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Perinatal asphyxia

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https://www.readbyqxmd.com/read/29441456/knowledge-attitude-and-practice-kap-study-of-pediatricians-on-infantile-spasms
#1
Vamsi Krishna Vaddi, Jitendra Kumar Sahu, Sumeet R Dhawan, Renu Suthar, Naveen Sankhyan
OBJECTIVE: To investigate the knowledge, attitude, and practice of Infantile Spasms among pediatricians. METHODS: A survey was carried out among pediatricians serving in Punjab, Haryana, Chandigarh, Himachal Pradesh and Delhi. The survey was done by Survey Monkey Software through emails by using a structured questionnaire between July 2016 and December 2017. RESULTS: A total of 236 pediatricians responded to the survey. Most of the respondents (95...
February 14, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29424938/observational-study-shows-that-it-is-feasible-to-provide-neuroprotective-treatment-for-neonatal-encephalopathy-in-low-income-countries
#2
T Biselele, J Bambi, G Naulaers, G Tabu, J Kapinga, V Bola, P Makaya, H Tjabbes, B Tady, C Peeters-Scholte
AIM: Perinatal asphyxia is one of the most frequent causes of neonatal morbidity and mortality worldwide and 96% of the burden of neonatal encephalopathy occurs in low-income countries. This study investigated the feasibility of providing neuroprotective treatment for neonatal encephalopathy in low-income countries. METHODS: Neonates with a gestational age of at least 36 weeks, with signs of perinatal asphyxia, were included in this 2015 observational study in three hospitals in Kinshasa, capital of the Democratic Republic of Congo...
February 9, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29420583/controlled-hypothermia-may-improve-surfactant-function-in-asphyxiated-neonates-with-or-without-meconium-aspiration-syndrome
#3
Chiara Autilio, Mercedes Echaide, Daniele De Luca, Jesús Pérez-Gil
BACKGROUND: Whole-body hypothermia (WBH) is used to improve neurological outcomes in perinatal asphyxia. Recent studies suggested a beneficial effect of hypothermia for some types of acute respiratory failure. However, no data are available about the biophysical function of human surfactant during WBH. We investigated whether WBH improves surfactant biophysical properties in asphyxiated neonates with or without meconium aspiration syndrome (MAS). METHODS: Non-bronchoscopic bronchoalveolar lavage (BAL) has been collected from 10 asphyxiated neonates (2 with MAS, 8 with no lung disease (NLD)) at different time-points (pre-WBH, 24h, 48h, 72h of WBH and post-WBH)...
2018: PloS One
https://www.readbyqxmd.com/read/29406989/excessive-fetal-movements-are-a-sign-of-fetal-compromise-which-merits-further-examination
#4
Alexander E P Heazell, Tomasina Stacey, Louise M O'Brien, Edwin A Mitchell, Jane Warland
Changes in fetal movement are associated with increased risk of stillbirth after 28 weeks of pregnancy. The majority of studies have focussed on maternal perception of reduced fetal movements, which is associated with stillbirth via placental dysfunction. Recent studies have also described an association between a single episode of excessive fetal movements and late stillbirth. We present a hypothesis that a sudden episode of excessive fetal activity indicates fetal compromise relating to underlying disturbance of the in utero environment, which if it persists can lead to fetal death...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29385640/randomised-controlled-trial-of-diazoxide-for-small-for-gestational-age-neonates-with-hyperinsulinaemic-hypoglycaemia-provided-early-hypoglycaemic-control-without-adverse-effects
#5
Binesh Balachandran, Kanya Mukhopadhyay, Naresh Sachdeva, Rama Walia, Savita Verma Attri
AIM: Hyperinsulinaemic hypoglycaemia (HH) is a very common cause of hypoglycaemia in small for gestational age (SGA) neonates. We compared using early oral diazoxide or a placebo for this patient group. METHODS: This was a randomised, double-blind, placebo-controlled trial that focused on SGA neonates born at at least 32 weeks of gestation with HH during the first five days of life. Neonates with severe perinatal asphyxia, sepsis or contraindications for oral feeds were excluded...
