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Carl Wu

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https://www.readbyqxmd.com/read/29774556/physiological-response-of-tomatoes-at-drought-heat-and-their-combination-followed-by-recovery
#1
Rong Zhou, Lingpeng Kong, Zhen Wu, Eva Rosenqvist, Yinlei Wang, Liping Zhao, Tongmin Zhao, Carl-Otto Ottosen
In nature, crops encounter a combination of abiotic stresses that severely limit yield. Our aim was to dynamically expose the changes of tomatoes' physiological parameters to drought, heat and their combination and thereby clarify the relationship between the responses to single and combined stress. We studied the effect of single and combined drought and heat stresses on the shoot and root of two tomato cultivars (Sufen No.14 as CV1; Jinlingmeiyu as CV2). After being exposed to combined stress for six days, the dry weight of shoot and root significantly decreased...
May 17, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29750252/whole-exome-sequencing-of-an-exceptional-longevity-cohort
#2
Haakon B Nygaard, E Zeynep Erson-Omay, Xiujuan Wu, Brianne A Kent, Cecily Q Bernales, Daniel M Evans, Matthew J Farrer, Carles Vilariño-Güell, Stephen M Strittmatter
Centenarians represent a unique cohort to study the genetic basis for longevity and factors determining the risk of neurodegenerative disorders, including Alzheimer's disease (AD). The estimated genetic contribution to longevity is highest in centenarians and supercententenarians, but few genetic variants have been shown to clearly impact this phenotype. While the genetic risk for AD and other dementias is now well understood, the frequency of known dementia risk variants in centenarians is not fully characterized...
May 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29730574/reduction-of-bacterial-attachment-on-hydroxyapatite-surfaces-using-hydrophobicity-and-chemical-functionality-to-enhance-surface-retention-and-prevent-attachment
#3
Jeannette Marine, Carl P Myers, Guillaume A Picquet, Lynette A Zaidel, Donghui Wu, Kathryn E Uhrich
Water-soluble, linear polymers with high-acid functionality are commonly used in oral care formulations to provide benefits such as bioactive complexation and delivery, as well as inhibition of the bacteria deposition and colonization, commonly referred to as 'anti-attachment'. Unfortunately, structure-activity relationship (SAR) studies of these polymers are scarce, thus, a systematic approach to design polymers with a desired property (e.g. anti-attachment) is limited. Multifunctional anti-attachment amphiphilic molecules (AMs) featuring a sugar backbone, hydrophobic arms, a poly(ethylene glycol) tail, and a chemical anchor effectively deposited on soft ceramic surfaces and reduced bacterial adhesion...
April 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29725364/asxl1-mutations-in-chinese-patients-with-essential-thrombocythemia
#4
Yan-Bo Nie, Meng Sun, Colin K He, Man-Kai Ju, Fu-Ling Zhou, San-Yun Wu, Yi Zhou, Li Liu, Hui Shen, Ting-Ting Huang, Pan Liu, Ying Xu, Liang Shao, Xue-Lan Zuo
Essential thrombocythemia (ET) is characterized by thrombotic and hemorrhagic events. The association of clinical characteristics of Chinese ET patients and additional sex combs like 1 (ASXL1) mutations in these patients has remained to be elucidated. In the present study, 72 newly diagnosed Chinese ET patients were enrolled to determine ASXL1 mutations. Mutations in ASXL1, Janus kinase (JAK)2, calreticulin (CALR) and myeloproliferative leukemia (MPL) genes were detected using Sanger sequencing, and data were statistically analyzed...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29466302/a-hexahomotrioxacalix-3-arene-based-ditopic-receptor-for-alkylammonium-ions-controlled-by-ag%C3%A2-%C2%BA-ions
#5
Xue-Kai Jiang, Yusuke Ikejiri, Chong Wu, Shofiur Rahman, Paris E Georghiou, Xi Zeng, Mark R J Elsegood, Carl Redshaw, Simon J Teat, Takehiko Yamato
A receptor cone-1 based on a hexahomotrioxacalix[3]arene bearing three pyridyl groups was successfully synthesized, which has a C₃-symmetric conformation and is capable of binding alkylammonium and metal ions simultaneously in a cooperative fashion. It can bind alkylammonium ions through the -cavity formed by three aryl rings. This behaviour is consistent with the cone-in/cone-out conformational rearrangement needed to reorganize the cavity for endo-complexation. As a C₃-symmetrical pyridyl-substituted calixarene, receptor cone-1 can also bind an Ag⁺ ion, and the nitrogen atoms are turned towards the inside of the cavity and interact with Ag⁺...
