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https://www.readbyqxmd.com/read/29230092/fetomaternal-and-pediatric-toxoplasmosis
#1
Helieh S Oz
Toxoplasmosis is one of the most important causes of foodborne illnesses and inflammatory complications, as well as congenital disorders. Promiscuous Toxoplasma is transmitted by contaminated food and animal produce, water, vegetations, fruits and sexually through semen. Toxoplasma infects nucleated cells with a unique tropism for muscles and central nervous system and a mind bugging malicious effect. Pregnant women with acute or reactivated toxoplasmosis can transmit Toxoplasma via transplacental to the fetus...
December 2017: Journal of pediatric infectious diseases
https://www.readbyqxmd.com/read/29202747/seroprevalence-of-toxoplasmosis-and-risk-factors-of-toxoplasma-gondii-infection-among-pregnant-women-in-sri-lanka-a-cross-sectional-study
#2
Devika Iddawela, Sanura Malinda Pallegoda Vithana, Chathura Ratnayake
BACKGROUND: Toxoplasma gondii is an intracellular protozoan infecting humans and animals. Infection in adults usually causes mild disease but greater importance lies in preventing transplacental transmission which can cause major foetal anomalies and is vital to identify infection in pregnancy. Research on this regard in Sri Lanka is scarce and would be beneficial in developing antenatal care strategies for improved foetal outcome. METHODS: A random sample of 536 pregnant women attending antenatal care in Teaching Hospital Peradeniya from 2010 to 2013 was recruited for this study...
December 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29187938/review-of-toxoplasmosis-in-morocco-seroprevalence-and-risk-factors-for-toxoplasma-infection-among-pregnant-women-and-hiv-infected-patients
#3
REVIEW
Majda Laboudi
Toxoplasmosis is a disease caused by a protozoal parasite: Toxoplasma gondii. This infection can cause severe illness when the organism is contracted congenitally or when it is reactivated in immunosuppressed people. In this paper we review for the first time prevalence and risk factors of T. gondii among pregnant women and HIV-infected adults in Morocco. A systematic review methodology was used to consult three databases: Pub Med, Science Direct and Google Scholar dated until 2015, regarding prevalence data and risk factors of infection among pregnant women and people living with HIV...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29157179/association-between-false-positive-torch-and-antiphospholipid-antibodies-in-healthy-pregnant-women
#4
S De Carolis, S Tabacco, F Rizzo, G Perrone, C Garufi, A Botta, S Salvi, P Benedetti Panici, A Lanzone
The present study investigated: (a) the presence of antiphospholipid antibodies and (b) the obstetric outcome in healthy pregnant women showing false-positive TORCH-Toxoplasmosis, Other: syphilis, varicella-zoster, Rubella, Cytomegalovirus (CMV), and Herpes infections-results. Data from 23 singleton healthy pregnancies with false-positive TORCH results were collected. Each woman was systematically screened for TORCH IgG and IgM during the pre-conception assessment and/or at the beginning of pregnancy. In the presence of IgM positivity, when indicated (CMV, toxoplasmosis, rubella, herpes simplex virus), IgG avidity was evaluated and, if possible, polymerase chain reaction was performed on an amniotic fluid sample in order to distinguish between primary infection or false positivity...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29156547/knowledge-and-practices-of-toxoplasmosis-among-clinical-laboratory-professionals-a-cross-sectional-study-in-durango-mexico
#5
Cosme Alvarado-Esquivel, Luis Francisco Sánchez-Anguiano, Luis Omar Berumen-Segovia, Jesús Hernández-Tinoco, Yazmin Del Rosario Rico-Almochantaf, Alfredo Cisneros-Camacho, Jorge Arturo Cisneros-Martínez
Background: The aim of this study was to determine the level of knowledge and practices about toxoplasmosis in a sample of clinical laboratory professionals in Mexico. Methods: 192 clinical laboratory professionals were surveyed. They were asked about (1) Toxoplasma gondii; (2) clinical manifestations, diagnosis, treatment, and epidemiology of toxoplasmosis; and (3) their practices with respect to toxoplasmosis. Results: The range of animals infected by T. gondii was known by 44.8% of participants. Clinical aspects of toxoplasmosis were known by up to 44...
