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https://www.readbyqxmd.com/read/29668128/tuberculosis-associated-with-tumor-necrosis-factor-%C3%AE-antagonists-case-description-and-analysis-of-reported-cases-in-colombia
#1
Leandro Galvis, Ángel Y Sánchez, Leonardo F Jurado, Martha I Murcia
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667077/a-case-of-beh%C3%A3-et-s-disease-with-various-gastrointestinal-findings
#2
Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Shuji Terai
Behçet's disease (BD) is a systemic inflammatory disorder involving the oral and genital mucosa, skin, eyes, gastrointestinal tract, joints, vasculature, and nervous. The gastrointestinal lesions accompanying with BD can extend along the full length of the tract, from the mouth to the anus, and show various clinical characteristics which is difficult to be differentiate from the other inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Hence, the differential diagnosis is difficult and can affect treatment outcomes...
April 17, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29666980/epidemiology-of-uveitis-in-a-us-population-based-study
#3
Marta Mora González, Marissé Masís Solano, Travis C Porco, Catherine E Oldenburg, Nisha R Acharya, Shan C Lin, Matilda F Chan
BACKGROUND: The purpose of this study is to assess the relationship between self-reported uveitis and purported demographic and clinical risk factors, using an American adult population extracted from the National Health and Nutrition Examination Survey (NHANES) for the years 2009 and 2010. This is a cross-sectional, population-based study using a sample of 5106 subjects between 20 and 69 years old. The main outcome for our study was the self-report of a diagnosis of uveitis. The demographic analysis included age, gender, and ethnicity...
April 17, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29664147/predictors-and-clinical-outcomes-of-follow-up-loss-in-patients-with-inflammatory-bowel-disease
#4
Dae Hyung Woo, Kyeong Ok Kim, Min Kyu Kang, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
BACKGROUND AND AIM: Nonadherence is a risk factor of disease worsening in inflammatory bowel disease (IBD). We analyzed the frequency, predictors, and clinical outcomes of patients with IBD who are lost to follow-up in outpatient clinics. METHODS: Medical records of 784 IBD patients visiting our IBD clinic between January 2010 and December 2015 were reviewed retrospectively. Overall, 285 newly diagnosed IBD patients who were followed up for at least 12 months were included in the analysis...
April 17, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29663629/examination-of-the-relationship-between-disease-activity-and-patient-reported-outcome-measures-in-an-inflammatory-bowel-disease-cohort
#5
Belinda D Jackson, Danny Con, Alexandra Gorelik, Danny Liew, Simon Knowles, Peter De Cruz
BACKGROUND: The extent to which disease activity impacts on patient reported outcomes (PROs) is unclear. AIMS: The purpose of this study was to examine the relationship between disease activity and PROs. METHODS: Adult IBD patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (SCCAI, HBI), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (HADS), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PROs...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29663265/telemedicine-and-mobile-health-technology-are-effective-in-the-management-of-digestive-diseases-a-systematic-review
#6
REVIEW
Brian C Helsel, Joel E Williams, Kristen Lawson, Jessica Liang, Jonathan Markowitz
BACKGROUND: Mobile applications and interactive websites are an increasingly used method of telemedicine, but their use lacks evidence in digestive diseases. AIM: This study aims to explore digestive disease studies that use telemedicine to effectively manage disease activity, help monitor symptoms, improve compliance to the treatment protocol, increase patient satisfaction, and enhance the patient-to-provider communication. METHODS: EBSCO, PubMed, and Web of Science databases were searched using Medical Subject Headings and other keywords to identify studies that utilized telemedicine in patients with digestive disease...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29659758/accelerated-clearance-of-infliximab-is-associated-with-treatment-failure-in-patients-with-corticosteroid-refractory-acute-ulcerative-colitis
#7
David Kevans, Sanjay Murthy, Diane R Mould, Mark S Silverberg
Background and Aims: A significant proportion of patients with corticosteroid-refractory acute ulcerative colitis [UC] fail therapy. We aimed to assess the pharmacokinetics [PK] of infliximab [IFX] in patients with corticosteroid-refractory acute UC and determine the association between induction IFX PK and short- and long-term therapy outcome. Methods: A population PK model was developed using data from 51 patients with UC [n = 42] and Crohn's disease [n = 9]. A subset of patients [n = 36] with acute corticosteroid-refractory UC (median Mayo score 11 [range 8-12]; 33 of 36 hospitalized; median corticosteroid dose at study entry 50mg prednisolone equivalent IV/oral) commencing IFX were studied to assess further correlations between PK from the first induction dose and therapy outcomes...