February 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29465985/identification-of-a-mycothiol-dependent-nitroreductase-from-mycobacterium-tuberculosis
#6
Ana Negri, Prisca Javidnia, Ran Mu, Xiaojie Zhang, Jeremie Vendome, Ben Gold, Julia Roberts, Dipti Barman, Thomas Ioerger, James C Sacchettini, Xiuju Jiang, Kristin Burns-Huang, Thulasi Warrier, Yan Ling, J David Warren, Deena A Oren, Thijs Beuming, Hongyao Wang, Jie Wu, Haitao Li, Kyu Y Rhee, Carl F Nathan, Gang Liu, Selin Somersan-Karakaya
The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant and complex mechanisms it has evolved for resisting nitrosative and oxidative stresses inflicted by host immunity. Improving our understanding of these defense pathways can reveal vulnerable points in Mtb pathogenesis. In this study, we combined genetic, structural, computational, biochemical, and biophysical approaches to identify a novel enzyme class represented by Rv2466c. We show that Rv2466c is a mycothiol-dependent nitroreductase of Mtb and can reduce the nitro group of a novel mycobactericidal compound using mycothiol as a cofactor...
February 21, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29455858/a-large-scale-multi-ancestry-genome-wide-study-accounting-for-smoking-behavior-identifies-multiple-significant-loci-for-blood-pressure
#7
Yun J Sung, Thomas W Winkler, Lisa de Las Fuentes, Amy R Bentley, Michael R Brown, Aldi T Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Yingchang Lu, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K Musani, Changwei Li, Mary F Feitosa, Tuomas O Kilpeläinen, Melissa A Richard, Raymond Noordam, Stella Aslibekyan, Hugues Aschard, Traci M Bartz, Rajkumar Dorajoo, Yongmei Liu, Alisa K Manning, Tuomo Rankinen, Albert Vernon Smith, Salman M Tajuddin, Bamidele O Tayo, Helen R Warren, Wei Zhao, Yanhua Zhou, Nana Matoba, Tamar Sofer, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Ilaria Gandin, Chuan Gao, Franco Giulianini, Anuj Goel, Sarah E Harris, Fernando Pires Hartwig, Andrea R V R Horimoto, Fang-Chi Hsu, Anne U Jackson, Mika Kähönen, Anuradhani Kasturiratne, Brigitte Kühnel, Karin Leander, Wen-Jane Lee, Keng-Hung Lin, Jian 'an Luan, Colin A McKenzie, He Meian, Christopher P Nelson, Rainer Rauramaa, Nicole Schupf, Robert A Scott, Wayne H H Sheu, Alena Stančáková, Fumihiko Takeuchi, Peter J van der Most, Tibor V Varga, Heming Wang, Yajuan Wang, Erin B Ware, Stefan Weiss, Wanqing Wen, Lisa R Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Tamuno Alfred, Najaf Amin, Dan Arking, Tin Aung, R Graham Barr, Lawrence F Bielak, Eric Boerwinkle, Erwin P Bottinger, Peter S Braund, Jennifer A Brody, Ulrich Broeckel, Claudia P Cabrera, Brian Cade, Yu Caizheng, Archie Campbell, Mickaël Canouil, Aravinda Chakravarti, Ganesh Chauhan, Kaare Christensen, Massimiliano Cocca, Francis S Collins, John M Connell, Renée de Mutsert, H Janaka de Silva, Stephanie Debette, Marcus Dörr, Qing Duan, Charles B Eaton, Georg Ehret, Evangelos Evangelou, Jessica D Faul, Virginia A Fisher, Nita G Forouhi, Oscar H Franco, Yechiel Friedlander, He Gao, Bruna Gigante, Misa Graff, C Charles Gu, Dongfeng Gu, Preeti Gupta, Saskia P Hagenaars, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, Albert Hofman, Barbara V Howard, Steven Hunt, Marguerite R Irvin, Yucheng Jia, Roby Joehanes, Anne E Justice, Tomohiro Katsuya, Joel Kaufman, Nicola D Kerrison, Chiea Chuen Khor, Woon-Puay Koh, Heikki A Koistinen, Pirjo Komulainen, Charles Kooperberg, Jose E Krieger, Michiaki Kubo, Johanna Kuusisto, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Benjamin Lehne, Cora E Lewis, Yize Li, Sing Hui Lim, Shiow Lin, Ching-Ti Liu, Jianjun Liu, Jingmin Liu, Kiang Liu, Yeheng Liu, Marie Loh, Kurt K