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toxoplasmosis diagnosis

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https://www.readbyqxmd.com/read/28086758/toxoplasmosis-associated-iris-involving-the-cns-a-case-report-with-longitudinal-analysis-of-t-cell-subsets
#1
Rita Rb-Silva, Claudia Nobrega, Eugénia Reiriz, Soraia Almeida, Rui Sarmento-Castro, Margarida Correia-Neves, Ana Horta
BACKGROUND: HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heightened inflammatory response toward infectious or non-infectious triggers, and it may affect different organs. Diagnosis of IRIS involving the central nervous system (CNS-IRIS) is challenging due to heterogeneous manifestations, absence of biomarkers to identify this condition, risk of long-term sequelae and high mortality...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056092/improvement-and-evaluation-of-loop-mediated-isothermal-amplification-for-rapid-detection-of-toxoplasma-gondii-infection-in-human-blood-samples
#2
Xi-Meng Sun, Yong-Sheng Ji, Xian-Yong Liu, Mei Xiang, Guang He, Li Xie, Jing-Xia Suo, Xun Suo
Loop-mediated isothermal amplification (LAMP), an attractive DNA amplification method, was developed as a valuable tool for the rapid detection of Toxoplasma gondii. In this study, species-specific LAMP primers were designed by targeting the AF146527 sequence, which was a conserved sequence of 200- to 300-fold repetitive 529 bp fragment of T.gondii. LAMP reaction system was optimized so that it could detect the minimal DNA sample such as a single tachyzoite or 10 copies of recombinant plasmid. No cross-reactivity was found when using DNA from other parasites as templates...
2017: PloS One
https://www.readbyqxmd.com/read/28052948/tb-or-not-to-be-kikuchi-fujimoto-disease-a-rare-but-important-differential-for-tb
#3
C McKenna, T Whitfield, N Patel, A Bonington
A 29-year-old British Pakistani woman presented with a 2-month history of drenching fevers, night sweats, lethargy and tender cervical and axillary lymphadenopathy. Initial investigations, bloods and imaging were unremarkable. Fever persisted during her admission, and treatment for tuberculosis (TB) lymphadenitis was started postbiopsy until histology confirmed a diagnosis of Kikuchi-Fujimoto's disease (KFD). KFD has a non-specific presentation of fever, night sweats and lymphadenopathy and commonly raises a clinical suspicion of a number of other serious conditions such as TB, lymphoma, HIV, systemic lupus erythematous, toxoplasmosis and infectious mononucleosis...
January 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/27999640/toxoplasmosis-in-iran-a-guide-for-general-physicians-working-in-the-iranian-health-network-setting-a-systematic-review
#4
REVIEW
Seyed Mohammad Alavi, Leila Alavi
BACKGROUND: Human toxoplasmosis is an important zoonotic infection worldwide which is caused by the intracellular parasite Toxoplasma gondii (T.gondii). The aim of this study was to review briefly the general aspects of toxoplasma infection in in Iranian health system network. METHODS: We searched published toxoplasmosis related articles in English databases including Science Direct, Pub Med, Scopus, Google Scholar, Magiran, Iran Medex, Iran Doc and Scientific Information Database (SID) for toxoplasmosis...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27992837/toxoplasma-infected-subjects-report-an-obsessive-compulsive-disorder-diagnosis-more-often-and-score-higher-in-obsessive-compulsive-inventory
#5
J Flegr, J Horáček
BACKGROUND: Latent toxoplasmosis, the life-long presence of dormant stages of Toxoplasma in immunoprivileged organs and of anamnestic IgG antibodies in blood, affects about 30% of humans. Infected subjects have an increased incidence of various disorders, including schizophrenia. Several studies, as well as the character of toxoplasmosis-associated disturbance of neurotransmitters, suggest that toxoplasmosis could also play an etiological role in Obsessive-Compulsive Disorder (OCD). METHODS: The aim of the present cross-sectional study performed on a population of 7471 volunteers was to confirm the association between toxoplasmosis and OCD, and toxoplasmosis and psychological symptoms of OCD estimated by the standard Obsessive-Compulsive Inventory-Revised (OCI-R)...
