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Crohn and ulcerative colitis

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https://www.readbyqxmd.com/read/29441457/effect-of-vsl-3-probiotic-in-a-patient-with-glycogen-storage-disease-type-ia-and-irritable-bowel-disease-like-disease
#1
Miguel Carnero-Gregorio, Alberto Molares-Vila, Alberte Corbalán-Rivas, Carlos Villaverde-Taboada, Carmen Rodríguez-Cerdeira
Gut Inflammatory bowel disease (IBD) is a group of chronic gastrointestinal disorders characterised by relapsing and remitting inflammation of the gastrointestinal tract. The two most common types of IBDs are ulcerative colitis and Crohn's disease. Patients with glycogen storage disease (GSD) type Ia present with gastrointestinal symptoms such as recurrent abdominal pain, bloating and changes in stool form or frequency, which is clinically difficult to distinguish from IBD. We report the case of a 36-year-old man with GSD type Ia and IBD-like disease...
February 13, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29441064/impact-of-cigarette-smoking-on-the-gastrointestinal-tract-inflammation-opposing-effects-in-crohn-s-disease-and-ulcerative-colitis
#2
REVIEW
Loni Berkowitz, Bárbara M Schultz, Geraldyne A Salazar, Catalina Pardo-Roa, Valentina P Sebastián, Manuel M Álvarez-Lobos, Susan M Bueno
Cigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer, Crohn's disease (CD), and several cancers. The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response. Paradoxically, cigarette smoking is a protective factor for the development and progression of ulcerative colitis (UC). UC and CD represent the two most important conditions of inflammatory bowel diseases, and share several clinical features...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29440933/population-based-cohort-study-on-comparative-effectiveness-and-safety-of-biologics-in-inflammatory-bowel-disease
#3
Riccardo Di Domenicantonio, Francesco Trotta, Silvia Cascini, Nera Agabiti, Anna Kohn, Antonio Gasbarrini, Marina Davoli, Antonio Addis
Background: The comparison of effectiveness and safety of anti-tumor necrosis factor-alpha agents for the treatment of inflammatory bowel disease (IBD) is relevant for clinical practice and stakeholders. Objective: The objective of this study was to compare the risk of abdominal surgery, steroid utilization, and hospitalization for infection in Crohn's disease (CD) or ulcerative colitis (UC) patients newly treated with infliximab (IFX) or adalimumab (ADA). Methods: A retrospective population-based cohort study was performed using health information systems data from Lazio region, Italy...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29439003/impact-of-red-and-processed-meat-and-fibre-intake-on-treatment-outcomes-among-patients-with-chronic-inflammatory-diseases-protocol-for-a-prospective-cohort-study-of-prognostic-factors-and-personalised-medicine
#4
Robin Christensen, Berit L Heitmann, Karina Winther Andersen, Ole Haagen Nielsen, Signe Bek Sørensen, Mohamad Jawhara, Anette Bygum, Lone Hvid, Jakob Grauslund, Jimmi Wied, Henning Glerup, Ulrich Fredberg, Jan Alexander Villadsen, Søren Geill Kjær, Jan Fallingborg, Seyed A G R Moghadd, Torben Knudsen, Jacob Brodersen, Jesper Frøjk, Jens Frederik Dahlerup, Anders Bo Bojesen, Grith Lykke Sorensen, Steffen Thiel, Nils J Færgeman, Ivan Brandslund, Tue Bjerg Bennike, Allan Stensballe, Erik Berg Schmidt, Andre Franke, David Ellinghaus, Philip Rosenstiel, Jeroen Raes, Mette Boye, Lars Werner, Charlotte Lindgaard Nielsen, Heidi Lausten Munk, Anders Bathum Nexøe, Torkell Ellingsen, Uffe Holmskov, Jens Kjeldsen, Vibeke Andersen
INTRODUCTION: Chronic inflammatory diseases (CIDs) are frequently treated with biological medications, specifically tumour necrosis factor inhibitors (TNFi)). These medications inhibit the pro-inflammatory molecule TNF alpha, which has been strongly implicated in the aetiology of these diseases. Up to one-third of patients do not, however, respond to biologics, and lifestyle factors are assumed to affect treatment outcomes. Little is known about the effects of dietary lifestyle as a prognostic factor that may enable personalised medicine...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29430672/review-article-predictors-of-response-to-vedolizumab-and-ustekinumab-in-inflammatory-bowel-disease
#5
REVIEW
A Barré, J-F Colombel, R Ungaro
BACKGROUND: Increased knowledge of pathways involved in the pathogenesis of IBD has led to the development of new treatment options for Crohn's disease (CD) and ulcerative colitis (UC). Two new biological agents have been recently approved for IBD: vedolizumab and ustekinumab. They have different therapeutic targets (α4 β7 integrin for vedolizumab and interleukin-12/23 pathways for ustekinumab) than the primary biological class, anti-tumour necrosis factor alpha (anti-TNF) agents. As the armamentarium for IBD increases in coming years, it will become important to understand factors associated with response in order to best position and personalise therapy...
