Jean Pierre Mendes Lima, Danielle Rayêe, Thaia Silva-Rodrigues, Paula Ribeiro Paes Pereira, Ana Paula Miranda Mendonca, Clara Rodrigues-Ferreira, Diego Szczupak, Anna Fonseca, Marcus F Oliveira, Flavia Regina Souza Lima, Roberto Lent, Antonio Galina, Daniela Uziel
Perinatal asphyxia remains a significant cause of neonatal mortality and is associated with long-term neurodegenerative disorders. In the present study, we evaluated cellular and subcellular damages to brain development in a model of mild perinatal asphyxia. Survival rate in the experimental group was 67%. One hour after the insult, intraperitoneally injected Evans blue could be detected in the fetuses' brains, indicating disruption of the blood-brain barrier. Although brain mass and absolute cell numbers (neurons and non-neurons) were not reduced after perinatal asphyxia immediately and in late brain development, subcellular alterations were detected...
March 26, 2018: Molecular Neurobiology