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https://www.readbyqxmd.com/read/29040183/the-prognostic-impact-of-the-pathological-response-to-neoadjuvant-dose-dense-therapy-for-ovarian-carcinoma
#1
Takahiro Ebata, Mayu Yunokawa, Hiroshi Yoshida, Seiko Bun, Tatsunori Shimoi, Akihiko Shimomura, Makoto Kodaira, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Tomoyasu Kato, Kenji Tamura
OBJECTIVE: The aim of this study was to assess the use of the pathological response to neoadjuvant chemotherapy (NAC) for predicting disease prognosis in patients with advanced ovarian cancer who received neoadjuvant dose-dense weekly paclitaxel and carboplatin (dd-TC) therapy. METHODS: We retrospectively investigated patients with advanced epithelial ovarian, tubal, or peritoneal carcinoma treated at our hospital from July 2004 to October 2014. Patients received dd-TC therapy as NAC followed by interval debulking surgery (IDS)...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29036303/the-safety-and-efficacy-of-carboplatin-plus-nanoparticle-albumin-bound-paclitaxel-in-the-treatment-of-non-small-cell-lung-cancer-patients-with-interstitial-lung-disease
#2
Yuichiro Yasuda, Yoshihiro Hattori, Rie Tohnai, Shoichi Ito, Yoshitaka Kawa, Yuko Kono, Yoshiko Urata, Munenobu Nogami, Daisuke Takenaka, Shunichi Negoro, Miyako Satouchi
Background: The optimal chemotherapy regimen for non-small cell lung cancer patients with interstitial lung disease is unclear. We therefore investigated the safety and efficacy of carboplatin plus nab-paclitaxel as a first-line regimen for non-small cell lung cancer in patients with interstitial lung disease. Methods: We retrospectively reviewed advanced non-small cell lung cancer patients with interstitial lung disease who received carboplatin plus nab-paclitaxel as a first-line chemotherapy regimen at Hyogo Cancer Center between February 2013 and August 2016...
September 28, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29034932/design-and-development-of-multifunctional-polyphosphoester-based-nanoparticles-for-ultrahigh-paclitaxel-dual-loading
#3
Fuwu Zhang, Sarosh Khan, Richen Li, Justin A Smolen, Shiyi Zhang, Guizhi Zhu, Lu Su, Ashlee A Jahnke, Mahmoud Elsabahy, Xiaoyuan Chen, Karen L Wooley
Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL(-1). The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.
October 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29034548/electroacupuncture-alleviates-chemotherapy-induced-pain-through-inhibiting-phosphorylation-of-spinal-camkii-in-rats
#4
Y Zhang, A Li, J Xin, K Ren, B M Berman, L Lao, R-X Zhang
BACKGROUND: Current medical treatments for chemotherapy-induced pain (CIP) are either ineffective or have adverse side effects. Acupuncture may alleviate CIP, but its effectiveness against this condition has not been studied. Paclitaxel causes neuropathic pain in cancer patients. METHODS: We evaluated the effects of electroacupuncture (EA) on paclitaxel-induced CIP in a rat model. Paclitaxel (2 mg/kg) or vehicle was injected (i.p.) on alternate days of 0-6. The resulting pain was treated with 10 Hz/2 mA/0...
