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Crohn and ulcerative colitis

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https://www.readbyqxmd.com/read/29240877/prepouch-ileitis-after-ileal-pouch-anal-anastomosis-patterns-of-presentation-and-risk-factors-for-failure-of-treatment
#1
Matteo Rottoli, Carlo Vallicelli, Eleonora Bigonzi, Paolo Gionchetti, Fernando Rizzello, Massimo P Di Simone, Gilberto Poggioli
Background and Aims: There is a lack in the literature about prepouch ileitis [PI], in particular regarding risk factors associated with failure of the medical treatment. Aim of the study is to analyse the characteristics of PI patients and to compare those who required surgery with those who were successfully treated with conservative therapy. Methods: All cases presenting a diagnosis of PI were included and analysed. Patients eventually requiring surgery were compared with those who were managed conservatively, for symptoms of presentation, endoscopic characteristics, and rate of response to medical treatment...
October 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29232213/postoperative-mortality-after-nonelective-surgery-for-inflammatory-bowel-disease-patients-in-the-era-of-biologics
#2
Carla F Justiniano, Christopher T Aquina, Adan Z Becerra, Zhaomin Xu, Courtney I Boodry, Alex A Swanger, John R T Monson, Fergal J Fleming
OBJECTIVE: The aim of the study was to analyze recent trends in the rate of nonelective surgery and corresponding mortality for inflammatory bowel disease (IBD) patients since the rise of biologic use. BACKGROUND: Modern biologic therapy has improved outcomes for IBD, but little is known about the impact on mortality rates after nonelective surgery. METHODS: New York's Statewide Planning & Research Cooperative System was queried for hospital admissions for ulcerative colitis (UC) with concurrent colectomy and Crohn disease (CD) with concurrent small bowel resection or colectomy from 2000 to 2013...
December 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29228844/the-adherence-to-the-therapy-in-inflammatory-bowel-disease-beyond-the-number-of-the-tablets
#3
Davide Giuseppe Ribaldone, Marta Vernero, Giorgio Maria Saracco, Rinaldo Pellicano, Fabio Finocchiaro, Gian Paolo Caviglia, Marco Astegiano
OBJECTIVES: The therapy of the inflammatory bowel diseases is quite complex. A partial compliance increases the relapse probability and the health expenditure. The aim of the study is to correctly study the adherence to the therapy in a single centre eliminating the bias of a different relationship of trust with different doctors. MATERIALS AND METHODS: We conducted a blind prospective study on the adherence evaluated for mesalazine. RESULTS: Three hundred and seventy-six patients were included in the final analysis...
December 11, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29228739/regulatory-role-of-nkg2d-nk-cells-in-intestinal-lamina-propria-by-secreting-double-edged-th1-cytokines-in-ulcerative-colitis
#4
Fan Wang, Pai-Lan Peng, Xue Lin, Ying Chang, Jing Liu, Rui Zhou, Jia-Yan Nie, Wei-Guo Dong, Qiu Zhao, Jin Li
The role of intestinal lamina propria (LP) NKG2D+ NK cells is unclear in regulating Th1/Th2 balance in ulcerative colitis (UC). In this study, we investigated the frequency of LP NKG2D+ NK cells in DSS-induced colitis model and intestinal mucosal samples of UC patients, as well as the secretion of Th1/Th2/Th17 cytokines in NK cell lines after MICA stimulation. The role of Th1 cytokines in UC was validated by bioinformatics analysis. We found that DSS-induced colitis in mice was characterized by a Th2-mediated process...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226154/reduced-transferrin-levels-in-active-inflammatory-bowel-disease
#5
Malgorzata Matusiewicz, Katarzyna Neubauer, Paulina Lewandowska, Andrzej Gamian, Malgorzata Krzystek-Korpacka
