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https://www.readbyqxmd.com/read/29161298/controlled-placement-of-multiple-cns-cell-populations-to-create-complex-neuronal-cultures
#1
D Soscia, A Belle, N Fischer, H Enright, A Sales, J Osburn, W Benett, E Mukerjee, K Kulp, S Pannu, E Wheeler
In vitro brain-on-a-chip platforms hold promise in many areas including: drug discovery, evaluating effects of toxicants and pathogens, and disease modelling. A more accurate recapitulation of the intricate organization of the brain in vivo may require a complex in vitro system including organization of multiple neuronal cell types in an anatomically-relevant manner. Most approaches for compartmentalizing or segregating multiple cell types on microfabricated substrates use either permanent physical surface features or chemical surface functionalization...
2017: PloS One
https://www.readbyqxmd.com/read/29160452/technical-issues-and-conservation-conditions-of-medicines-in-the-primary-health-care-of-the-brazilian-unified-health-system
#2
Ediná Alves Costa, Patrícia Sodré Araújo, Marcelo Tavares Pereira, Ana Cristina Souto, Gisélia Santana Souza, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Alvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the technical issues and conditions of medicines conservation in Primary Health Care of Brazilian regions, responsible for pharmacy/dispensing unit profile; environmental, storage, and dose fractioning conditions; inventory control and waste management; fire and electrical failure safety items; transportation problems; advertising regulation; and pharmacovigilance. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços (National Survey on Access, Use and Promotion of Rational Use of Medicines - Services)-, a cross-sectional and exploratory study, of evaluative nature, consisting of an information survey within a representative sample of municipalities, stratified by Brazilian regions, which constitute the study domains, and a sample of Primary Health Care services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160066/bn-nanosheet-polymer-films-with-highly-anisotropic-thermal-conductivity-for-thermal-management-application
#3
Yuanpeng Wu, Ye Xue, Si Qin, Dan Liu, Xuebin Wang, Xiao Hu, Jingliang Li, Xungai Wang, Yoshio Bando, Dmitri Golberg, Ying Chen, Yury Gogotsi, Weiwei Lei
Development of advanced thermal transport materials is a global challenge. Two-dimensional nanomaterials have been demonstrated as promising candidates for the thermal management applications. Here, we report a boron nitride (BN) nanosheet/polymer composite film with excellent flexibility and toughness prepared by vacuum-assisted filtration. The mechanical performance of the composite film is highly flexible and robust. It is noteworthy that the film exhibits highly anisotropic properties, with superior in-plane thermal conductivity around 200 W m-1 K-1 and extremely low through-plane thermal conductivity (1...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29158954/the-relationship-between-segmental-rolling-ability-and-lumbar-multifidus-activation-time
#4
Nicole Clark, Michael L Voight, Ashley M Campbell, Sherry Pierce, Pat Sells, Ryan Cook, Clint Henley, Lindsey Schiller
Background: Segmental rolling has been utilized as an assessment and intervention tool to identify and affect dysfunction of the upper quarter, core, and lower quarter. One theory to explain dysfunctional segmental rolling is a lack of segmental spinal control / stabilization. Faulty muscle firing sequencing has been related to poor spinal stability, however to date, no assessment tool exists to evaluate a patient's motor coordination of local and global musculature. Purpose: The purpose of this study was to assess the temporal sequence of lumbar multifidus activation associated with anterior deltoid activation, and to determine if faulty sequencing was associated with the inability to segmentally roll in subjects without mobility restrictions...
