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https://www.readbyqxmd.com/read/29353431/sensitive-electrochemical-detection-of-microrna-21-based-on-propylamine-functionalized-mesoporous-silica-with-glucometer-readout
#1
Kun Deng, Yong Zhang, Xuedong Tong
A new homogeneous electrochemical sensing system was developed for sensitive detection of microRNA-21 (miRNA-21) based on target-induced glucose release from propylamine-functionalized mesoporous silica nanoparticle (MSN) with glucometer readout. Glucose molecules (as the signal tracers) were initially gated into the pores through the interaction of the negatively charged anchor DNA with the aminated MSN. Upon addition of target miRNA, the analyte competitively hybridized with anchor DNA to form the RNA-DNA duplex, thus resulting in detachment of anchor DNA from the MSN accompanying the pore opening...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353126/evaluation-of-gamma-contribution-in-a-neutron-calibration-field-of-am-be241-source
#2
Thiem Ngoc Le, Hoai-Nam Tran, Thang Duc Duong, Quynh Ngoc Nguyen, Tuan Quang Ho, Giap Van Trinh, Khai Tuan Nguyen
The paper presents the evaluation of gamma contribution in a neutron calibration field of a 241Am-Be source. The characterization of gamma flux spectra and gamma ambient dose equivalent rates has been performed using a portable NaI(Tl) gamma spectrometer. For obtaining the gamma ambient dose equivalent rates from the measured spectra, two approaches were applied based on the applications of the G(E) function and the ICRP 74 conversion factors, respectively. Comparison of the gamma ambient dose equivalent rates obtained from the two approaches shows an agreement within 5%...
January 6, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29352237/wearable-sweat-rate-sensors-for-human-thermal-comfort-monitoring
#3
Jai Kyoung Sim, Sunghyun Yoon, Young-Ho Cho
We propose watch-type sweat rate sensors capable of automatic natural ventilation by integrating miniaturized thermo-pneumatic actuators, and experimentally verify their performances and applicability. Previous sensors using natural ventilation require manual ventilation process or high-power bulky thermo-pneumatic actuators to lift sweat rate detection chambers above skin for continuous measurement. The proposed watch-type sweat rate sensors reduce operation power by minimizing expansion fluid volume to 0...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351337/a-portable-prototype-magnetometer-to-differentiate-ischemic-and-non-ischemic-heart-disease-in-patients-with-chest-pain
#4
Shima Ghasemi-Roudsari, Abbas Al-Shimary, Benjamin Varcoe, Rowena Byrom, Lorraine Kearney, Mark Kearney
BACKGROUND: Magnetocardiography (MCG) is a non-invasive technique used to measure and map cardiac magnetic fields. We describe the predictive performance of a portable prototype magnetometer designed for use in acute and routine clinical settings. We assessed the predictive ability of the measurements derived from the magnetometer for the ruling-out of healthy subjects and patients whose chest pain has a non-ischemic origin from those with ischemic heart disease (IHD). METHODS: MCG data were analyzed from a technical performance study, a pilot clinical study, and a young healthy reference group...
2018: PloS One
https://www.readbyqxmd.com/read/29351280/a-generic-framework-for-individual-based-modelling-and-physical-biological-interaction
#5
Asbjørn Christensen, Patrizio Mariani, Mark R Payne
The increased availability of high-resolution ocean data globally has enabled more detailed analyses of physical-biological interactions and their consequences to the ecosystem. We present IBMlib, which is a versatile, portable and computationally effective framework for conducting Lagrangian simulations in the marine environment. The purpose of the framework is to handle complex individual-level biological models of organisms, combined with realistic 3D oceanographic model of physics and biogeochemistry describing the environment of the organisms without assumptions about spatial or temporal scales...
2018: PloS One
https://www.readbyqxmd.com/read/29350517/cellphone-enabled-microwell-based-microbead-aggregation-assay-for-portable-biomarker-detection
#6
Weiwei Cui, Meihang He, Luye Mu, Zuzeng Lin, Yanyan Wang, Wei Pang, Mark A Reed, Xuexin Duan
Quantitative biomarker detection methods featured with rapidity, high accuracy, and label-free are demonstrated for the development of point-of-care (POC) technologies or "beside" diagnostics. Microbead aggregation via protein-specific linkage provides an effective approach for selective capture of biomarkers from the samples, and can directly readout the presence and amount of the targets. However, sensors or microfluidic analyzers that can accurately quantify the microbead aggrega-tion are scared. In this work, we demonstrate a microwell-based microbeads analyzing system, by which online manipula-tions of microbeads including trapping, arraying, and rotations can be realized, providing a series of microfluidic approaches to layout the aggregated microbeads for further convenient characterizations...