Inflammatory bowel disease (IBD) is an inflammatory disease of unclear etiopathogenesis and challenging diagnosis, frequently complicated by anemia and malnutrition. C-reactive protein (CRP) remains the only biochemical marker of clinical relevance. The aim of this study was to test hypothesis that transferrin, coinfluenced by inflammation, malnutrition, anemia, and oxidative stress, may better reflect global IBD patient's condition than any other more specific index. Transferrin and other indices of inflammation, anemia, malnutrition, and oxidative stress were measured in 137 IBD patients (Crohn's disease (CD): n = 63 and ulcerative colitis (UC): n = 74) and 97 controls...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29226115/body-composition-in-crohn-s-disease-and-ulcerative-colitis-correlation-with-disease-severity-and-duration
#6
Dawesh P Yadav, Saurabh Kedia, Kumble Seetharama Madhusudhan, Sawan Bopanna, Sandeep Goyal, Saransh Jain, Naval K Vikram, Raju Sharma, Govind K Makharia, Vineet Ahuja
Background: Results on body composition in Crohn's disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration. Methods: Patients of CD/UC following between Dec 2014 and Dec 2015 who consented for bioimpedance analysis for body fat measurement were included. Lean mass and fat-free mass index (FFMI) were calculated with standard formulae...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29223444/association-of-vedolizumab-level-anti-drug-antibodies-and-%C3%AE-4%C3%AE-7-occupancy-with-response-in-patients-with-inflammatory-bowel-diseases
#7
Bella Ungar, Uri Kopylov, Miri Yavzori, Ella Fudim, Orit Picard, Adi Lahat, Daniel Coscas, Matti Waterman, Ola Haj-Natour, Noam Orbach-Zingboim, Ren Mao, Minhu Chen, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin
BACKGROUND & AIMS: There are few data available on the real-life pharmacokinetic and pharmacodynamics features of vedolizumab, a monoclonal antibody against integrin α4β7. We performed a prospective study of patients with inflammatory bowel diseases (IBD) treated with vedolizumab to determine serum drug concentrations, formation of anti-vedolizumab antibodies (AVAs), and integrin α4β7 saturation. METHODS: We performed a prospective study of 106 patients with IBD (67 with Crohn's disease and 39 with ulcerative colitis) treated with vedolizumab from September 2014 through March 2017 at 2 tertiary medical centers in Israel...
December 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29223139/novel-treatments-for-inflammatory-bowel-disease
#8
Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of treatment options aimed at a variety of pathological mechanisms offers new hope for customized therapies. Beyond anti-tumor necrosis factor agents, selective lymphocyte trafficking inhibitors have been proposed as potent drugs for IBD. Among these, vedolizumab has recently been approved for both Crohn's disease and ulcerative colitis...
December 11, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29216767/prevalence-and-factors-associated-with-gluten-sensitivity-in-inflammatory-bowel-disease
#9
Berkeley N Limketkai, Rachel Sepulveda, Tressia Hing, Neha D Shah, Monica Choe, David Limsui, Shamita Shah
OBJECTIVES: Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD. METHODS: Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Data on IBD characteristics were abstracted from the medical records...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29216329/characterization-of-fusobacterium-varium-fv113-g1-isolated-from-a-patient-with-ulcerative-colitis-based-on-complete-genome-sequence-and-transcriptome-analysis
#10
Tsuyoshi Sekizuka, Yumiko Ogasawara, Toshifumi Ohkusa, Makoto Kuroda
Fusobacterium spp. present in the oral and gut flora is carcinogenic and is associated with the risk of pancreatic and colorectal cancers. Fusobacterium spp. is also implicated in a broad spectrum of human pathologies, including Crohn's disease and ulcerative colitis (UC). Here we report the complete genome sequence of Fusobacterium varium Fv113-g1 (genome size, 3.96 Mb) isolated from a patient with UC. Comparative genome analyses totally suggested that Fv113-g1 is basically assigned as F. varium, in particular, it could be reclassified as notable F...
