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Lamellar keratoplasty

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https://www.readbyqxmd.com/read/29305888/comparative-immunological-study-of-penetrating-and-anterior-lamellar-keratoplasty-in-a-murine-model
#1
Hyun Soo Lee, Ji Young Kwon, Choun-Ki Joo
In lamellar keratoplasty, the diseased part of a cornea is replaced while the healthy tissue remains. lamellar keratoplasty has the advantage of better graft survival compared to penetrating keratoplasty (PK). We compared the immunological responses to PK and anterior lamellar keratoplasty (ALK) in a murine model. PK or ALK was performed using C57BL/6 donor grafts and BALB/c recipients, and graft opacity was assessed to evaluate graft rejection up to 8 weeks. We evaluated the immunological responses in both groups, which were not clinically considered as graft failure on postoperative day 21...
January 3, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29301767/avoiding-big-bubble-complications-outcomes-of-layer-by-layer-deep-anterior-lamellar-keratoplasty-in-children
#2
Uri Elbaz, Caitriona Kirwan, Carl Shen, Asim Ali
BACKGROUND/AIMS: To describe the visual and clinical outcomes of manual layer-by-layer deep anterior lamellar keratoplasty (DALK) in a paediatric population. METHODS: The charts of all children who underwent DALK surgery between January 2007 and January 2015 were reviewed retrospectively. Data collected included preoperative and postoperative spectacle-corrected distance visual acuity (CDVA), intraoperative and postoperative complications including graft rejection and failure...
January 4, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29296552/endothelial-cell-loss-in-penetrating-keratoplasty-endothelial-keratoplasty-and-deep-anterior-lamellar-keratoplasty
#3
Bo-I Ku, Yi-Ting Hsieh, Fung-Rong Hu, I-Jong Wan, Wei-Li Chen, Yu-Chih Hou
PURPOSE: To compare endothelial cell density (ECD) loss rates in penetrating keratoplasty (PKP), Descemet's stripping automated endothelial keratoplasty (DSAEK), and deep anterior lamellar keratoplasty (DALK). DESIGN: Single-center, multiple-surgeon, retrospective cohort study. MATERIALS AND METHODS: Patients who received PKP, DSAEK, or DALK from 2009 to 2014 were analyzed (68 vs. 38 vs. 11 patients, respectively). We excluded patients with therapeutic PKP or regraft, infection, endothelial rejection, or uncontrolled glaucoma...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29296551/surgical-outcome-of-deep-anterior-lamellar-keratoplasty-with-air-assisted-manual-dissection-for-corneas-with-previous-inflammation-or-fibrosis
#4
Yi-Ju Ho, Cheng-Hsiu Wu, Hung-Chi Chen, Chin-Shi Hsiao, Yi-Jen Hsueh, David Hui-Kang Ma
PURPOSE: To report our experience in air-assisted manual dissection deep anterior lamellar keratoplasty (DALK) for the treatment of corneal scar with previous inflammation and fibrosis. MATERIALS AND METHODS: We retrospectively reviewed the medical history of 21 patients (male:female = 13:8 mean age 41.9 years old) with corneal pathology from previous infection and inflammation. Trephination diameter ranged from 7.0 to 8.0 mm, and the graft was oversized by 0.25-0...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29275378/results-of-viscobubble-deep-anterior-lamellar-keratoplasty-after-failure-of-pneumatic-dissection
#5
Vincenzo Scorcia, Valentina De Luca, Andrea Lucisano, Adriano Carnevali, Giovanna Carnovale Scalzo, Cristina Bovone, Massimo Busin
AIM: To report the outcomes of bubble formation obtained by means of intrastromal injection of ophthalmic viscoelastic device (OVD) after failure of pneumatic dissection for deep anterior lamellar keratoplasty (DALK). METHODS: DALK was performed in 140 keratoconic eyes of 130 patients by injecting air and OVD only secondarily, after pneumatic dissection had failed; the bubble formation rates after air and OVD injection were recorded; complications, best spectacle-corrected visual acuity (BSCVA) and corneal tomographic parameters were evaluated 3 months, 6 months and 12 months postoperatively, as well as after complete suture removal...