January 19, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29350323/william-e-vidaver-1921-2017-an-innovator-enthusiastic-scientist-inspiring-teacher-and-a-wonderful-friend
#7
A H Jay Burr, Aaron Vidaver, Ulrich Schreiber, Doug Bruce, Danielle J Donnelly
William (Bill) E. Vidaver (February 2, 1921-August 31, 2017), who did his Ph.D. with Laurence (Larry) R. Blinks at Stanford (1964) and a postdoc with C. Stacy French (1965), taught and did research at Simon Fraser University (SFU) for almost 30 years. Here he published over 80 papers in photosynthesis-related areas co-authored by his graduate students, postdocs, visiting professors and SFU colleagues. He developed a unique high-pressure cuvette for the study of oxygen exchange and studied high-pressure effects in photosynthesis...
January 19, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29350190/development-and-validation-of-a-high-resolution-mapping-platform-to-aid-in-the-public-awareness-of-radiological-hazards
#8
Peter George Martin, Dean Connor, Oliver David Payton, Macarena Leal-Olloqui, Anya C Keatley, Thomas B Scott
The distribution, quantification and exposure-related effects of radiation in the environment, arising from both natural and anthropogenic sources, is of great (and growing) concern for global populations. Recent events at the Fukushima Daiichi Nuclear Plant (FDNPP) have further highlighted the importance of developing radiation mapping technologies that not only contribute to the continued assessment of contamination, but can also serve as an educational tool for members of the public regarding its behaviour and extent...
January 19, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29350018/allergy-and-high-trait-anxiety-are-related-to-increases-in-heart-rate-variability-results-of-naturalistic-long-term-design-study
#9
J Rajcani, P Solarikova, I Brezina
A number of studies report heart rate variability (HRV) changes in allergic as well as high trait anxious people, and associations between allergic inflammation and trait anxiety. This study investigated HRV of 20 low anxious allergic, 19 healthy high trait anxious and 18 healthy low anxious, in naturalistic setting. On arranged research days, subjects performed measurements using portable ECG device and subjective self-assessment of perceived stress. Five repeated measurements data from each subject have shown increases in overall HRV, as well as HRV on respiratory frequencies in both allergy and high trait anxiety...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29349733/point-of-care-ultrasound-pocus-of-the-upper-airway
#10
REVIEW
Kong Eric You-Ten, Naveed Siddiqui, Wendy H Teoh, Michael S Kristensen
Airway management is a critical skill in the practice of several medical specialities including anesthesia, emergency medicine, and critical care. Over the years mounting evidence has showed an increasing role of ultrasound (US) in airway management. The objective of this narrative review is to provide an overview of the indications for point-of-care ultrasound (POCUS) of the upper airway. The use of US to guide and assist clinical airway management has potential benefits for both provider and patient. Ultrasound can be utilized to determine airway size and predict the appropriate diameter of single-lumen endotracheal tubes (ETTs), double-lumen ETTs, and tracheostomy tubes...
January 18, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29348058/elemental-assessment-of-vegetation-via-portable-x-ray-fluorescence-pxrf-spectrometry
#11
Candice McGladdery, David C Weindorf, Somsubhra Chakraborty, Bin Li, Laura Paulette, Dorina Podar, Delaina Pearson, Nana Yaw O Kusi, Bogdan Duda
Elemental concentrations in vegetation are of critical importance, whether establishing plant essential element concentrations (toxicity vs. deficiency) or investigating deleterious elements (e.g., heavy metals) differentially extracted from the soil by plants. Traditionally, elemental analysis of vegetation has been facilitated by acid digestion followed by quantification via inductively coupled plasma (ICP) or atomic absorption (AA) spectroscopy. Previous studies have utilized portable X-ray fluorescence (PXRF) spectroscopy to quantify elements in soils, but few have evaluated the vegetation...
January 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29347598/electric-generation-and-ratcheted-transport-of-contact-charged-drops
#12
Charles A Cartier, Jason R Graybill, Kyle J M Bishop
We describe a simple microfluidic system that enables the steady generation and efficient transport of aqueous drops using only a constant voltage input. Drop generation is achieved through an electrohydrodynamic dripping mechanism by which conductive drops grow and detach from a grounded nozzle in response to an electric field. The now-charged drops are transported down a ratcheted channel by contact charge electrophoresis powered by the same voltage input used for drop generation. We investigate how the drop size, generation frequency, and transport velocity depend on system parameters such as the liquid viscosity, interfacial tension, applied voltage, and channel dimensions...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346441/a-portable-system-for-processing-donated-whole-blood-into-high-quality-components-without-centrifugation
#13
Sean C Gifford, Briony C Strachan, Hui Xia, Eszter Vörös, Kian Torabian, Taylor A Tomasino, Gary D Griffin, Benjamin Lichtiger, Fleur M Aung, Sergey S Shevkoplyas
BACKGROUND: The use of centrifugation-based approaches for processing donated blood into components is routine in the industrialized world, as disparate storage conditions require the rapid separation of 'whole blood' into distinct red blood cell (RBC), platelet, and plasma products. However, the logistical complications and potential cellular damage associated with centrifugation/apheresis manufacturing of blood products are well documented. The objective of this study was to evaluate a proof-of-concept system for whole blood processing, which does not employ electromechanical parts, is easily portable, and can be operated immediately after donation with minimal human labor...