January 31, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29383582/trend-and-causes-of-neonatal-mortality-in-a-level-iii-children-s-hospital-in-shanghai-a-15-year-retrospective-study
#6
Xue-Lian Wang, Jin Wang, Lin Yuan, Wen-Jing Shi, Yun Cao, Chao Chen
BACKGROUND: To determine the trend and causes of neonatal mortality in a large level III neonatal intensive care unit in Shanghai during a 15-year period. METHODS: This is a retrospective, single-centered study. All neonates who died during the period from January 1, 1999 to December 31, 2013 at Children's Hospital of Fudan University were included. We extracted relevant clinical information from their medical records, analyzed neonatal mortality rate and the characteristics of these patients, and compared neonatal deaths between different periods and populations...
January 30, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29382476/-factors-associated-with-epilepsy-in-children-in-mexico-a-case-control-study
#7
Ma Del Rosario Cruz-Cruz, Jorge Gallardo-Elías, Sergio Paredes-Solís, José Legorreta-Soberanis, Miguel Flores-Moreno, Neil Andersson
BACKGROUND: Epilepsy is the most common chronic neurological disease in the world. In Mexico, epilepsy is among the diseases more related to mortality due to non-infectious diseases in children. The objective of the study was to identify the factors associated with epilepsy in children entitled to the Mexican Social Security Institute (IMSS), in Acapulco, Mexico. METHODS: We carried out a case-control study from April 2010 to April 2011. We selected 118 cases from the database of outpatient pediatric neurology with epilepsy diagnostic with two year of evolution according to the International League Against Epilepsy criteria...
September 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29378710/evaluation-of-a-system-specific-function-to-describe-the-pharmacokinetics-of-benzylpenicillin-in-term-neonates-undergoing-moderate-hypothermia
#8
Yuma A Bijleveld, Timo R de Haan, Johanna H van der Lee, Floris Groenendaal, Peter H Dijk, Arno van Heijst, Rogier C J de Jonge, Koen P Dijkman, Henrica L M van Straaten, Monique Rijken, Inge A Zonnenberg, Filip Cools, Alexandra Zecic, Debbie H G M Nuytemans, Anton H van Kaam, Ron A A Mathôt
The pharmacokinetic (PK) properties of i.v. benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as to date these are unknown. To do so, a system-specific modeling approach was applied, in which our recently developed covariate model describing developmental and temperature induced changes in amoxicillin clearance (CL) in the same patient study population, was incorporated into a population PK model of benzylpenicillin with a priori birthweight (BW) based allometric scaling...
January 29, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29346139/blood-biomarkers-for-evaluation-of-perinatal-encephalopathy-state-of-the-art
#9
Ernest M Graham, Allen D Everett, Jean-Christophe Delpech, Frances J Northington
PURPOSE OF REVIEW: The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. RECENT FINDINGS: Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE)...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29335023/early-neonatal-glutaric-aciduria-type-i-hidden-by-perinatal-asphyxia-a-case-report
#10
Giacomo Biasucci, Nicola Morelli, Federica Natacci, Massimo Mastrangelo
BACKGROUND: Perinatal asphyxia (PA) occurs in about 2 to 10 per 1000 live full-term births. Although neonatal epileptic seizures are observed in up to 60% of cases, PA may mimic or subtend other conditions. Hypoxia related brain injury is particularly relevant, as it may have permanent effects on neuropsychomotor development. Antepartum obstetric conditions, may, in turn, lead to hypoxic-ischemic damage to the fetus and the newborn, often underlying PA. Herein, a case of PA that hid and triggered signs and symptoms of Glutaric Aciduria type I (GA-I), is reported...
January 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29301489/intrapartum-fetal-deaths-and-unexpected-neonatal-deaths-in-the-republic-of-ireland-2011-2014-a-descriptive-study
#11
K McNamara, K O'Donoghue, R A Greene
BACKGROUND: Intrapartum fetal death, the death of a fetus during labour, is a tragic outcome of pregnancy. The intrapartum death rate of a country is reflective of the care received by mothers and babies in labour and it is through analysing these cases that good aspects of care, as well as areas for improvement can be identified. Investigating unexpected neonatal deaths that may be associated with an intrapartum event is also helpful to fully appraise intrapartum care. This is a descriptive study of intrapartum fetal deaths and unexpected neonatal deaths in Ireland from 2011 to 2014...