October 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29033758/resection-of-locally-advanced-pancreatic-neoplasms-after-neoadjuvant-chemotherapy-with-nab-paclitaxel-and-gemcitabine-following-folfirinox-failure
#5
Sarah Hahn, Ahmet Ayav, Anthony Lopez
The incidence of pancreatic cancer has dramatically increased over the past years, but the prognosis has not improved. Between 30 and 40% of tumors are considered locally advanced, essentially due to vascular involvement. In recent years, new chemotherapy protocols with high response rates have been developed. FOLFIRINOX seems to be an interesting option in this situation, but hematologic toxicity could be an obstacle to its prescription. Nab-paclitaxel and gemcitabine offer significant response rates with a reasonable safety profile...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033565/double-receptor-targeting-multifunctional-iron-oxide-nanoparticles-drug-delivery-system-for-the-treatment-and-imaging-of-prostate-cancer
#6
Md Shakir Uddin Ahmed, Ahmad Bin Salam, Clayton Yates, Kyle Willian, Jesse Jaynes, Timothy Turner, Mohamed O Abdalla
As an alternative therapeutic treatment to reduce or eliminate the current side effects associated with advanced prostate cancer (PCa) chemotherapy, a multifunctional double-receptor-targeting iron oxide nanoparticles (IONPs) (luteinizing hormone-releasing hormone receptor [LHRH-R] peptide- and urokinase-type plasminogen activator receptor [uPAR] peptide-targeted iron oxide nanoparticles, LHRH-AE105-IONPs) drug delivery system was developed. Two tumor-targeting peptides guided this double-receptor-targeting nanoscale drug delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29031923/deae-dextran-coated-paclitaxel-nanoparticles-act-as-multifunctional-nano-system-for-intranuclear-delivery-to-triple-negative-breast-cancer-through-vegf-and-notch1-inhibition
#7
Anita K Bakrania, Bhavesh C Variya, Lalji V Rathod, Snehal S Patel
Triple negative breast cancer revolution has identified a plethora of therapeutic targets making it apparent that a single target for its treatment could be rare hence creating an urge to develop robust technologies for combination drug therapy. Paclitaxel, hailed as the most significant advancement in chemotherapy faces several underpinnings due to its low solubility and permeability. Advancing research has demonstrated the role of interferons in cancer. DEAE-Dextran, an emerging molecule with evidence of interferon induction was utilized in the present study to develop a nanoformulation in conjugation with paclitaxel to target multiple therapeutic pathways, with diminution of paclitaxel adverse effects and develop a specific targeted nano system...
October 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29031225/cube-shaped-theranostic-paclitaxel-prodrug-nanocrystals-with-surface-functionalization-of-spc-and-mpeg-dspe-for-imaging-and-chemotherapy
#8
Fuqiang Guo, Jiajia Shang, Hai Zhao, Kangrong Lai, Yang Li, Zhongxiong Fan, Zhenqing Hou, Guanghao Su
As one of nanomedicine delivery systems (NDSs), drug nanocrystals exhibited an excellent anticancer effect. Recently, differences of internalization mechanisms and subcellular localization of both drug nanocrystals and small molecular free drug have drawn much attention. In this paper, paclitaxel (PTX) as a model anticancer drug was directly labeled with 4-chloro-7-nitro-1, 2, 3-benzoxadiazole (NBD-Cl) (a drug-fluorophore conjugate Ma et al. (2016) and Wang et al. (2016) [1,2] (PTX-NBD)). PTX-NBD was synthesized by nucleophilic substitution reaction of PTX with NBD-Cl in high yield and characterized by fluorescence, XRD, ESI-MS, and FT-IR analysis...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29030633/the-best-platinum-regimens-for-chemo-naive-incurable-non-small-cell-lung-cancer-network-meta-analysis
#9
Nobuyuki Horita, Akimichi Nagashima, Kentaro Nakashima, Yuji Shibata, Kentaro Ito, Atsushi Goto, Takeharu Yamanaka, Takeshi Kaneko
Platinum regimens still play a key role in chemotherapy for incurable non-small cell lung cancer (NSCLC). Although guidelines list many platina regimens, the best regimens have not yet clarified. Electronic searches were carried out during November 26th-28th, 2016. We included individually randomized trials comparing two or more platinum regimes for incurable chemo-naive NSCLC published in English full papers. The platinum doublets should be either Cisplatin (CDDP), Carboplatin (CBDCA), or Nedaplatin (CDGP) plus one of the third-generation agents...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030301/biodegradable-zwitterionic-sulfobetaine-polymer-and-its-conjugate-with-paclitaxel-for-sustained-drug-delivery
#10
Haotian Sun, Michael Yu Zarng Chang, Wei-I Cheng, Qing Wang, Alex Commisso, Meghan Capeling, Yun Wu, Chong Cheng
