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tear osmolarity

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https://www.readbyqxmd.com/read/28431436/enhanced-tearing-by-electrical-stimulation-of-the-anterior-ethmoid-nerve
#1
Mark Brinton, Andrea L Kossler, Zara M Patel, James Loudin, Manfred Franke, Christopher N Ta, Daniel Palanker
Purpose: Electrical neurostimulation enhances tear secretion, and can be applied to treatment of dry eye disease. Using a chronic implant, we evaluate the effects of stimulating the anterior ethmoid nerve on the aqueous, lipid, and protein content of secreted tears. Methods: Neurostimulators were implanted beneath the nasal mucosa in 13 New Zealand white rabbits. Stimulations (2.3-2.8 mA pulses of 75-875 μs in duration repeated at 30-100 Hz for 3 minutes) were performed daily, for 3 weeks to measure changes in tear volume (Schirmer test), osmolarity (TearLab osmometer), lipid (Oil-Red-O staining), and protein (BCA assay, mass spectrometry)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28380091/tear-osmolarity-and-ocular-surface-parameters-in-patients-with-psoriasis
#2
Goktug Demirci, Sevil Karaman Erdur, Rukiye Aydin, Ali Balevi, Mustafa Eliacik, Mustafa Ozsutcu, Oktay Olmuscelik
Purpose: The aim of this study was to evaluate tear osmolarity, tear film function, and ocular surface changes in patients with psoriasis. Methods: At a single center, 30 eyes of 30 patients with psoriasis (group 1) and 30 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT) test, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity measurement...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28368991/ocular-surface-parameters-predicting-patient-satisfaction-after-a-single-vectored-thermal-pulsation-procedure-for-management-of-symptomatic-meibomian-gland-dysfunction
#3
Allister Gibbons, Daniel Waren, Nilufer Yesilirmak, Kendra Davis, Felipe Valenzuela, Juan C Murillo, Victor L Perez
PURPOSE: To evaluate the ocular surface parameters that could predict patient satisfaction after single application of vectored thermal pulsation (VTP). METHODS: This is a retrospective interventional case series; it included consecutive patients who underwent bilateral VTP for management of symptomatic meibomian gland dysfunction (MGD). Patients received a full ocular surface evaluation. The outcome was patient subjective improvement during the first 3-4 months after 3 follow-up visits...
March 31, 2017: Cornea
https://www.readbyqxmd.com/read/28367524/effects-of-adjuvant-omega-3-fatty-acid-supplementation-on-dry-eye-syndrome-following-cataract-surgery-a-randomized-clinical-trial
#4
Mehrdad Mohammadpour, Shima Mehrabi, Narges Hassanpoor, Reza Mirshahi
PURPOSE: To investigate the effect of omega-3 polyunsaturated fatty acid supplement on qualitative and quantitative subjective (ocular surface disease index [OSDI]) and objective (Schirmer's test, tear break up time [TBUT], and tear osmolarity) dry eye indices after cataract surgery. METHODS: In this randomized clinical study, 61 eyes of 48 patients complaining of new onset dry eye symptoms after phacoemulsification were enrolled. Subjects were randomly allocated into two groups using urn randomization...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28366362/femtosecond-laser-assisted-laser-in-situ-keratomileusis-versus-photorefractive-keratectomy-effect-on-ocular-surface-condition
#5
Paola Sauvageot, Gemma Julio, Juan Alvarez de Toledo, Victor Charoenrook, Rafael I Barraquer
PURPOSE: To compare ocular surface characteristics in eyes after femtosecond laser-assisted laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). SETTING: Centro de Oftalmologia Barraquer, Barcelona, Spain. DESIGN: Prospective comparative observational study. METHODS: Patients with myopia who had femtosecond laser-assisted LASIK or PRK were included. Tear osmolarity, the Ocular Surface Disease Index questionnaire, Schirmer I, corneal sensitivity, tear breakup time (TBUT), and corneal fluorescein staining were evaluated preoperatively and 3, 6, and 12 months postoperatively...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28346481/edaravone-protects-against-hyperosmolarity-induced-oxidative-stress-and-apoptosis-in-primary-human-corneal-epithelial-cells
#6
Yanwei Li, Haifeng Liu, Wei Zeng, Jing Wei
An increase in the osmolarity of tears induced by excessive evaporation of the aqueous tear phase is a major pathological mechanism behind dry eye. Exposure of epithelial cells on the surface of the human eye to hyperosmolarity leads to oxidative stress, mitochondrial dysfunction, and apoptosis. Edaravone, a hydroxyl radical scavenging agent, is clinically used to reduce neuronal damage following ischemic stroke. In this study, we found that treatment with hyperosmotic media at 400 and 450 mOsM increased the levels of ROS and mitochondrial oxidative damage, which were ameliorated by edaravone treatment in a dose-dependent manner...