January 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29286929/correlation-of-hematocrit-and-apgar-scores-in-newborns-of-women-with-hypertensive-disorders-in-pregnancy
#12
Helen Chioma Okoye, Benedict Nwogoh, Odutola Israel Odetunde
OBJECTIVES: To compare the incidence of polycythemia in newborns of women with hypertensive disorders in pregnancy (HDP) with those of normotensive mothers, to determine the incidence of perinatal stress using Apgar scores and to correlate hematocrit with Apgar scores in these newborn. STUDY DESIGN: This was a hospital-based comparative study conducted in the University of Port Harcourt Teaching Hospital, Nigeria. MAIN OUTCOME MEASURES: Apgar scores of 200 newborns- 100 from mothers with HDP (case group) and 100 from normotensive mothers (control group)- were taken at 1st and 5th minute of birth and cord blood samples collected to determine hematocrit...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29278628/perinatal-complications-in-two-cohort-groups-of-preterm-newborns-in-intensive-care-unit-for-children-s-diseases-of-university-clinical-hospital-mostar
#13
Vedran Bjelanović, Marjana Jerković Raguž, Matea Galić, Ana Čuljak, Ivana Bjelanović, Vajdana Tomić
AIM: To determine the frequency and type of complications in two cohort groups of preterm newborns. SUBJECTS AND METHODS: The research involved 100 preterm newborns divided into two groups according to their gestational age: newborns from 24 to 33+6/7 weeks GA and newborns from 34 to 36+6/7 weeks GA. Parameters which were observed with mother were: age, number of births, course and complications in pregnancy. Parameters with infant: gestational age, weight, newborn small for gestational age (IUGR), asphyxia, respiratory distress syndrome, sepsis, hyperbilirubinemia, apnea, anemia, intracranial hemorrhage and metabolic disorder (hypoglycaemia, hypocalcaemia)...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29277048/comparison-of-planned-caesarean-delivery-and-planned-vaginal-delivery-in-women-with-a-twin-pregnancy-a-nation-wide-cohort-study
#14
Simone M T A Goossens, Sabine Ensing, Mark A H B M van der Hoeven, Frans J M E Roumen, Jan G Nijhuis, Ben W Mol
OBJECTIVE: To compare, in women with twin pregnancy with the first twin in cephalic position, neonatal morbidity and mortality rates after planned Ceasarean delivery (CD) versus planned vaginal delivery (VD). STUDY DESIGN: A nationwide cohort study on women pregnant with twins and the first child in cephalic position, who delivered between 32 + 0-41 + 0 weeks between 2000 and 2012 in the Netherlands, using multivariate logistic regression analysis to compare neonatal morbidity and mortality according to planned delivery mode, and looked at subgroups 32 + 0-36 + 6 and 37 + 0-41 + 0 weeks...
December 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29276422/incidence-and-predictors-of-mortality-among-newborns-with-perinatal-asphyxia-a-4-year-prospective-study-of-newborns-delivered-in-health-care-facilities-in-enugu-south-east-nigeria
#15
Uchenna Ekwochi, Nwabueze I Asinobi, Chidiebere DI Osuorah, Ikenna K Ndu, Christian Ifediora, Ogechukwu F Amadi, Chukwunonso C Iheji, Casmir Jg Orjioke, Wilfred O Okenwa, Bernadette Ifeyinwa Okeke
Fatalities from perinatal asphyxia remain high in developing countries, and continually assessing its risk factors will help improve outcomes in these settings. We explored how some identified risk factors predict mortality in asphyxiated newborns, to assist clinicians in prioritizing interventions. This was a 4-year prospective study conducted at the Enugu State University Teaching Hospital, Enugu, Nigeria. All newborns who met the study criteria that were admitted to this facility in this period were enrolled and monitored...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/29248460/%C3%AE-%C3%AE-t-cells-contribute-to-injury-in-the-developing-brain
#16
Anna-Maj Albertsson, Xiaoli Zhang, Regina Vontell, Dan Bi, Roderick T Bronson, Veena Supramaniam, Ana A Baburamani, Sha Hua, Arshed Nazmi, Susanna Cardell, Changlian Zhu, Harvey Cantor, Carina Mallard, Henrik Hagberg, Jianmei W Leavenworth, Xiaoyang Wang
Brain injury in premature infants, especially periventricular leukomalacia, is an important cause of neurological disabilities. Inflammation contributes to the development of perinatal brain injury, but the essential mediators leading to brain injury in early life remain largely unknown. Neonates have reduced capacity for mounting conventional αβT-cell responses. However γδT-cells are already functionally competent during early development and are important in early life immunity. We investigated the potential contribution of γδT-cells to preterm brain injury by using postmortem brains from human preterm infants with periventricular leukomalacia and two animal models of preterm brain injury-the hypoxic-ischemic mouse model and a fetal sheep asphyxia model...