February 12, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29430323/declining-use-of-combination-infliximab-and-immunomodulator-for-inflammatory-bowel-disease-in-the-community-setting
#6
Joshua C Berkowitz, Joanna Stein-Fishbein, Sundas Khan, Richard Furie, Keith S Sultan
AIM: To describe trends of combination therapy (CT) of infliximab (IFX) and immunomodulator (IMM) for inflammatory bowel disease (IBD) in the community setting. METHODS: A retrospective study was conducted of all IBD patients referred for IFX infusion to our community infusion center between 04/01/01 and 12/31/14. CT was defined as use of IFX with either azathioprine, 6-mercaptopurine, or methotrexate. We analyzed trends of CT usage overall, for Crohn's disease (CD) and ulcerative colitis (UC), and for the subgroups of induction patients...
February 6, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29429045/evidence-based-clinical-practice-guidelines-for-inflammatory-bowel-disease
#7
REVIEW
Katsuyoshi Matsuoka, Taku Kobayashi, Fumiaki Ueno, Toshiyuki Matsui, Fumihito Hirai, Nagamu Inoue, Jun Kato, Kenji Kobayashi, Kiyonori Kobayashi, Kazutaka Koganei, Reiko Kunisaki, Satoshi Motoya, Masakazu Nagahori, Hiroshi Nakase, Fumio Omata, Masayuki Saruta, Toshiaki Watanabe, Toshiaki Tanaka, Takanori Kanai, Yoshinori Noguchi, Ken-Ichi Takahashi, Kenji Watanabe, Toshifumi Hibi, Yasuo Suzuki, Mamoru Watanabe, Kentaro Sugano, Tooru Shimosegawa
Inflammatory bowel disease (IBD) is a chronic disorder involving mainly the intestinal tract, but possibly other gastrointestinal and extraintestinal organs. Although etiology is still uncertain, recent knowledge in pathogenesis has accumulated, and novel diagnostic and therapeutic modalities have become available for clinical use. Therefore, the previous guidelines were urged to be updated. In 2016, the Japanese Society of Gastroenterology revised the previous versions of evidence-based clinical practice guidelines for ulcerative colitis (UC) and Crohn's disease (CD) in Japanese...
February 10, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29426615/low-childhood-high-density-lipoprotein-cholesterol-levels-and-subsequent-risk-for-chronic-inflammatory-bowel-disease
#8
Markku Voutilainen, Nina Hutri-Kähönen, Päivi Tossavainen, Taina Sipponen, Niina Pitkänen, Tomi Laitinen, Eero Jokinen, Tapani Rönnemaa, Jorma S A Viikari, Olli T Raitakari, Markus Juonala
BACKGROUND AND AIMS: Several genetic and environmental risk factors have been linked to chronic inflammatory bowel disease (IBD). The incidence of IBD has significantly increased in developed countries during last decades. The aim of the present study was to examine childhood risk factors for subsequent IBD diagnosis in a longitudinal cohort study of children and adolescents. METHODS: A Finnish study population consisting of 3551 children and adolescents originally evaluated as part of the Cardiovascular Risk in Young Finns study in 1980...