Lohman, Jirong Long, Tin Louie, Reedik Mägi, Anubha Mahajan, Thomas Meitinger, Andres Metspalu, Lili Milani, Yukihide Momozawa, Andrew P Morris, Thomas H Mosley, Peter Munson, Alison D Murray, Mike A Nalls, Ubaydah Nasri, Jill M Norris, Kari North, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R Palmas, Nicholette D Palmer, James S Pankow, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, Olli T Raitakari, Frida Renström, Treva K Rice, Paul M Ridker, Antonietta Robino, Jennifer G Robinson, Lynda M Rose, Igor Rudan, Charumathi Sabanayagam, Babatunde L Salako, Kevin Sandow, Carsten O Schmidt, Pamela J Schreiner, William R Scott, Sudha Seshadri, Peter Sever, Colleen M Sitlani, Jennifer A Smith, Harold Snieder, John M Starr, Konstantin Strauch, Hua Tang, Kent D Taylor, Yik Ying Teo, Yih Chung Tham, André G Uitterlinden, Melanie Waldenberger, Lihua Wang, Ya X Wang, Wen Bin Wei, Christine Williams, Gregory Wilson, Mary K Wojczynski, Jie Yao, Jian-Min Yuan, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, John C Chambers, Yii-Der Ida Chen, Ulf de Faire, Ian J Deary, Tõnu Esko, Martin Farrall, Terrence Forrester, Paul W Franks, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo Lessa Horta, Yi-Jen Hung, Jost B Jonas, Norihiro Kato, Jaspal S Kooner, Markku Laakso, Terho Lehtimäki, Kae-Woei Liang, Patrik K E Magnusson, Anne B Newman, Albertine J Oldehinkel, Alexandre C Pereira, Susan Redline, Rainer Rettig, Nilesh J Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E Wagenknecht, Nicholas J Wareham, Hugh Watkins, David R Weir, Ananda R Wickremasinghe, Tangchun Wu, Wei Zheng, Yoichiro Kamatani, Cathy C Laurie, Claude Bouchard, Richard S Cooper, Michele K Evans, Vilmundur Gudnason, Sharon L R Kardia, Stephen B Kritchevsky, Daniel Levy, Jeff R O'Connell, Bruce M Psaty, Rob M van Dam, Mario Sims, Donna K Arnett, Dennis O Mook-Kanamori, Tanika N Kelly, Ervin R Fox, Caroline Hayward, Myriam Fornage, Charles N Rotimi, Michael A Province, Cornelia M van Duijn, E Shyong Tai, Tien Yin Wong, Ruth J F Loos, Alex P Reiner, Jerome I Rotter, Xiaofeng Zhu, Laura J Bierut, W James Gauderman, Mark J Caulfield, Paul Elliott, Kenneth Rice, Patricia B Munroe, Alanna C Morrison, L Adrienne Cupples, Dabeeru C Rao, Daniel I Chasman
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries...
March 1, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29437406/combined-forward-backward-asymmetry-measurements-in-top-antitop-quark-production-at-the-tevatron
#8
T Aaltonen, V M Abazov, B Abbott, B S Acharya, M Adams, T Adams, J P Agnew, G D Alexeev, G Alkhazov, A Alton, S Amerio, D Amidei, A Anastassov, A Annovi, J Antos, G Apollinari, J A Appel, T Arisawa, A Artikov, J Asaadi, W Ashmanskas, A Askew, S Atkins, B Auerbach, K Augsten, A Aurisano, V Aushev, Y Aushev, C Avila, F Azfar, F Badaud, W Badgett, T Bae, L Bagby, B Baldin, D V Bandurin, S Banerjee, A Barbaro-Galtieri, E Barberis, P Baringer, V E Barnes, B A Barnett, P Barria, J F Bartlett, P Bartos, U Bassler, M Bauce, V Bazterra, A Bean, F Bedeschi, M Begalli, S Behari, L Bellantoni, G Bellettini, J Bellinger, D Benjamin, A Beretvas, S B Beri, G Bernardi, R Bernhard, I Bertram, M Besançon, R Beuselinck, P C Bhat, S Bhatia, V Bhatnagar, A Bhatti, K R Bland, G Blazey, S Blessing, K Bloom, B Blumenfeld, A Bocci, A Bodek, A Boehnlein, D Boline, E E Boos, G Borissov, D Bortoletto, M Borysova, J Boudreau, A Boveia, A Brandt, O Brandt, L Brigliadori, M Brochmann, R Brock, C Bromberg, A Bross, D Brown, E Brucken, X B Bu, J Budagov, H S Budd, M Buehler, V Buescher, V Bunichev, S Burdin, K Burkett, G Busetto, P Bussey, C P Buszello, P Butti, A Buzatu, A Calamba, E Camacho-Pérez, S Camarda, M Campanelli, F Canelli, B Carls, D