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27988201/early-detection-of-toxoplasma-gondii-infection-by-using-a-interferon-gamma-release-assay-a-review
#6
REVIEW
Shima Mahmoudi, Setareh Mamishi, Xun Suo, Hossein Keshavarz
Antibody-based serological tests are currently the most common diagnostic methods for detection of Toxoplasma gondii; however, these tests bear several limitations. Recently, Interferon-gamma release assay (IGRA), a T-cell-based test, was introduced as an in vitro test for detection of T. gondii infection. Few studies have investigated the potential role of cell immunity in diagnosis of toxoplasmosis. IGRA accurately distinguished infected from uninfected individuals, showing strong lymphocyte activation after in vitro stimulation with T...
December 14, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27974541/characterization-and-diagnostic-application-of-trypanosoma-cruzi-trypomastigote-excreted-secreted-antigens-shed-in-extracellular-vesicles-released-from-infected-mammalian-cells
#7
Norma L Bautista-López, Momar Ndao, Fabio Vasquez Camargo, Takeshi Nara, Takeshi Annoura, Darryl B Hardie, Christoph H Borchers, Armando Jardim
Chagas disease, caused by Trypanosoma cruzi, although endemic in many parts of Central and South America, is emerging as a global health threat through the potential contamination of blood supplies. Consequently, in the absence of a gold standard assay for the diagnosis of Chagas additional antigens or strategies are needed. A proteomic analysis of the trypomastigote excreted secreted antigens (TESA) associated with exosomal vesicles shed by T. cruzi identified ∼80 parasite proteins; with the majority being trans-sialidases...
December 14, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27956093/late-diagnosis-of-congenital-toxoplasmosis-based-on-serological-follow-up-a-case-report
#8
Céline Dard, Cathy Chemla, Hélène Fricker-Hidalgo, Marie-Pierre Brenier-Pinchart, Marie Baret, Alexandre Mzabi, Isabelle Villena, Hervé Pelloux
Toxoplasma gondii is a protozoan parasite infecting up to one third of the world's population. T. gondii infection is usually benign in immunocompetent patients but can be life-threatening when congenitally transmitted. Congenital toxoplasmosis presentation ranges from severe central nervous system and ocular features, to a well appearing newborn with onset of complications late in childhood. The diagnosis of subclinical form remains important since early treatment reduces later complications such as chorioretinitis...
December 9, 2016: Parasitology International
https://www.readbyqxmd.com/read/27940418/toxoplasmosis-versus-lymphoma-cerebral-lesion-characterization-using-dsc-mri-revisited
#9
Elizabeth H Dibble, Jerrold L Boxerman, Grayson L Baird, John E Donahue, Jeffrey M Rogg
OBJECTIVE: CNS toxoplasmosis and lymphoma are often indistinguishable by conventional contrast-enhanced MRI. There is limited literature on the diagnostic efficacy of dynamic susceptibility contrast (DSC) MRI for differentiating these entities. This study assesses the clinical utility of relative cerebral blood volume (rCBV) for making a diagnosis and determines rCBV thresholds for differentiation using contemporary DSC-MRI. PATIENTS AND METHODS: Thirteen patients with 25 lesions (13 toxoplasmosis and 12 lymphoma) and pre-treatment DSC-MRI were identified retrospectively...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27892751/decline-in-ocular-toxoplasmosis-over-40-years-at-a-tertiary-referral-practice-in-the-united-states
#10
Joshua H Hou, Sarju S Patel, Asim V Farooq, Asad A Qadir, Howard H Tessler, Debra A Goldstein
PURPOSE: To identify whether there has been a decline in ocular toxoplasmosis at a tertiary uveitis practice. METHODS: Retrospective review of new patients at the University of Illinois Uveitis Service from 1973 to 2012. RESULTS: There were 6820 patients with adequate records for inclusion; 323 (4.7%) were diagnosed with ocular toxoplasmosis. There was a 78.0% decline in prevalence of ocular toxoplasmosis from 2008 to 2012 compared with 1973 to 1977...
