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https://www.readbyqxmd.com/read/29444665/comparison-of-1-year-outcomes-after-ahmed-glaucoma-valve-implantation-with-and-without-ologen-adjuvant
#1
Tai Jun Kim, Sohyun Kang, Jin Wook Jeoung, Young Kook Kim, Ki Ho Park
BACKGROUND: Many studies have investigated the clinical benefits of Ologen for trabeculectomy. However, its benefits for Ahmed glaucoma valve (AGV) implantation have not been investigated as extensively. The aim of this study was to compare the 1-year outcomes of AGV implantation with and without Ologen adjuvant for the treatment of refractory glaucoma. METHODS: This retrospective study included a total of 20 eyes of 20 glaucoma patients, who were followed for at least 1-year after undergoing AGV implantation...
February 14, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29420103/conjunctival-flap-with-biodegradable-collagen-matrix-implantation-for-the-treatment-of-scleromalacia-after-periocular-surgery
#2
Kyung Eun Han, Sangchul Yoon, Roo Min Jun, Tae-Im Kim, Eung Kweon Kim, Kyoung Yul Seo
PURPOSE: To report a new surgical procedure using biodegradable collagen matrix (Ologen) implantation with conjunctival flap for reconstruction of scleromalacia after periocular surgery. METHODS: A total of 26 areas of 25 eyes in 25 patients were included. We divided all eyes according to the preoperative extent of calcified plaque or scleral defect as follows: small, large, and large and severe. Morphologic outcomes were graded from 0 to 7, with higher scores indicating worse cosmetic outcomes...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29296557/use-of-biodegradable-collagen-glycosaminoglycan-copolymer-matrix-implant-to-reduce-postoperative-fibrosis-in-strabismus-surgery
#3
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa, Antonio Carlos Centelhas, Diogo Gonçalves Dos Santos Martins
The occurrence of restrictive strabismus after conjunctival surgeries is widely described in the literature. Fibrosis causes adherence of the conjunctiva to the Tenon's capsule, intermuscular membrane, adipose orbital tissue, sclera, and extraocular muscle tissue. Fibrosis causes adherence of the conjunctiva to the Tenon's capsule, intermuscular membrane, adipose orbital tissue, sclera, and extraocular muscle tissue. We report a case of the use of a biodegradable collagen-glycosaminoglycan copolymer matrix implant (Ologen®) as an alternative adjuvant, used as a spacer to mechanically separate the subconjunctival and episcleral tissues to prevent fibrosis in a patient undergoing a surgical correction for a strabismus with a restrictive component due to previous surgeries of pterygium excision...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260410/suprachoroidal-drainage-with-collagen-sheet-implant-a-novel-technique-for-non-penetrating-glaucoma-surgery
#4
Peter Szurman, Kai Januschowski, Karl Thomas Boden, Anna-Maria Seuthe
PURPOSE: Our purpose was both to introduce the new technique of suprachoroidal drainage with collagen sheet implantation as a novel technique of non-penetrating glaucoma surgery and to present first results of a prospective pilot study. METHODS: A superficial rectangular sclera flap of half-scleral thickness sized 4 × 4.5 mm is dissected anteriorly until clear cornea. Then, a second scleral flap is created underneath the first one sized 3.5x4mm and is cut down full-thickness to the choroid exposing the suprachoroidal space...