Carlsmith, R Carosi, S Carrillo, B Casal, M Casarsa, B C K Casey, H Castilla-Valdez, A Castro, P Catastini, S Caughron, D Cauz, V Cavaliere, A Cerri, L Cerrito, S Chakrabarti, K M Chan, A Chandra, A Chapelain, E Chapon, G Chen, Y C Chen, M Chertok, G Chiarelli, G Chlachidze, K Cho, S W Cho, S Choi, D Chokheli, B Choudhary, S Cihangir, D Claes, A Clark, C Clarke, J Clutter, M E Convery, J Conway, M Cooke, W E Cooper, M Corbo, M Corcoran, M Cordelli, F Couderc, M-C Cousinou, C A Cox, D J Cox, M Cremonesi, D Cruz, J Cuevas, R Culbertson, J Cuth, D Cutts, A Das, N d'Ascenzo, M Datta, G Davies, P de Barbaro, S J de Jong, E De La Cruz-Burelo, F Déliot, R Demina, L Demortier, M Deninno, D Denisov, S P Denisov, M D'Errico, S Desai, C Deterre, K DeVaughan, F Devoto, A Di Canto, B Di Ruzza, H T Diehl, M Diesburg, P F Ding, J R Dittmann, A Dominguez, S Donati, M D'Onofrio, M Dorigo, A Driutti, A Drutskoy, A Dubey, L V Dudko, A Duperrin, S Dutt, M Eads, K Ebina, R Edgar, D Edmunds, A Elagin, J Ellison, V D Elvira, Y Enari, R Erbacher, S Errede, B Esham, H Evans, A Evdokimov, V N Evdokimov, S Farrington, A Fauré, L Feng, T Ferbel, J P Fernández Ramos, F Fiedler, R Field, F Filthaut, W Fisher, H E Fisk, G Flanagan, R Forrest, M Fortner, H Fox, J Franc, M Franklin, J C Freeman, H Frisch, S Fuess, Y Funakoshi, C Galloni, P H Garbincius, A Garcia-Bellido, J A García-González, A F Garfinkel, P Garosi, V Gavrilov, W Geng, C E Gerber, H Gerberich, E Gerchtein, Y Gershtein, S Giagu, V Giakoumopoulou, K Gibson, C M Ginsburg, G Ginther, N Giokaris, P Giromini, V Glagolev, D Glenzinski, O Gogota, M Gold, D Goldin, A Golossanov, G Golovanov, G Gomez, G Gomez-Ceballos, M Goncharov, O González López, I Gorelov, A T Goshaw, K Goulianos, E Gramellini, P D Grannis, S Greder, H Greenlee, G Grenier, Ph Gris, J-F Grivaz, A Grohsjean, C Grosso-Pilcher, S Grünendahl, M W Grünewald, T Guillemin, J Guimaraes da Costa, G Gutierrez, P Gutierrez, S R Hahn, J Haley, J Y Han, L Han, F Happacher, K Hara, K Harder, M Hare, A Harel, R F Harr, T Harrington-Taber, K Hatakeyama, J M Hauptman, C Hays, J Hays, T Head, T Hebbeker, D Hedin, H Hegab, J Heinrich, A P Heinson, U Heintz, C Hensel, I Heredia-De La Cruz, M Herndon, K Herner, G Hesketh, M D Hildreth, R Hirosky, T Hoang, J D Hobbs, A Hocker, B Hoeneisen, J Hogan, M Hohlfeld, J L Holzbauer, Z Hong, W Hopkins, S Hou, I Howley, Z Hubacek, R E Hughes, U Husemann, M Hussein, J Huston, V Hynek, I Iashvili, Y Ilchenko, R Illingworth, G Introzzi, M Iori, A S Ito, A Ivanov, S Jabeen, M Jaffré, E James, D Jang, A Jayasinghe, B Jayatilaka, E J Jeon, M S Jeong, R Jesik, P Jiang, S Jindariani, K Johns, E Johnson, M Johnson, A Jonckheere, M Jones, P Jonsson, K K Joo, J Joshi, S Y Jun, A W Jung, T R Junk, A Juste, E Kajfasz, M Kambeitz, T Kamon, P E Karchin, D Karmanov, A Kasmi, Y Kato, I Katsanos, M Kaur, R Kehoe, S Kermiche, W Ketchum, J Keung, N Khalatyan, A Khanov, A Kharchilava, Y N Kharzheev, B Kilminster, D H Kim, H S Kim, J E Kim, M J Kim, S H Kim, S B Kim, Y J Kim, Y K Kim, N Kimura, M Kirby, I Kiselevich, J M Kohli, K Kondo, D J Kong, J Konigsberg, A V Kotwal, A V Kozelov, J Kraus, M Kreps, J Kroll, M Kruse, T Kuhr, A Kumar, A Kupco, M Kurata, T Kurča, V A Kuzmin, A T Laasanen, S Lammel, S Lammers, M Lancaster, K Lannon, G Latino, P Lebrun, H S Lee, H S Lee, J S Lee, S W Lee, W M Lee, X Lei, J Lellouch, S Leo, S Leone, J D Lewis, D Li, H Li, L Li, Q Z Li, J K Lim, A Limosani, D Lincoln, J Linnemann, V V Lipaev, E Lipeles, R Lipton, A Lister, H Liu, Q Liu, T Liu, Y Liu, A Lobodenko, S Lockwitz, A Loginov, M Lokajicek, R Lopes de Sa, D Lucchesi, A Lucà, J Lueck, P Lujan, P Lukens, R Luna-Garcia, G Lungu, A L Lyon, J Lys, R Lysak, A K A Maciel, R Madar, R