A fully biodegradable zwitterionic polymer and the corresponding conjugate with paclitaxel (PTX) were synthesized as promising biomaterials. Allyl-functionalized polylactide (PLA) was employed as the precursor of polymer backbones. UV-induced thiol-ene reaction was conducted to conjugate thiol-functionalized sulfobetaine (SB) with the PLA-based backbone. The resulting zwitterionic polymer did not exhibit considerable cytotoxicity. A polymer-drug conjugate was also obtained by thiol-ene reaction of both thiol-functionalized SB and PTX with allyl-functionalized PLA...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29029595/2-hydroxyoleic-acid-inserted-liposomes-as-a-multifunctional-carrier-of-anticancer-drugs
#11
Eun-Ji Jang, Woo Rim Choi, Soo-Yeon Kim, Soon-Seok Hong, Inmoo Rhee, Sang-Jin Lee, Sung Weon Choi, Han-Gon Choi, Soo-Jeong Lim
Studies have shown that insertion of oleic acid into lipid bilayers can modulate the membrane properties of liposomes so as to improve their function as drug carriers. Considering that 2-hydroxyoleic acid (2OHOA), a potential antitumor agent currently undergoing clinical trials, is a derivative of oleic acid, we explored the possibility of developing 2OHOA-inserted liposomes as a multifunctional carrier of antitumor drugs in the present study. The insertion of 2OHOA into lipid bilayers was confirmed by surface charge determination and differential scanning calorimetry...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29027598/a-randomized-phase-ii-study-of-weekly-paclitaxel-with-or-without-pelareorep-in-patients-with-metastatic-breast-cancer-final-analysis-of-canadian-cancer-trials-group-ind-213
#12
V Bernstein, S L Ellard, S F Dent, D Tu, M Mates, S K Dhesy-Thind, L Panasci, K A Gelmon, M Salim, X Song, M Clemons, D Ksienski, S Verma, C Simmons, H Lui, K Chi, H Feilotter, L J Hagerman, L Seymour
BACKGROUND: Pelareorep, a serotype 3 reovirus, has demonstrated preclinical and early clinical activity in breast cancer and synergistic cytotoxic activity with microtubule targeting agents. This multicentre, randomized, phase II trial was undertaken to evaluate the efficacy and safety of adding pelareorep to paclitaxel for patients with metastatic breast cancer (mBC). METHODS: Following a safety run-in of 7 patients, 74 women with previously treated mBC were randomized either to paclitaxel 80 mg/m(2) intravenously on days 1, 8, and 15 every 4 weeks plus pelareorep 3 × 10(10) TCID50 intravenously on days 1, 2, 8, 9, 15, and 16 every 4 weeks (Arm A) or to paclitaxel alone (Arm B)...
October 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29027523/-role-of-tenascin-%C3%B0-in-triple-negative-breast-cancer
#13
O P Popova, S Yu Bogomazova, A A Ivanov
AIM: to establish a relationship between the main markers tumor stem cells (TSCs), CD44, and CD24, the level of tenascin C production, and chemoresistance in triple-negative breast cancer (BC). SUBJECTS AND METHODS: Thirty biopsy specimens from triple-negative BC patients who had conventionally received preoperative chemotherapy followed by surgery were selected in the investigation. All the selected patients were conventionally assigned to neoadjuvant polychemotherapy (PCT) with paclitaxel and carboplatin...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29027133/combination-of-a-chemopreventive-agent-and-paclitaxel-in-cd44-targeted-hybrid-nanoparticles-for-breast-cancer-treatment
#14
Bao Ngoc Tran, Hanh Thuy Nguyen, Jong Oh Kim, Chul Soon Yong, Chien Ngoc Nguyen
The CD44 receptor, which is upregulated in many cancer cells, provides a selective cellular surface for targeted drug delivery systems. We developed a hybrid nanocarrier for the CD44-targeted delivery of ibuprofen (IBU) and paclitaxel (PTX). The solid lipid nanoparticles (SLNs) were prepared by a hot-melt oil/water emulsion technique and then coated with hyaluronic acid (HA) by electrostatic interactions. The final SLN were spherical with a hydrodynamic diameter (Z) of 72.16 ± 2.9 nm, polydispersity index (PDI) of 0...
October 12, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29027049/acute-phase-dynamics-of-circulating-tumor-cells-after-paclitaxel-and-doxorubicin-chemotherapy-in-breast-cancer-mouse-models
#15
Yayoi Adachi, Mayumi Yoshimura, Keiko Nishida, Hisanobu Usuki, Keiko Shibata, Masaya Hattori, Naoto Kondo, Yasushi Yatabe, Hiroji Iwata, Toyone Kikumori, Yasuhiro Kodera, Hayao Nakanishi
PURPOSE: Circulating tumor cells (CTCs) can provide a potentially minimal invasive source for monitoring chemotherapeutic effects. However, detailed in vivo dynamics of CTC after chemotherapy remain largely unknown. METHODS: We monitored CTC number and morphology early after chemotherapy using a newly developed cytology-based CTC detection device and triple-negative breast cancer mouse CTC models with spontaneous lung metastatic potential. RESULTS: Paclitaxel inhibited cell growth of breast cancer cells by mainly G2/M cell cycle arrest and partly apoptosis, whereas doxorubicin inhibited cell growth mainly by apoptosis and partly G2 cell cycle arrest in vitro...
