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https://www.readbyqxmd.com/read/29327757/rapid-and-sensitive-detection-of-neuron-specific-enolase-with-a-polydopamine-coated-plasmonic-chip-utilizing-a-rear-side-coupling-method
#1
M Toma, S Izumi, K Tawa
A rapid and sensitive detection of a cancer marker, neuron specific enolase (NSE), is demonstrated by using a disposable silver plasmonic chip functionalized with a mussel-inspired polydopamine (PDA) coating. A plasmonic chip consisting of a diffraction grating coated with a silver thin film is used for the excitation of propagating surface plasmon resonance through a rear-side grating coupling method. Simple and quick bio-functionalization of the sensor surface is performed by PDA coating which requires 20 min for deposition, and allows direct attachment of the capture antibody without using any coupling agents...
January 12, 2018: Analyst
https://www.readbyqxmd.com/read/29247745/thymidine-kinase-1-combined-with-cea-cyfra21-1-and-nse-improved-its-diagnostic-value-for-lung-cancer
#2
Z F Jiang, M Wang, J L Xu
AIMS: Thymidine kinase 1 (TK1) is a tumor biomarker in human malignancies. The purpose of this study was to evaluate the diagnostic efficiency of this marker for lung cancer using the combined analysis of carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA21-1), neuron specific enolase (NSE) and TK1. MAIN METHODS: From 2013 to 2014, 147 patients with lung cancer and 228 patients with lung benign diseases who were admitted to our hospital were reviewed...
December 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/29238236/pro-gastrin-releasing-peptide-progrp-as-a-biomarker-in-small-cell-lung-cancer-diagnosis-monitoring-and-evaluation-of-treatment-response
#3
REVIEW
Ewa Wojcik, Jan Kanty Kulpa
Lung cancer belongs to malignant tumors that possess the highest rates of morbidity and mortality in the world. A number of morphological, biological and clinical features justify the distinction of small-cell carcinoma with respect to the other histological types of lung cancer. The predominant neuroendocrine phenotype is critical for the selection of biomarkers used in diagnostics, monitoring and evaluation of treatment response; early onset relapses in patients with small-cell lung cancer (SCLC) and the evaluation of their prognosis...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29191973/blocking-the-feedback-loop-between-neuroendocrine-differentiation-and-macrophages-improves-the-therapeutic-effects-of-enzalutamide-mdv3100-on-prostate-cancer
#4
Chao Wang, Guang Peng, Hai Huang, Fei Liu, De-Pei Kong, Ke-Qin Dong, Li-He Dai, Zhe Zhou, Kai-Jian Wang, Jun Yang, Yan-Qiong Cheng, Xu Gao, Min Qu, Hongru Wang, Feng Zhu, Qin-Qin Tian, Dan Liu, Li Cao, Xingang Cui, Chuanliang Xu, Dan-Feng Xu, Yinghao Sun
PURPOSE: Androgen-deprivation therapy (ADT), including enzalutamide, induces resistance in prostate cancer (PCa); ADT resistance is associated with neuroendocrine differentiation (NED) and tumor-associated macrophages (TAMs). This study aimed to investigate the association between enzalutamide-induced NED and TAMs and its mechanism. EXPERIMENTAL DESIGN: The association between enzalutamide-induced NED and TAMs was investigated by immunohistochemistry using PCa tissues, enzalutamide-resistant mouse xenografts and a co-culture system...