2017: PloS One
https://www.readbyqxmd.com/read/29216019/familial-association-of-granulocyte-macrophage-colony-stimulating-factor-autoantibodies-in-inflammatory-bowel-disease
#11
Sandra S Wright, Anna Trauernicht, Erin Bonkowski, Courtney A McCall, Elizabeth A Maier, Ramona Bezold, Kathleen Lake, Claudia Chalk, Bruce C Trapnell, Mi-Ok Kim, Subra Kugathasan, Lee A Denson
OBJECTIVES: Elevated Granulocyte-Macrophage Colony Stimulating Factor auto-antibodies (GM-CSF Ab) are associated with increased intestinal permeability and stricturing behavior in Crohn's Disease (CD). We tested for familial association of serum GM-CSF Ab level in CD and Ulcerative Colitis (UC) families. METHODS: Serum GM-CSF Ab concentration was determined in 230 pediatric CD probands and 404 of their unaffected parents and siblings, and 45 UC probands and 71 of their unaffected parents and siblings...
December 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29213281/the-nimo-scandinavian-study-a-prospective-observational-study-of-iron-isomaltoside-treatment-in-patients-with-iron-deficiency
#12
Svein Oskar Frigstad, Anne Haaber, Antal Bajor, Jan Fallingborg, Per Hammarlund, Ole K Bonderup, Håkan Blom, Terje Rannem, Per M Hellström
Background: Intravenous iron allows for efficient and well-tolerated treatment in iron deficiency and is routinely used in diseases of the gastrointestinal tract. Objective: The aims of this study were to determine the probability of relapse of iron deficiency over time and to investigate treatment routine, effectiveness, and safety of iron isomaltoside. Methods: A total of 282 patients treated with iron isomaltoside were observed for two treatments or a minimum of one year...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29211912/intestinal-t-cell-profiling-in-inflammatory-bowel-disease-linking-t-cell-subsets-to-disease-activity-and-disease-course
#13
Carolijn Smids, Carmen S Horjus Talabur Horje, Julia Drylewicz, Britt Roosenboom, Marcel J M Groenen, Elly van Koolwijk, Ellen G van Lochem, Peter J Wahab
Introduction: A dysregulated intestinal T-cell response is presumed in patients with Inflammatory Bowel Disease (IBD). In this longitudinal study, we investigated the changes in intestinal T lymphocyte subsets in IBD at first presentation and over time during endoscopic active or inactive disease and relate them to disease activity and outcome. Material & method: We included 129 newly diagnosed patients (87 Crohn´s Disease (CD), 42 ulcerative colitis (UC)) and 19 healthy controls (HC)...
December 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29211899/exome-sequencing-and-genotyping-identify-a-rare-variant-in-nlrp7-gene-associated-with-ulcerative-colitis
#14
Alexandros Onoufriadis, Kristina Stone, Antreas Katsiamides, Ariella Amar, Yasmin Omar, Katrina de Lange, Kirstin Taylor, Jeffrey C Barrett, Richard Pollok, Bu'Hussain Hayee, John C Mansfield, Jeremy D Sanderson, Michael A Simpson, Christopher G Mathew, Natalie J Prescott
Background and aims: Although genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) have identified a large number of common disease susceptibility alleles for both Crohn's disease (CD) and ulcerative colitis (UC), a substantial fraction of IBD heritability remains unexplained, suggesting that rare coding genetic variants may also have a role in pathogenesis. We used high-throughput sequencing in families with multiple cases of IBD, followed by genotyping of cases and controls, to investigate whether rare protein altering genetic variants are associated with susceptibility to IBD...
December 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29210919/the-role-of-combination-therapy-in-pediatric-inflammatory-bowel-disease-ibd-a-clinical-report-from-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#15
Andrew S Day, Ajay S Gulati, Nishaben Patel, Brendan Boyle, K T Park, Shehzad A Saeed
The treatment goal for children suffering from inflammatory bowel disease (IBD) has been evolving with biologic therapies like anti-TNF agents assuming a more central role in treatment of more aggressive and extensive phenotype. Earlier introduction of anti-TNF agents have shown to be more effective and may even alter the natural history of IBD. However, development of anti-drug antibodies (ADA) limits long term usage and leads to dose adjustment in almost half of patients treated with these medications. One of the strategies to minimize the development of ADA has been concomitant use of immunomodulator (IM) medications, resulting in fewer infusion reactions and sustained trough levels, potentially lowering the need for dose adjustments...
