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acute pancreatitis review

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https://www.readbyqxmd.com/read/27909037/safety-and-efficacy-of-stereotactic-body-radiation-therapy-combined-with-s-1-simultaneously-followed-by-sequential-s-1-as-an-initial-treatment-for-locally-advanced-pancreatic-cancer-silapanc-trial-study-design-and-rationale-of-a-phase-ii-clinical-trial
#1
Xiaofei Zhu, Xiaoping Ju, Fei Cao, Fang Fang, Shuiwang Qing, Yuxin Shen, Zhen Jia, Yangsen Cao, Huojun Zhang
INTRODUCTION: Upfront surgeries are not beneficial to most patients with pancreatic cancer. Therefore, more emphasis has been placed chemoradiotherapy in locally advanced pancreatic cancer recently. Gemcitabine-based regimens or FOLFIRINOX (a chemotherapy regimen including leucovorin, 5-FU, irinotecan, oxaliplatin) has been proven as a standard chemotherapy in pancreatic cancer. However, severe toxicities may prevent the completion of chemotherapy. S-1 has showed better objective response rates, similar overall survival rates and progression-free survival rates compared with gemcitabine, revealing that S-1 may be a potential candidate in treating pancreatic cancer, especially for patients refractory to gemcitabine...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27906430/recurrent-acute-pancreatitis-in-bowel-malrotation
#2
G Alessandri, A Amodio, L Landoni, N De' Liguori Carino, C Bassi
OBJECTIVE: Recurrent acute pancreatitis is an uncommon diagnosis in teenagers. Excluded alcohol and biliary stones, more prevalent aetiologies in these group of patients are genetic pancreatitis, pancreatic duct system abnormalities, neoplasia, traumas and congenital abnormalities of the duodenum such as duodenal duplication or diverticulum. Two reported cases of recurrent pancreatitis associated to midgut malrotation were described in English literature. Bowel malrotation is a difficult diagnosis in a teenager or a young adult and a common delay is documented...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27882260/intrascrotal-collection-in-an-acute-pancreatitis-a-case-report-and-review-of-the-literature
#3
L Moens, P Yengue Yengue, C Assenmacher
Context. An inguinoscrotal swelling occurring during an acute pancreatitis is very rare. Case Report. We report a case of right inguinoscrotal swelling appearing in connection with an interstitial edematous acute pancreatitis. We have noticed a spontaneous complete reduction of the right inguinoscrotal swelling after 10 days. Conclusion. The management of a scrotal swelling should be the least invasive possible method but also the most complete possible method to avoid unnecessary interventions. The exclusion of a pathology that could affect the vital prognosis of the testis remains the absolute priority...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27873041/the-diagnostic-challenge-of-the-sequelae-of-acute-pancreatitis-on-ct-imaging-a-pictorial-essay
#4
REVIEW
Mark Hughey, Myles Taffel, Robert K Zeman, Smita Patel, Michael C Hill
PURPOSE: The purpose of the study was to present a pictorial review of the long-term sequelae of acute pancreatitis on CT imaging as these findings can cause diagnostic confusion in the absence of a proper clinical history and/or prior CT imaging. METHODS: We retrospectively identified 81 patients who had an episode of acute pancreatitis with diagnostic findings on CT and also underwent one or more follow-up CT scans at least 1 month beyond the acute episode. The residual findings on all follow-up CT scans were tabulated, including the time interval since the initial bout of acute pancreatitis...
November 21, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27868439/-the-treatment-of-walled-off-pancreatic-necrosis-review
#5
Zsolt Szentkereszty, Klaudia Balog, Lídia Balázs, Adrien Csiszkó
: Walled-off pancreatic necrosis is a late complication of severe acute pancreatitis that generally needs some interventions. The aim of this review is to analyse the indications, technical aspects and limits of these therapeutic options. The development of the walled-off pancreatic necrosis needs 4-6 weeks from the onset of the disease. The necrosectomy is recommended after this time. Endoscopic necrosectomy offers good results if the necrosis is in retrogastric or retroduodenal localisations...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27864960/the-interplay-between-diabetes-and-pancreatitis-two-case-reports-of-sudden-natural-deaths-and-a-review-of-the-literature
#6
Daniel C Butler, Anthony J Emanuel, Sally E Self, Nicholas I Batalis
Diabetes mellitus (DM) is a common disease involving insulin resistance or deficit that, when left unchecked, may cause severe hyperglycemia and subsequent end-organ damage. Acute pancreatitis (AP) is inflammation of the pancreas that can lead to significant morbidity and mortality. AP and DM both account for a significant amount of sudden deaths, and rarely both disease processes may be present in the same decedent, causing some difficulty in wording the cause of death statement. Although much research has been directed at studying the causes and risk factors for AP and DM, there is a complex interplay between these diseases that is not fully understood...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27848953/immunopathogenesis-of-pancreatitis
#7
REVIEW
T Watanabe, M Kudo, W Strober
The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due to a genetic- or environment-based abnormality of intracellular acinar trypsinogen activation and thus to the induction of acinar cell injury that, in turn, sets in motion an intra-pancreatic inflammatory process. More recent studies, reviewed here, present strong evidence that while such trypsinogen activation is likely a necessary first step in the inflammatory cascade underlying pancreatitis, sustained pancreatic inflammation is dependent on damage-associated molecular patterns-mediated cytokine activation causing the translocation of commensal (gut) organisms into the circulation and their induction of innate immune responses in acinar cells...