October 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29026300/noncovalent-interaction-assisted-drug-delivery-system-with-highly-efficient-uptake-and-release-of-paclitaxel-for-anticancer-therapy
#16
Yuping Wei, Liang Ma, Liang Zhang, Xia Xu
An effective drug delivery system requires efficient drug uptake and release inside cancer cells. Here, we report a novel drug delivery system, in which paclitaxel (PTX) interacts with a novel cell penetrating peptide (CPP) through noncovalent interaction designed based on molecular simulations. This CPP/PTX complex confers high efficiency in delivering PTX into cancer cells not by endocytosis but by an energy-independent pathway. Once inside cells, the noncovalent interaction between PTX and the CPP may allow fast release of PTX within cells due to the direct translocation of CPP/PTX...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29025675/acetal-linked-pegylated-paclitaxel-prodrugs-forming-free-paclitaxel-loaded-ph-responsive-micelles-with-high-drug-loading-capacity-and-improved-drug-delivery
#17
Da Huang, Yaping Zhuang, Hong Shen, Fei Yang, Xing Wang, Decheng Wu
Endosomal pH-responsive micellar nanoparticles were prepared by self-assembly of an amphiphilic poly(ethylene glycol)-acetal-paclitaxel (PEG-acetal-PTX) prodrug, and free PTX could be encapsulated in the hydrophobic core of the nanoparticles. These nanoparticles exhibited excellent storage stability for over 6months under normal conditions, but disassembled quickly in response to faintly acidic environment. Incorporating physical encapsulation and chemical conjugation, the PTX concentration in the nanoparticles solution could reach as high as 3665μg/mL, accompanying with a high drug loading capacity of 60...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024661/paclitaxel-reduces-axonal-bclw-to-initiate-ip3r1-dependent-axon-degeneration
#18
Sarah E Pease-Raissi, Maria F Pazyra-Murphy, Yihang Li, Franziska Wachter, Yusuke Fukuda, Sara J Fenstermacher, Lauren A Barclay, Gregory H Bird, Loren D Walensky, Rosalind A Segal
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons required for transmission of sensory information; axonal degeneration causes impaired tactile sensation and persistent pain. Currently the molecular mechanisms of CIPN are not understood, and there are no available treatments. Here we show that the chemotherapeutic agent paclitaxel triggers CIPN by altering IP3 receptor phosphorylation and intracellular calcium flux, and activating calcium-dependent calpain proteases...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29019326/epidemiology-and-outcomes-with-platinum-based-chemotherapy-in-recurrent-or-metastatic-carcinoma-cervix-in-a-developing-country-experience-from-a-tertiary-oncology-centre-in-southern-india
#19
K C Lakshmaiah, Aditi Harsh Thanky, D Lokanatha, K Govind Babu, Linu Jacob, Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev, Aparna Sridharmurthy
INTRODUCTION: Carcinoma cervix is the leading cause of cancer in Indian women. Recurrent/metastatic cervix is the most aggressive form of the disease. There is paucity of data in this setting in Indian women regarding outcomes with palliative chemotherapy. METHODS: We retrospectively analyzed hospital registry data between January 2013 and December 2014 for recurrent/metastatic carcinoma cervix patients who were planned for palliative chemotherapy and assessed their demographic parameters, response and survival outcomes with chemotherapy...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29016978/comparative-proteomic-analyses-of-two-taxus-species-taxus-%C3%A3-media-and-taxus-mairei-reveals-variations-in-the-metabolisms-associated-with-paclitaxel-and-other-metabolites
#20
Juan Hao, Hong Guo, Xinai Shi, Ye Wang, Qinghua Wan, Yaobin Song, Lei Zhang, Ming Dong, Chenjia Shen
Taxus species are well-known for paclitaxel, which exhibits antitumor activities and is used for treating various cancers. Although most Taxus species are widely spread in many areas, few studies have characterized the variations in the metabolisms among different Taxus species. Using an integrated approach involving 'tandem mass tag' labeling and liquid chromatography-tandem mass spectrometry (HPLC/MS), proteomes of T. media and T. mairei were investigated, and 4078 proteins were quantified. Screening and classification of differential expressed proteins revealed many metabolism-associated proteins...
August 30, 2017: Plant & Cell Physiology
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