November 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29158835/theranostic-role-of-32-p-atp-as-radiopharmaceutical-for-the-induction-of-massive-cell-death-within-avascular-tumor-core
#5
Mirco Galiè, Federico Boschi, Ilaria Scambi, Flavia Merigo, Pasquina Marzola, Luisa Altabella, Umberto Lavagnolo, Andrea Sbarbati, Antonello E Spinelli
Drug inaccessibility to vast areas of the tumor parenchyma is amongst the major hurdles for conventional therapies. Treatment efficacy rapidly decreases with distance from vessels and most of the tumor cells survive therapy. Also, between subsequent cycles of treatment, spared cancer cells replace those killed near the vessels, improving their access to nutrients, boosting their proliferation rate, and thus enabling tumor repopulation. Because of their property of "acting at a distance," radioisotopes are believed to overcome the physical barrier of vascular inaccessibility...
2017: Theranostics
https://www.readbyqxmd.com/read/29158126/physiological-and-behavioral-responses-of-an-arboreal-mammal-to-smoke-and-charcoal-ash-substrate
#6
Julia Nowack, Clare Stawski, Gerhard Körtner, Fritz Geiser
The recent observation that torpor plays a key role in post-fire survival has been mainly attributed to the reduced food resources after fires. However, some of these adjustments can be facilitated or amplified by environmental changes associated with fires, such as the presence of a charcoal-ash substrate. In a previous experiment on a small terrestrial mammal the presence of charcoal and ash linked to food restriction intensified torpor use. However, whether fire cues also act as a trigger of torpor use when food is available and whether they affect other species including arboreal mammals remains elusive...
November 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29157150/assessment-of-urinary-protein-composition-in-response-to-consecutive-days-of-wildland-firefighting
#7
Nobuo Yasuda, Brent C Ruby
The purpose of this study was to examine the pattern of urinary protein excretion induced by three consecutive days of wildland firefighting. Eighteen male active duty military personnel were served as the participants. All testing consisting of three consecutive days was conducted at a Northwestern USA fire camp. All participants consumed military-based foods containing 2620-2864 kcal/day. The work activity was evaluated with an accelerometer in association with body weight and hydration markers over the experimental period...
November 20, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29156294/phospholipase-a1-based-cross-reactivity-among-venoms-of-clinically-relevant-hymenoptera-from-neotropical-and-temperate-regions
#8
Amilcar Perez-Riverol, Luís Gustavo Romani Fernandes, Alexis Musacchio Lasa, José Roberto Aparecido Dos Santos-Pinto, Débora Moitinho Abram, Gabriel Hideki Izuka Moraes, Frederic Jabs, Michaela Miehe, Henning Seismman, Mario Sergio Palma, Ricardo de Lima Zollner, Edzard Spillner, Márcia Regina Brochetto-Braga
Molecular cross-reactivity caused by allergen homology or cross-reactive carbohydrate determinants (CCDs) is a major challenge for diagnosis and immunotherapy of insect venom allergy. Venom phospholipases A1 (PLA1s) are classical, mostly non-glycosylated wasp and ant allergens that provide diagnostic benefit for differentiation of genuine sensitizations from cross-reactivity. As CCD-free molecules, venom PLA1s are not causative for CCD-based cross-reactivity. Little is known however about the protein-based cross-reactivity of PLA1 within vespid species...
November 17, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29156272/a-quantitative-assessment-of-distributions-and-sources-of-tropospheric-halocarbons-measured-in-singapore
#9
Sayantan Sarkar, Wei Hong Fan, Shiguo Jia, Donald R Blake, Jeffrey S Reid, Puji Lestari, Liya E Yu
This work reports the first ground-based atmospheric measurements of 26 halocarbons in Singapore, an urban-industrial city-state in Southeast (SE) Asia. A total of 166 whole air canister samples collected during two intensive 7 Southeast Asian Studies (7SEAS) campaigns (August-October 2011 and 2012) were analyzed for C1-C2 halocarbons using gas chromatography-electron capture/mass spectrometric detection. The halocarbon dataset was supplemented with measurements of selected non-methane hydrocarbons (NMHCs), C1-C5 alkyl nitrates, sulfur gases and carbon monoxide to better understand sources and atmospheric processes...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156218/use-of-luminescent-gunshot-residues-markers-in-forensic-context-part-ii
#10
A M Arouca, M A M Lucena, R J Rossiter, M Talhavini, I T Weber
Gunshot residues (GSR) are important physical evidence in firearm-related crimes. Recently developed non-toxic ammunition, however, requires a new methodology for its characterization. To overcome this drawback, the introduction of noncommercial luminescent markers in ammunition was proposed. These markers, synthesized and added to the gunpowder, presented as a versatile tool for GSR analysis, since they require UV radiation alone to visualize the luminescent GSR (LGSR). This has opened up new perspectives for understanding GSR behavior at a crime scene...
