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Newcastle diabetes

Sarah J Pickett, John P Grady, Yi Shiau Ng, Gráinne S Gorman, Andrew M Schaefer, Ian J Wilson, Heather J Cordell, Doug M Turnbull, Robert W Taylor, Robert McFarland
Objective: The pathogenic mitochondrial DNA m.3243A>G mutation is associated with a wide range of clinical features, making disease prognosis extremely difficult to predict. We aimed to understand the cause of this heterogeneity. Methods: We examined the phenotypic profile of 238 adult m.3243A>G carriers (patients and asymptomatic carriers) from the UK MRC Mitochondrial Disease Patient Cohort using the Newcastle Mitochondrial Disease Adult Scale. We modeled the role of risk factors for the development of specific phenotypes using proportional odds logistic regression...
March 2018: Annals of Clinical and Translational Neurology
P Papi, C Letizia, A Pilloni, L Petramala, V Saracino, D Rosella, G Pompa
OBJECTIVE: Metabolic syndrome (MetS) is defined as a spectrum of conditions associated with an increased risk of developing CVD and type 2 diabetes. MetS include: hyperglycemia, hypertension, visceral obesity, dyslipidemia with elevated values of triglycerides (TG) and low levels of HDL. The aim of this review is to provide current knowledge of the relationship between MetS, its components and peri-implant diseases. MATERIALS AND METHODS: An electronic literature search was conducted in the English language in several databases...
February 2018: European Review for Medical and Pharmacological Sciences
Swapnil Hiremath, Jeanne Françoise Kayibanda, Benjamin J W Chow, Dean Fergusson, Greg A Knoll, Wael Shabana, Brianna Lahey, Olivia McBride, Alexandra Davis, Ayub Akbari
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is defined as worsening of renal function after the administration of iodinated contrast material. In patients with cardiovascular disease, kidney disease, and/or diabetes, renin-angiotensin system blockers, non-steroidal anti-inflammatory drugs, diuretics, and metformin can increase the risk of CI-AKI when undergoing contrast imaging. Despite CI-AKI being the leading iatrogenic cause of acute kidney injury, there is a lack of sufficient scientific evidence supporting which drugs should be stopped, when they should be stopped, and when they should be resumed...
February 21, 2018: Systematic Reviews
Wilson Kwong, George Tomlinson, Denice S Feig
OBJECTIVE: Obesity during pregnancy is associated with a number of adverse obstetrical outcomes, including gestational diabetes, macrosomia and preeclampsia. There is increasing evidence that bariatric surgery may decrease the risk of these outcomes. Our aim was to evaluate the benefits and risks of bariatric surgery in obese women on obstetrical outcomes. DATA SOURCES: A systematic literature search using MEDLINE, Embase, Cochrane, Web of Science and PubMed from inception up to December 12, 2016...
February 15, 2018: American Journal of Obstetrics and Gynecology
Arash Akhavan Rezayat, Malihe Dadgar Moghadam, Mohammad Ghasemi Nour, Matin Shirazinia, Hamidreza Ghodsi, Mohammad Reza Rouhbakhsh Zahmatkesh, Mitra Tavakolizadeh Noghabi, Benyamin Hoseini, Kambiz Akhavan Rezayat
Background/aims: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Some risk factors are known to influence the development of non-alcoholic fatty liver disease, but the effect of tobacco smoking on the progression of non-alcoholic fatty liver disease is controversial. The main goal of this systematic review and meta-analysis is to investigate the association between smoking and non-alcoholic fatty liver disease. Method: Electronic databases (PubMed, Scopus, and ISI Web of Science) were searched to find published articles on non-alcoholic fatty liver disease and smoking until December 2016...
2018: SAGE Open Medicine
Peiwen Li, Cong Zhang, Peng Gao, Xiaowan Chen, Bin Ma, Dehao Yu, Yongxi Song, Zhenning Wang
Increasing evidence suggests that metformin use is associated with a decreased risk of cancer. The traditional therapies for gastric cancer (GC) are gastrectomy and chemoradiotherapy; however, these therapies may cause certain adverse effects, which affect a patient's quality of life, and the overall survival rate is low. At present, little is known about whether the use of metformin decreases the risk of GC in patients with type 2 diabetes. Therefore, in the present study, a systematic review was performed to analyze the effect of metformin on GC...
