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Brain natriuretic peptide

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https://www.readbyqxmd.com/read/29786749/long-noncoding-rna-myocardial-infarction%C3%A2-associated-transcript-is-associated-with-the-microrna%C3%A2-150%C3%A2-5p-p300-pathway-in-cardiac-hypertrophy
#1
Zhao Li, Yamin Liu, Xiaofan Guo, Guozhe Sun, Qun Ma, Ying Dai, Guangshuo Zhu, Yingxian Sun
In numerous diseases, abnormal expression of myocardial infarction‑associated transcript (MIAT) has been reported to be involved in cell proliferation, apoptosis and migration. However, whether this long non‑coding RNA MIAT has a regulatory effect on heart hypertrophy requires further investigation. To this end, the present study evaluated MIAT in hypertrophic cardiomyocytes in vitro and in vivo. Neonatal rat ventricular myocytes (NRVMs) were induced by isoproterenol (ISO) to create a cell hypertrophy model, and mice were intraperitoneally injected with ISO to establish an animal model...
May 21, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29778854/proposed-stages-of-myocardial-phenotype-development-in-fabry-disease
#2
Sabrina Nordin, Rebecca Kozor, Katia Medina-Menacho, Amna Abdel-Gadir, Shanat Baig, Daniel M Sado, Ilaria Lobascio, Elaine Murphy, Robin H Lachmann, Atul Mehta, Nicola C Edwards, Uma Ramaswami, Richard P Steeds, Derralynn Hughes, James C Moon
OBJECTIVES: The authors sought to explore the Fabry myocardium in relation to storage, age, sex, structure, function, electrocardiogram changes, blood biomarkers, and inflammation/fibrosis. BACKGROUND: Fabry disease (FD) is a rare, x-linked lysosomal storage disorder. Mortality is mainly cardiovascular with men exhibiting cardiac symptoms earlier than women. By cardiovascular magnetic resonance, native T1 is low in FD because of sphingolipid accumulation. METHODS: A prospective, observational study of 182 FD (167 adults, 15 children; mean age 42 ± 17 years, 37% male) who underwent cardiovascular magnetic resonance including native T1, late gadolinium enhancement (LGE), and extracellular volume fraction, 12-lead electrocardiogram, and blood biomarkers (troponin and N-terminal pro-brain natriuretic peptide)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29777760/peripheral-intravenous-volume-assessment-piva-for-quantitating-volume-overload-in-patients-hospitalized-with-acute-decompensated-heart-failure-a-pilot-study
#3
Merrick Miles, Bret D Alvis, Kyle Hocking, Franz Baudenbacher, Christy Guth, JoAann Lindenfeld, Colleen Brophy, Susan Eagle
BACKGROUND: To determine the feasibility of Peripheral Intravenous Volume Assessment (PIVA) of venous waveforms for assessing volume overload in patients admitted to the hospital with acute decompensated heart failure (ADHF). METHODS: Venous waveforms were captured from a peripheral intravenous catheter in subjects admitted for ADHF and healthy age-matched controls. Admission PIVA signal, brain natriuretic peptide, and chest radiographic measurements were related to the net volume removed during diuresis...
May 16, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29774373/cardiovascular-system-changes-in-rheumatoid-arthritis-patients-with-continued-low-disease-activity
#4
Małgorzata Biskup, Wojciech Biskup, Maria Majdan, Bożena Targońska-Stępniak
Systemic inflammation and disease activity seem to contribute to excessive prevalence of cardiovascular (CV) diseases (CVDs) in patients with rheumatoid arthritis (RA). The objective of the study was to assess chosen CV parameters in RA patients who have continuous low disease activity. The study group consisted of 70 RA patients without known CVD and 33 healthy controls, of a comparable age. All RA patients had continued low disease activity (DAS28 ≤ 3.2) from 2 to 7 years. The groups were assessed for: blood pressure, serum amino-terminal pro-brain natriuretic peptide (NT-proBNP), carotid intima media thickness (cIMT), electrocardiography (ECG), ejection fraction (EJ) and diastolic dysfunction (E/A ratio) in echocardiography...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29773102/-over-expression-of-bdnf-inhibits-angiotensin-ii-induced-apoptosis-of-cardiomyocytes-in-sd-rats
#5
Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong Li
Objective To investigate the role and molecular mechanism of brain-derived neurotrophic factor (BDNF) against the process of cardiomyocyte hypertrophy and apoptosis. Methods Cardiomyocyte hypertrophy were estabolished by angiotensin II (Ang II) in neonatal cardiomyocytes in vitro and incomplete ligature of abdominal aorta of SD rats in vivo. BDNF over-expressing recombinant vector pcDNA5-BDNF was transfected into cardiomyocytes by liposomes. Immunofluorescence staining was used to detect the effect of BDNF transfection on the surface area of myocardial cells...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29770745/2706-km-cycling-in-two-weeks-effects-on-cardiac-function-in-six-elderly-male-athletes
#6
Thomas Morville, Mads Rosenkilde, Nick Mattsson, Flemming Dela, Jørn W Helge, Hanne K Rasmusen
INTRODUCTION: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion. METHODS: We studied six elderly male athletes (61±8 years (mean ± SD); baseline VO2 max 48±5 ml·kg-1 · min-1 ) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km...