December 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29118494/comparison-between-ologen-implant-and-different-concentrations-of-mitomycin-c-as-an-adjuvant-to-trabeculectomy-surgery
#5
Zeiad H Eldaly, Ali A Maasoud, Mohamed S Saad, Abdelsalam A Mohamed
CONTEXT: Trabeculectomy is the most common surgical procedure for treatment of glaucoma. To improve success rates, adjuvants were utilized as Mitomycin C (MMC) and Ologen implant. AIMS: This study aims to establish efficacy and safety of Ologen implant versus MMC in trabeculectomy. SETTING AND DESIGN: A prospective, comparative clinical study was conducted at the Department of Ophthalmology, Assiut University, between December 2014 and April 2016...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29117004/outcomes-of-trabeculectomy-and-phacotrabeculectomy-with-collagen-matrix-implant-ologen-and-low-dose-mitomycin-c-two-year-follow-up
#6
Miguel A Castejón, Miguel A Teus, Gema Bolivar, Javier Paz, Beatriz Castaño
PURPOSE: To analyse the results achieved in lowering intraocular pressure (IOP) after trabeculectomy or combined surgery (phacotrabeculectomy) with low-dose mitomycin C (MMC) using the Ologen Collagen Matrix implant (Ologen CM). METHODS: This retrospective study included 58 eyes from 47 consecutive patients with glaucoma who underwent filtering surgery alone or combined with cataract surgery. The study group included 29 eyes that underwent trabeculectomy (14 eyes) or phacotrabeculectomy (15 eyes) with low-dose MMC (0...
November 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29102674/protective-effects-of-biodegradable-collagen-implants-on-thinned-sclera-after-strabismus-surgery-a-paired-eye-study
#7
Tae Keun Yoo, Sueng-Han Han, Jinu Han
PURPOSE: To determine the efficacy of a biodegradable Ologen (Aeon Astron Europe BV, Leiden, The Netherlands) collagen matrix in reducing the blue color change due to exposed thinned sclera after strabismus surgery. METHODS: Fourteen patients with intermittent exotropia undergoing symmetric bilateral lateral rectus recession surgery were included in this prospective, randomized, paired-eye controlled study. In each patient, Ologen was implanted at the original rectus insertion site in one randomly selected eye; the other eye underwent conventional surgery...
November 1, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29049735/clinical-and-biological-evaluations-of-biodegradable-collagen-matrices-for-glaucoma-drainage-device-implantation
#8
COMPARATIVE STUDY
Minjung Song, Seunghyun Lee, Deokyeong Choe, Sera Kim, Young Hoon Roh, Seungsoo Rho
Purpose: To characterize the clinical and biological properties of biodegradable collagen matrices (BCMs) for possible glaucoma drainage device implantation. Methods: A total of 68 refractory glaucoma eyes, followed up postoperatively for at least 6 months, were consecutively enrolled after retrospective chart review. The BCM-augmented Ahmed valve implantations (BAAVI) using our Ologen-6 and Ologen-7 valves were performed and compared with a conventional method...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28574500/subconjunctival-implantation-of-ologen-collagen-matrix-to-treat-ocular-hypotony-after-filtration-glaucoma-surgery
#9
M Tanito, A Okada, Y Mori, I Sano, Y Ikeda, E Fujihara
PurposeTo report the results of subconjunctival ologen Collagen Matrix implantation to manage ocular hypotony after filtration glaucoma surgery.Patients and methodsThis retrospective observational case series included 12 consecutive implantations of ologen in nine eyes of nine Japanese subjects (five men, four women; mean age±SD, 72.1±12.7 years) who underwent subconjunctival implantation of the device to treat hypotony after glaucoma filtration surgery. Demographic data and surgical results were collected by chart review...
October 2017: Eye
https://www.readbyqxmd.com/read/28573046/a-comparative-study-the-use-of-collagen-implant-versus-mitomycin-c-in-combined-trabeculotomy-and-trabeculectomy-for-treatment-of-primary-congenital-glaucoma
#10
Alaa Abdel Sadek Singab, Osama Ali Mohammed, Mohammed Iqbal Hafez Saleem, Mortada Ahmed Abozaid
PURPOSE: To compare Ologen implant versus mitomycin-C (MMC) in combined trabeculotomy and trabeculectomy as a treatment of primary congenital glaucoma. SETTING: Sohag University Hospital, Egypt. DESIGN: A prospective comparative study. METHODS: Thirty-four eyes of twenty-one patients with primary congenital glaucoma were included in this study. All patients were subjected to preoperative evaluation including complete anterior segment examination under general anesthesia...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28468021/comparison-of-the-outcomes-of-trabeculectomy-with-5-fluorouracil-versus-ologen-implant-in-primary-open-angle-glaucoma
#11
Wisam Shihadeh, Ihab Massad, Yousef Khader, Ahmed Al-Rawi, Tala Alshalakhti
PURPOSE: To compare the outcomes of trabeculectomy with 5-fluorouracil (5-FU) versus Ologen™ implant in patients with primary open-angle glaucoma. METHODS: A retrospective chart review was performed of patients with primary open-angle glaucoma who underwent trabeculectomy using either Ologen or 5-FU over 12 consecutive months. The patients had moderate-to-advanced primary open-angle glaucoma and uncontrolled intraocular pressure (IOP) on maximally tolerated medical treatment...