November 28, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27882478/unexpected-hosts-imaging-parasitic-diseases
#11
REVIEW
Pablo Rodríguez Carnero, Paula Hernández Mateo, Susana Martín-Garre, Ángela García Pérez, Lourdes Del Campo
Radiologists seldom encounter parasitic diseases in their daily practice in most of Europe, although the incidence of these diseases is increasing due to migration and tourism from/to endemic areas. Moreover, some parasitic diseases are still endemic in certain European regions, and immunocompromised individuals also pose a higher risk of developing these conditions. This article reviews and summarises the imaging findings of some of the most important and frequent human parasitic diseases, including information about the parasite's life cycle, pathophysiology, clinical findings, diagnosis, and treatment...
November 23, 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/27876472/evaluation-of-recombinant-antigens-in-combination-and-single-formula-for-diagnosis-of-feline-toxoplasmosis
#12
Abdelbaset Eweda Abdelbaset, Hend Alhasan, Doaa Salman, Mohamed Hassan Karram, Mahmoud Abd Ellah Rushdi, Xuan Xuenan, Makoto Igarashi
Cats are the only definitive hosts of Toxoplasma gondii and constitute an essential source of infection to all warm blooded animals and humans. Diagnosis of T. gondii infection in cats is fundamental for proper management and control of infection in humans and animals. In the current study, we have evaluated the diagnostic performance of tachyzoite lysate antigen (TLA) and different T. gondii recombinant antigens including surface antigen 2 (SAG2), dense granule proteins 2, 6, 7, 15 (GRA2, GRA6, GRA7, GRA15) and microneme 10 protein (MIC10) in immunoglobulin G enzyme linked-immunosorbent assay (IgG ELISA) using cat serum samples, with reference to latex agglutination test (LAT)...
November 19, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27874221/ultrasound-guided-core-needle-biopsy-of-cervical-lymph-nodes-in-the-diagnosis-of-toxoplasmosis
#13
Woojin Cho, Min Kyung Kim, Jung Suk Sim
BACKGROUND: Our study investigates whether the histopathological features of toxoplasmic lymphadenitis (TL), specifically noncaseating microgranuloma and follicular hyperplasia, can be obtained by sonographic-guided core needle biopsy (CNB) of cervical lymph nodes. METHODS: Thirty-two patients seen from June 2014 to March 2015 were positive for toxoplasma immunoglobulin M antibody. Among those patients, 21 underwent CNB of a cervical lymph node and were enrolled in this study...
November 22, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27861692/-gestational-and-congenital-toxoplasmosis-a-practical-approach-to-disease-notification
#14
Jaqueline Dario Capobiango, Regina Mitsuka Breganó, Fabiana Maria Ruiz Lopes Mori, Italmar Teodorico Navarro, Josemari Sawczuk de Arruda Campos, Linda Tsuiko Tatakihara, Thalita Bento Talizin, Monica Dos Santos, Tayná Rolim Galvão Pereira, Simone Garani Narciso, Edna Maria Vissoci Reiche
OBJECTIVE: to demonstrate the experience of implanting toxoplasmosis notification during pregnancy and congenital toxoplasmosis in a Sentinel Unit (SU) and describe reported cases. METHODS: this was a descriptive study of the implantation of a notification protocol using a specific notification form for suspected cases of toxoplasmosis in pregnant women and congenital toxoplasmosis in a reference center in Paraná State, Brazil, from August 2013 to August 2014. RESULTS: all 64 suspected cases were notified and case investigation was completed by the SU Epidemiology Sector; 63 received prenatal care and 51 received treatment during pregnancy; 7 of the children being clinically monitored had confirmed diagnosis of congenital toxoplasmosis...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27833967/diagnosing-hiv-associated-cerebral-diseases-the-importance-of-neuropathology-in-understanding-hiv
#15
Ioan Alexandru Diaconu, LaurenŢiu MihăiŢă Stratan, Luciana Nichita, Victoria Aramă, Valentina Ruxandra Moroti Constantinescu, Alexandra Ioana Diaconu, Daniela Adriana Ion
The study aims to compare two aspects concerning the diagnosis of acquired immune deficiency syndrome (AIDS)-associated central nervous system (CNS) pathology (neuroAIDS): clinical diagnoses issued ante mortem with pathology results issued post mortem. The group of 39 human immunodeficiency virus (HIV)-positive patients was created over 23 years and is limited by marked heterogeneity. The enrolled cases were treated at the "Prof. Dr. Matei Bals" National Institute for Infectious Diseases, Bucharest, Romania, deceased due to AIDS-related complications and underwent brain necropsies performed in the Pathology Laboratory at the "Colentina" Clinical Hospital, Bucharest...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#16
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27822344/central-nervous-system-toxoplasmosis-in-relapsed-hodgkin-s-lymphoma-a-case-report
#17
Hassan Abolghasemi, Ehsan Shahverdi, Ramezan Jafari, Fardin Dolatimehr, Azam Khandani
INTRODUCTION: Patients with immunosuppression have an increased incidence of toxoplasmosis characterized by involvement of the central nervous system. Only a few cases of toxoplasmosis associated with immunosuppressive agents have been reported. Such cases have been reported in immune suppressed patients outside the Iran, but a search of the literature has not revealed any previous reports from this country. CASE PRESENTATION: We described a 17- year -old male, a known case of Hodgkin's lymphoma with the diagnosis of central nervous system (CNS) toxoplasmosis...