November 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29153066/-age-related-prevalence-of-toxoplasmosis-among-pregnant-women-in-hatay-estimation-depending-on-model
#6
Meryem Çetin, Şirin Çetin
Toxoplasmosis, caused by the obligate intracellular protozoan Toxoplasma gondii, is a common parasitic infection affecting approximately one-third of the world population. T.gondii infections are usually acquired by ingesting raw or insufficiently cooked meat and from unwashed fruits and vegetables contaminated with soil or water with cat feces. Primary infection acquired during pregnancy can cause severe congenital abnormalities in the fetus such as neurologic and ocular malformations, abortion, or stillbirth according to the degree of infection...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29131528/the-design-of-a-social-cost-benefit-analysis-of-preventive-interventions-for-toxoplasmosis-an-example-of-the-one-health%C3%A2-approach
#7
A W M Suijkerbuijk, P F van Gils, A A Bonačić Marinović, T L Feenstra, L M Kortbeek, M-J J Mangen, M Opsteegh, G A de Wit, J W B van der Giessen
Toxoplasma gondii infections cause a large disease burden in the Netherlands, with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €44 million annually. Infections in humans occur via exposure to oocysts in the environment and after eating undercooked meat containing tissue cysts, leading to asymptomatic or mild symptoms, but potentially leading to the development of ocular toxoplasmosis. Infection in pregnant women can lead to stillbirth and disorders in newborns...
November 12, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29098702/risk-assessment-of-human-toxoplasmosis-associated-with-the-consumption-of-pork-meat-in-italy
#8
Roberto Condoleo, Laura Rinaldi, Stefania Sette, Ziad Mezher
Toxoplasmosis is a cosmopolitan disease and has a broad range of hosts, including humans and several wild and domestic animals. The human infection is mostly acquired through the consumption of contaminated food and pork meat has been recognized as one of the major sources of transmission. There are, however, certain fundamental differences between countries; therefore, the present study specifically aims to evaluate the exposure of the Italian population to Toxoplasma gondii through the ingestion of several types of pork meat products habitually consumed in Italy and to estimate the annual number of human infections within two subgroups of the population...
November 3, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29067206/molecular-detection-and-phylogenetic-analyses-of-toxoplasma-gondii-from-naturally-infected-sheep-in-northern-and-central-tunisia
#9
Mariem Rouatbi, Yosra Amdouni, Safa Amairia, Mohamed R Rjeibi, Said Sammoudi, Mourad Rekik, Mohamed Gharbi
Toxoplasmosis is a worldwide zoonosis caused by the parasitic protozoan Toxoplasma gondii. It can infect all warm-blooded vertebrate species and causes abortions and birth defects in pregnant women and pregnant ewes. The objective of this study was to estimate the prevalence of infection with T. gondii in sheep meat in the region of Sidi Bouzid (central Tunisia) and Beja (northern Tunisia), the realization of a descriptive study of risk factors and the phylogenetic analyses of T. gondii. Neck muscle samples were obtained from 174 ewes and ewe lamb slaughtered in Sidi Bouzid and 150 lambs slaughtered in Beja...
February 2017: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29064352/seroprevalence-of-anti-toxoplasma-gondii-antibodies-among-lebanese-pregnant-women
#10
Hasan Nahouli, Nour El Arnaout, Elias Chalhoub, Elie Anastadiadis, Hiba El Hajj
OBJECTIVE: Toxoplasma gondii, the causative agent of toxoplasmosis, is a zoonotic obligate intracellular protozoan parasite responsible for the infection of almost one-third of the world's population. T. gondii is particularly threatening for primo-infected pregnant women and may lead, following vertical transplacental transmission, to spontaneous abortion, miscarriage, or severe manifestations in the newborn. The aim of this study was to provide an updated estimate of the seroprevalence of anti-T...
October 24, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29020460/toxoplasma-gondii-infection-and-food-consumption-a-systematic-review-and-meta-analysis-of-case-controlled-studies
#11
Simone Belluco, Giulia Simonato, Marzia Mancin, Mario Pietrobelli, Antonia Ricci
BACKGROUND: Toxoplasmosis is a zoonotic disease causing severe symptoms in pregnant women and immunocompromised individuals. On average, worldwide, around 30% of people are seropositive. The oral transmission route is of great significance and food, particularly meat, is an important transmission vehicle for T. gondii. However, the role of different food matrices is debated. OBJECTIVES: The aim of this review was to assess the risk of humans developing acute T. gondii infection via the foodborne route...