Madrak, P Maestro, R Magaña-Villalba, S Malik, S Malik, V L Malyshev, G Manca, A Manousakis-Katsikakis, J Mansour, L Marchese, F Margaroli, P Marino, J Martínez-Ortega, K Matera, M E Mattson, A Mazzacane, P Mazzanti, R McCarthy, C L McGivern, R McNulty, A Mehta, P Mehtala, M M Meijer, A Melnitchouk, D Menezes, P G Mercadante, M Merkin, C Mesropian, A Meyer, J Meyer, T Miao, F Miconi, D Mietlicki, A Mitra, H Miyake, S Moed, N Moggi, N K Mondal, C S Moon, R Moore, M J Morello, A Mukherjee, M Mulhearn, Th Muller, P Murat, M Mussini, J Nachtman, Y Nagai, J Naganoma, E Nagy, I Nakano, A Napier, M Narain, R Nayyar, H A Neal, J P Negret, J Nett, P Neustroev, H T Nguyen, T Nigmanov, L Nodulman, S Y Noh, O Norniella, T Nunnemann, L Oakes, S H Oh, Y D Oh, T Okusawa, R Orava, J Orduna, L Ortolan, N Osman, C Pagliarone, A Pal, E Palencia, P Palni, V Papadimitriou, N Parashar, V Parihar, S K Park, W Parker, R Partridge, N Parua, A Patwa, G Pauletta, M Paulini, C Paus, B Penning, M Perfilov, Y Peters, K Petridis, G Petrillo, P Pétroff, T J Phillips, G Piacentino, E Pianori, J Pilot, K Pitts, C Plager, M-A Pleier, V M Podstavkov, L Pondrom, A V Popov, S Poprocki, K Potamianos, A Pranko, M Prewitt, D Price, N Prokopenko, F Prokoshin, F Ptohos, G Punzi, J Qian, A Quadt, B Quinn, P N Ratoff, I Razumov, I Redondo Fernández, P Renton, M Rescigno, F Rimondi, I Ripp-Baudot, L Ristori, F Rizatdinova, A Robson, T Rodriguez, S Rolli, M Rominsky, M Ronzani, R Roser, J L Rosner, A Ross, C Royon, P Rubinov, R Ruchti, F Ruffini, A Ruiz, J Russ, V Rusu, G Sajot, W K Sakumoto, Y Sakurai, A Sánchez-Hernández, M P Sanders, L Santi, A S Santos, K Sato, G Savage, V Saveliev, M Savitskyi, A Savoy-Navarro, L Sawyer, T Scanlon, R D Schamberger, Y Scheglov, H Schellman, P Schlabach, E E Schmidt, M Schott, C Schwanenberger, T Schwarz, R Schwienhorst, L Scodellaro, F Scuri, S Seidel, Y Seiya, J Sekaric, A Semenov, H Severini, F Sforza, E Shabalina, S Z Shalhout, V Shary, S Shaw, A A Shchukin, T Shears, P F Shepard, M Shimojima, O Shkola, M Shochet, I Shreyber-Tecker, V Simak, A Simonenko, P Skubic, P Slattery, K Sliwa, J R Smith, F D Snider, G R Snow, J Snow, S Snyder, S Söldner-Rembold, H Song, L Sonnenschein, V Sorin, K Soustruznik, R St Denis, M Stancari, J Stark, N Stefaniuk, D Stentz, D A Stoyanova, M Strauss, J Strologas, Y Sudo, A Sukhanov, I Suslov, L Suter, P Svoisky, K Takemasa, Y Takeuchi, J Tang, M Tecchio, P K Teng, J Thom, E Thomson, V Thukral, M Titov, D Toback, S Tokar, V V Tokmenin, K Tollefson, T Tomura, D Tonelli, S Torre, D Torretta, P Totaro, M Trovato, Y-T Tsai, D Tsybychev, B Tuchming, C Tully, F Ukegawa, S Uozumi, L Uvarov, S Uvarov, S Uzunyan, R Van Kooten, W M van Leeuwen, N Varelas, E W Varnes, I A Vasilyev, F Vázquez, G Velev, C Vellidis, A Y Verkheev, C Vernieri, L S Vertogradov, M Verzocchi, M Vesterinen, M Vidal, D Vilanova, R Vilar, J Vizán, M Vogel, P Vokac, G Volpi, P Wagner, H D Wahl, R Wallny, M H L S Wang, S M Wang, J Warchol, D Waters, G Watts, M Wayne, J Weichert, L Welty-Rieger, W C Wester, D Whiteson, A B Wicklund, S Wilbur, H H Williams, M R J Williams, G W Wilson, J S Wilson, P Wilson, B L Winer, P Wittich, M Wobisch, S Wolbers, H Wolfmeister, D R Wood, T Wright, X Wu, Z Wu, T R Wyatt, Y Xie, R Yamada, K Yamamoto, D Yamato, S Yang, T Yang, U K Yang, Y C Yang, W-M Yao, T Yasuda, Y A Yatsunenko, W Ye, Z Ye, G P Yeh, K Yi, H Yin, K Yip, J Yoh, K Yorita, T Yoshida, S W Youn, G B Yu, I Yu, J M Yu, A M Zanetti, Y Zeng, J Zennamo, T G Zhao, B Zhou, C Zhou, J Zhu, M Zielinski, D Zieminska, L Zivkovic, S Zucchelli
The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of sqrt[s]=1.96  TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A_{FB}^{tt[over ¯]}=0...