January 2018: Oncology Letters
Shu-Lan Liu, A-Juan Zheng, Li Ding
BACKGROUND: Type 1 diabetes mellitus (T1DM) is a T-cell mediated autoimmune disease with a complex genetic and immunological background. Evidence suggests that killer cell immunoglobulin-like receptor (KIR) genes are associated with T1DM, but the results are inconsistent. Here, we conducted a meta-analysis to comprehensively evaluate the effect of KIR genes on the risk of T1DM. METHODS: The PubMed, Web of Science, the Chinese Biomedical Database, and Chinese National Knowledge Infrastructure databases were systematically searched to select studies on the association between KIR polymorphisms and T1DM...
December 2017: Medicine (Baltimore)
Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice Pa Zeegers, Markus Horneber, Roberto D'Amico, Catherine M Crespi
BACKGROUND: This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES: To gather and present evidence needed to address two research questions:1. What is the aetiological relationship between selenium exposure and cancer risk in humans?2...
January 29, 2018: Cochrane Database of Systematic Reviews
Yao-Yao Zhou, Xiao-Dong Zhou, Sheng-Jie Wu, Xian-Qing Hu, Biao Tang, Sven van Poucke, Xiao-Yan Pan, Wen-Jun Wu, Xue-Mei Gu, Shen-Wen Fu, Ming-Hua Zheng
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has been linked to an increased risk of cardiovascular disease (CVD). To explore the impact of diabetes mellitus (DM) as a cardiovascular risk factor, this meta-analysis quantitatively assessed the association of NAFLD and CVD in diabetic patients. METHODS: PubMed, EMBASE, and the Cochrane Library database were analyzed until the end of March 2017. Original studies analyzing the association between NAFLD and cardiovascular risk factors in the diabetic population were included...
January 18, 2018: European Journal of Gastroenterology & Hepatology
Mark Y Z Wong, Ryan E K Man, Eva K Fenwick, Preeti Gupta, Ling-Jun Li, Rob M van Dam, Mary F Chong, Ecosse L Lamoureux
INTRODUCTION: The evidence linking dietary intake with diabetic retinopathy (DR) is growing but unclear. We conducted a systematic review of the association between dietary intake and DR. METHODS: We systematically searched PubMed, Embase, Medline, and the Cochrane Central register of controlled trials, for publications between January 1967 and January 2017 using standardized criteria for diet and DR. Interventional and observational studies investigating micro- and macro-nutrient intakes; food and beverage consumptions; and dietary patterns were included...
2018: PloS One
Paulo H R F Almeida, Thales B C Silva, Francisco de Assis Acurcio, Augusto A Guerra Júnior, Vania E Araújo, Leonardo M Diniz, Brian Godman, Alessandra M Almeida, Juliana Alvares
INTRODUCTION: Insulin analog glargine (GLA) has been available as one of the therapeutic options for patients with type 1 diabetes mellitus to enhance glycemic control. Studies have shown that a decrease in the frequency of hypoglycemic episodes improves the quality of life (QoL) of diabetic patients. However, there are appreciable acquisition cost differences between different insulins. Consequently, there is a need to assess their impact on QoL to provide future guidance to health authorities...
January 10, 2018: Patient
Filippo Graziani, Stefano Gennai, Anna Solini, Morena Petrini
AIM: To update the available evidence on the impact of periodontitis on diabetes control, incidence and complications. METHODS: Observational studies on the effect of periodontitis on diabetes, published after 2012, were identified through electronic databases and hand-searched journals. Findings were summarized by evidence tables, using PRISMA statement. Quality of the included studies was evaluated through the Newcastle Ottawa scale. RESULTS: Healthy individuals with periodontitis exhibit a poor glycaemic control and a higher risk of developing diabetes...
February 2018: Journal of Clinical Periodontology
Yanbo Zhang, Yunhui Gong, Hongmei Xue, Jingyuan Xiong, Guo Cheng
BACKGROUND: Gestational diabetes mellitus (GDM) is an increasingly prevalent disorder, associated with low blood vitamin D (VD) level. OBJECTIVES: To evaluate the relationship between VD and GDM. SEARCH STRATEGY: EMBASE, MEDLINE, Cochrane library and China Biology Medicine disc were searched till May 2017. The references of previous studies were screened. SELECTION CRITERIA: Observational studies on the relationship between VD and GDM free from Hawthorne effect and randomized controlled trials of VD supplementation during pregnancy for preventing or treating GDM were included...