January 31, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29424399/-presence-of-intracellular-escherichia-coli-in-patients-with-inflammatory-bowel-disease
#9
Marjorie De La Fuente, Isidora Chahuán, RocÍo Gutiérrez, David Díaz-Jiménez, Mauricio Olivares, Roberto Vidal, Daniela Simian, Carolina Figueroa, Rodrigo Quera, Marcela A Hermoso
BACKGROUND: Different strains of invasive Escherichia coli (E. coli), isolated from intestinal mucosa of patients, are related to the pathogenesis of inflammatory bowel diseases (IBD). AIM: To evaluate an association between intracellular E. coli and IBD; its clinical characteristics and use of steroids. MATERIAL AND METHODS: Sixty one patients with Crohn's disease and 83 with ulcerative colitis were studied. To determine the intracellular E...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29422814/t-cell-immune-response-against-cytomegalovirus-in-peripheral-blood-and-colonic-mucosa-from-ulcerative-colitis-and-crohn-s-disease-patients
#10
Seung-Joo Nam, Eun Sun Kim, Yoon Tae Jeen
No abstract text is available yet for this article.
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29422796/quality-indicators-in-inflammatory-bowel-disease
#11
REVIEW
Sameer K Berry, Gil Y Melmed
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic, debilitating, and expensive condition affecting millions of people globally. There is significant variation in the quality of care for patients with IBD across North America, Europe, and Asia; this variation suggests poor quality of care due to overuse, underuse, or misuse of health services and disparity of outcomes. Several initiatives have been developed to reduce variation in care delivery and improve processes of care, patient outcomes, and reduced healthcare costs...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29422795/immunological-pathogenesis-of-inflammatory-bowel-disease
#12
REVIEW
Seung Hoon Lee, Jeong Eun Kwon, Mi-La Cho
Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 main clinical phenomena: Crohn's disease (CD) and ulcerative colitis (UC). The pathogenesis of IBD, including CD and UC, involves the presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes, and gene variants. Although many investigations have tried to identify novel pathogenic factors associated with IBD that are related to environmental, genetic, microbial, and immune response factors, a full understanding of IBD pathogenesis is unclear...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29420705/differential-expression-of-micrornas-in-peripheral-blood-mononuclear-cells-identifies-autophagy-and-tgf-beta-related-signatures-aberrantly-expressed-in-inflammatory-bowel-disease
#13
Aylia Mohammadi, Orlaith B Kelly, Melissa Filice, Boyko Kabakchiev, Michelle I Smith, Mark S Silverberg
Background and Aims: MicroRNAs (miRNAs) have emerged as important regulators in inflammatory bowel disease (IBD). This study investigated differential expression of miRNAs across clinical phenotypes in a well-characterized cohort of IBD patients and healthy controls (HCs). Methods: A cohort with Crohn's disease (CD), ulcerative colitis (UC), and HC was prospectively accrued. Total RNA was extracted from peripheral blood mononuclear cells for all subjects. MiRNA expression was measured using NanoString Technologies...
February 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29420429/elevated-venous-thromboembolism-risk-following-colectomy-for-ibd-is-equal-to-those-for-colorectal-cancer-for-ninety-days-after-surgery
#14
Fadwa Ali, Sadeer G Al-Kindi, Jacqueline J Blank, Carrie Y Peterson, Kirk A Ludwig, Timothy J Ridolfi
BACKGROUND: The risk of postoperative venous thromboembolism is high in patients with colon cancer and IBD. Although The American Society of Colon and Rectal Surgeons suggests posthospital prophylaxis after surgery in patients with colon cancer, there are no such recommendations for patients with IBD. OBJECTIVE: This study aims to analyze the incidence and risk factors for postoperative venous thromboembolism. DESIGN: This was a retrospective review using the Explorys platform...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29417331/risk-factors-for-clostridium-difficile-isolation-in-inflammatory-bowel-disease-a-prospective-study
#15
Dejan Micic, Andres Yarur, Alex Gonsalves, Vijaya L Rao, Susan Broadaway, Russell Cohen, Sushila Dalal, John N Gaetano, Laura R Glick, Ayal Hirsch, Joel Pekow, Atsushi Sakuraba, Seth T Walk, David T Rubin
