisted-laser-in-situ-keratomileusis-versus-photorefractive-keratectomy-effect-on-ocular-surface-condition
#17
Paola Sauvageot, Gemma Julio, Juan Alvarez de Toledo, Victor Charoenrook, Rafael I Barraquer
PURPOSE: To compare ocular surface characteristics in eyes after femtosecond laser-assisted laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). SETTING: Centro de Oftalmologia Barraquer, Barcelona, Spain. DESIGN: Prospective comparative observational study. METHODS: Patients with myopia who had femtosecond laser-assisted LASIK or PRK were included. Tear osmolarity, the Ocular Surface Disease Index questionnaire, Schirmer I, corneal sensitivity, tear breakup time (TBUT), and corneal fluorescein staining were evaluated preoperatively and 3, 6, and 12 months postoperatively...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28346481/edaravone-protects-against-hyperosmolarity-induced-oxidative-stress-and-apoptosis-in-primary-human-corneal-epithelial-cells
#18
Yanwei Li, Haifeng Liu, Wei Zeng, Jing Wei
An increase in the osmolarity of tears induced by excessive evaporation of the aqueous tear phase is a major pathological mechanism behind dry eye. Exposure of epithelial cells on the surface of the human eye to hyperosmolarity leads to oxidative stress, mitochondrial dysfunction, and apoptosis. Edaravone, a hydroxyl radical scavenging agent, is clinically used to reduce neuronal damage following ischemic stroke. In this study, we found that treatment with hyperosmotic media at 400 and 450 mOsM increased the levels of ROS and mitochondrial oxidative damage, which were ameliorated by edaravone treatment in a dose-dependent manner...
2017: PloS One
https://www.readbyqxmd.com/read/28339681/on-tear-film-breakup-tbu-dynamics-and-imaging
#19
Richard J Braun, Tobin A Driscoll, Carolyn G Begley, P Ewen King-Smith, Javed I Siddique
We report the results of some recent experiments to visualize tear film dynamics. We then study a mathematical model for tear film thinning and tear film breakup (TBU), a term from the ocular surface literature. The thinning is driven by an imposed tear film thinning rate which is input from in vivo measurements. Solutes representing osmolarity and fluorescein are included in the model. Osmolarity causes osmosis from the model ocular surface, and the fluorescein is used to compute the intensity corresponding closely to in vivo observations...
February 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28338565/corneal-nerve-morphology-sensitivity-and-tear-neuropeptides-in-contact-lens-wear
#20
Blanka Golebiowski, Cecilia Chao, Fiona Stapleton, Isabelle Jalbert
PURPOSE: To determine tear neuropeptide levels in contact lens wearers and non-wearers, and to examine relationships with indices of corneal innervation, tear function, and ocular discomfort. METHODS: A cross-sectional, single-visit, investigator-masked pilot study. Assessments included Ocular Comfort Index (OCI), central and mid-peripheral corneal nerve density and morphology (HRT-Rostock), corneal sensitivity (Cochet-Bonnet aesthesiometer), tear Substance P and calcitonin gene-related peptide (CGRP) concentration (ELISA), in situ tear osmolarity (TearLab), tear secretion (Phenol Red Thread), and noninvasive tear break-up time (NITBUT; Keeler Tearscope)...
April 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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