November 6, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29155774/operation-of-a-25-kwth-calcium-looping-pilot-plant-with-high-oxygen-concentrations-in-the-calciner
#11
María Erans, Michal Jeremias, Vasilije Manovic, Edward J Anthony
Calcium looping (CaL) is a post-combustion CO2 capture technology that is suitable for retrofitting existing power plants. The CaL process uses limestone as a cheap and readily available CO2 sorbent. While the technology has been widely studied, there are a few available options that could be applied to make it more economically viable. One of these is to increase the oxygen concentration in the calciner to reduce or eliminate the amount of recycled gas (CO2, H2O and impurities); therefore, decreasing or removing the energy necessary to heat the recycled gas stream...
October 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29152203/pyric-carnivory-raptor-use-of-prescribed-fires
#12
Torre J Hovick, Devan A McGranahan, R Dwayne Elmore, John R Weir, Samuel D Fuhlendorf
Fire is a process that shaped and maintained most terrestrial ecosystems worldwide. Changes in land use and patterns of human settlement have altered fire regimes and led to fire suppression resulting in numerous undesirable consequences spanning individual species and entire ecosystems. Many obvious and direct consequences of fire suppression have been well studied, but several, albeit less obvious, costs of alteration to fire regimes on wildlife are unknown. One such phenomenon is the response of carnivores to fire events-something we refer to as pyric-carnivory...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29151402/difference-in-first-aid-activity-during-mass-casualty-training-based-on-having-taken-an-educational-course
#13
Youichi Yanagawa, Kazuhiko Omori, Kouhei Ishikawa, Ikuto Takeuchi, Kei Jitsuiki, Toshihiko Yoshizawa, Jun Sato, Hideyuki Matsumoto, Masaru Tsuchiya, Hiromichi Osaka
BACKGROUND: The Japanese Association for Disaster Medicine developed a mass casualty life support (MCLS) course to improve cooperation among medical practitioners during a disaster, which is essential for reducing the rates of preventable disaster death. We investigated whether there was difference in first aid activity among members of the ambulance service during mass casualty training based on having taken the MCLS course. METHODS: Mass casualty training was held at the fire department of Numazu City...
November 20, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29151188/dry-flue-gas-desulfurization-by-product-application-effects-on-plant-uptake-and-soil-storage-changes-in-a-managed-grassland
#14
Jason R Burgess-Conforti, Kristofor R Brye, David M Miller, Erik D Pollock, Lisa S Wood
Environmental regulations mandate that sulfur dioxide (SO2) be removed from the flue gases of coal-fired power plants, which results in the generation of flue gas desulfurization (FGD) by-products. These FGD by-products may be a viable soil amendment, but the large amounts of trace elements contained in FGD by-products are potentially concerning. The objective of this study was to evaluate the effects of land application of a high-Ca dry FGD (DFGD) by-product on trace elements in aboveground biomass and soil...
November 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29150965/i-thought-he-was-going-to-set-our-house-on-fire
#15
Nancy Lutwak
Recently the wife of an octogenarian suffering from dementia brought her husband to the emergency department stating, "I can't take care of him anymore. He is becoming more aggressive. I thought he was going to set our house on fire last night". She recounted finding her husband in the kitchen at the range turning the dials. This article is protected by copyright. All rights reserved.
