keyword
https://read.qxmd.com/read/38537133/analysis-of-graft-detachments-and-re-bubblings-after-450-descemet-membrane-endothelial-keratoplasty-procedures
#1
JOURNAL ARTICLE
Louise Massia Menkene, Tim Berger, Tarek Safi, Loïc Hamon, Cristian Munteanu, Berthold Seitz, Loay Daas
PURPOSE: To objectify the indication for re-bubbling by analyzing graft detachments (GDs) after Descemet membrane endothelial keratoplasty. METHODS: In this retrospective monocentric observational study, re-bubbling cases of 450 Descemet membrane endothelial keratoplasties and the percentage of the residual gas filling (RGF) in the anterior chamber on the first postoperative day were collected. The number/location/extent of GDs and the corneal thickness above GDs were analyzed using anterior segment optical coherence tomography...
March 27, 2024: Cornea
https://read.qxmd.com/read/38535558/hepatitis-c-epidemiology-insights-from-a-comprehensive-cohort-study-in-asst-melegnano-and-martesana-lombardia-region-northern-italy
#2
JOURNAL ARTICLE
Michele Nardone, Dario Di Stasio, Alberta Lucchese, Daniele Gentili, Giulia Cattabianchi, Carlo Signorelli, Pierangelo Sarchi, Giovanna Pulcrano, Valentino Lembo, Paola Maria Pirola, Dorina Lauritano, Francesco Carinci
Hepatitis C virus (HCV) infection is a significant public health problem affecting 58 million people worldwide, including 3.9 million in Europe. Many of these infections go undiagnosed because chronic infection is often asymptomatic. This observational cohort study presents a detailed examination of hepatitis C virus epidemiology in Lombardia (Italy) and was conducted within the ASST "Melegnano e della Martesana". The study involved comprehensive HCV screening of 3290 patients accessing the collection points and/or hospitalized in the facilities of the ASST from 20 May 2022 to 13 April 2023...
February 28, 2024: Pathogens
https://read.qxmd.com/read/38526555/herbicides-in-the-initial-growth-and-chlorophyll-indices-of-sugarcane-in-pre-sprouted-seedlings
#3
JOURNAL ARTICLE
Ana Ligia Giraldeli, André Felipe Moreira Silva, Gustavo Soares da Silva, Lucas da Silva Araújo, Luísa Carolina Baccin, Giovani Apolari Ghirardello, Ricardo Victoria Filho
The aim of the present study was to assess the selectivity of herbicides applied in the pre and post-planting of pre-sprouted seedlings (PSS). The experiment was conducted in a greenhouse, using a completely randomized design, with nine treatments and four repetitions. The IACSP95-5000 cultivar was used. The treatments consisted of herbicides applied in five doses as follows: in pre-planting: sulfentrazone, diclosulam, imazapic, and imazapyr, in post-planting: ethoxysulfuron, halosulfuron, 2,4-D and MSMA, and a control treatment without herbicide...