November 16, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27843953/considerations-for-defining-cytokine-dose-duration-and-milieu-that-are-appropriate-for-modeling-chronic-low-grade-inflammation-in-type-2-diabetes
#8
REVIEW
Craig S Nunemaker
Proinflammatory cytokines have been implicated in the pathophysiology of both type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D is an autoimmune disease involving the adaptive immune system responding to pancreatic beta-cells as antigen-presenting cells. This attracts immune cells that surround pancreatic islets (insulitis) and secrete cytokines, such as IL-1beta, IFN-gamma, and TNF-alpha, in close proximity to pancreatic beta-cells. In contrast, there is little evidence for such a focused autoimmune response in T2D...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27833385/ansa-pancreatica-as-a-predisposing-factor-for-recurrent-acute-pancreatitis
#9
Takana Yamakawa Hayashi, Wataru Gonoi, Takeharu Yoshikawa, Naoto Hayashi, Kuni Ohtomo
AIM: To determine the non-biased prevalence and clinical significance of ansa pancreatica in patients with acute pancreatitis using magnetic resonance imaging (MRI). METHODS: Our institutional review board approved this cross-sectional study, which consisted of a community-based cohort of 587 consecutive participants in a whole-body health-check program, and 73 subjects with episode of acute pancreatitis (55 patients with a single episode of acute pancreatitis, and 18 patients with recurrent acute pancreatitis)...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27826206/necrotizing-pancreatitis-challenges-and-solutions
#10
REVIEW
Victoria A Bendersky, Mohan K Mallipeddi, Alexander Perez, Theodore N Pappas
Acute pancreatitis is a common disease that can progress to gland necrosis, which imposes significant risk of morbidity and mortality. In general, the treatment for pancreatitis is a supportive therapy. However, there are several reasons to escalate to surgery or another intervention. This review discusses the pathophysiology as well as medical and interventional management of necrotizing pancreatitis. Current evidence suggests that patients are best served by delaying interventions for at least 4 weeks, draining as a first resort, and debriding recalcitrant tissue using minimally invasive techniques to promote or enhance postoperative recovery while reducing wound-related complications...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27826137/imaging-in-pancreatic-disease
#11
REVIEW
Julien Dimastromatteo, Teresa Brentnall, Kimberly A Kelly
Pancreatic diseases, chronic pancreatitis, pancreatic cancer and diabetes mellitus, taken together, occur in >10% of the world population. Pancreatic diseases, as with other diseases, benefit from early intervention and appropriate diagnosis. Although imaging technologies have given clinicians an unprecedented toolbox to aid in clinical decision-making, advances in these technologies and development of molecular-based diagnostic tools could enable physicians to identify diseases at an even earlier stage and, thereby, improve patient outcomes...
November 9, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27824485/the-value-of-secretin-enhanced-mrcp-in-patients-with-recurrent-acute-pancreatitis
#12
Kumar Sandrasegaran, Bilal Tahir, Udaykamal Barad, Evan Fogel, Fatih Akisik, Temel Tirkes, Stuart Sherman
OBJECTIVE: The purpose of this study is to assess the additional value of secretin-enhanced MRCP over conventional (non-secretin-enhanced) MRCP in diagnosing disease in patients with recurrent acute pancreatitis. MATERIALS AND METHODS: A retrospective review of a radiology database found 72 patients with recurrent acute pancreatitis who had secretin-enhanced MRCP and ERCP correlation within 3 months of each other between January 2007 and December 2011. Of these patients, 54 had no history of pancreatic tumor or surgery and underwent MRI more than 3 months after an episode of acute pancreatitis...
November 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27821124/severe-leptospirosis-and-pancreatitis-a-case-series-from-a-leptospirosis-outbreak-in-anuradhapura-district-sri-lanka
#13
N J Herath, C J Kamburapola, S B Agampodi
BACKGROUND: Acute pancreatitis is identified as an atypical and rare presentation of leptospirosis. In this report, we discuss a case series of severe leptospirosis with pancreatitis as a main complication during an unusual outbreak of leptospirosis in Anuradhapura district, Sri Lanka. CASE PRESENTATION: We retrospectively reviewed clinical presentation, investigations, treatment and outcome of six confirmed cases of severe leptospirosis admitted to intensive care unit (ICU) of Teaching Hospital, Anuradhapura, within a three months period from November 2014 to January 2015...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27821030/prognostic-scores-in-acute-pancreatitis-a-review
#14
REVIEW
Z Balcı, M Ö Kılıç, K Şenol, A Erdoğan, M Tez
Predicting the course of an attack of acute pancreatitis still represents a challenge for the physicians.Some early interventions such as endoscopic retrograde cholangiopancreatography and sphincterotomy, admission to the intensive care unit, enteral feeding, and prophylactic antibiotics have been proven to decrease morbidity and mortality in patients of high-risk groups. However, acute pancreatitis has a potential of morbidity and mortality, and therefore early diagnosis and objective assessment of severity of the disease is fundamental...