2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28455543/-early-atrophy-of-the-conjunctiva-after-trabeculectomy-with-mitomycin-c-and-collagen-matrix-implant
#12
R Siggel, T Dietlein
Complete atrophy of the filtration bleb is a very rare complication after trabeculectomy with mitomycin C and collagen matrix implant (Ologen®, Aeon Astron Corporation, Taipei, Taiwan). Clinically, the atrophy can present similar to blebitis. We report the case of a 71-year-old woman, in whom we resected the atrophic conjunctiva and reconstructed a filtration bleb using an amniotic membrane.
April 28, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28291960/trabeculectomy-with-ologen-versus-mitomycin-c-in-juvenile-open-angle-glaucoma-a-1-year-study
#13
RANDOMIZED CONTROLLED TRIAL
Fathi El-Sayyad, Heba Magdy Ahmed El-Saied, Mohamad Amr Salah Eddin Abdelhakim
BACKGROUND: We assessed bleb morphology and the intraocular pressure (IOP)-lowering effect of trabeculectomy with ologen compared to mitomycin C (MMC) in juvenile open-angle glaucoma (JOAG). METHODS: This is a prospective interventional comparative study conducted on 40 eyes (20 patients) with medically uncontrolled JOAG, randomly operating one eye for trabeculectomy with ologen (group A: 20 eyes) and the other with MMC (group B: 20 eyes). IOP measurement, SITA standard perimetry, and spectral domain optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) thickness were all done pre- and postoperatively...
2017: Ophthalmic Research
https://www.readbyqxmd.com/read/27661986/trabeculectomy-combined-with-collagen-matrix-implant-ologen
#14
Claudio I Perez, Felipe Mellado, Alex Jones, Ricardo Colvin
PURPOSE OF THE STUDY: The purpose of the study was to report and evaluate outcomes of trabeculectomy with use of a subconjunctival biodegradable collagen matrix implant. PATIENTS AND METHODS: Retrospective review of trabeculectomy with Ologen implant of 65 eyes of 58 patients by the same surgeon from October, 2011 to October, 2014. Exclusion criteria were <6 months of follow-up after surgery, and uveitic or neovascular glaucoma. Demographic characteristics of the study population, visual acuity, intraocular pressure (IOP), glaucoma medications, bleb characteristics, and early and late postoperative complications were recorded...
January 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/27646334/safety-and-efficacy-of-collagen-matrix-implantation-in-infantile-glaucoma
#15
Eman M Elhefney, Hossam T Al-Sharkawy, Hanem M Kishk, Hossam Abouelkheir
PURPOSE: To evaluate the preliminary results of biodegradable collagen matrix implant (Ologen) designed to improve outcome in patients with infantile glaucoma undergoing combined trabeculotomy and trabeculectomy. METHODS: A biodegradable collagen matrix (OculusGen) was placed in the subconjunctival space, partially over the scleral flap and the sclera in 20 eyes of 11 patients with infantile glaucoma who underwent combined trabeculotomy and trabeculectomy. Patients were examined preoperatively and on the first postoperative day with multiple postoperative follow-up visits within 12 months after surgery...