March 25, 2024: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://read.qxmd.com/read/38525540/the-role-of-nano-systems-in-the-delivery-of-glucose-lowering-drugs-for-the-pre-emption-and-treatment-of-diabetes-associated-atherosclerosis
#4
REVIEW
Luke James Conroy, Alyssa McCann, Nan Zhang, Monica de Gaetano
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2 diabetes has become increasingly common, particularly in younger individuals. Diabetes leads to many vascular complications, including atherosclerosis. Atherosclerosis is a cardiovascular disease characterized by lipid-rich plaques within the vasculature. Plaques develop over time, restricting blood flow; and can therefore be the underlying cause of major adverse cardiovascular events, including myocardial infarction and stroke...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38522901/efficacy-of-computed-tomography-based-evaluation-of-myocardial-extracellular-volume-combined-with-red-flags-for-early-screening-of-concealed-cardiac-amyloidosis-in-patients-with-atrial-fibrillation
#5
JOURNAL ARTICLE
Hirochika Yamasaki, Hidekazu Kondo, Tomoaki Shiroo, Naohiro Iwata, Teruaki Masuda, Taiki Makita, Yuki Iwabuchi, Kota Tanazawa, Masaki Takahashi, Yuma Ono, Naoko Ogawa, Taisuke Harada, Kazuki Mitarai, Shuichiro Yamauchi, Masayuki Takano, Nozomi Kodama, Kei Hirota, Miho Miyoshi, Keisuke Yonezu, Katsunori Tawara, Ichitaro Abe, Shotaro Saito, Akira Fukui, Tomoko Fukuda, Hidefumi Akioka, Tetsuji Shinohara, Kumiko Akiyoshi, Yasushi Teshima, Kunio Yufu, Tsutomu Daa, Etsuro Matsubara, Yoshiki Asayama, Mitsuharu Ueda, Naohiko Takahashi
BACKGROUND: The prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) in atrial fibrillation (AF) patients remains unclear. We explored the efficacy of computed tomography-based myocardial extracellular volume (CT-ECV) combined with red flags for the early screening of concealed ATTR-CM in AF patients undergoing catheter ablation.Methods and Results: Patients referred for AF ablation at Oita University Hospital were prescreened using the red-flag signs defined by echocardiographic or electrocardiographic findings, medical history, symptoms, and blood biochemical findings...
March 22, 2024: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/38522854/comparison-of-glecaprevir-pibrentasvir-and-sofosbuvir-ledipasvir-in-patients-with-hepatitis-c-virus-genotype-1-and-2-in-south-korea
#6
JOURNAL ARTICLE
Hyun Deok Shin, Il Han Song, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Hyuk Soo Eun, Seok Hyun Kim, Byung Seok Lee, Hee Bok Chae, Seok Hwan Kim, Myung Joon Song, Soon Yeong Ko, Suk Bae Kim
BACKGROUND/AIMS: This study compared the effectiveness and safety of glecaprevir/pibrentasvir (GLE/PIB) and sofosbuvir/ledipasvir (SOF/LDV) in real-life clinical practice. METHODS: The data from genotype 1 or 2 chronic hepatitis C patients treated with GLE/PIB or sofosbuvir + ribavirin or SOF/LDV in South Korea were collected retrospectively. The analysis included the treatment completion rate, sustained virologic response at 12 weeks (SVR12) test rate, treatment effectiveness, and adverse events...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38522804/functional-acetabular-component-positioning-during-direct-anterior-approach-hip-arthroplasty-using-a-novel-three-dimensional-virtual-mesh-imaging-system-with-fluoroscopy
#7
JOURNAL ARTICLE
Francesca Coxe, Andrew Jordan, Zachary Wong, Jonathan Spaan, Renee Ren, Edwin P Su
INTRODUCTION: Optimal position of total hip arthroplasty (THA) components is critical for joint mechanics and stability. Acetabular component positioning during supine surgery in direct anterior approach (DAA) THA may be different in the standing position postoperatively, which traditional fluoroscopy is unable to predict. A novel three-dimensional (3D) image analysis technology (IAT) that uses artificial intelligence to measure the tilt and rotation of the pelvis has enabled prediction of component positioning from supine to standing...
March 22, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38520548/improved-patient-reported-outcomes-with-the-direct-anterior-approach-versus-the-posterior-approach-for-total-hip-arthroplasty-in-the-early-post-operative-period
#8
JOURNAL ARTICLE
Omar Sarhan, Martinus Megalla, Nareena Imam, Anna N Ren, Roberta E Redfern, Gregg R Klein
BACKGROUND: Patients undergoing total hip arthroplasty (THA) with the direct anterior approach (DAA) may experience faster recovery but may also have better baseline health than those who undergo THA with the posterior approach (PA). This study aimed to compare patient-reported outcome measures (PROMs) between the DAA and PA while controlling for baseline factors. METHODS: This is a secondary data analysis from a prospective cohort study of patients utilizing a smartphone-based care management platform following THA...