April 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29657930/establishment-and-development-of-the-first-biobank-of-inflammatory-bowel-disease-suspected-to-primary-immunodeficiency-diseases-in-iran
#8
Roya Sherkat, Soodabeh Rostami, Majid Yaran, Mohammad Hassan Emami, Hosein Saneian, Hamid Tavakoli, Peyman Adibi, Mahdieh Behnam, Saba Sheykhbahaei, Bahram Bagherpour, Razieh Khoshnevisan, Somayeh Najafi
Background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran. Materials and Methods: This study was designed to provide the IBDSPIDB to have a high-quality DNA, RNA, and cDNA...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29657833/paradoxical-arthritis-occurring-during-anti-tnf-in-patients-with-inflammatory-bowel-disease-histological-and-immunological-features-of-a-complex-synovitis
#9
Stefano Alivernini, Daniela Pugliese, Barbara Tolusso, Laura Bui, Luca Petricca, Luisa Guidi, Luisa Mirone, Gian Ludovico Rapaccini, Francesco Federico, Gianfranco Ferraccioli, Alessandro Armuzzi, Elisa Gremese
Objective: Paradoxical arthritis under tumour necrosis factor inhibitor (TNF-i) for inflammatory bowel disease (IBD) has been described. This study aims to evaluate the histological features of paired synovial tissue (ST) and colonic mucosa (CM) tissue in patients with IBD developing paradoxical arthritis under TNF-i. Methods: Patients with IBD without history of coexisting joint involvement who developed arthritis under TNF-i were enrolled. Each patient underwent ST biopsy and ileocolonoscopy with CM biopsies...
2018: RMD Open
https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#10
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29649328/association-between-kir-hla-combination-and-ulcerative-colitis-and-crohn-s-disease-in-a-japanese-population
#11
Hiromi Saito, Atsuhiro Hirayama, Takeji Umemura, Satoru Joshita, Kenji Mukawa, Tomoaki Suga, Eiji Tanaka, Masao Ota
Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD). Natural killer cell responses play a crucial role in autoimmune disease through innate immunity, in which killer cell immunoglobulin-like receptors (KIRs) are closely involved. Although the genetic combination of KIRs with their specific HLA class I ligands has been associated with IBD in Caucasians, such KIR-HLA receptor-ligand combinations are not fully understood in the Japanese. We investigated 14 KIR genes along with HLA-Bw and -C ligands in 90 patients with UC and 50 patients with CD and compared them with the characteristics of 325 healthy control subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29623442/therapeutic-drug-monitoring-in-pediatric-inflammatory-bowel-disease
#12
REVIEW
Nicholas Carman, David R Mack, Eric I Benchimol
PURPOSE OF REVIEW: Therapeutic drug monitoring (TDM) has emerged as a useful tool to optimize the use of drug therapies in adults with inflammatory bowel disease (IBD), including both Crohn's disease (CD) and ulcerative colitis (UC), especially during the use of biological therapies, for which the pharmacokinetics and pharmacodynamics are highly variable among patients. Fewer data exist in children. This review examines the current literature on TDM in pediatric IBD. RECENT FINDINGS: Drug clearance is affected by a number of patient and disease factors...
April 5, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29623105/subtherapeutic-concentrations-of-infliximab-and-adalimumab-are-associated-with-increased-disease-activity-in-crohn-s-disease
#13
Arne Carlsen, Roald Omdal, Kristian Øgreid Leitao, Kjetil Isaksen, Anne Kristine Hetta, Lars Normann Karlsen, Lars Aabakken, Nils Bolstad, David Warren, Knut E A Lundin, Tore Grimstad
Background: Low anti-tumor necrosis factor α (TNFα) serum concentrations may result in lack of treatment response in patients with inflammatory bowel disease. We determined the anti-TNFα drug concentrations in patients with inflammatory bowel disease and investigated whether or not subtherapeutic drug concentrations were associated with increased levels of disease activity. Methods: In a single-center cross-sectional study, we included patients with ulcerative colitis or Crohn's disease who were receiving infliximab or adalimumab maintenance therapy...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29620794/systematic-review-with-meta-analysis-association-between-acetaminophen-and-nonsteroidal-anti-inflammatory-drugs-nsaids-and-risk-of-crohn-s-disease-and-ulcerative-colitis-exacerbation
#14
REVIEW
O O Moninuola, W Milligan, P Lochhead, H Khalili
BACKGROUND: Unlike acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) have generally been thought to be associated with increased risk of IBD exacerbation. AIM: To carry out a systematic review and meta-analysis of previous studies examining the association between acetaminophen and NSAIDs including cyclooxygenase (COX-2) inhibitors use, and risk of Crohn's disease (CD) and ulcerative colitis (UC) exacerbation. METHODS: We identified published manuscripts and abstracts through 1 March 2017 by systematic search of Medline, Embase, Cochrane and other trial registries...