May 17, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29765615/prognostic-significance-of-repeated-brain-natriuretic-peptide-measurements-after-percutaneous-transluminal-septal-myocardial-ablation-in-patients-with-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#7
Keitaro Akita, Hikaru Tsuruta, Shinsuke Yuasa, Mitsushige Murata, Keiichi Fukuda, Yuichiro Maekawa
Objectives: To evaluate whether repeated brain natriuretic peptide (BNP) measurements after percutaneous transluminal septal myocardial ablation (PTSMA) provide prognostic information regarding the response to PTSMA in patients with drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Background: Plasma BNP levels are associated with clinical outcomes in patients with HOCM. However, the prognostic value of plasma BNP level changes before and after PTSMA remains unclear...
2018: Open Heart
https://www.readbyqxmd.com/read/29764552/-construction-of-death-early-warning-model-for-patients-with-septic-myocardial-depression-a-retrospective-analysis-of-129-patients
#8
Jianping Huang, Yangqing Zhou, Haifen Liu
OBJECTIVE: To explore the death risk factors of septic myocardial depression (SMD) and their predictive effect, and to set up a death early-warning model. METHODS: A retrospective analysis was conducted. The patients with SMD admitted to emergency department and rescue room of Beilun Branch of the First Affiliated Hospital of Zhejiang University Medical College from January 2015 to November 2017 were enrolled. The patients were divided into survival group and non-survival group according to 28-day outcome, and the gender, age, and the initial examination parameters [white blood cell (WBC) count, neutrophil (Neut) count, activated partial thromboplastin time (APTT), procalcitonin (PCT), D-dimer, C-reactive protein (CRP), cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left atrium diameter (LAD)] of both groups were compared...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764506/cardiotoxicity-of-5-fluorouracil-and-capecitabine-in-chinese-patients-a-prospective-study
#9
Jianjun Peng, Chao Dong, Chang Wang, Weihua Li, Hao Yu, Min Zhang, Qun Zhao, Bo Zhu, Jun Zhang, Wenliang Li, Fenghua Wang, Qiong Wu, Wenhao Zhou, Ying Yuan, Meng Qiu, Gong Chen
BACKGROUND: 5-Fluorouracil (5-FU) and capecitabine-associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date. In the present study, we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU- and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China...
May 11, 2018: Cancer communications
https://www.readbyqxmd.com/read/29761310/characteristics-of-patients-with-a-relatively-greater-minimum-ve-vco-2-against-peak-vo-2-and-impaired-exercise-tolerance
#10
Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima
PURPOSE: Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2 ) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2 ) is representative of pulmonary arterial blood flow in individuals without pulmonary disease. Usually, minVE/VCO2 has a strong relationship with the peak oxygen uptake (VO2 ), but dissociation can occur. Therefore, we investigated the relationship between minVE/VCO2 and predicted peak VO2 (peak VO2 %) and evaluated the parameters associated with a discrepancy between these two parameters...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29754170/cardiac-support-device-asd-delivers-bone-marrow-stem-cells-repetitively-to-epicardium-has-promising-curative-effects-in-advanced-heart-failure
#11
Shizhong Yue, Muhammad Naveed, Wang Gang, Dingding Chen, Zhijie Wang, Feng Yu, Xiaohui Zhou
Ventricular restraint therapy is a non-transplant surgical option for the management of advanced heart failure (HF). To augment the therapeutic applications, it is hypothesized that ASD shows remarkable capabilities not only in delivering stem cells but also in dilated ventricles. Male SD rats were divided into four groups (n = 6): normal, HF, HF + ASD, and HF + ASD-BMSCs respectively. HF was developed by left anterior descending (LAD) coronary artery ligation in all groups except normal group. Post-infarcted electrocardiography (ECG) and brain natriuretic peptide (BNP) showed abnormal heart function in all model groups and HF + ASD-BMSCs group showed significant improvement as compared to other HF, HF + ASD groups on day 30...
