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https://www.readbyqxmd.com/read/29037015/comparison-of-spot-sign-blend-sign-and-black-hole-sign-for-outcome-prediction-in-patients-with-intracerebral-hemorrhage
#1
Peter B Sporns, Michael Schwake, André Kemmling, Jens Minnerup, Wolfram Schwindt, Thomas Niederstadt, Rene Schmidt, Uta Hanning
BACKGROUND AND PURPOSE: Blend sign (BS) and black hole sign (BHS) on non-contrast computed tomography (NCCT) and spot sign (SS) on CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored. METHODS: In this retrospective study, inclusion criteria were: 1) spontaneous ICH and 2) NCCT and CTA performed on admission within 6 hours after onset of symptoms...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037006/microrna-150-5p-improves-risk-classification-for-mortality-within-90-days-after-acute-ischemic-stroke
#2
Natalie Scherrer, Francois Fays, Beat Mueller, Andreas Luft, Felix Fluri, Mirjam Christ-Crain, Yvan Devaux, Mira Katan
BACKGROUND AND PURPOSE: Micro ribonucleic acid-150-5p (miR-150-5p) regulates proinflammatory cytokines as well as vessel integrity. We evaluated the incremental prognostic value of logarithm (log) of miR-150-5p plasma levels after ischemic stroke. METHODS: In a prospective cohort study, levels of miR-150-5p were measured within 72 hours of symptom onset in 329 ischemic stroke patients. The outcome measures were unfavorable functional outcome (assessed by the modified Rankin Scale score >2) and mortality within 90 days...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036973/-predictive-value-of-cardiac-magnetic-resonance-derived-parameters-on-the-improvement-of-left-ventricular-function-in-patients-with-acute-viral-myocarditis
#3
H C Ouyang, F C Ouyang, L L Mai, Y Y Chen, Y Z Hu, H X Chen, W S Li
Objective: To evaluate the predictive value of cardiac magnetic resonance (CMR)-derived parameters on the improvement of left ventricular function in patients with acute viral myocarditis. Methods: Forty patients, who referred for acute viral myocarditis in our hospital from September 2011 to September 2015, were prospectively enrolled in this study.All patients were examined by CMR during hospitalization for acute viral myocarditis (baseline) and after 12 months.The CMR sequences include: two dimension steady state free precession, 2D SSFP; triple inversion recovery, triple IR; early gadolinium enhancement; phase sensitive inversion recovery turbo field echo, PSIR TFE...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036868/a-modified-job-demand-control-support-model-for-active-duty-police
#4
Elisabeth Elgmark Andersson, Louise Bæk Larsen, Nerrolyn Ramstrand
BACKGROUND: The Job demand control support model (JDCS) is one of the most widely used theoretical models relating job characteristics to health and wellbeing. OBJECTIVE: This study aimed to assess the predictive power of the JDCS model for determining job satisfaction and fatigue in uniformed Swedish police. An additional aim was to determine if predictive power of the model would be improved with the addition of two occupation specific items. METHODS: Questionnaire data, based upon the Swedish Work Environment Survey were collected from Swedish police (n = 4244)...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036850/methodology-for-the-development-of-normative-data-for-spanish-speaking-pediatric-populations
#5
D Rivera, J C Arango-Lasprilla
OBJECTIVE: To describe the methodology utilized to calculate reliability and the generation of norms for 10 neuropsychological tests for children in Spanish-speaking countries. METHOD: The study sample consisted of over 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Inclusion criteria for all countries were to have between 6 to 17 years of age, an Intelligence Quotient of≥80 on the Test of Non-Verbal Intelligence (TONI-2), and score of <19 on the Children's Depression Inventory...