August 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27788185/congenital-toxoplasmosis-in-chronically-infected-and-subsequently-challenged-ewes
#18
Thaís Rabelo Dos Santos, Gabriela da Silva Magalhães Faria, Bruna Martins Guerreiro, Nathalia Helena Pereira da Silva Dal Pietro, Welber Daniel Zanetti Lopes, Helenara Machado da Silva, João Luis Garcia, Maria Cecília Rui Luvizotto, Katia Denise Saraiva Bresciani, Alvimar José da Costa
This experiment studied congenital transmission in sheep experimentally infected with oocysts of Toxoplasma gondii and reinfected at one of three stages of pregnancy. Twenty ewes were experimentally infected with T. gondii strain ME49 (day 0). After the T. gondii infection became chronic (IFAT≤512), the ewes were allocated with rams for coverage. After the diagnosis of pregnancy, these ewes were allocated into four experimental groups (n = 5): I-reinfected with T. gondii on the 40th day of gestation (DG); II-reinfected on DG 80; III-reinfected on DG 120; and IV-saline solution on DG 120 (not reinfected)...
2016: PloS One
https://www.readbyqxmd.com/read/27786246/hiv-associated-opportunistic-cns-infections-pathophysiology-diagnosis-and-treatment
#19
REVIEW
Lauren N Bowen, Bryan Smith, Daniel Reich, Martha Quezado, Avindra Nath
Nearly 30 years after the advent of antiretroviral therapy (ART), CNS opportunistic infections remain a major cause of morbidity and mortality in HIV-positive individuals. Unknown HIV-positive disease status, antiretroviral drug resistance, poor drug compliance, and recreational drug abuse are factors that continue to influence the morbidity and mortality of infections. The clinical and radiographic pattern of CNS opportunistic infections is unique in the setting of HIV infection: opportunistic infections in HIV-positive patients often have characteristic clinical and radiological presentations that can differ from the presentation of opportunistic infections in immunocompetent patients and are often sufficient to establish the diagnosis...
October 27, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27762467/immunoglobulin-m-indirect-fluorescent-antibody-test-for-the-diagnosis-of-acute-toxoplasmosis-during-pregnancy-in-the-avidity-era-a-14-year-experience-at-the-tuscany-reference-center-for-infectious-diseases-in-pregnancy-florence-italy
#20
Michele Trotta, Beatrice Borchi, Lorenzo Zammarchi, Gaetana Sterrantino, Michela Brogi, Seble Tekle Kiros, Chiara Lorini, Guglielmo Bonaccorsi, Maria Grazia Colao, Alessandro Bartoloni
AIM: The aim of this study was to evaluate immunoglobulin M indirect-fluorescent antibody test (IgM IFAT) for the diagnosis of acute or chronic Toxoplasma infection in pregnancy. METHODS: Pregnant women with suspected acute toxoplasmosis referred to the Tuscany Reference Center for Infectious Diseases in Pregnancy during the period 1998-2012 were retrospectively enrolled. All women were tested with a panel of serological tests, including enzyme-linked immunosorbent assay for IgG avidity and IgM IFAT...
December 2016: Journal of Obstetrics and Gynaecology Research
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