May 12, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29754152/brain-natriuretic-peptide-regulated-expression-of-inflammatory-cytokines-in-lipopolysaccharide-lps-activated-macrophages-via-nf-%C3%AE%C2%BAb-and-mitogen-activated-protein-kinase-mapk-pathways
#12
Xiong Li, Hao Peng, Jiongxing Wu, Yangcheng Xu
BACKGROUND This study aimed to investigate the effects of recombinant human brain natriuretic peptide (rhBNP) on IL-6, TNF-α, and IL-10 secretion in LPS-activated RAW 264.7 cells and human peripheral blood mononuclear cells (PBMCs) in vitro and to explore the related signaling pathways of the regulation mechanisms of BNP in systemic inflammatory response syndrome (SIRS). MATERIAL AND METHODS MTT assay was used to evaluate the effects of rhBNP on cell viabilities. Lipopolysaccharide (LPS) was used to induce inflammation response...
May 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29753374/beneficial-effects-of-pentoxifylline-plus-losartan-dual-therapy-in-type-2-diabetes-with-nephropathy
#13
Soghra Rabizadeh, Fatemeh Dehghani Firouzabadi, Sina Noshad, Sadaf Esteghamati, Mohsen Afarideh, Alireza Ghajar, Morsaleh Ganji, Mohammad Saadat, Behnam Heidari, Mohammad Taghi Najafi, Manouchehr Nakhjavani, Alireza Esteghamati
BACKGROUND: This study was designed to comparatively assess the effects of add-on pentoxifylline to losartan versus increasing the dose of losartan on serum N-terminal pro-brain natriuretic peptide (NT-proBNP), serum highly sensitive C-reactive protein (hsCRP) and the urinary albumin excretion (UAE) rate in patients with type 2 diabetes and nephropathy. METHODS: In an open-label, single-center, parallel-group, randomized clinical trial (NCT03006952), 30 patients received b...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29752563/alamandine-attenuates-hypertension-and-cardiac-hypertrophy-in-hypertensive-rats
#14
Chi Liu, Chuan-Xi Yang, Xi-Ru Chen, Bo-Xun Liu, Yong Li, Xiao-Zhi Wang, Wei Sun, Peng Li, Xiang-Qing Kong
Oral administration of the peptide alamandine has antihypertensive and anti-fibrotic effects in rats. This work aimed to determine whether subcutaneous alamandine injection would attenuate hypertension and cardiac hypertrophy, and improve the function of a major target of hypertension-related damage, the left ventricle (LV), in spontaneously hypertensive rats (SHRs). This was examined in vivo in SHRs and normotensive rats subjected to 6-week subcutaneous infusion of alamandine or saline control, and in vitro in H9C2-derived and primary neonatal rat cardiomyocytes treated with angiotensin (Ang) II to model cardiac hypertrophy...
May 12, 2018: Amino Acids
https://www.readbyqxmd.com/read/29752386/nppa-and-nppb-act-redundantly-during-zebrafish-cardiac-development-to-confine-avc-marker-expression-and-reduce-cardiac-jelly-volume
#15
Daniela R Grassini, Anne K Lagendijk, Jessica E De Angelis, Jason Da Silva, Angela Jeanes, Nicole Zettler, Neil I Bower, Benjamin M Hogan, Kelly A Smith
Atrial natriuretic peptide ( nppa/anf ) and brain natriuretic peptide ( nppb/bnp ) form a gene cluster with expression in the chambers of the developing heart. Despite restricted expression, a function in cardiac development has not been demonstrated by mutant analysis. This is attributed to functional redundancy however their genomic location in cis has impeded formal analysis. Using genome-editing, we generated mutants for nppa and nppb and found single mutants indistinguishable from wildtype whereas nppa / nppb double mutants display heart morphogenesis defects and pericardial oedema...