INTRODUCTION: Clostridium difficile is the most commonly isolated stool pathogen in inflammatory bowel disease (IBD). Traditional risk factors for C. difficile may not exist in patients with IBD, and no prior studies have assessed the risk factors for the isolation of C. difficile in both symptomatic and asymptomatic IBD outpatients. METHODS: We prospectively recruited consecutive IBD patients presenting to our outpatient clinic between April 2015 and February 2016...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29416670/genomic-landscape-of-colitis-associated-cancer-indicates-the-impact-of-chronic-inflammation-and-its-stratification-by-mutations-in-the-wnt-signaling
#16
Masashi Fujita, Nagahide Matsubara, Ikuo Matsuda, Kazuhiro Maejima, Ayako Oosawa, Tomoki Yamano, Akihiro Fujimoto, Mayuko Furuta, Kaoru Nakano, Aya Oku-Sasaki, Hiroko Tanaka, Yuichi Shiraishi, Raúl Nicolás Mateos, Kenta Nakai, Satoru Miyano, Naohiro Tomita, Seiichi Hirota, Hiroki Ikeuchi, Hidewaki Nakagawa
Inflammatory bowel disease (IBD) increases the risk of colorectal cancer, known as colitis-associated cancer (CAC). It is still unclear what driver mutations are caused by chronic inflammation and lead to CAC development. To get insight into this issue, we investigated somatic alterations in CAC. We performed exome sequencing of 22 fresh CACs and targeted sequencing of 43 genes on 90 archive specimens from Japanese CAC patients, of which 58 were ulcerative colitis (UC) and 32 were Crohn's disease (CD). Consistently with the previous reports, TP53 was commonly mutated (66%) whereas APC, KRAS and SMAD4 were mutated less frequently (16%, 11% and 11%, respectively)...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413211/gastrointestinal-traumatic-injuries-gastrointestinal-perforation
#17
REVIEW
Maria A Revell, Marcia A Pugh, Melanie McGhee
The abdomen is a big place even in a small person. Gastrointestinal trauma can result in injury to the stomach, small bowel, colon, or rectum. Traumatic causes include blunt or penetrating trauma, such as gunshot wounds, stabbings, motor vehicle collisions, and crush injuries. Nontraumatic causes include appendicitis, Crohn disease, cancer, diverticulitis, ulcerative colitis, blockage of the bowel, and chemotherapy. The mechanism of injury will affect both the nature and severity of any resulting injuries. Treatment must address the critical and emergent nature of these injuries as well as issues that affect all trauma situations, which include management of hemodynamic instability...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29411411/emergency-department-utilisation-for-inflammatory-bowel-disease-in-the-united-states-from-2006-to-2014
#18
S Ballou, W Hirsch, P Singh, V Rangan, J Nee, J Iturrino, T Sommers, J Zubiago, N Sengupta, A Bollom, M Jones, A C Moss, S N Flier, A S Cheifetz, A Lembo
BACKGROUND: Despite advances in treatment, patients with inflammatory bowel disease (IBD) frequently require emergency department (ED) visits and hospitalisations. AIMS: To analyse trends in ED visits and subsequent hospitalisations for IBD in the United States (US). METHODS: Data were analysed from the Nationwide Emergency Department Sample (NEDS) years 2006-2014. The NEDS is the largest all-payer ED database in the US, weighted to represent 135 million visits/year...
February 7, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29411405/fibrosis-in-ulcerative-colitis-is-directly-linked-to-severity-and-chronicity-of-mucosal-inflammation
#19
I O Gordon, N Agrawal, E Willis, J R Goldblum, R Lopez, D Allende, X Liu, D Y Patil, L Yerian, F El-Khider, C Fiocchi, F Rieder
BACKGROUND: Fibrosis in ulcerative colitis has remained largely unexplored despite its clinical implications. AIMS: This cross-sectional study was aimed at characterising the presence, anatomical location and degree of ulcerative colitis-associated fibrosis and its possible link to clinical parameters. METHODS: Seven hundred and six individual tissue cross-sections derived every 10 cm along the length of 89 consecutive Ulcerative colitis colectomy specimens were examined and compared to Crohn's disease colitis, diverticular disease and uninvolved areas from colorectal cancer patients...
February 6, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29408835/incidence-and-factors-correlating-with-incisional-hernia-following-open-bowel-resection-in-patients-with-inflammatory-bowel-disease-a-review-of-1000-patients
#20
Tomas M Heimann, Santosh Swaminathan, Adrian J Greenstein, Randolph M Steinhagen
OBJECTIVE: The aim of this study was to identify the incidence and factors associated with the development of incisional hernia (IH) in patients with inflammatory bowel disease (IBD) undergoing open bowel resections. BACKGROUND: Predisposing factors for IH have not been well studied in patients with IBD undergoing open bowel resection. The role of duration of the disease, nutritional factors, anti-inflammatory treatment, previous operative procedures, wound infection, and other complicating factors remains unclear...
March 2018: Annals of Surgery
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