March 23, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38518542/elucidating-the-association-between-direct-acting-antivirals-and-parkinson-s-disease-in-patients-with-hepatitis-c-virus-infection
#9
JOURNAL ARTICLE
Pilar Hernandez-Con, Raj Desai, David Nelson, Haesuk Park
BACKGROUND: Some epidemiological studies have found an increased association between Parkinson's disease (PD) and chronic hepatitis C virus (HCV) infection. Although a few studies have also found a decreased risk of PD with interferon-α therapy, the effect of direct-acting antivirals (DAAs) on Parkinson's disease remains unclear. The current study seeks to assess and elucidate the association between DAAs and PD in patients newly diagnosed with chronic HCV infection. METHODS: We conducted a retrospective cohort study of patients ≥18 years diagnosed with HCV using MarketScan Commercial and Medicare Supplemental database (2012-2019)...
March 19, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38512034/-3-deazaadenosine-3-daa-accelerates-japanese-encephalitis-virus-replication-and-down-regulates-levels-of-inflammatory-factors-in-mouse-and-hamster-cells
#10
JOURNAL ARTICLE
Xueyun Li, Min Yao, Yuexiang Li, Zhirong Cheng, Shizhe Zhang, Fanglin Zhang, Xin Lyu
Objective To investigate the effect of 3-deazaadenosine (3-DAA), an N6 -methyladenosine (m6 A) methylation modification inhibitor, on the replication of the Japanese encephalitis virus (JEV). Methods Neuro2a mouse neuroblastoma cells, N9 mouse microglial cells, and BHK baby hamster kidney cells were exposed to JEV and then treated with 3-DAA. JEV was also injected into the footpad of adult C57BL/6 mice, which were then administered 3-DAA intraperitoneally. Real-time quantitative PCR was utilized to measure mRNA expression levels of JEV, interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), monocyte chemoattractant protein 1 (MCP-1), inducible nitric oxide synthase (iNOS), arginase 1 (Arg1), interferon (IFN)-α, IFN-β, IFN-γ, and C-X-C motif chemokine ligand 10 (CXCL10) in the cells and mouse brain tissues...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38510786/the-efficacy-of-on-site-integration-screening-and-microelimination-programs-for-chronic-hepatitis-c-in-a-detection-center-a-comparison-of-the-treatment-outcomes-and-characteristics-of-incarcerated-patients-and-outpatients
#11
JOURNAL ARTICLE
Hsuan-Yuan Chang, Su-Hung Wang, Hsing-Tao Kuo, Ming-Jen Sheu, I-Che Feng, Chung-Han Ho, Jui-Yi Chen, Chi-Shu Sun, Chi-Hsing Chen, Cheng-Yi Lin, Chun-Chi Yang
We aimed to analyze the different patient characteristics and treatment outcomes (such as sustained viral response, SVR) between incarcerated patients with chronic hepatitis C (CHC) and those with CHC from the outpatient department through an on-site integrated screening and microelimination program in a detection center. In this retrospective study, which ran from May 2021 to April 2022, we included 32 consenting male prisoners aged at least 20 years who were willing to participate in the study. Members of the control group (who received DAAs in an outpatient setting) were selected from the treated CHC patient databank of individuals who received DAA regimens at Chi Mei Hospital between January 2021 and December 2022...