2018: PloS One
https://www.readbyqxmd.com/read/29346286/a-more-efficient-transportable-and-scalable-system-for-real-time-activities-and-exercises-recognition
#14
Kévin Chapron, Valère Plantevin, Florentin Thullier, Kévin Bouchard, Elise Duchesne, Sébastien Gaboury
Many people in the world are affected by muscle wasting, especially the population hits by myotonic dystrophy type 1 (DM1). Those people are usually given a program of multiple physical exercises to do. While DM1 and many other people have difficulties attending commercial centers to realize their program, a solution is to develop such a program completable at home. To this end, we developed a portable system that patients could bring home. This prototype is an improved version of the previous one using Wi-Fi, as this new prototype runs on BLE technology...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29345623/affordable-and-accurate-large-scale-hybrid-functional-calculations-on-gpu-accelerated-supercomputers
#15
Laura E Ratcliff, Augustin Degomme, José A Flores-Livas, Stefan Goedecker, Luigi Genovese
Performing high accuracy hybrid functional calculations for condensed matter systems containing a large number of atoms is at present computationally very demanding or even out of reach if high quality basis sets are used. We present a highly optimized multiple GPU implementation of the exact exchange operator which allows one to perform fast hybrid functional density-functional theory calculations with systematic basis sets without additional approximations for up to a thousand atoms...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29345541/running-mechanics-and-metabolic-responses-with-water-bottles-and-bottle-belt-holders
#16
Heather K Vincent, Laura A Zdziarski, Kyle Fallgatter, Giorgio Negron, Cong Chen, Trevor Leavitt, MaryBeth Horodyski, Joseph G Wasser, Kevin R Vincent
PURPOSE: This study determined whether differential kinematics, kinetics, rates of energy use and cardiopulmonary responses occurred during running with water bottles and bottle belt holders compared to running only. METHODS: Trained runners (N=42; 27.2±6.4 yr) ran on an instrumented treadmill for four conditions in a randomized order: 1) control run (CON); 2) hand-held full water bottle (FULL, 16.9 fluid oz; 454 g); 3) hand-held half-full water bottle (HALF, 8...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29345538/real-time-monitoring-of-nanoscale-tio2-concentration-by-spectrophotometry-implications-of-agglomeration-due-to-natural-organic-matter-and-multivalent-ions
#17
Andrew B Holmes, Frank X Gu
The study of the environmental fate of nanoscale TiO2 (n-TiO2) is a major recent research focus which requires a rapid and accurate on-site concentration determination method. Inductively coupled plasma mass spectroscopy (ICP-MS) has been the most widely used method for determining the concentration of n-TiO2 in environmental samples; however, poses many challenges, such as hazardous hydrofluoric acid pre-treatment and clear limitations in mobile on-site measurement and monitoring. This study demonstrates that industrial wastewater containing natural organic matter (NOM) can present a major challenge to the analysis of n-TiO2 by ICP-MS, and introduces a spectrophotometry technique that can be used as an alternative...
January 18, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29345430/wearable-wireless-tyrosinase-bandage-and-microneedle-sensors-toward-melanoma-screening
#18
Bianca Ciui, Aida Martin, Rupesh K Mishra, Barbara Brunetti, Tatsuo Nakagawa, Thomas J Dawkins, Mengjia Lyu, Cecilia Cristea, Robert Sandulescu, Joseph Wang
Wearable bendable bandage-based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29344749/diagnosis-of-sleep-apnea-in-patients-with-stable-chronic-heart-failure-using-a-portable-sleep-test-diagnostic-device
#19
Inês Araújo, Filipa Marques, Sandra André, Manuel Araújo, Sara Marques, Rita Ferreira, Patrícia Moniz, Margarida Proença, Pedro Borrego, Cândida Fonseca
PURPOSE: ApneaLink is a portable device for the screening of sleep apnea, a prevalent and underdiagnosed comorbidity in heart failure patients. A prospective cross-sectional study in patients with chronic heart failure was carried out to assess the sensitivity and specificity of apnea-hypopnea index (AHI) measurements using ApneaLink against the standard polysomnography test. METHODS: Adult patients with a prior hospitalization in an acute heart failure hospital unit were recruited for the study...
January 17, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29342953/review-of-recent-metamaterial-microfluidic-sensors
#20
REVIEW
Ahmed Salim, Sungjoon Lim
Metamaterial elements/arrays exhibit a sensitive response to fluids yet with a small footprint, therefore, they have been an attractive choice to realize various sensing devices when integrated with microfluidic technology. Micro-channels made from inexpensive biocompatible materials avoid any contamination from environment and require only microliter-nanoliter sample for sensing. Simple design, easy fabrication process, light weight prototype, and instant measurements are advantages as compared to conventional (optical, electrochemical and biological) sensing systems...
January 15, 2018: Sensors
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