October 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036824/alzheimer-s-disease-biomarkers-and-future-decline-in-cognitive-normal-older-adults
#6
Julien Dumurgier, Bernard J Hanseeuw, Frances B Hatling, Kelly A Judge, Aaron P Schultz, Jasmeer P Chhatwal, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Bradley T Hyman, Teresa Gómez-Isla
BACKGROUND: Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer's disease (AD) modifying therapies move toward preclinical stages. OBJECTIVE: To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults. METHODS: 84 cognitively normal subjects (mean age 72.0 years, 59% women) were recruited through the Massachusetts Alzheimer's Disease Research Center and the Harvard Aging Brain Study and followed over 3 years...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036812/altered-gut-microbiota-in-a-mouse-model-of-alzheimer-s-disease
#7
Ling Zhang, Ying Wang, Xia Xiayu, Changhua Shi, Wei Chen, Nan Song, Xinjing Fu, Rui Zhou, Yan-Feng Xu, Lan Huang, Hua Zhu, Yunlin Han, Chuan Qin
The topic of gut microbiota is currently attracting considerable interest as a potential factor in Alzheimer's disease (AD). However, the extent and time course of alterations in the gut microbiota, and their effects on AD pathology remain uncertain. Herein, we compared the fecal microbiomes and fecal short chain fatty acid composition (SCFAs) between wild-type and AD model mice at different ages under strictly controlled specific pathogen free conditions, and also conducted microscopic investigations of intestinal structures...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036792/are-helicobacter-pylori-highly-cytotoxic-genotypes-and-cardia-gastric-adenocarcinoma-linked-lessons-from-iran
#8
Seyedeh Zahra Bakhti, Saeid Latifi-Navid, Saber Zahri, Fatemeh Sadat Bakhti, Naser Hajavi, Abbas Yazdanbod
BACKGROUND: Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial. OBJECTIVE: We aimed to examine the linkage of H. pylori highly cytotoxic genotypes to CGA in Iranian populations as a model. METHODS: A total of 601 Iranian patients were enrolled...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29036765/development-of-an-anaerobic-threshold-hrlt-hrvt-estimation-equation-using-the-heart-rate-threshold-hrt-during-the-treadmill-incremental-exercise-test
#9
Joo-Ho Ham, Hun-Young Park, Youn-Ho Kim, Sang-Kon Bae, Byung-Hoon Ko, Sang-Seok Nam
PURPOSE: The purpose of this study was to develop a regression model to estimate the heart rate at the lactate threshold (HRLT) and the heart rate at the ventilatory threshold (HRVT) using the heart rate threshold (HRT), and to test the validity of the regression model. METHODS: We performed a graded exercise test with a treadmill in 220 normal individuals (men: 112, women: 108) aged 20-59 years. HRT, HRLT, and HRVT were measured in all subjects. A regression model was developed to estimate HRLT and HRVT using HRT with 70% of the data (men: 79, women: 76) through randomization (7:3), with the Bernoulli trial...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29036723/converting-from-transdermal-to-buccal-formulations-of-buprenorphine-a-pharmacokinetic-meta-model-simulation-in-healthy-volunteers
#10
Tony Priestley, Arvind K Chappa, Diane R Mould, Richard N Upton, Neil Shusterman, Steven Passik, Vicente J Tormo, Stephen Camper
OBJECTIVE:  To develop a model to predict buprenorphine plasma concentrations during transition from transdermal to buccal administration. DESIGN:  Population pharmacokinetic model-based meta-analysis of published data. METHODS:  A model-based meta-analysis of available buprenorphine pharmacokinetic data in healthy adults, extracted as aggregate (mean) data from published literature, was performed to explore potential conversion from transdermal to buccal buprenorphine...
September 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036699/pain-related-acceptance-as-a-mediator-in-the-fear-avoidance-model-of-chronic-pain-a-preliminary-study
#11
Sophie Lykkegaard Ravn, Maria Louison Vang, Henrik Bjarke Vaegter, Tonny Elmose Andersen
Objective: The fear avoidance model has served as a popular, heuristic model in explaining the transition from acute to chronic pain. In addition, the significance of pain-related acceptance in chronic pain development and adjustment is underlined in a vast number of empirical studies. The objective of the current preliminary study was to investigate pain-related acceptance as a mediator within the key cognitive relationships proposed by the fear avoidance model of chronic pain. Materials and Methods: In a cross-sectional design, bodily pain, pain catastrophizing, fear avoidance beliefs, and pain-related acceptance were assessed by questionnaires in 125 chronic pain patients in a Danish multidisciplinary pain center...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036698/chromosomal-context-affects-the-molecular-evolution-of-sex-linked-genes-and-their-autosomal-counterparts-in-turtles-and-other-vertebrates
#12
Srihari Radhakrishnan, Nicole Valenzuela
Sex chromosomes evolve differently from autosomes because natural selection acts distinctly on them given their reduced recombination and smaller population size. Various studies of sex-linked genes compared to different autosomal genes within species support these predictions. Instead, here we take a novel alternative approach comparing the rate of evolution between subsets of genes that are sex-linked in selected reptiles/vertebrates and the same genes located in autosomes in other amniotes. We report for the first time the faster evolution of Z-linked genes in a turtle (the Chinese soft-shell turtle Pelodiscus sinensis) relative to autosomal orthologs in other taxa, including turtles with temperature-dependent sex determination (TSD)...
September 27, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29036674/detecting-and-characterizing-micrornas-of-diverse-genomic-origins-via-mirvial
#13
Jing Xia, Lun Li, Tiantian Li, Zhiwei Fang, Kevin Zhang, Junfei Zhou, Hai Peng, Weixiong Zhang
MicroRNAs form an essential class of post-transcriptional gene regulator of eukaryotic species, and play critical parts in development and disease and stress responses. MicroRNAs may originate from various genomic loci, have structural characteristics, and appear in canonical or modified forms, making them subtle to detect and analyze. We present miRvial, a robust computational method and companion software package that supports parameter adjustment and visual inspection of candidate microRNAs. Extensive results comparing miRvial and six existing microRNA finding methods on six model organisms, Mus musculus, Drosophila melanogaste, Arabidopsis thaliana, Oryza sativa, Physcomitrella patens and Chlamydomonas reinhardtii, demonstrated the utility and rigor of miRvial in detecting novel microRNAs and characterizing features of microRNAs...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036624/genomic-signatures-of-sexual-conflict
#14
Katja R Kasimatis, Thomas C Nelson, Patrick C Phillips
Sexual conflict is a specific class of intergenomic conflict that describes the reciprocal sex-specific fitness costs generated by antagonistic reproductive interactions. The potential for sexual conflict is an inherent property of having a shared genome between the sexes and therefore is an extreme form of an environment-dependent fitness effect. In this way, many of the predictions from environment-dependent selection can be used to formulate expected patterns of whole-genome evolution under sexual conflict...