2024: International Journal of Hepatology
https://read.qxmd.com/read/38509793/non-liver-related-mortality-in-the-daa-era-insights-from-post-svr-patients-with-and-without-previous-hcc-history
#12
JOURNAL ARTICLE
Satoshi Miuma, Hisamitsu Miyaaki, Tatsuki Ichikawa, Toshihisa Matsuzaki, Takashi Goto, Yasuhiro Kamo, Masaya Shigeno, Naoyuki Hino, Keisuke Ario, Kenji Yanagi, Takuya Tsutsumi, Nobuyoshi Fukushima, Suguru Nakashiki, Kazufumi Yamasaki, Keisuke Hamasaki, Hidetaka Shibata, Kazuhiko Arima, Shinobu Yamamichi, Mio Yamashima, Kosuke Takahashi, Yasuhiko Nakao, Masanori Fukushima, Masafumi Haraguchi, Ryu Sasaki, Eisuke Ozawa, Naota Taura, Kazuhiko Nakao
BACKGROUND AND AIMS: Mortality after sustained virological response (SVR) with interferon-free direct-acting antiviral (IFN-free DAA) therapy is crucial for optimizing post-SVR patient care, but it remains unclear, especially regarding non-liver-related mortality. METHODS: Consecutive post-SVR patients from 14 institutions were stratified into three cohorts: A (without advanced fibrosis and without prior HCC), B (with advanced fibrosis and without prior HCC), and C (curative HCC treatment)...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38506230/pcr-testing-for-herpesviruses-in-aqueous-humor-samples-from-patients-with-and-without-clinical-corneal-endothelial-graft-rejection
#13
JOURNAL ARTICLE
Yaser Abu Dail, Loay Daas, Elias Flockerzi, Cristian Munteanu, Julian Kahlert, Sigrun Smola, Berthold Seitz
To compare prevalence of positive PCR tests for herpesviruses between patients with and without a history of clinical corneal endothelial allograft rejection (AGR). Retrospective cross-sectional study with two-group comparison. A total of 307 aqueous humor (AH) samples from 235 Patients and 244 eyes who underwent penetrating keratoplasty or Descemet membrane endothelial keratoplasty or had a diagnostic AH aspiration due to clinical AGR between 2019 and 2023 were tested for DNA of herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV)...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38501893/skeletal-muscle-mass-increases-after-viral-eradication-with-direct-acting-antivirals-in-patients-with-chronic-hepatitis-c-a-longitudinal-study
#14
JOURNAL ARTICLE
Marta Paula Pereira Coelho, Thais Pontello de Vries, Aline Marcos Pires, Milena Pereira Parreira, Érika Ramos de Alvarenga, Rodrigo Dias Cambraia, Rodrigo Ribeiro Dos Santos, Juliana Maria Trindade Bezerra, Enrico Antonio Colosimo, Gifone Aguiar Rocha, Luciana Diniz Silva
BACKGROUND: Results of studies evaluating the effect of viral eradication following direct-acting antiviral (DDA) therapy on skeletal muscle mass of patients with chronic hepatitis C (CHC) are scarce. AIM: To assess the components of sarcopenia (low muscle mass, low muscle strength and low physical performance) in a cohort of CHC individuals before and after DAA therapy. METHODS: We performed a longitudinal study of patients with CHC who underwent body composition assessment before (T0), and at 12 (T1) and 48 (T2) weeks after DDA therapy...