November 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29150865/enhanced-mu-opioid-receptor-dependent-opioidergic-modulation-of-striatal-cholinergic-transmission-in-dyt1-dystonia
#16
Giulia Ponterio, Annalisa Tassone, Giuseppe Sciamanna, Valentina Vanni, Maria Meringolo, Massimo Santoro, Nicola Biagio Mercuri, Paola Bonsi, Antonio Pisani
BACKGROUND: Mu opioid receptor activation modulates acetylcholine release in the dorsal striatum, an area deeply involved in motor function, habit formation, and reinforcement learning as well as in the pathophysiology of different movement disorders, such as dystonia. Although the role of opioids in drug reward and addiction is well established, their involvement in motor dysfunction remains largely unexplored. METHODS: We used a multidisciplinary approach to investigate the responses to mu activation in 2 mouse models of DYT1 dystonia (Tor1a(+/Δgag) mice, Tor1a(+/-) torsinA null mice, and their respective wild-types)...
November 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29150838/gi-530159-a-novel-selective-mechano-sensitive-k2p-channel-opener-reduces-rat-dorsal-root-ganglion-drg-neuron-excitability
#17
Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Mathie
BACKGROUND AND PURPOSE: TREK two pore domain potassium channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pathophysiological conditions, has been severely hampered by the lack of potent and/or selective activators and inhibitors. In this study we describe a new, selective opener of TREK channels, GI-530159 (4,4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline)...
November 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29150760/slow-passage-through-a-hopf-bifurcation-in-excitable-nerve-cables-spatial-delays-and-spatial-memory-effects
#18
L M Bilinsky, S M Baer
It is well established that in problems featuring slow passage through a Hopf bifurcation (dynamic Hopf bifurcation) the transition to large-amplitude oscillations may not occur until the slowly changing parameter considerably exceeds the value predicted from the static Hopf bifurcation analysis (temporal delay effect), with the length of the delay depending upon the initial value of the slowly changing parameter (temporal memory effect). In this paper we introduce new delay and memory effect phenomena using both analytic (WKB method) and numerical methods...
November 17, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29149879/risk-management-of-emergency-service-vehicle-crashes-in-the-united-states-fire-service-process-outputs-and-recommendations
#19
David P Bui, Keshia P Porter, Stephanie Griffin, Dustin D French, Alesia M Jung, Stephen Crothers, Jefferey L Burgess
BACKGROUND: Emergency service vehicle crashes (ESVCs) are a leading cause of death in the United States fire service. Risk management (RM) is a proactive process for identifying occupational risks and reducing hazards and unwanted events through an iterative process of scoping hazards, risk assessment, and implementing controls. We describe the process, outputs, and lessons learned from the application of a proactive RM process to reduce ESVCs in US fire departments. METHODS: Three fire departments representative of urban, suburban, and rural geographies, participated in a facilitated RM process delivered through focus groups and stakeholder discussion...
November 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29149606/chronic-stress-alters-striosome-circuit-dynamics-leading-to-aberrant-decision-making
#20
Alexander Friedman, Daigo Homma, Bernard Bloem, Leif G Gibb, Ken-Ichi Amemori, Dan Hu, Sebastien Delcasso, Timothy F Truong, Joyce Yang, Adam S Hood, Katrina A Mikofalvy, Dirk W Beck, Norah Nguyen, Erik D Nelson, Sebastian E Toro Arana, Ruth H Vorder Bruegge, Ki A Goosens, Ann M Graybiel
Effective evaluation of costs and benefits is a core survival capacity that in humans is considered as optimal, "rational" decision-making. This capacity is vulnerable in neuropsychiatric disorders and in the aftermath of chronic stress, in which aberrant choices and high-risk behaviors occur. We report that chronic stress exposure in rodents produces abnormal evaluation of costs and benefits resembling non-optimal decision-making in which choices of high-cost/high-reward options are sharply increased...
November 16, 2017: Cell
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