April 5, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29620595/pulmonary-function-test-abnormalities-in-children-with-inflammatory-bowel-disease-is-it-common
#15
Doaa Mohamed El Amrousy, Samir Hassan, Heba El-Ashry, Mohamed Yousef, Ragia Sharshar
OBJECTIVE: The aim of the study was to evaluate the frequency and type of pulmonary dysfunction in newly diagnosed children with inflammatory bowel disease (IBD) and the correlation between pulmonary function tests (PFTs) and IBD activity. METHODS: It is an observational case-control study. One hundred newly diagnosed children with IBD were enrolled as the patient group, which was subdivided into 52 with Crohn disease (CD) and 48 with ulcerative colitis (UC). Fifty healthy children matched for age, sex, height, and body mass index (BMI) served as the control group...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29617306/development-of-colorectal-targeted-dietary-supplement-tablets-containing-natural-purple-rice-bran-oil-as-a-colorectal-chemopreventive
#16
Busaban Sirithunyalug, Chalermpong Saenjum, Suporn Charumanee, Bhagavathi Sundaram Sivamaruthi, Chaiyavat Chaiyasut, Jakkapan Sirithunyalug, Pratchaya Tipduangta
Colorectal cancer occurs due to various factors. The important risks are dietary lifestyle and inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. It has been found that the inhibitory enzyme cyclooxygenase-2 (COX-2) in the colorectal region can potentially reduce the risk of colorectal cancer. The present study investigated rice bran oil from natural purple rice bran, which exhibits antioxidant and anti-inflammatory activity. This study aimed to evaluate the bioactive compound content of natural purple rice bran oil (NPRBO) derived from native Thai purple rice and the anti-inflammatory activity of NPRBO in colorectal cancer cells, and to develop a colorectal delivery platform in the form of film-coated tablets...
April 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29616750/comparison-of-two-models-of-inflammatory-bowel-disease-in-rats
#17
Cristina Sorina Catana, Cristian Magdas, Flaviu Alexandru Tabaran, Elena Cristina Crăciun, Georgiana Deak, Virginia Ana Magdaş, Vasile Cozma, Călin Mircea Gherman, Ioana Berindan-Neagoe, Dan Lucian Dumitraşcu
BACKGROUND: There is a need for experimental animal models for inflammatory bowel diseases (IBD), but no proposed model has been unanimously accepted. OBJECTIVES: The aim of this study was to develop 2 affordable models of IBD in rats and to compare them. MATERIAL AND METHODS: We produced IBD in rats using either dextran sodium sulfate (DSS) or 2, 4, 6-trinitrobenzene sulfonic acid (TNBS). The requirements for experimental models were: a predictable clinical course, histopathology and inflammation similar to human ulcerative colitis (UC) and Crohn's disease (CD)...
March 26, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29610943/restless-legs-syndrome-is-a-relevant-comorbidity-in-patients-with-inflammatory-bowel-disease
#18
Janek Becker, Felix Berger, Katharina A Schindlbeck, Denis Poddubnyy, Peter M Koch, Jan C Preiß, Britta Siegmund, Frank Marzinzik, Jochen Maul
BACKGROUND AND AIMS: In patients with inflammatory bowel disease (IBD), restless legs syndrome (RLS) may occur as an extraintestinal disease manifestation. Iron deficiency (ID) or folate deficiency/vitamin B12 deficiency (FD/VB12 D) has previously been described to cause RLS. Here, we determined the prevalence and severity of RLS in IBD patients and evaluated the effect of iron and/or folic acid/vitamin B12 supplementation. METHODS: Patients were screened for ID and RLS by a gastroenterologist...
April 3, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29607052/changing-nationwide-trends-in-endoscopic-medical-and-surgical-admissions-for-inflammatory-bowel-disease-2003-2013
#19
Ahmir Ahmad, Anthony A Laverty, Chris Alexakis, Tom Cowling, Sonia Saxena, Azeem Majeed, Richard C G Pollok
Background and study aims: In the last decade, there have been major advances in inflammatory bowel disease (IBD) management but their impact on hospital admissions requires evaluation. We aim to investigate nationwide trends in IBD surgical/medical elective and emergency admissions, including endoscopy and cytokine inhibitor infusions, between 2003 and 2013. Patients and methods: We used Hospital Episode Statistics and population data from the UK Office for National Statistics...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29606936/vedolizumab-as-a-potential-culprit-in-the-development-of-ovarian-teratoma
#20
Judy A Trieu, Mohammad Bilal, Gurinder Luthra
Vedolizumab is a new humanized monoclonal antibody that has been reserved for those with moderate-to-severe Crohn's disease and ulcerative colitis who have failed immunomodulator and TNF-α antagonist therapy, and for those who have an increased risk for developing progressive multifocal leukoencephalopathy. Because it targets gastrointestinal tract-specific lymphocytes, meta-analyses and integrated studies have shown that vedolizumab causes fewer extraintestinal adverse effects, such as opportunistic infections and malignancies, compared with anti-TNF therapies...
September 2017: Case Reports in Gastroenterology
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