November 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29152494/d-dimer-level-is-related-to-the-prognosis-of-patients-with-small-cell-lung-cancer
#5
Xuqin Jiang, Xiaodong Mei, Huimei Wu, Xiaojuan Chen
Background: Although the significance of D-dimer in cancer patients has been extensively studied and plasma D-dimer levels have been reported to be abnormally high in certain types of lung cancer patients, its prognostic value for small cell lung cancer (SCLC) remains largely unknown. Methods: One hundred and seven newly diagnosed SCLC patients were enrolled in this study. Variables including the clinical features, pre-treatment levels of D-dimer, serum neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) were extracted...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29145241/the-prognostic-value-of-the-serum-neuron-specific-enolase-and-lactate-dehydrogenase-in-small-cell-lung-cancer-patients-receiving-first-line-platinum-based-chemotherapy
#6
Xiaofan Liu, Weiming Zhang, Wen Yin, Yang Xiao, Changzhi Zhou, Yi Hu, Shuang Geng
The aim of this study was to investigate the associations of serum levels of neuron-specific enolase (NSE), pro-gastrin releasing peptide (ProGRP), and lactate dehydrogenase (LDH) with clinical response and survival in small cell lung cancer (SCLC) patients receiving first-line platinum-based chemotherapy.One hundred thirty-six patients with SCLC were recruited in this study. All the patients received first-line platinum-based chemotherapy. Clinical efficacy was assessed according to Response Evaluation Criteria in Solid Tumors v1...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29113785/label-free-electrochemical-immunoassay-for-neuron-specific-enolase-based-on-3d-macroporous-reduced-graphene-oxide-polyaniline-film
#7
Qi Zhang, Xiaoyan Li, Chunhua Qian, Li Dou, Feng Cui, Xiaojun Chen
The content of neuron specific enolase (NSE) in serum is considered to be an essential indicator of small cell lung cancer (SCLC). Here, a novel label-free electrochemical immunoassay for the detection of NSE based on the three dimensionally macroporous reduced graphene oxide/polyaniline (3DM rGO/PANI) film has been proposed. The 3DM rGO/PANI film was constructed by electrochemical co-deposition of GO and aniline into the interspaces of a sacrificial silica opal template modified Au slice. During the co-deposition, GO was successfully reduced by aniline and PANI could be deposited on the surfaces of rGO sheets...
January 1, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29113400/evaluation-of-factors-associated-with-platinum-sensitivity-status-and-survival-in-limited-stage-small-cell-lung-cancer-patients-treated-with-chemoradiotherapy
#8
Qiang Wen, Xue Meng, Peng Xie, Shijiang Wang, Xindong Sun, Jinming Yu
In this retrospective study, we analyzed the association of clinicopathological factors and therapeutic plans with platinum-sensitivity status and survival of limited-stage small cell lung cancer (LS-SCLC) patients. We enrolled 452 LS-SCLC patients with 279 platinum sensitive and 173 platinum refractory patients. The low serum neuro-specific enolase levels (NSE; p = 0.011), neutrophil-to-lymphocyte ratios (NLR; p = 0.013) and higher objective response rates (p = 0.003) were associated with sensitive group but not the refractory group...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29061216/-utility-of-multiple-increased-lung-cancer-tumor-markers-in-treatment-of-patients-with-advanced-lung-adenocarcinoma
#9
Yan Peng, Yan Wang, Xuezhi Hao, Junling Li, Yutao Liu, Hongyu Wang
BACKGROUND: Among frequently-used tumor markers in lung cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125), cytokeratin 19 (CYFRA21-1) and squamous carcinoma antigen (SCC), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP) are respectively expressed highly in lung adenocarcinoma, lung squamous carcinoma and small cell lung cancer. By comparing patients with multiple increased tumor markers (group A) and patients with increase of CEA and/or CA125 (group B), this study aims to investigate the utility of multiple increased tumor markers in therapeutic evaluation and prediction of disease relapsing in patients with advanced lung adenocarcinoma...
