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https://www.readbyqxmd.com/read/29912762/oral-and-otorhinolaryngological-findings-in-adults-who-were-diagnosed-with-pediatric-onset-crohn-s-disease-a-controlled-study
#1
Anu Haaramo, Heikki Alapulli, Liisa Aine, Jetta Tuokkola, Ulla Saarnisto, Risto P Roine, Anne Pitkäranta, Kaija-Leena Kolho
BACKGROUND: Up to 50% of pediatric patients with Crohn's disease (CD) report oral manifestations, but less is known about their oral health when they become adults. GOALS: Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once they reached adulthood, to look for predisposing factors and to compare the findings to matched controls. STUDY: Adult patients diagnosed with CD in childhood at the Children's Hospital, University of Helsinki, Finland, after 2000 were invited for a follow-up appointment in 2016 and 24 were examined by a dentist and otorhinolaryngologist...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29901557/association-between-infliximab-drug-and-antibody-levels-and-therapy-outcome-in-pediatric-inflammatory-bowel-diseases
#2
Bella Ungar, Yoav Glidai, Miri Yavzori, Orit Picard, Ella Fudim, Avishay Lahad, Yael Haberman, Dror S Shouval, Ilana Weintraub, Rami Eliakim, Shomron Ben-Horin, Batia Weiss
OBJECTIVES: While infliximab pharmacokinetics are associated with therapy outcome in adult IBD population, limited data is available in pediatric patients. We aimed to define the relationship between Infliximab trough and antibodies' levels (IFX-TL, ATI) and clinical, biomarker remission. METHODS: IFX-TL and ATI were routinely obtained between 2011-2017. Associations with clinical and inflammatory (C-reactive protein, CRP) end-points were studied throughout the first year of infliximab therapy...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29899757/different-clinical-outcomes-in-crohn-s-disease-patients-with-esophagogastroduodenal-jejunal-and-proximal-ileal-disease-involvement-is-l4-truly-a-single-phenotype
#3
Ren Mao, Rui-Han Tang, Yun Qiu, Bai-Li Chen, Jing Guo, Sheng-Hong Zhang, Xue-Hua Li, Rui Feng, Yao He, Zi-Ping Li, Zhi-Rong Zeng, Rami Eliakim, Shomron Ben-Horin, Min-Hu Chen
Background: The Montreal classification defines L4 Crohn's disease (CD) as any disease location proximal to the terminal ileum, which anatomically includes L4-esophagogastroduodenal (EGD), L4-jejunal, and L4-proximal ileal involvement. L4-jejunal disease was established to be associated with poor prognosis. However, the outcome of patients with L4-proximal ileal disease or L4-EGD remains to be clarified. Our study aimed to investigate whether the outcome differs among CD patients with L4-EGD, L4-jejunal, and L4-proximal ileal disease...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29881302/tumor-necrosis-factor-%C3%AE-induced-protein-3-a20-is-dysregulated-in-pediatric-crohn-disease
#4
Deenaz Zaidi, Hien Q Huynh, Matthew W Carroll, Shairaz Baksh, Eytan Wine
Purpose: A significant feature of pediatric inflammatory bowel diseases (IBD), which include Crohn disease (CD), and ulcerative colitis (UC), is failure to suppress inflammation. The inability to regulate inflammation renders a major challenge toward establishing effective treatments in IBD. Nuclear factor kappa-light-chain-enhancer of activated B-cells-induced inflammation is inhibited by A20 through interactions with TAX1BP1 (Tax1-binding protein 1) and A20-binding inhibitor of NF-κβ activation (ABIN)-1 (A20 binding and inhibitor of NF-κβ) and upon phosphorylation by inhibitor of nuclear factor kappa-β kinase subunit beta (IKKβ), which stabilizes it...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29867171/obesity-and-response-to-infliximab-in-patients-with-inflammatory-bowel-diseases-pooled-analysis-of-individual-participant-data-from-clinical-trials
#5
Siddharth Singh, James Proudfoot, Ronghui Xu, William J Sandborn
OBJECTIVES: To assess whether obesity may affect response to infliximab, we conducted an individual participant data pooled analysis using data from clinical trials of infliximab in inflammatory bowel diseases (IBD), using the Yale Open Data Access (YODA) Project. METHODS: We analyzed individual participant data from four clinical trials of infliximab in adults with IBD (ACCENT-I, SONIC, ACT-1, and -2). Patients were categorized as obese (body mass index [BMI] ≥ 30 kg/m2 ) vs...