January 26, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29436711/evidence-for-dispensability-of-protein-kinase-r-in-host-control-of-tuberculosis
#9
Shashirekha Mundhra, Ruslana Bryk, Natalie Hawryluk, Tuo Zhang, Xiuju Jiang, Carl F Nathan
Genetic deficiency of protein kinase R (PKR) in mice was reported to enhance macrophage activation in vitro in response to interferon-γ (IFNγ) and to reduce the burden of Mycobacterium tuberculosis (Mtb) in vivo (Wu et al. PloS One. 2012 7:e30512). Consistent with this, treatment of wild-type (WT) macrophages in vitro with a novel PKR inhibitor (Bryk et al., Bioorg. Med. Chem. Lett. 2011 21:4108-4114) also enhanced IFN-γ-dependent macrophage activation (Wu et al. PloS One. 2012 7:e30512). Here we show that co-treatment with IFN-γ and a new PKR inhibitor identified herein to be highly but not completely selective likewise induced macrophages to produce more reactive nitrogen intermediates (RNI) and tumor necrosis factor alpha (TNF-α) and less interleukin 10 (IL-10) than seen with IFN-γ alone...
April 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29414943/genomics-of-the-origin-and-evolution-of-citrus
#10
Guohong Albert Wu, Javier Terol, Victoria Ibanez, Antonio López-García, Estela Pérez-Román, Carles Borredá, Concha Domingo, Francisco R Tadeo, Jose Carbonell-Caballero, Roberto Alonso, Franck Curk, Dongliang Du, Patrick Ollitrault, Mikeal L Roose, Joaquin Dopazo, Frederick G Gmitter, Daniel S Rokhsar, Manuel Talon
The genus Citrus, comprising some of the most widely cultivated fruit crops worldwide, includes an uncertain number of species. Here we describe ten natural citrus species, using genomic, phylogenetic and biogeographic analyses of 60 accessions representing diverse citrus germ plasms, and propose that citrus diversified during the late Miocene epoch through a rapid southeast Asian radiation that correlates with a marked weakening of the monsoons. A second radiation enabled by migration across the Wallace line gave rise to the Australian limes in the early Pliocene epoch...
February 15, 2018: Nature
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#11
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29274429/retinoic-acid-synthesis-by-ng2-expressing-cells-promotes-a-permissive-environment-for-axonal-outgrowth
#12
Maria B Goncalves, Yue Wu, Diogo Trigo, Earl Clarke, Tony Malmqvist, John Grist, Carl Hobbs, Thomas P Carlstedt, Jonathan P T Corcoran
Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads to regeneration in the adult nervous system and numerous studies have shown that the specific activation of the retinoic acid receptor β (RARβ) is required for this process. Here we identify a novel mechanism by which neuronal RARβ activation results in the endogenous synthesis of RA which is released in association with exosomes and acts as a positive cue to axonal/neurite outgrowth. Using an established rodent model of RARβ induced axonal regeneration, we show that neuronal RARβ activation upregulates the enzymes involved in RA synthesis in a cell specific manner; alcohol dehydrogenase7 (ADH7) in neurons and aldehyde dehydrogenase 2 (Raldh2) in NG2 expressing cells (NG2+ cells)...
March 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29196075/outcomes-after-allogeneic-transplant-in-patients-with-wiskott-aldrich-syndrome
#13
Alexander Ngwube, I Celine Hanson, Jordan Orange, Nicholas L Rider, Filiz Seeborg, William Shearer, Lenora Noroski, Sarah Nicholas, Lisa Forbes, Kathryn Leung, Ghadir Sasa, Swati Naik, Meenakshi Hegde, Bilal Omer, Nabil Ahmed, Carl Allen, Stephen Gottschalk, Meng-Fen Wu, Hao Liu, Malcolm Brenner, Helen Heslop, Robert Krance, Caridad Martinez
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by a triad of immunodeficiency, eczema, and thrombocytopenia. Currently, hematopoietic stem cell transplantation (HSCT) is the most reliable curative treatment with excellent results for patients with HLA-matched family or unrelated donors. However, even after fully myeloablative preparative regimens, mixed donor chimerism is a potential concern. We performed a retrospective chart review of 12 children who underwent allogeneic HSCT for WAS to report our experience...