2017: PloS One
https://www.readbyqxmd.com/read/28339681/on-tear-film-breakup-tbu-dynamics-and-imaging
#7
Richard J Braun, Tobin A Driscoll, Carolyn G Begley, P Ewen King-Smith, Javed I Siddique
We report the results of some recent experiments to visualize tear film dynamics. We then study a mathematical model for tear film thinning and tear film breakup (TBU), a term from the ocular surface literature. The thinning is driven by an imposed tear film thinning rate which is input from in vivo measurements. Solutes representing osmolarity and fluorescein are included in the model. Osmolarity causes osmosis from the model ocular surface, and the fluorescein is used to compute the intensity corresponding closely to in vivo observations...
February 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28338565/corneal-nerve-morphology-sensitivity-and-tear-neuropeptides-in-contact-lens-wear
#8
Blanka Golebiowski, Cecilia Chao, Fiona Stapleton, Isabelle Jalbert
PURPOSE: To determine tear neuropeptide levels in contact lens wearers and non-wearers, and to examine relationships with indices of corneal innervation, tear function, and ocular discomfort. METHODS: A cross-sectional, single-visit, investigator-masked pilot study. Assessments included Ocular Comfort Index (OCI), central and mid-peripheral corneal nerve density and morphology (HRT-Rostock), corneal sensitivity (Cochet-Bonnet aesthesiometer), tear Substance P and calcitonin gene-related peptide (CGRP) concentration (ELISA), in situ tear osmolarity (TearLab), tear secretion (Phenol Red Thread), and noninvasive tear break-up time (NITBUT; Keeler Tearscope)...
April 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28328296/the-relationship-between-metabolic-syndrome-its-components-and-dry-eye-a-cross-sectional-study
#9
Sevil Karaman Erdur, Rukiye Aydin, Mustafa Ozsutcu, Oktay Olmuscelik, Mustafa Eliacik, Goktug Demirci, Mehmet Selim Kocabora
PURPOSE: The aim of this study was to evaluate tear osmolarity and tear film function and ocular surface changes in patients with metabolic syndrome. METHODS: 108 eyes of 64 patients with metabolic syndrome (group 1) and 110 eyes of 55 healthy individuals (group 2) were included in this cross-sectional study. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT), and tear osmolarity...
March 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28295445/omega-3-supplementation-is-neuroprotective-to-corneal-nerves-in-dry-eye-disease-a-pilot-study
#10
Holly Rose Chinnery, Cecilia Naranjo Golborne, Laura Elizabeth Downie
PURPOSE: To investigate whether oral, long-chain omega-3 (ω-3) essential fatty acid (EFA) supplementation, for 3 months, induces changes to the central corneal sub-basal nerve plexus in dry eye disease and whether nerve alterations correlate with clinical findings. METHODS: This prospective, comparative study involved the final 12 participants enrolled in a randomised, double-masked, placebo-controlled clinical trial of 60 participants with moderate dry eye disease...
March 12, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28291206/-potential-for-use-of-hydroxypropyl-guar-in-tear-substitute-therapy
#11
V V Brzhesky, S Yu Golubev
Of the large number of polymers used in artificial tear formulations, natural polysaccharides - hydroxypropyl guar, sodium hyaluronate, chondroitin sulfate, dextran, etc., are gaining more and more popularity. Hydroxypropyl guar stands out through its ability to form a long-lasting structured matrix adhered to the damaged ocular surface and ensuring good wettability of the latter and regeneration of epithelial cells. At that, the viscosity of hydroxypropyl guar increases with increasing tear pH (which, in turn, correlates with the severity of xerosis) and further prolongs the moisturizing effect...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28257381/effect-of-sleep-position-on-the-ocular-surface
#12
David Alevi, Henry D Perry, Alexander Wedel, Eric Rosenberg, Limor Alevi, Eric D Donnenfeld
PURPOSE: Dry eye disease is a multifactorial disease with numerous well-documented risk factors. However, to date, sleep position has not been associated with this condition. After observing patients in our practice, we believe that the sleep position in some cases may significantly affect dry eye and meibomian gland dysfunction (MGD). METHODS: This is a single-centered, cross-sectional, noninterventional, institutional review board-approved, single-masked, nonrandomized study of 100 patients whose complaints were related to dry eye disease and a control group of 25 age-matched asymptomatic patients...
May 2017: Cornea
https://www.readbyqxmd.com/read/28255838/the-correlation-between-plasma-osmolarity-and-tear-osmolarity
#13
Maika Kobayashi, Tsutomu Igarashi, Hisatomo Takahashi, Chiaki Fujimoto, Hisaharu Suzuki, Hiroshi Takahashi
PURPOSE: To the correlation between plasma osmolarity (Posm) and tear osmolarity (Tosm) in patients (54 patients, 88 eyes) who underwent cataract surgery was evaluated. METHODS: Before cataract surgery, routine pre-operative biochemical tests were performed, and Posm was determined from blood samples. Also, Tosm was measured using the TearLab system, and objective signs including tear break-up time (BUT), fluorescein staining, lissamine green staining, and Schirmer's test were evaluated...