October 11, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28883820/decidual-macrophage-functional-polarization-during-abnormal-pregnancy-due-to-toxoplasma-gondii-role-for-lilrb4
#12
Zhidan Li, Mingdong Zhao, Teng Li, Jing Zheng, Xianbing Liu, Yuzhu Jiang, Haixia Zhang, Xuemei Hu
During gestation, Toxoplasma gondii infection produces a series of complications including stillbirths, abortions, and congenital malformations. The inhibitory receptor, LILRB4, which is mainly expressed by professional antigen-presenting cells (especially macrophages and dendritic cells) may play an important immune-regulatory role at the maternal-fetal interface. To assess the role of LILRB4 during T. gondii infection, LILRB4(-/-) and T. gondii infected pregnant mouse models were established. Further, human primary-decidual macrophages were treated with anti-LILRB4 neutralizing antibody and then infected with T...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28693432/seroprevalence-and-risk-factors-of-toxoplasma-gondii-infection-in-pregnant-women-from-bobo-dioulasso-burkina-faso
#13
Sanata Bamba, Mamoudou Cissé, Ibrahim Sangaré, Adama Zida, Souleymane Ouattara, Robert T Guiguemdé
BACKGROUND: Toxoplasmosis is one of the common worldwide parasitic zoonosis due to Toxoplasma gondii (T. gondii). Toxoplasmosis during pregnancy can result in fetal and neonatal death or various congenital defects. The aim of this study was to assess the seroprevalence and risk factors of T. gondii infection in pregnant women following antenatal care (ANC) services at Bobo Dioulasso. METHODS: A cross-sectional study was conducted enrolling a sample of 316 pregnant women attending ANC at centers for maternal and child health of Bobo-Dioulasso town from March 2013 to February 2014...
July 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28689893/evaluation-of-serological-and-molecular-tests-used-to-identify-toxoplasma-gondii-infection-in-pregnant-women-attended-in-a-public-health-service-in-s%C3%A3-o-paulo-state-brazil
#14
Fernando Henrique Antunes Murata, Marina Neves Ferreira, Vera Lucia Pereira-Chioccola, Lígia Cosentino Junqueira Franco Spegiorin, Cristina da Silva Meira-Strejevitch, Ricardo Gava, Aparecida Perpétuo Silveira-Carvalho, Luiz Carlos de Mattos, Cinara Cássia Brandão de Mattos
Toxoplasmosis during pregnancy can have severe consequences. The use of sensitive and specific serological and molecular methods is extremely important for the correct diagnosis of the disease. We compared the ELISA and ELFA serological methods, conventional PCR (cPCR), Nested PCR and quantitative PCR (qPCR) in the diagnosis of Toxoplasma gondii infection in pregnant women without clinical suspicion of toxoplasmosis (G1=94) and with clinical suspicion of toxoplasmosis (G2=53). The results were compared using the Kappa index, and the sensitivity, specificity, positive predictive value and negative predictive value were calculated...
June 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28670634/prevalence-of-toxoplasma-gondii-igg-and-igm-and-associated-risk-factors-among-hiv-positive-and-hiv-negative-patients-in-vhembe-district-of-south-africa
#15
Renay Ngobeni, Amidou Samie
BACKGROUND: Toxoplasma gondii is a zoonotic parasite that has arisen as an important opportunistic infection that causes morbidity and mortality especially in HIV positive patients. This study was carried out to determine the sero-prevalence of T. gondii (IgG and IgM) and the associated risk factors among HIV positive and negative patients in Northern South Africa. MATERIALS AND METHODS: The study was conducted in the Vhembe District in Limpopo province from April 2012 to January 2013...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28668985/toxoplasma-genotyping-in-congenital-toxoplasmosis-in-upper-egypt-evidence-of-type-i-strain
#16
Hanan E M Eldeek, Alzahraa Abdel Raouf Ahmad, Mohamed Ahmed El-Mokhtar, Abdel Rahman M M Abdel Kader, Ahmad M Mandour, Mahmoud Elhady M Mounib
Toxoplasma gondii has subpopulation structures in different geographical regions caused by less frequent sexual recombination, population sweeps, and biogeography. The majority of strains isolated in North America and Europe fall into one of three clonal lineages, referred to as types I, II, and III. So far, little is known about genetics of Toxoplasma strains in Africa. The present study aimed to determine the genotype of Toxoplasma strains obtained directly from trophoblastic/placental tissues of 29 complicated pregnant women using multilocus nested-PCR-RFLP technique depending on four independent genetic loci (5' SAG2 and 3' SAG2), SAG3, GRA6, and BTUB genes...