March 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29180699/mutant-idh1-dependent-chromatin-state-reprogramming-reversibility-and-persistence
#14
Sevin Turcan, Vladimir Makarov, Julian Taranda, Yuxiang Wang, Armida W M Fabius, Wei Wu, Yupeng Zheng, Nour El-Amine, Sara Haddock, Gouri Nanjangud, H Carl LeKaye, Cameron Brennan, Justin Cross, Jason T Huse, Neil L Kelleher, Pavel Osten, Craig B Thompson, Timothy A Chan
Mutations in IDH1 and IDH2 (encoding isocitrate dehydrogenase 1 and 2) drive the development of gliomas and other human malignancies. Mutant IDH1 induces epigenetic changes that promote tumorigenesis, but the scale and reversibility of these changes are unknown. Here, using human astrocyte and glioma tumorsphere systems, we generate a large-scale atlas of mutant-IDH1-induced epigenomic reprogramming. We characterize the reversibility of the alterations in DNA methylation, the histone landscape, and transcriptional reprogramming that occur following IDH1 mutation...
January 2018: Nature Genetics
https://www.readbyqxmd.com/read/29152055/correction-to-structure-based-design-of-non-natural-peptidic-macrocyclic-mcl-1-inhibitors
#15
Jeffrey W Johannes, Stephanie Bates, Carl Beigie, Matthew A Belmonte, John Breen, Shenggen Cao, Paolo A Centrella, Matthew A Clark, John W Cuozzo, Christoph E Dumelin, Andrew D Ferguson, Sevan Habeshian, David Hargreaves, Camil Joubran, Steven Kazmirski, Anthony D Keefe, Michelle L Lamb, Haiye Lan, Yunxia Li, Hao Ma, Scott Mlynarski, Martin J Packer, Philip B Rawlins, Daniel W Robbins, Haidong Shen, Eric A Sigel, Holly H Soutter, Nancy Su, Dawn M Troast, Haiyun Wang, Kate F Wickson, Chengyan Wu, Ying Zhang, Qiuying Zhao, Xiaolan Zheng, Alexander W Hird
[This corrects the article DOI: 10.1021/acsmedchemlett.6b00464.].
November 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29120600/recoil-effect-and-photoemission-splitting-of-trions-in-monolayer-mos-2
#16
Qicheng Zhang, Carl H Naylor, Zhaoli Gao, Ruizhe Wu, Irfan Haider Abidi, Meng-Qiang Zhao, Yao Ding, Aldrine Abenoja Cagang, Minghao Zhuang, Xuewu Ou, Zhengtang Luo
The 2D geometry nature and low dielectric constant in transition-metal dichalcogenides lead to easily formed strongly bound excitons and trions. Here, we studied the photoluminescence of van der Waals heterostructures of monolayer MoS2 and graphene at room temperature and observed two photoluminescence peaks that are associated with trion emission. Further study of different heterostructure configurations confirms that these two peaks are intrinsic to MoS2 and originate from a bound state and Fermi level, respectively, of which both accept recoiled electrons from trion recombination...
November 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/29116093/the-challenge-of-mapping-the-human-connectome-based-on-diffusion-tractography
#17
Klaus H Maier-Hein, Peter F Neher, Jean-Christophe Houde, Marc-Alexandre Côté, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E Reddick, John O Glass, David Qixiang Chen, Yuanjing Feng, Chengfeng Gao, Ye Wu, Jieyan Ma, H Renjie, Qiang Li, Carl-Fredrik Westin, Samuel Deslauriers-Gauthier, J Omar Ocegueda González, Michael Paquette, Samuel St-Jean, Gabriel Girard, François Rheault, Jasmeen Sidhu, Chantal M W Tax, Fenghua Guo, Hamed Y Mesri, Szabolcs Dávid, Martijn Froeling, Anneriet M Heemskerk, Alexander Leemans, Arnaud Boré, Basile Pinsard, Christophe Bedetti, Matthieu Desrosiers, Simona Brambati, Julien Doyon, Alessia Sarica, Roberta Vasta, Antonio Cerasa, Aldo Quattrone, Jason Yeatman, Ali R Khan, Wes Hodges, Simon Alexander, David Romascano, Muhamed Barakovic, Anna Auría, Oscar Esteban, Alia Lemkaddem, Jean-Philippe Thiran, H Ertan Cetingul, Benjamin L Odry, Boris Mailhe, Mariappan S Nadar, Fabrizio Pizzagalli, Gautam Prasad, Julio E Villalon-Reina, Justin Galvis, Paul M Thompson, Francisco De Santiago Requejo, Pedro Luque Laguna, Luis Miguel Lacerda, Rachel Barrett, Flavio Dell'Acqua, Marco Catani, Laurent Petit, Emmanuel Caruyer, Alessandro Daducci, Tim B Dyrby, Tim Holland-Letz, Claus C Hilgetag, Bram Stieltjes, Maxime Descoteaux
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent)...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29116004/reproductive-profiles-and-risk-of-breast-cancer-subtypes-a-multi-center-case-only-study
#18
Olivier Brouckaert, Anja Rudolph, Annouschka Laenen, Renske Keeman, Manjeet K Bolla, Qin Wang, Adelheid Soubry, Hans Wildiers, Irene L Andrulis, Volker Arndt, Matthias W Beckmann, Javier Benitez, Carl Blomqvist, Stig E Bojesen, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Georgia Chenevix-Trench, Ji-Yeob Choi, Sten Cornelissen, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Mikael Eriksson, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Graham G Giles, Anna González-Neira, Pascal Guénel, Per Hall, Antoinette Hollestelle, John L Hopper, Hidemi Ito, Michael Jones, Daehee Kang, Julia A Knight, Veli-Matti Kosma, Jingmei Li, Annika Lindblom, Jenna Lilyquist, Artitaya Lophatananon, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Keitaro Matsuo, Kenneth Muir, Heli Nevanlinna, Paolo Peterlongo, Katri Pylkäs, Suleeporn Saajrang, Caroline Seynaeve, Chen-Yang Shen, Xiao-Ou Shu, Melissa C Southey, Anthony Swerdlow, Soo-Hwang Teo, Rob A E M Tollenaar, Thérèse Truong, Chiu-Chen Tseng, Alexandra J van den Broek, Carolien H M van Deurzen, Robert Winqvist, Anna H Wu, Cheng Har Yip, Jyh-Cherng Yu, Wei Zheng, Roger L Milne, Paul D P Pharoah, Douglas F Easton, Marjanka K Schmidt, Montserrat Garcia-Closas, Jenny Chang-Claude, Diether Lambrechts, Patrick Neven
BACKGROUND: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. METHODS: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC)...