September 27, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29036618/unsuccessful-treatment-in-pulmonary-tuberculosis-factors-and-a-consequent-predictive-model
#15
Ana Costa-Veiga, Teodoro Briz, Carla Nunes
Background: Cure is particularly valuable in pulmonary cases (PTB), as unsuccessful treatment fuels incidence and resistance to antibiotics. This study aims to identify individual factors of PTB unsuccessful treatment in Portugal and to develop a consequent predictive model. Methods: Using the Portuguese TB surveillance database (SVIG-TB), PTB cases older than 15 years notified from 2000 to 2012 in Continental Portugal were analyzed. Unsuccessful treatment included the WHO categories (failure, default, death and transferred out)...
October 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036616/deeploc-prediction-of-protein-subcellular-localization-using-deep-learning
#16
José Juan Almagro Armenteros, Casper Kaae Sønderby, Søren Kaae Sønderby, Henrik Nielsen, Ole Winther
Motivation: The prediction of eukaryotic protein subcellular localization is a well-studied topic in bioinformatics due to its relevance in proteomics research. Many machine learning methods have been successfully applied in this task, but in most of them, predictions rely on annotation of homologues from knowledge databases. For novel proteins where no annotated homologues exist, and for predicting the effects of sequence variants, it is desirable to have methods for predicting protein properties from sequence information only...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036587/latent-profile-analysis-and-conversion-to-psychosis-characterizing-subgroups-to-enhance-risk-prediction
#17
Kristin M Healey, David L Penn, Diana Perkins, Scott W Woods, Richard S E Keefe, Jean Addington
BACKGROUND: Groups at clinical high risk (CHR) of developing psychosis are heterogeneous, composed of individuals with different clusters of symptoms. It is likely that there exist subgroups, each associated with different symptom constellations and probabilities of conversion. METHOD: Present study used latent profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as measured by multiple instruments, including category instances (CAT)...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036581/secondary-use-of-electronic-health-record-data-for-clinical-workflow-analysis
#18
Michelle R Hribar, Sarah Read-Brown, Isaac H Goldstein, Leah G Reznick, Lorinna Lombardi, Mansi Parikh, Winston Chamberlain, Michael F Chiang
Objective: Outpatient clinics lack guidance for tackling modern efficiency and productivity demands. Workflow studies require large amounts of timing data that are prohibitively expensive to collect through observation or tracking devices. Electronic health records (EHRs) contain a vast amount of timing data - timestamps collected during regular use - that can be mapped to workflow steps. This study validates using EHR timestamp data to predict outpatient ophthalmology clinic workflow timings at Oregon Health and Science University and demonstrates their usefulness in 3 different studies...
September 26, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29036557/standardizing-biomass-reactions-and-ensuring-complete-mass-balance-in-genome-scale-metabolic-models
#19
Siu H J Chan, Jingyi Cai, Lin Wang, Margaret N Simons-Senftle, Costas D Maranas
Motivation: In a genome-scale metabolic model, the biomass produced is defined to have a molecular weight (MW) of 1 g mmol -1 . This is critical for correctly predicting growth yields, contrasting multiple models and more importantly modeling microbial communities. However, the standard is rarely verified in the current practice and the chemical formulae of biomass components such as proteins, nucleic acids and lipids are often represented by undefined side groups (e.g. X, R). Results: We introduced a systematic procedure for checking the biomass weight and ensuring complete mass balance of a model...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036552/using-foliar-spectral-properties-to-assess-the-effects-of-drought-on-plant-water-potential
#20
Lorenzo Cotrozzi, John J Couture, Jeannine Cavender-Bares, Clayton C Kingdon, Beth Fallon, George Pilz, Elisa Pellegrini, Cristina Nali, Philip A Townsend
Drought frequency is predicted to increase in future environments. Leaf water potential (ΨLW) is commonly used to evaluate plant water status, but traditional measurements can be logistically difficult and require destructive sampling. We used reflectance spectroscopy to characterize variation in ΨLW of Quercus oleoides Schltdl. & Cham. under differential water availability and tested the ability to predict pre-dawn ΨLW (PDΨLW) using spectral data collected hours after pressure chamber measurements on dark-acclimated leaves...
September 19, 2017: Tree Physiology
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