May 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27599174/outcomes-of-trabeculectomy-augmented-with-subconjunctival-and-subscleral-ologen-implantation-in-primary-advanced-glaucoma
#16
Dewang Angmo, Meenakshi Wadhwani, Ashish Dutt Upadhyay, Shreyas Temkar, Tanuj Dada
PURPOSE: To evaluate the efficacy and safety of trabeculectomy with combined subconjunctival and subscleral ologen implant in eyes with advanced glaucomatous optic neuropathy. DESIGN: This is a retrospective, noncomparative case series. METHODS: Twenty seven eyes of 23 patients with advanced primary glaucoma who underwent fornix-based trabeculectomy with insertion of ologen both subsclerally and subconjunctivally along with low dose Mitomycin-C (0...
January 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/27539152/ahmed-glaucoma-valve-implantation-with-ologen-%C3%A2-collagen-matrix-for-the-surgical-treatment-of-feline-glaucoma
#17
Kang-Hyo Park, Joon-Young Kim, Seoung-Woo Choo, Hun-Young Yoon, Soon-Wuk Jeong
An Ahmed valve implantation with an Ologen(®) Collagen Matrix (Ologen(®) CM, Aeon Astron, Leiden, the Netherlands) was performed for the treatment of uncontrolled glaucoma in a cat. This cat was a 5-year-old castrated Russian Blue male with a 12-week history of conjunctival hyperemia and mydriasis of the left eye. During the ophthalmic examination, the intraocular pressure (IOP) oculus sinister (OS) was 52 mmHg, and a narrow iridocorneal angle (ICA) was detected by gonioscopy. Medical treatment with Cosopt(®) (2% dorzolamide and 0...
August 19, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27256305/trabeculectomy-with-ologen-in-secondary-glaucomas-following-failed-trabeculectomy-with-mmc-comparative-study
#18
COMPARATIVE STUDY
H M A El-Saied, M A S E Abdelhakim
PurposeWe aimed to assess the IOP-lowering effect of trabeculectomy with ologen in refractory secondary glaucoma following failed trabeculectomy with mitomycin C (MMC), and to compare its surgical outcome between open angle (SOAG) and angle closure (SACG) cases.MethodsThis is a prospective interventional comparative study conducted on 40 eyes (40 patients) with medically uncontrolled secondary glaucoma. Patients were divided into group A: 18 eyes (18 patients) with SOAG, and group B: 22 eyes (22 patients) with SACG...
August 2016: Eye
https://www.readbyqxmd.com/read/26946419/biodegradable-collagen-matrix-implant-versus-mitomycin-c-in-trabeculectomy-five-year-follow-up
#19
RANDOMIZED CONTROLLED TRIAL
Salvatore Cillino, Alessandra Casuccio, Francesco Di Pace, Carlo Cagini, Lucia Lee Ferraro, Giovanni Cillino
BACKGROUND: Clinical studies comparing trabeculectomy augmented with Ologen implant (OLO) versus trabeculectomy plus mitomycin-C (MMC) show contradictory results. To obtain long-term data, we report an extended 5-year follow-up trial evaluating the safety and efficacy of OLO as adjuvant compared to low-dosage MMC in trabeculectomy. METHODS: Forty glaucoma patients (40 eyes) assigned to trabeculectomy with MMC or Ologen. PRIMARY OUTCOME: target IOP at ≤21, ≤17 and ≤15 mmHg; complete and qualified success endpoint rates...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/26717247/biocompatibility-of-a-fish-scale-derived-artificial-cornea-cytotoxicity-cellular-adhesion-and-phenotype-and-in%C3%A2-vivo-immunogenicity
#20
T H van Essen, L van Zijl, T Possemiers, A A Mulder, S J Zwart, C-H Chou, C C Lin, H J Lai, G P M Luyten, M J Tassignon, N Zakaria, A El Ghalbzouri, M J Jager
PURPOSE: To determine whether a fish scale-derived collagen matrix (FSCM) meets the basic criteria to serve as an artificial cornea, as determined with in vitro and in vivo tests. METHODS: Primary corneal epithelial and stromal cells were obtained from human donor corneas and used to examine the (in)direct cytotoxicity effects of the scaffold. Cytotoxicity was assessed by an MTT assay, while cellular proliferation, corneal cell phenotype and adhesion markers were assessed using an EdU-assay and immunofluorescence...
March 2016: Biomaterials
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