October 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29050327/prognostic-and-predictive-value-of-serum-carcinoembryonic-antigen-levels-in-advanced-non-small-cell-lung-cancer-patients-with-epidermal-growth-factor-receptor-sensitive-mutations-and-receiving-tyrosine-kinase-inhibitors
#10
Xin Min Zhao, Jing Zhao, Kai Lin Xing, Si Sun, Zhi Guo Luo, Hui Jie Wang, Jia Lei Wang, Jian Hua Chang, Xiang Hua Wu
BACKGROUND: Despite the widespread use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in advanced or recurrent non-small cell lung cancer (NSCLC), no biomarkers for predicting the efficacy of EGFR-TKIs in patients with EGFR-sensitive mutations have yet been identified. The purpose of our study was to explore the effect of baseline serum tumor markers in stage IIIB/IV NSCLC patients treated with EGFR-TKIs. METHODS: One hundred and seventy-seven patients with stage IIIB/IV NSCLC who harbored EGFR-sensitive mutations and were treated with EGFR-TKIs were retrospectively reviewed...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049328/ca-19-9-and-ca-125-as-potential-predictors-of-disease-recurrence-in-resectable-lung-adenocarcinoma
#11
Sofi Isaksson, Per Jönsson, Nastaran Monsef, Hans Brunnström, Pär-Ola Bendahl, Mats Jönsson, Johan Staaf, Maria Planck
OBJECTIVES: Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. MATERIAL AND METHODS: Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28970953/overexpression-of-neuron-specific-enolase-as-a-prognostic-factor-in-patients-with-gastric-cancer
#12
Taejin Park, Young-Joon Lee, Sang-Ho Jeong, Sang-Kyung Choi, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Miyeong Park, Young-Sool Hah, Jiyun Yoo, Woo-Song Ha, Soon-Chan Hong, Gyung Hyuck Ko
PURPOSE: Enolase is a cytoplasmic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway. The aim of this study was to investigate whether the overexpression of neuron-specific enolase (NSE) can serve as a prognostic factor in patients with gastric cancer (GC). MATERIALS AND METHODS: To assess its prognostic value in GC, NSE expression was measured by immunohistochemistry in a clinically annotated tissue microarray comprising of 327 human GC specimens...
September 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28969076/systematic-review-and-meta-analysis-of-the-efficacy-of-serum-neuron-specific-enolase-for-early-small-cell-lung-cancer-screening
#13
Lang Huang, Jian-Guo Zhou, Wen-Xiu Yao, Xu Tian, Shui-Ping Lv, Ting-You Zhang, Shu-Han Jin, Yu-Ju Bai, Hu Ma
We performed a pooled analysis of the efficacy of serum neuron-specific enolase (NSE) levels for early detection of small cell lung cancer (SCLC) in patients with benign lung diseases and healthy individuals. Comprehensive searches of several databases through September 2016 were conducted. The quality of the included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Ultimately, 33 studies containing 9546 samples were included in the review. Pooled sensitivity of NSE for detecting SCLC was 0...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969023/pretreatment-serum-lactate-level-as-a-prognostic-biomarker-in-patients-undergoing-supratentorial-primary-brain-tumor-resection
#14
Chung-Chih Shih, Tzong-Shiun Lee, Fon-Yih Tsuang, Pei-Lin Lin, Ya-Jung Cheng, Hsiao-Liang Cheng, Chun-Yu Wu
INTRODUCTION: Malignant primary brain tumors are one of the most aggressive cancers. Pretreatment serum nonneuronal biomarkers closely associated with postoperative outcomes are of high clinical relevance. The present study aimed to identify potential pretreatment serum biomarkers that may influence oncological outcomes in patients with primary brain tumors. METHODS: A total of 74 patients undergoing supratentorial primary brain tumor resection were enrolled. Before tumor resection, serum neuronal biomarkers, namely neuron-specific enolase (NSE), S100β, and glial fibrillary acidic protein (GFAP), and serum nonneuronal biomarkers, namely neutrophil gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), and lactate, were measured and associated postoperative oncological outcomes, including brain tumor grading, progression-free survival (PFS), and overall survival (OS), were compared...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967066/clinical-implications-for-pro-grp-in-small-cell-lung-cancer-a-single-center-experience
#15
Stefano Cavalieri, Daniele Morelli, Antonia Martinetti, Giulia Galli, Federico Nichetti, Filippo de Braud, Marco Platania
BACKGROUND: Recently, pro-gastrin-releasing peptide (pro-GRP) became available as an alternative sensitive, specific and reliable tumor marker for patients with small cell lung cancer (SCLC), both in limited (LD) and diffuse disease (DD). METHODS: We retrospectively analyzed pro-GRP, neuron-specific enolase (NSE) and CEA in patients with SCLC and non-small cell lung cancer (NSCLC). Serum pro-GRP level was measured with electrochemiluminescence at our laboratory (cutoff 77...