December 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29246356/a-novel-magnetic-resonance-imaging-score-predicts-neurodevelopmental-outcome-after-perinatal-asphyxia-and-therapeutic-hypothermia
#17
Lauren C Weeke, Floris Groenendaal, Kalyani Mudigonda, Mats Blennow, Maarten H Lequin, Linda C Meiners, Ingrid C van Haastert, Manon J Benders, Boubou Hallberg, Linda S de Vries
OBJECTIVE: To assess the predictive value of a novel magnetic resonance imaging (MRI) score, which includes diffusion-weighted imaging as well as assessment of the deep grey matter, white matter, and cerebellum, for neurodevelopmental outcome at 2 years and school age among term infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia. STUDY DESIGN: This retrospective cohort study (cohort 1, The Netherlands 2008-2014; cohort 2, Sweden 2007-2012) including infants born at >36 weeks of gestational age treated with therapeutic hypothermia who had an MRI in the first weeks of life...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29242417/phase-changing-material-for-therapeutic-hypothermia-in-neonates-with-hypoxic-ischemic-encephalopathy-a-multi-centric-study
#18
Niranjan Thomas, Thangaraj Abiramalatha, Vishnu Bhat, Manoj Varanattu, Suman Rao, Sanjay Wazir, Leslie Lewis, Umamaheswari Balakrishnan, Srinivas Murki, Jaikrishnan Mittal, Ashish Dongara, Y N Prashantha, Somashekhar Nimbalkar
OBJECTIVE: To assess the feasibility and safety of cooling asphyxiated neonates using phase changing material based device across different neonatal intensive care units in India. DESIGN: Multi-centric uncontrolled clinical trial. SETTING: 11 level 3 neonatal units in India from November 2014 to December 2015. PARTICIPANTS: 103 newborn infants with perinatal asphyxia, satisfying pre-defined criteria for therapeutic hypothermia...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29241628/-care-of-the-newborn-with-perinatal-asphyxia-candidate-for-therapeutic-hypothermia-during-the-first-six-hours-of-life-in-spain
#19
Juan Arnaez, Alfredo Garcia-Alix, Sara Calvo, Simón Lubián-López
INTRODUCTION: The process of care and assistance from birth to the starting of therapeutic hypothermia (TH) is crucial in order to improve its effectiveness and prevent the worsening of hypoxic-ischaemic injury. METHODS: A national cross-sectional study carried out in 2015 by use of a questionnaire sent to all level iii units on the care of the newborn≥35 weeks gestation within the first hours of life after a perinatal asphyxia event. According to clinical practice guidelines, the quality of care was compared between the hospitals that carried out or did not carry out TH, and according to the level of care...
December 11, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29234502/nuchal-cord-and-its-implications
#20
REVIEW
Morarji Peesay
Nuchal cord occurs when the umbilical cord becomes wrapped around the fetal neck 360 degrees. Nuchal cords occur in about 10-29% of fetuses and the incidence increases with advancing gestation age. Most are not associated with perinatal morbidity and mortality, but a few studies have shown that nuchal cord can affect the outcome of delivery with possible long-term effects on the infants. Nuchal cords are more likely to cause problems when the cord is tightly wrapped around the neck, with effects of a tight nuchal cord conceptually similar to strangulation...
2017: Maternal Health, Neonatology and Perinatology
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