November 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29209121/fatal-gastrointestinal-histoplasmosis-15-years-after-orthotopic-liver-transplantation
#16
Nikita Agrawal, David Ej Jones, Jessica K Dyson, Tim Hoare, Sharon A Melmore, Stephanie Needham, Nick P Thompson
We report a case of ileo-colonic Histoplasmosis without apparent respiratory involvement in a patient who had previously undergone an orthotopic liver transplant (OLT) for primary biliary cholangitis 15 years earlier. The recipient lived in the United Kingdom, a non-endemic region for Histoplasmosis. However, she had previously lived in rural southern Africa prior to her OLT. The patient presented with iron deficiency anaemia, diarrhoea, abdominal pain and progressive weight loss. She reported no previous foreign travel, however, it later became known that following her OLT she had been on holiday to rural southern Africa...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29206816/optimizing-selection-of-biologics-in-inflammatory-bowel-disease-development-of-an-online-patient-decision-aid-using-conjoint-analysis
#17
Christopher V Almario, Michelle S Keller, Michelle Chen, Karen Lasch, Lyann Ursos, Julia Shklovskaya, Gil Y Melmed, Brennan M R Spiegel
OBJECTIVES: Recent drug approvals have increased the availability of biologic therapies for inflammatory bowel disease (IBD), making it difficult for patients with ulcerative colitis (UC) and Crohn's disease (CD) to navigate treatment options. Here we developed a conjoint analysis to examine patient decision-making surrounding biologic medicines for IBD. We used the results to create an online patient decision aid that generates a unique "preferences report" for each patient to assist with shared decision-making with their provider...
December 5, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29206751/the-impact-of-clostridium-difficile-infection-on-mortality-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#18
Raseen Tariq, Cindy C Y Law, Sahil Khanna, Sanjay Murthy, Jeffrey D McCurdy
BACKGROUND AND AIMS: Clostridium difficile infection (CDI) has been associated with an increased mortality risk among patients with inflammatory bowel disease (IBD) in multiple observational studies. We performed a systematic review and meta-analysis to help clearly define the magnitude of risk in IBD patients with and without CDI, and to assess the risk in individual IBD subtypes. METHODS: A systematic search of multiple electronic databases was conducted for observational studies reporting the risk of mortality in IBD, stratified by the presence of CDI...
December 4, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29206211/the-imbalance-between-n-6-n-3-polyunsaturated-fatty-acids-and-inflammatory-bowel-disease-a-comprehensive-review-and-future-therapeutic-perspectives
#19
REVIEW
Eleonora Scaioli, Elisa Liverani, Andrea Belluzzi
Eating habits have changed dramatically over the years, leading to an imbalance in the ratio of n-6/n-3 polyunsaturated fatty acids (PUFAs) in favour of n-6 PUFAs, particularly in the Western diet. Meanwhile, the incidence of inflammatory bowel disease (IBD) is increasing worldwide. Recent epidemiological data indicate the potential beneficial effect of n-3 PUFAs in ulcerative colitis (UC) prevention, whereas consumption of a higher ratio of n-6 PUFAs versus n-3 PUFAs has been associated with an increased UC incidence...
December 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29205426/systematic-review-with-meta-analysis-thiopurines-decrease-the-risk-of-colorectal-neoplasia-in-patients-with-inflammatory-bowel-disease
#20
REVIEW
M J Lu, X Y Qiu, X Q Mao, X T Li, H J Zhang
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a high risk of developing colorectal neoplasia. AIM: To investigate whether thiopurines can decrease the risk of developing colorectal neoplasia in patients with ulcerative colitis (UC) or Crohn's disease (CD). METHODS: We conducted a meta-analysis of 24 observational studies involving 76,999 participants to evaluate the risks of developing colorectal neoplasia in IBD patients receiving thiopurine treatment...
December 4, 2017: Alimentary Pharmacology & Therapeutics
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