May 11, 2018: Development
https://www.readbyqxmd.com/read/29748420/daily-remote-ischaemic-conditioning-following-acute-myocardial-infarction-a-randomised-controlled-trial
#16
Andrew Peter Vanezis, Jayanth Ranjit Arnold, Glenn Rodrigo, Florence Y Lai, Radek Debiec, Sheraz Nazir, Jamal Nasir Khan, Leong L Ng, Kamal Chitkara, John G Coghlan, Simon Lee Hetherington, Gerry P McCann, Nilesh J Samani
BACKGROUND: Remote ischaemic conditioning (rIC) is a cardioprotective tool which has shown promise in preclinical and clinical trials in the context of acute ischaemia. Repeated rIC post myocardial infarction may provide additional benefits which have not previously been tested clinically. METHODS: The trial assessed the role of daily rIC in enhancing left ventricular ejection fraction (LVEF) recovery in patients with impaired LVEF (<45%) after ST segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (P-PCI)...
May 10, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29746994/shenfu-formula-reduces-cardiomyocyte-apoptosis-in-heart-failure-rats-by-regulating-micrornas
#17
Xu Yan, Hongjin Wu, Jianxun Ren, Yuna Liu, Shengqi Wang, Jiyuan Yang, Shuyan Qin, Delin Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Shenfu decoction consists of the water extract from the dried root or rootstalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (Fuzi, Heishunpian in Chinese). Shenfu Formula has been used as a folk Chinese medicine for thousands of years. Recent studies have shown that Shenfu injection can enhance cardiac function and regulate arrhythmia. AIM OF THE STUDY: Shenfu Formula plays an important role in the treatment of heart failure...
May 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29734386/renal-papillary-tip-extract-stimulates-bnp-production-and-excretion-from-cardiomyocytes
#18
Itaru Goto, Ryuji Okamoto, Ryotaro Hashizume, Noboru Suzuki, Rie Ito, Keiichi Yamanaka, Hiromitsu Saito, Hiroshi Kiyonari, Isao Tawara, Yuki Kageyama, Yoshito Ogihara, Yusuf Ali, Norikazu Yamada, Naoyuki Katayama, Masaaki Ito
BACKGROUND: Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It is also known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease; however, the mechanism remains unclear. METHODS AND RESULTS: We developed a BNP reporter mouse and occasionally found that this promoter was activated specifically in the papillary tip of the kidneys, and its activation was not accompanied by BNP mRNA expression...
2018: PloS One
https://www.readbyqxmd.com/read/29733490/the-efficacy-of-serum-brain-natriuretic-peptide-for-the-early-detection-of-portopulmonary-hypertension-in-biliary-atresia-patients-before-liver-transplantation
#19
Koichiro Yoshimaru, Toshiharu Matsuura, Yoshiaki Takahashi, Yusuke Yanagi, Hazumu Nagata, Shouichi Ohga, Tomoaki Taguchi
Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patients with liver cirrhosis. The aim of this study was to elucidate the efficacy of BNP measurement for the follow-up of patients with BA. Thirty-two patients with BA were identified from September 2011 to December 2016...
May 7, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29729375/clinical-predictive-biomarkers-for-normoalbuminuric-diabetic-kidney-disease
#20
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
AIMS: A portion of patients with diabetes mellitus follow the progression of a non-albuminuria-based pathway; i.e., normoalbuminuric diabetic kidney disease (NA-DKD). However, the risk factors which determine NA-DKD are not yet fully understood. This cross-sectional study was therefore aimed to investigate the association between various biomarker levels and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus and normoalbuminuria (T2D-NA). METHODS: We measured cardiovascular disease (CVD) [serum osteoprotegerin (OPG), plasma brain natriuretic peptide (BNP), cardio-ankle vascular index (CAVI)], tubular damage [urinary L-type fatty acid binding protein (L-FABP)], and inflammatory [serum tumornecrosis factor (TNF) α and its receptors (TNFRs)] biomarkers in 314 patients with T2D-NA...
May 3, 2018: Diabetes Research and Clinical Practice
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