March 19, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38495284/autoimmune-hepatitis-and-primary-sclerosing-cholangitis-after-direct-acting-antiviral-treatment-for-hepatitis-c-virus-a-case-report
#15
Yoshiki Morihisa, Hobyung Chung, Shuichiro Towatari, Daisuke Yamashita, Tetsuro Inokuma
BACKGROUND: Chronic hepatitis C virus (HCV) infection is a major global health concern that leads to liver fibrosis, cirrhosis, and cancer. Regimens containing direct-acting antivirals (DAAs) have become the mainstay of HCV treatment, achieving a high sustained virological response (SVR) with minimal adverse events. CASE SUMMARY: A 74-year-old woman with chronic HCV infection was treated with the DAAs ledipasvir, and sofosbuvir for 12 wk and achieved SVR. Twenty-four weeks after treatment completion, the liver enzyme and serum IgG levels increased, and antinuclear antibody became positive without HCV viremia, suggesting the development of autoimmune hepatitis (AIH)...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38487594/hepatitis-c-virus-infection-and-hospital-related-outcomes-a-systematic-review
#16
REVIEW
Michelle Ng, Patrizia Maria Carrieri, Lindila Awendila, Maria Eugenia Socías, Rod Knight, Lianping Ti
BACKGROUND: People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use. Direct-acting antivirals (DAAs) have the potential to alleviate this burden; however, the evidence on the impact of HCV infection and hospital outcomes is undetermined. This systematic review aims to assess this research gap, including how DAAs may modify the relationship between HCV infection and hospital-related outcomes. METHODS: We searched five databases up to August 2022 to identify relevant studies evaluating the impact of HCV infection on hospital-related outcomes...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38472013/severe-ulcerative-keratopathy-following-implantation-of-an-acellular-porcine-corneal-stromal-lenticule-in-a-patient-with-keratoconus
#17
Tim Berger, Ursula Schlötzer-Schrehardt, Fidelis Flockerzi, Loay Daas, Elias Flockerzi, Berthold Seitz
PURPOSE: To report a case of ulcerative keratopathy following implantation of acellular porcine corneal stroma (APCS) in a patient with keratoconus (KC). METHODS: A 58 year-old patient initially presented with an ulcerative keratopathy in the left eye. Previously, several corneal procedures (including radial keratotomy, laser-in-situ keratomileusis, crosslinking) were performed for KC. Eight months ago, an APCS lenticule (Xenia corneal implant, Gebauer Medizintechnik GmbH, Neuhausen, Germany) was implanted into a stromal pocket because of progressive keratectasia...
March 11, 2024: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://read.qxmd.com/read/38467856/-comparison-of-immunogenic-and-crystalline-endothelial-deposits-after-descemet-membrane-endothelial-keratoplasty%C3%A2-dmek-a%C3%A2-report-of-two-cases
#18
JOURNAL ARTICLE
Paul Kohlhas, Loay Daas, Berthold Seitz, Loïc Hamon
No abstract text is available yet for this article.
March 11, 2024: Ophthalmologie
https://read.qxmd.com/read/38467555/investigating-the-effect-of-polymerase-inhibitors-on-cellular-proliferation-computational-studies-cytotoxicity-cdk1-inhibitory-potential-and-lc-ms-ms-cancer-cell-entrapment-assays
#19
JOURNAL ARTICLE
Faten Farouk, Ibrahim M Ibrahim, Salma Sherif, Heba Gamal Abdelhamed, Marwa Sharaky, Ahmed A Al-Karmalawy
Directly acting antivirals (DAAs) are a breakthrough in the treatment of HCV. There are controversial reports on their tendency to induce hepatocellular carcinoma (HCC) in HCV patients. Numerous reports have concluded that the HCC is attributed to patient-related factors while others are inclined to attribute this as a DAA side-effect. This study aims to investigate the effect of polymerase inhibitor DAAs, especially daclatasivir (DLT) on cellular proliferation as compared to ribavirin (RBV). The interaction of DAAs with variable cell-cycle proteins was studied in silico...
March 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38466424/alpha-fetoprotein-producing-endometrioid-carcinoma-arising-in-an-adenomyoma-of-the-uterus
#20
JOURNAL ARTICLE
Yuzo Oyama, Takahiro Kusaba, Kasumi Takao, Eri Obata, Mitsutake Yano, Kazuhiro Kawamura, Haruto Nishida, Tsutomu Daa
We report a case of alpha-fetoprotein-producing endometrioid carcinoma (AFP-EC) that originated within an adenomyoma of the uterine corpus. A 76-year-old Japanese woman was incidentally discovered to have a uterine tumor along with multiple lung nodules. Upon surgical removal of the uterus, it was revealed that the tumor was situated within the adenomyoma. The tumor exhibited microfollicular structures and solid growth patterns, with hyaline globules, clear cell glands, and primitive tumor cells. Immunohistochemical analysis indicated the presence of germ cell markers, including AFP, SALL4, and glypican3, leading to final diagnosis of AFP-EC...
March 11, 2024: Medical Molecular Morphology
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