June 5, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29860529/evolution-of-pediatric-inflammatory-bowel-disease-unclassified-ibd-u-incorporated-with-serological-and-gene-expression-profiles
#6
Raguraj Chandradevan, Tatyana Hofmekler, Kajari Mondal, Nusrat Harun, Suresh Venkateswaran, Hari K Somineni, Cortney R Ballengee, Mi-Ok Kim, Anne Griffiths, Joshua D Noe, Wallace V Crandall, Scott Snapper, Shervin Rabizadeh, Joel R Rosh, Thomas D Walters, Madeline Bertha, Marla C Dubinsky, Lee A Denson, Cary G Sauer, James F Markowitz, Neal S LeLeiko, Jeffrey S Hyams, Subra Kugathasan
Background: Inflammatory bowel disease (IBD) mainly consists of Crohn's disease (CD) and ulcerative colitis (UC). About 10%-15% of patients with IBD cannot be firmly diagnosed with CD or UC; hence, they are initially diagnosed as inflammatory bowel disease unclassified (IBD-U). Having a firm diagnosis is clearly preferred to guide treatment choices, and better understanding of the nature of IBD-U is required. Methods: We performed an analysis of a subset of pediatric subjects from an inception IBD cohort of patients initially enrolled in a prospective multicenter study (the RISK study)...
May 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29851761/academic-stress-may-contribute-to-the-onset-of-pediatric-inflammatory-bowel-diseases
#7
Mahesh Z Krishna, Keisha R Barton, Carla M Perez, Seema Mehta Walsh, Amit Assa, Richard Kellermayer
It is currently unclear whether seasonality affects the onset of inflammatory bowel diseases (IBDs: Crohn's disease and ulcerative colitis) in children. Here, we examined the records of pediatric IBD patients diagnosed between 2009 and 2015 in a discovery cohort of 169 cases and a validation cohort of 122 subjects, where the month of symptoms onset could be determined. No seasonal patterns could be identified in respect to conception, birth and disease onset. An annual rhythm of symptomatic onset, however, correlating with academic semesters was identified...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29850811/multicenter-evaluation-of-emergency-department-treatment-for-children-and-adolescents-with-crohn-s-disease-according-to-race-ethnicity-and-insurance-payor-status
#8
Jennifer L Dotson, Michael D Kappelman, Josh Bricker, Rebecca Andridge, Deena J Chisolm, Wallace V Crandall
Background: Racial and socioeconomic disparities exist in the treatment and outcomes of children and adults with Crohn's disease (CD). This study investigated the impact of race and insurance status on emergency department (ED) evaluation and treatment among children with CD in the United States. Methods: Data from the Pediatric Health Information System included ED visits between January 2007 and December 2013 for patients aged ≤21 years with a primary diagnosis of CD, or a secondary diagnosis of CD plus a primary CD-related diagnosis...
May 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29843908/malnutrition-increases-the-risk-of-30-day-complications-after-surgery-in-pediatric-patients-with-crohn-disease
#9
Mitchell R Ladd, Alejandro V Garcia, Ira L Leeds, Courtney Haney, Maria M Oliva-Hemker, Samuel Alaish, Emily Boss, Daniel S Rhee
BACKGROUND: Pediatric patients with Crohn disease (CD) are frequently malnourished, yet how this affects surgical outcomes has not been evaluated. This study aims to determine the effects of malnourishment in children with CD on 30-day outcomes after surgery. STUDY DESIGN: The ACS NSQIP-Pediatric database from 2012 to 2015 was used to select children aged 5-18 with CD who underwent bowel surgery. BMI-for-age Z-scores were calculated based on CDC growth charts and 2015 guidelines of pediatric malnutrition were applied to categorize severity of malnutrition into none, mild, moderate, or severe...
April 27, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29800422/a-simple-endoscopic-score-modified-for-the-upper-gastrointestinal-tract-in-crohn-s-disease-ugi-ses-cd-a-report-from-the-imagekids-study
#10
Oren Ledder, Peter Church, Ruth Cytter-Kuint, Maria Martínez-León, Malgorzata Sladek, Eva Coppenrath, Batia Weiss, Baruch Yerushalmi, Javier Martin de Carpi, Larisa Duchano, Alexander Towbin, Amit Assa, Ron Shaoul, M L Mearin, George Alex, Anne Griffiths, Dan Turner
Objective: There is no standardized endoscopic description of upper gastrointestinal (UGI) disease in Crohn's disease (CD). We prospectively applied the Simple Endoscopic Score for CD (SES-CD) to the UGI tract as a planned sub-study of the multicenter prospective ImageKids study. We aimed to assess the utility of the UGI-SES-CD and its clinical significance in pediatric CD. Design: Patients underwent an esophagogastroduodenoscopy (EGD), ileocolonoscopy and magnetic resonance enterography (MRE) with explicit clinical data recorded...