December 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
Ailbhe Spillane, Celine Larkin, Paul Corcoran, Karen Matvienko-Sikar, Fiona Riordan, Ella Arensman
BACKGROUND: Little research has been conducted into the physical health implications of suicide bereavement compared to other causes of death. There is some evidence that suicide bereaved parents have higher morbidity, particularly in terms of chronic illness. This systematic review aims to examine the physical and psychosomatic morbidities of people bereaved by a family member's suicide and compare them with family members bereaved by other modes of death. METHODS: MEDLINE, EMBASE, CINAHL, and PsycINFO were searched from 1985 to February 2016...
December 12, 2017: BMC Public Health
Tingting Wang, Hanlin Fu, Lizhang Chen, Yang Xu
To estimate the status of pregnancy complications among women with polycystic ovary syndrome (PCOS) through a systematic review of published literatures.
 Methods: Systematic literature searches were conducted in PubMed, Web of Science, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu and China Biology Medicine disc (CBMdisc), as well as the relevant articles published from inception to April 1st 2017, which reported the prevalence of pregnancy complications among women with PCOS...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Wenwen Guo, Baihui Zhang, Xia Wang
INTRODUCTION: Irisin is a newly discovered myokine, which is involved in energy metabolism and associated with "browning" of the white adipose tissue, obesity, diabetes mellitus and metabolic syndrome. It's still uncertain that whether irisin level is associated with coronary artery disease. The purpose of this study is to explore the relationship between irisin levels and coronary artery disease. EVIDENCE ACQUISITION: A search of PubMed, MEDLINE, Elsevier Science Direct, Springer, Web of Science and China National Knowledge Infrastructure (CNKI) for studies published from 2000 to 2017 was undertaken to identify relevant studies...
November 20, 2017: Minerva Endocrinologica
Karen L Søgaard, Christina Ellervik, Jannet Svensson, Steffen U Thorsen
BACKGROUND: The incidence of type 1 diabetes (T1D) is rising, which might be due to the influence of environmental factors. Biological and epidemiological evidence has shown that excess iron is associated with beta-cell damage and impaired insulin secretion. AIM: In this review, our aim was to assess the association between iron and the risk of T1D. METHODS: A systematic literature search was performed in PubMed and EMBASE in July 2016. Studies investigating the effect of iron status/intake on the risk of developing T1D later were included, and study quality was evaluated...
July 2017: Review of Diabetic Studies: RDS
Jong-Lim Kim, Jin Yong Shin, Si-Gyun Roh, Suk Choo Chang, Nae-Ho Lee
Lower extremity amputation is a source of morbidity and mortality among diabetic patients. This meta-analysis aimed to identify significant laboratory data in patients with diabetic foot ulcer with high rates of lower extremity amputation. We performed a systematic literature review and meta-analysis using MEDLINE, EMBASE, and Cochrane databases. We extracted and evaluated 11 variables from the included studies based on amputation rates. This study used the Newcastle-Ottawa Scale to assess the quality of the studies...
November 1, 2017: International Journal of Lower Extremity Wounds
Vivian Yawei Guo, Bing Cao, Chunyan Cai, Kenneth King-Yip Cheng, Bernard Man Yung Cheung
AIMS: Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. METHODS: A systematic search of studies from the MEDLINE, EMBASE, Pubmed and Web of Science using fetuin-A, diabetes and various synonyms was conducted up to June 5, 2017. Relevant studies were extracted by two reviewers independently...
November 11, 2017: Acta Diabetologica
Faustino R Pérez-López, Samuel J Martínez-Domínguez, Andrea Viñas, Raquel Pérez-Tambo, Alberto Lafita, Héctor Lajusticia, Peter Chedraui
OBJECTIVE: To perform a systematic review and meta-analysis regarding endometriosis and the risk of gestational diabetes mellitus (GDM). METHODS: We carried out a search of the following databases: Medline, Embase, Web of Science, Cochrane Library, Scopus, Scielo,, the UK Clinical Trials Gateway, and the Australian New Zealand Clinical Trials Registry, from inception through April 28 2017, without language restrictions, in order to evaluate the effect of endometriosis over GDM risk, in women with and without endometriosis...
November 5, 2017: Gynecological Endocrinology
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