September 25, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28928901/systematic-correlation-analyses-of-circulating-tumor-cells-with-clinical-variables-and-tumor-markers-in-lung-cancer-patients
#16
Xu Wang, Kewei Ma, Zhiguang Yang, Jiuwei Cui, Hua He, Andrew R Hoffman, Ji-Fan Hu, Wei Li
Measurement of circulating tumor cells (CTC) offers promise as a clinical biomarker to monitor disease status, therapeutic response, and progression in cancer patients. However, its clinical value in lung cancer patients has not been fully explored. We systematically evaluate the association of CTCs with clinical variables and tumor markers in a cohort of lung cancer patients. Using the CELLSEARCH System, CTCs were detected in both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) patients prior to therapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28910952/-establishment-of-cut-off-value-of-serum-pro-gastrin-releasing-peptide-for-diagnosis-of-small-cell-lung-cancer-and-evaluation-on-the-clinical-diagnosis-efficiency
#17
D Shen, B B Han, F Chen, B J Wei, C J Cui, G J Wang, W Cui
Objective: To determine critical reference value (cut-off value) of serum pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase(NSE) in the diagnosis of small cell lung cancer(SCLC). To evaluate the clinical significance of serum levels of ProGRP and NSE in diagnosis and differential diagnosis in SCLC. Methods: Three hundred and fifty-two SCLC patients, 163 non small cell lung cancer(NSCLC)patients , 193 benign pulmonary disease patients and 140 healthy people visiting in National Cancer Hospital were analyzed retrospectively from January 2014 to July 2017...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28903317/pd-l1-and-c-met-expression-and-survival-in-patients-with-small-cell-lung-cancer
#18
Lulu Miao, Yunyun Lu, Yanjun Xu, Gu Zhang, Zhiyu Huang, Lei Gong, Yun Fan
BACKGROUND: Blocking the binding between the PD-1 and PD-L1 has been reported to produce antitumor responses. The MET/HGF axis appears to be another signaling pathway frequently altered in small cell lung cancer (SCLC). Our study was aimed to investigate the expression and prognostic roles of PD-L1 and c-MET in SCLC. METHODS: The expression levels of PD-L1 and c-MET were evaluated by immunohistochemical analysis in 83 SCLC specimens. Survival analysis was performed using the Kaplan-Meier method...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28885659/the-role-of-serum-neuron-specific-enolase-in-patients-with-prostate-cancer-a-systematic-review-of-the-recent-literature
#19
Barbara Muoio, Mariarosa Pascale, Enrico Roggero
In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa...
September 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28877268/combining-pet-ct-with-serum-tumor-markers-to-improve-the-evaluation-of-histological-type-of-suspicious-lung-cancers
#20
Rifeng Jiang, Ximin Dong, Wenzhen Zhu, Qing Duan, Yunjing Xue, Yanxia Shen, Guopeng Zhang
OBJECTIVE: Histological type is important for determining the management of patients with suspicious lung cancers. In this study, PET/CT combined with serum tumor markers were used to evaluate the histological type of lung lesions. MATERIALS AND METHODS: Patients with suspicious lung cancers underwent 18F-FDG PET/CT and serum tumor markers detection. SUVmax of the tumor and serum levels of tumor markers were acquired. Differences in SUVmax and serum levels of tumor markers among different histological types of lung cancers and between EGFR mutation statues of adenocarcinoma were compared...
2017: PloS One
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