November 7, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29098954/guidelines-for-genome-scale-analysis-of-biological-rhythms
#19
Michael E Hughes, Katherine C Abruzzi, Ravi Allada, Ron Anafi, Alaaddin Bulak Arpat, Gad Asher, Pierre Baldi, Charissa de Bekker, Deborah Bell-Pedersen, Justin Blau, Steve Brown, M Fernanda Ceriani, Zheng Chen, Joanna C Chiu, Juergen Cox, Alexander M Crowell, Jason P DeBruyne, Derk-Jan Dijk, Luciano DiTacchio, Francis J Doyle, Giles E Duffield, Jay C Dunlap, Kristin Eckel-Mahan, Karyn A Esser, Garret A FitzGerald, Daniel B Forger, Lauren J Francey, Ying-Hui Fu, Frédéric Gachon, David Gatfield, Paul de Goede, Susan S Golden, Carla Green, John Harer, Stacey Harmer, Jeff Haspel, Michael H Hastings, Hanspeter Herzel, Erik D Herzog, Christy Hoffmann, Christian Hong, Jacob J Hughey, Jennifer M Hurley, Horacio O de la Iglesia, Carl Johnson, Steve A Kay, Nobuya Koike, Karl Kornacker, Achim Kramer, Katja Lamia, Tanya Leise, Scott A Lewis, Jiajia Li, Xiaodong Li, Andrew C Liu, Jennifer J Loros, Tami A Martino, Jerome S Menet, Martha Merrow, Andrew J Millar, Todd Mockler, Felix Naef, Emi Nagoshi, Michael N Nitabach, Maria Olmedo, Dmitri A Nusinow, Louis J Ptáček, David Rand, Akhilesh B Reddy, Maria S Robles, Till Roenneberg, Michael Rosbash, Marc D Ruben, Samuel S C Rund, Aziz Sancar, Paolo Sassone-Corsi, Amita Sehgal, Scott Sherrill-Mix, Debra J Skene, Kai-Florian Storch, Joseph S Takahashi, Hiroki R Ueda, Han Wang, Charles Weitz, Pål O Westermark, Herman Wijnen, Ying Xu, Gang Wu, Seung-Hee Yoo, Michael Young, Eric Erquan Zhang, Tomasz Zielinski, John B Hogenesch
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. These methods hold significant promise for future discovery, particularly when combined with computational modeling. However, genome-scale experiments are costly and laborious, yielding "big data" that are conceptually and statistically difficult to analyze. There is no obvious consensus regarding design or analysis...
October 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29074736/molecular-basis-of-cenp-c-association-with-the-cenp-a-nucleosome-at-yeast-centromeres
#20
Hua Xiao, Feng Wang, Jan Wisniewski, Alexey K Shaytan, Rodolfo Ghirlando, Peter C FitzGerald, Yingzi Huang, Debbie Wei, Shipeng Li, David Landsman, Anna R Panchenko, Carl Wu
Histone CENP-A-containing nucleosomes play an important role in nucleating kinetochores at centromeres for chromosome segregation. However, the molecular mechanisms by which CENP-A nucleosomes engage with kinetochore proteins are not well understood. Here, we report the finding of a new function for the budding yeast Cse4/CENP-A histone-fold domain interacting with inner kinetochore protein Mif2/CENP-C. Strikingly, we also discovered that AT-rich centromere DNA has an important role for Mif2 recruitment. Mif2 contacts one side of the nucleosome dyad, engaging with both Cse4 residues and AT-rich nucleosomal DNA...
October 1, 2017: Genes & Development
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