May 25, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29788410/differentiation-between-pediatric-irritable-bowel-syndrome-and-inflammatory-bowel-disease-based-on-fecal-scent-proof-of-principle-study
#11
Sofie Bosch, Nora van Gaal, Roy P Zuurbier, James A Covington, Alfian N Wicaksono, Maarten H Biezeveld, Marc A Benninga, Chris J Mulder, Nanne K H de Boer, Tim G J de Meij
Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs)...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788152/early-arthritis-is-associated-with-failure-of-immunosuppressive-drugs-and-severe-pediatric-crohn-s-disease-evolution
#12
Naïm Ouldali, Jean-Pierre Hugot, Jérôme Viala, Mohamed Damir, Christine Martinez-Vinson, Ulrich Meinzer
Background: Crohn's disease (CD) is a chronic relapsing inflammatory disease. To optimize therapeutic decision making, it is essential to identify parameters that allow early prediction of a severe disease course. The aim of this study was to assess the link between arthritis and medium-term therapeutic failure in pediatric CD. Methods: We conducted a population-based cohort study with prospectively collected electronic data. To be included, patients must be younger than 17 years and have a confirmed CD diagnosed between 2005 and 2014...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29783232/peculiarities-of-crohn-s-disease-in-children-the-way-from-diagnosis-verification-to-the-development-of-complications-clinical-case
#13
Tetyana O Kryuchko, Olha A Poda, Inna M Nesina, Vira P Harshman
OBJECTIVE: Introduction: Despite increasing frequency of inflammatory diseases of the intestine in the children worldwide, verification of Crohn's disease (CD) diagnosis in pediatric practice has not studied yet and it is difficult for clinician to determine the stage of the disease. The aim of our study was to analyze clinical case of Crohn's disease (CD) in a child based on literature data and own monitoring. PATIENTS AND METHODS: Materials and methods: 13 year old patient was involved in our examination who took complex lab and instrumental investigation, which allows verifying inflammatory intestinal pathology such as Crohn's disease...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29764567/-features-and-management-of-very-early-onset-inflammatory-bowel-disease
#14
Jie-Yu You
Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease of unknown etiology. This disease includes three main types: Crohn′s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U). IBD is frequently presented in adults, but in recent years, there is a rising incidence in pediatric populations. Very early onset IBD (VEO-IBD) is a fraction of pediatric IBD, but they have exclusive phenotypic and genetic characteristics such that they are accompanied by severe disease course and resistance to conventional therapy...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29760546/thiopurines-are-negatively-associated-with-anthropometric-parameters-in-pediatric-crohn-s-disease
#15
Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews, Cheng-Shiun Leu
AIM: To determine the distribution of anthropometric parameter (AP)- z -scores and characterize associations between medications/serum biomarkers and AP- z -scores in pediatric Crohn's disease (CD). METHODS: CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants' demographic characteristics and key variables of interest. Paired t -tests were used to compare AP- z -scores calculated based on CA (CA z -scores) and bone age (BA) (BA z -scores) for interpretation of AP's...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#16
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29740348/could-sodium-chloride-be-an-environmental-trigger-for-immune-mediated-diseases-an-overview-of-the-experimental-and-clinical-evidence
#17
REVIEW
Eric Toussirot, Matthieu Béreau, Charline Vauchy, Philippe Saas
Immune mediated diseases (IMDs) are complex chronic inflammatory diseases involving genetic and environmental factors. Salt intake has been proposed as a diet factor that can influence the immune response. Indeed, experimental data report the influence of sodium chloride on the differentiation of naive CD4+ T cells into IL-17 secreting T helper (Th) cells (Th17 cells), by a mechanism involving the serum glucocorticoid kinase-1 (SGK1) that promotes the expression of the IL-23 receptor (IL-23R). The IL-23/IL-23R is critical for pathogenic inflammatory Th17 cell differentiation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29724086/the-long-term-effect-of-early-anti-tumor-necrosis-factor-on-restoration-of-growth-in-pediatric-crohn-s-disease
#18
EDITORIAL
Jung Ok Shim, Yoon Tae Jeen
No abstract text is available yet for this article.
May 15, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29718391/serologic-reactivity-reflects-clinical-expression-of-ulcerative-colitis-in-children
#19
Elizabeth A Spencer, Sonia M Davis, David R Mack, Brendan M Boyle, Anne M Griffiths, Neal S LeLeiko, Cary G Sauer, David J Keljo, James F Markowitz, Susan S Baker, Joel R Rosh, Robert N Baldassano, Maria Oliva-Hemker, Marian D Pfefferkorn, Anthony R Otley, Melvin B Heyman, Joshua D Noe, Ashish S Patel, Paul A Rufo, M Alison Marquis, Thomas D Walters, Margaret H Collins, Subra Kugathasan, Lee A Denson, Jeffrey S Hyams, Marla C Dubinsky
Background: In contrast to pediatric Crohn's disease (CD), little is known in pediatric ulcerative colitis (UC) about the relationship between disease phenotype and serologic reactivity to microbial and other antigens. Aim: The aim of this study was to examine disease phenotype and serology in a well-characterized inception cohort of children newly diagnosed with UC during the PROTECT Study (Predicting Response to Standardized Pediatric Colitis Therapy). Methods: Patients were recruited from 29 participating centers...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29718299/improving-quality-in-the-care-of-patients-with-inflammatory-bowel-diseases
#20
Matthew D Egberg, Ajay S Gulati, Ziad F Gellad, Gil Y Melmed, Michael D Kappelman
Efforts to improve healthcare quality were firmly established before the Institute of Medicine (IOM) historic 2000 and 2001 reports, To Err is Human Building a Safer Health System and Crossing the Quality Chasm: A New Health System for the 21st Century Despite the long-standing healthcare quality improvement (QI) efforts that date back to the turn of the 20th century, the IOM reports significantly advanced the awareness of healthcare quality deficits and the resulting risk to patients from those gaps in care...
April 27, 2018: Inflammatory Bowel Diseases
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