March 2, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28243058/effects-of-3-trehalose-as-an-adjuvant-treatment-after-lasik
#14
Antonio J Mateo Orobia, Paula Casas Pascual, José Á Cristóbal Bescós, Diana Perez García, Carlos Peiro Embid, M Ángeles Del Buey Sayas, Valentyna Korobko Kulikova, Noelia Lafuente Ojeda
PURPOSE: To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis. DESIGN: Interventional prospective comparative single-blind study. SETTING: Department of Ophthalmology, Hospital Quirón Zaragoza, Spain. METHODS: A total of 26 eyes (13 patients) were included, of which 12 eyes (group 1) received conventional treatment with lubricant drops of hyaluronic acid (0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28243020/correlation-between-tear-osmolarity-and-other-ocular-surface-parameters-in-primary-sj%C3%A3-gren-s-syndrome
#15
Mirinae Kim, Hyun Seung Kim, Kyung-Sun Na
PURPOSE: To investigate the relationships between tear osmolarity and other ocular surface parameters and to determine the diagnostic value of tear osmolarity in primary Sjögren's syndrome (SS) using tear film break-up time, Schirmer I test, and cornea/conjunctiva staining. METHODS: We included 310 eyes of 155 patients diagnosed with dry eye disease (39 primary SS and 116 non-Sjögren dry eye disease) at Seoul St. Mary's Hospital from August 2010 to January 2015...
February 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28207920/paper-based-microfluidic-system-for-tear-electrolyte-analysis
#16
Ali K Yetisen, Nan Jiang, Ali Tamayol, Guillermo U Ruiz-Esparza, Yu Shrike Zhang, Sofía Medina-Pando, Aditi Gupta, James S Wolffsohn, Haider Butt, Ali Khademhosseini, Seok-Hyun Yun
The analysis of tear constituents at point-of-care settings has a potential for early diagnosis of ocular disorders such as dry eye disease, low-cost screening, and surveillance of at-risk subjects. However, current minimally-invasive rapid tear analysis systems for point-of-care settings have been limited to assessment of osmolarity or inflammatory markers and cannot differentiate between dry eye subclassifications. Here, we demonstrate a portable microfluidic system that allows quantitative analysis of electrolytes in the tear fluid that is suited for point-of-care settings...
March 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28184150/randomized-masked-in-vitro-comparison-of-three-commercially-available-tear-film-osmometers
#17
Guillermo Rocha, Eric Gulliver, Armand Borovik, Clara C Chan
PURPOSE: The purpose of this study was to compare the precision and accuracy of commercially available tear film osmometers. METHODS: Contrived tear solution target values representing the physiological range of tear osmolarity (normal eyes 297 mOsm/L, moderately dry eyes 342 mOsm/L, and severe dry eyes 383 mOsm/L) were constructed using a mix of mono- and divalent electrolytes, metabolites, serum albumin, and pH balanced to 7.4. Solution values were randomized and masked from the investigators during testing...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28166657/ocular-surface-effects-of-repeated-application-of-povidone-iodine-in-patients-receiving-frequent-intravitreal-injections
#18
Habiba Saedon, Jennifer Nosek, Julian Phillips, Nirodhini Narendran, Yit C Yang
BACKGROUND: The aim of this study was to investigate the patient reported symptoms and objective signs of tear film and ocular surface abnormalities experienced by patients undergoing repeated exposure to povidone iodine as a consequence of requiring frequent intravitreal injections for wet macular degeneration. METHODS: This was a prospective study of consecutive patients who had received recent povidone 5% solution for sterile preparation of intravitreal injection less than 3 months prior to inclusion with a total of at least 3 intravitreal injections for macular degeneration...
February 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28147407/-significance-of-new-methods-of-examining-the-tear-film-in-dry-eye-disease-tear-film-osmolarity-and-matrix-metalloproteinases-mmp-9
#19
M Schargus, G Geerling, S C Joachim
Dry eye disease is one of the most common diagnoses in ophthalmology. A variety of subjective and objective test methods with imprecise limits and highly different sensitivities and specificities complicate the diagnosis. Especially mild to moderate pathological findings can be misdiagnosed. In recent years, new options have opened, through the development of new, clinical practicable diagnostic equipment, for example, for the analysis of tear film osmolarity or matrix metalloproteinases (MMP-9). The value of tear film osmolarity and determination of MMP-9 levels in the diagnosis of dry eye and its subtypes will be discussed and evaluated objectively, on the basis of published study results...
February 1, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28122407/effects-of-latisse-bimatoprost-0-03-per-cent-topical-solution-on-the-ocular-surface
#20
Etty Bitton, Claudine Courey, Pamela Giancola, Vasile Diaconu, Jack Wise, Walter Wittich
PURPOSE: LATISSE is marketed for the treatment of hypotrichosis (loss of eyelashes), using a prostamide analogue and preserved with benzalkonium chloride, which is an effective preservative; however, it also causes irritation to the ocular surface. LATISSE is applied to the lid margin; however, with the blink, some solution may fall onto the ocular surface. The objective of this study was to assess the effects of LATISSE on the ocular surface over two months. METHODS: Non-dry eye participants interested in eyelash lengthening were invited to a prospective uncontrolled, open-label clinical study using LATISSE for two months...
January 25, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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