July 1, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28647172/infection-related-microcephaly-after-the-2015-and-2016-zika-virus-outbreaks-in-brazil-a-surveillance-based-analysis
#17
Wanderson Kleber de Oliveira, Giovanny Vinícius Araújo de França, Eduardo Hage Carmo, Bruce Bartholow Duncan, Ricardo de Souza Kuchenbecker, Maria Inês Schmidt
BACKGROUND: On Nov 11, 2015, the Brazilian Ministry of Health declared a Public Health Emergency of National Concern in response to an increased number of microcephaly cases, possibly related to previous Zika virus outbreaks. We describe the course of the dual epidemics of the Zika virus infection during pregnancy and microcephaly in Brazil up to Nov 12, 2016, the first anniversary of this declaration. METHODS: We used secondary data for Zika virus and microcephaly cases obtained through the Brazilian Ministry of Health's surveillance systems from Jan 1, 2015, to Nov 12, 2016...
August 26, 2017: Lancet
https://www.readbyqxmd.com/read/28640004/ocular-lesions-in-congenital-toxoplasmosis-in-santa-isabel-do-iva%C3%A3-paran%C3%A3-brazil
#18
Ana Paula Sanders, Tatiane Dos Santos, Cleusa Kimie Koike Felipe, Maria Lucia Estevão, Caroni Cícero, Fernanda Evangelista, Carlos Alexandre Manrique, Angélica Sayuri Mizutani, Ana Lucia Falavigna-Guilherme
We verified clinical and psychopedagogic aspects of congenital cases with ocular sequelae, 13 years after toxoplasmosis outbreak in Santa Isabel do Ivaí, and current seroprevalence of this zoonosis in pregnant women. Audiologic and ophthalmologic evaluations were performed in congenital cases, in addition to collection of clinical and psychopedagogic data. In pregnant women, current seroprevalence was observed. Among affected teenagers, 2 of 5 are behind in school grade, and 4 of 5 reported learning difficulties, requiring psychopedagogic monitoring, as well as ocular complaints...
September 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28630065/ccr5-is-involved-in-interruption-of-pregnancy-in-mice-infected-with-toxoplasma-gondii-during-early-pregnancy
#19
Maki Nishimura, Kousuke Umeda, Masayuki Suwa, Hidefumi Furuoka, Yoshifumi Nishikawa
Toxoplasmosis can cause abortion in pregnant humans and other animals; however, the mechanism of abortion remains unknown. C-C chemokine receptor type 5 (CCR5) is essential for host defense against Toxoplasma gondii infection. To investigate the relationship between CCR5 and abortion in toxoplasmosis, we inoculated wild-type and CCR5-deficient (CCR5(-/-)) mice with T. gondii tachyzoites intraperitoneally on day 3 of pregnancy (embryonic day 3 [E3]). The pregnancy rate decreased as pregnancy progressed in infected wild-type mice...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28610938/toxoplasmosis-seroprevalence-in-pregnant-women-and-serological-and-molecular-screening-in-neonatal-umbilical-cord-blood
#20
Mahshad Shieh, Mojtaba Didehdar, Reza Hajihossein, Farzam Ahmadi, Zahra Eslamirad
Toxoplasmosis is a common zoonotic disease that can also be transmitted from the mother to the embryo, with the risk of congenital infection varying around the world. The aim of this study was to screen pregnant women and their neonates for toxoplasmosis by serologic and molecular methods and assess the impact of risk factors associated with toxoplasmosis on the rate of congenital infection. This study was conducted at a regional maternity hospital in Arak, the capital of the Markazi Province in Iran, during a period of six months...
October 2017: Acta Tropica
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