Sayoki Mfinanga, Cecilia Kanyama, Charles Kouanfack, Saulos Nyirenda, Sokoine Lesikari Kivuyo, Timothée Boyer-Chammard, Sam Phiri, Jonathon Ngoma, Meshack Shimwela, Daniel Nkungu, Lauriane Nomene Fomete, Rehema Simbauranga, Chimwemwe Chawinga, Nicaine Ngakam, Tom Heller, Sandrine Sa'a Lontsi, Elnara Aghakishiyeva, Katri Jalava, Sebastian Fuller, Anne-Marie Reid, Radha Rajasingham, David S Lawrence, Mina C Hosseinipour, Emma Beaumont, John Bradley, Shabbar Jaffar, Olivier Lortholary, Thomas Harrison, Síle F Molloy, Aude Sturny-Leclère, Angela Loyse
BACKGROUND: Four decades into the HIV epidemic, CNS infection remains a leading cause of preventable HIV-related deaths in routine care. The Driving Reduced AIDS-associated Meningo-encephalitis Mortality (DREAMM) project aimed to develop, implement, and evaluate pragmatic implementation interventions and strategies to reduce mortality from HIV-related CNS infection. METHODS: DREAMM took place in five public hospitals in Cameroon, Malawi, and Tanzania. The main intervention was a stepwise algorithm for HIV-related CNS infections including bedside rapid diagnostic testing and implementation of WHO cryptococcal meningitis guidelines...
October 2023: Lancet HIV