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27813504/todani-choledochal-cyst-type-ii-case-report-and-review
#15
Solange Marcela Farías Molina, Rafael Lisandro Castillo Machado, Natalia Carolina Sanhueza Palma, Jeannette Alejandra Calzadilla Riveras
: Choledochal cyst is a rare pathological condition, which represents 1% of benign diseases of the biliary tract. It is seen with significant frequency in childhood, with a higher prevalence in females, and a greater diagnostic incidence in Asia. Diagnosis is primarily based on clinical suspicion. Its symptoms are variable, and its treatment, depending on the type, is surgical. CASE REPORT: a male patient, 46 years old, with clinical symptoms of acute pancreatitis as a complication of a choledochal cyst Todani type II is diagnosed during his hospital stay with cholangial magnetic resonance...
October 20, 2016: Medwave
https://www.readbyqxmd.com/read/27806778/-experience-of-minimal-access-video-assisted-retroperitoneal-debridement-in-treatment-of-infected-pancreatic-necrosis
#16
J Feng, Z W Liu, S W Cai, H H Jiao, J D Du, X L Xin, J Y Chen, P F Wang, L He, S C Lu, Y Y Xiao, M Q Wang
Objective: To explore the experience of minimal-access video-assisted retroperitoneal debridement in treatment of infected pancreatic necrosis(IPN). Methods: A retrospective review was performed on 12 patients with IPN who underwent minimal-access video-assisted retroperitoneal debridement between June 2008 and June 2013 in People's Liberation Army General Hospital and First Affiliated Hospital of People's Liberation Army General Hospital, respectively.There were 10 male patients and 2 female patients aging from 33 to 55 years with mean age of(43±8)years...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27795842/stem-cells-in-the-treatment-of-insulin-dependent-diabetes-mellitus
#17
M A Borisov, O S Petrakova, I G Gvazava, E N Kalistratova, A V Vasiliev
Diabetes affects over 350 million people worldwide, with the figure projected to rise to nearly 500 million over the next 20 years, according to the World Health Organization. Insulin-dependent diabetes mellitus (type 1 diabetes) is an endocrine disorder caused by an autoimmune reaction that destroys insulin-producing β-cells in the pancreas, which leads to insulin deficiency. Administration of exogenous insulin remains at the moment the treatment mainstay. This approach helps to regulate blood glucose levels and significantly increases the life expectancy of patients...
July 2016: Acta Naturae
https://www.readbyqxmd.com/read/27790515/cystic-dystrophy-of-the-duodenum-due-to-heterotopic-pancreas-a-case-report-and-review-of-literature
#18
Gunjan Shailesh Desai, Aniruddha Phadke, Dattaprasanna Kulkarni
Cystic Dystrophy and Heterotopic Pancreas (CDHP) is a rare cause of chronic pancreatitis, duodenal obstruction and obstructive jaundice. The diagnosis is often delayed and requires multimodal imaging with Computed Tomography (CT), Magnetic Resonance Cholangio-Pancreatography (MRCP) and Endoscopic Ultrasound (EUS). The treatment is not standardized but Pancreatoduodenectomy (PD) provides long-term relief in some cases. The present case is about a 47-year-old male with history of alcohol abuse for 10 years who presented with a history of recurrent acute pancreatitis...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785928/lomitapide-for-the-treatment-of-hypertriglyceridemia
#19
Amanda J Brahm, Robert A Hegele
Severe genetic forms of hypertriglyceridemia carry a risk of life-threatening pancreatitis and lack available effective treatments. Lomitapide is a microsomal triglyceride transfer protein inhibitor currently approved for treatment of homozygous familial hypercholesterolemia that may be useful in the management of severe hypertriglyceridemia. Areas covered: Published trials of lomitapide that reported plasma triglyceride response were reviewed, as was a case report of a patient with hypertriglyceridemia who was treated for 13 years with lomitapide...
November 9, 2016: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/27782962/the-causal-evaluation-of-acute-recurrent-and-chronic-pancreatitis-in-children-consensus-from-the-insppire-group
#20
Cheryl E Gariepy, Melvin B Heyman, Mark E Lowe, John F Pohl, Steven L Werlin, Michael Wilschanski, Bradley Barth, Douglas S Fishman, Steven D Freedman, Matthew J Giefer, Tanja Gonska, Ryan Himes, Sohail Z Husain, Veronique D Morinville, Chee Y Ooi, Sarah Jane Schwarzenberg, David M Troendle, Elizabeth Yen, Aliye Uc
: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates over the past decade. However, as pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. OBJECTIVES: To review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research...
October 25, 2016: Journal of Pediatric Gastroenterology and Nutrition
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