December 23, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29274023/vector-analysis-of-femtosecond-laser-assisted-astigmatic-keratotomy-after-deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty
#6
Fouad anNakhli, Ashbala Khattak
PURPOSE: To compare the refractive and keratometric changes induced by femtosecond laser astigmatic keratotomy (AK) for suture-out post-keratoplasty astigmatism in deep anterior lamellar keratoplasty (group I) and penetrating keratoplasty (group II). SETTING: Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia. DESIGN: Retrospective, comparative, interventional study. METHODS: This study comprised 15 eyes in group I and 35 eyes in group II...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260096/an-unusual-case-of-acute-angle-closure-glaucoma-following-deep-anterior-lamellar-keratoplasty-using-the-big-bubble-technique
#7
Samir Jabbour, Adam Muzychuk, Younes Agoumi, Mona Harissi-Dagher
Purpose: To report the first case of acute angle closure due to a high-pressure Descemet membrane detachment following deep anterior lamellar keratoplasty (DALK) using the "big bubble" technique. Observations: A 25-year-old man underwent DALK surgery for keratoconus using the "big bubble" technique in which an air bubble is injected in deep stroma to promote dissection of underlying Descemet membrane from stroma. Surgery was uneventful and the patient was discharged home in good conditions...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259313/tuck-in-lamellar-keratoplasty-with-an-lenticule-obtained-by-small-incision-lenticule-extraction-for-treatment-of-post-lasik-ectasia
#8
Yang Jiang, Ying Li, Shan Yang, Thomas Chengxuan Lu
Corneal ectasia is a rare but serious post-operative complication of LASIK. Our main aim was to describe and evaluate the efficacy and safety of tuck-in lamellar keratoplasty with an lenticule obtained by SMILE for treatment of Post LASIK Ectasia. Tuck-in lamellar keratoplasty was performed on three post-LASIK cornea ectasia patients (three eyes) with central corneal thickness less than 400 µm. Each patient was monitored for at least 12 months. Our primary outcomes measured pre and post-operatively included: Anterior segment optical coherence tomography(AS-OCT), corneal topography and monitored by slit-lamp microscopy...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235270/lamellar-keratoplasty-using-position-guided-surgical-needle-and-m-mode-optical-coherence-tomography
#9
Sungwon Shin, Jung Kweon Bae, Yujin Ahn, Hyeongeun Kim, Geonho Choi, Young-Sik Yoo, Choun-Ki Joo, Sucbei Moon, Woonggyu Jung
Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the cornea. Even though DALK is a well-known transplant method, it is still challenged to manipulate the needle inside the cornea under the surgical microscope, which varies its surgical yield. Here, we introduce the DALK protocol based on the position-guided needle and M-mode optical coherence tomography (OCT)...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29227340/corneal-transplantation-in-new-zealand-2000-to-2009
#10
Alexandra Z Crawford, Thiyagaraj Krishnan, Susan E Ormonde, Dipika V Patel, Charles N McGhee
PURPOSE: To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS: All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevant clinical records were assessed for this period and 2 years after. All intraoperative or postoperative adverse events/complications, visual acuity, and graft outcomes were recorded...
December 8, 2017: Cornea
https://www.readbyqxmd.com/read/29215393/therapeutic-effects-of-lamellar-keratoplasty-on-terrien-marginal-degeneration
#11
Lin Li, Hualei Zhai, Lixin Xie, Jun Cheng, Weiwei Liu
PURPOSE: To evaluate the therapeutic effects of lamellar keratoplasty (LK) on Terrien marginal degeneration (TMD). METHODS: Retrospective interventional case series. Medical records of 63 patients (71 eyes) who received LK for TMD at Qingdao Eye Hospital, Shandong Eye Institute from December 1995 to March 2014 were reviewed. A total of 56 eyes were treated with partial LK and 15 eyes with total LK. Complications, visual acuity recovery, and graft status were evaluated...
December 5, 2017: Cornea
https://www.readbyqxmd.com/read/29192684/early-deep-anterior-lamellar-keratoplasty-for-fungal-keratitis-poorly-responsive-to-medical-treatment
#12
F Sabatino, E Sarnicola, C Sarnicola, G M Tosi, P Perri, V Sarnicola
PurposeTo investigate the efficacy of early therapeutic deep anterior lamellar keratoplasty (DALK) in eradicating fungal keratitis that is poorly responsive to medical treatment.Patients and methodsTwenty-three eyes (23 patients) underwent early therapeutic DALK within 15 to 50 days from the onset of symptoms. The adopted eligibility criteria for early DALK included the following: active fungal keratitis affecting the optical zone with ulcer confined in the 6.00 mm central cornea; deeper than 150 μm but not exceeding 300 μm; and poorly responsive to medical treatment...
December 1, 2017: Eye
https://www.readbyqxmd.com/read/29191679/intraocular-pressure-measurements-and-corneal-biomechanical-properties-using-a-dynamic-scheimpflug-analyzer-after-several-keratoplasty-techniques-versus-normal-eyes
#13
J Hugo, E Granget, G Ho Wang Yin, M Sampo, L Hoffart
PURPOSE: To evaluate the biomechanical properties of the cornea and their impact on intraocular pressure (IOP) measurement after lamellar keratoplasty, compared to healthy eyes, using a non-contact tonometer with a Scheimpflug camera. METHODS: This study, from 2014 to 2015, included 22 primary DSAEK, 5 DALK, 6 DSAEK after PK, and 50 control eyes. Using a non-contact tonometer with a high-speed Scheimpflug camera (CORVIS ST, Oculus Optikgeräte GmbH, Wetzlar, Germany), several biomechanical parameters were recorded, including radius at highest concavity (Rhc) and defomation amplitude (DA)...
November 27, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29165417/-pterygium-etiology-pathogenesis-treatment
#14
S A Malozhen, S V Trufanov, D A Krakhmaleva
Pterygium is a degenerative condition characterized by fibrovascular outgrowth of conjunctiva over the cornea. Many theories exist that try to explain its pathogenesis. The current belief is that this disease is multifactorial with ultraviolet radiation being the most important trigger. Attention is also paid to such factors as tear film changes, cytokines and growth factors disbalance, immunologic disturbances, genetic mutations, and viral infections. Modern classifications consider the rate of fibrovascular growth, its progressive potential, and histological features...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29149876/impact-of-donor-graft-quality-on-deep-anterior-lamellar-keratoplasty-dalk
#15
Friederike Schaub, Philip Enders, Werner Adler, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl
BACKGROUND: To evaluate main features of donor tissue that may influence clinical outcome or complication rate after deep anterior lamellar keratoplasty (DALK). METHODS: Donor tissue parameters of 84 consecutive corneal donor grafts used for big-bubble DALK surgery between June 2011 and December 2014 in 84 eyes of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome parameters of recipient eyes 12 months after surgery and 3 months after total suture removal...
November 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29146479/visual-outcome-of-penetrating-keratoplasty-deep-anterior-lamellar-keratoplasty-and-descemet-membrane-endothelial-keratoplasty
#16
Clàudia Garrido, Genís Cardona, Josep L Güell, Jaume Pujol
PURPOSE: A single-center, cross-sectional study was designed to assess and compare objective and subjective quality of vision of patients intervened with penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK) and Descemet membrane endothelial keratoplasty (DMEK). METHODS: Forty-six patients previously intervened with PK (22 eyes), DALK (7 eyes) and DMEK (17 eyes) were recruited. Visual evaluation included spherical and cylindrical refraction, distance corrected visual acuity (DCVA), photopic contrast sensitivity (CS), optical quality, measured with the HD Analyzer (objective scattering index [OSI], MTF cut-off and Strehl ratio), and ocular and corneal aberrometry, measured with the KR-1W Wavefront Analyzer...
November 13, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/29133660/predescemetocele-a-distinct-clinical-entity
#17
Priya Narang, Amar Agarwal, Dhivya Ashok Kumar
The case report incorporates a Fourier-domain optical coherence tomography (OCT) examination for demonstration of the existence of pre-Descemet's layer (PDL; Dua's layer) overlying a descemetocele and demonstrates predescemetocele as a separate clinical entity. The prospective analysis was done in two cases that had descemetocele, and OCT demonstrated the presence of PDL over an unruptured descemetocele that offers resilience and can be treated with an elective deep anterior lamellar keratoplasty or a penetrating keratoplasty...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133630/non-contact-lens-related-acanthamoeba-keratitis
#18
REVIEW
Prashant Garg, Paavan Kalra, Joveeta Joseph
The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Trauma and exposure to contaminated water are the main predisposing factors for the disease. Association with CLs is seen only in small fraction of cases. Contrary to classical description experience in India suggests that out of proportion pain, ring infiltrate, and radial keratoneuritis are seen in less than a third of cases...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29132691/-practical-assessment-of-dsaek-in-the-management-of-endothelial-decompensation-following-penetrating-keratoplasty
#19
E Neiter, C Goetz, F Tortuyaux, A Ehrhardt, N Houmad, J-M Perone
PURPOSE: To report our anatomical and functional results as well as possible complications of the first six Descemet's stripping endothelial keratoplasties (DSAEK) performed in our department for endothelial decompensation after penetrating keratoplasty (PK) METHODS: This was a retrospective and observational monocentric study of six patients with DSAEK after prior PK between January 2015 and July 2016. The data collected were: demographic characteristics (age, sex), ophthalmological comorbidities, initial indication for PK, delay between PK and DSAEK...
November 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29118505/descemet-s-membrane-macroperforation-during-interface-irrigation-in-big-bubble-deep-anterior-lamellar-keratoplasty
#20
Mohammed Ziaei, Susan E Ormonde
This report describes the macroperforation of descemet's membrane (DM) during irrigation of the interface following successful removal of stromal tissue in big bubble (BB) deep anterior lamellar keratoplasty (DALK). A 42-year-old woman with keratoconus underwent a BB DALK procedure. After successful formation of Type 2 bubble and removal of stromal tissue, interface irrigation was performed to remove residual viscoelastic. This led to a macroperforation of DM, and the case was converted to penetrating keratoplasty...
September 2017: Oman Journal of Ophthalmology
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