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Eclipta alba

Peicheng Shen, Xuejun Yang, Jian Jiang, Xianxian Wang, Tingyu Liang, Liqun He
Mesangial cells of glomerulus which could produce and degrade several ECMs, take part in the repair and update of mesangial matrix and GBM, regulate glomerular filtration rate, secret cytokines and phagocytose immune complexes contribute a lot to physiological functions and pathological reactions of glomerular. There inflammation response of abnormal proliferation induced by LPS could lead to renal damage. Herein, wedelolactone, an active chemical constituent extracted from leaves of Eclipta alba, was used to explore if it could be an effective inhibitor of the proliferative response of HRMCs...
2017: American Journal of Translational Research
Navneet Kumar Yadav, Rakesh Kumar Arya, Kapil Dev, Chetan Sharma, Zakir Hossain, Sanjeev Meena, K R Arya, J R Gayen, Dipak Datta, R K Singh
As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control...
2017: Oxidative Medicine and Cellular Longevity
Rufi Tambe, Aditi Patil, Pankaj Jain, Jayant Sancheti, Gauresh Somani, Sadhana Sathaye
CONTEXT: Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. OBJECTIVE: The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically induced acute and chronic models in mice. MATERIALS AND METHODS: The methanol extract (16.85% w/w) of E. alba leaves was subjected to fractionation for isolation of luteolin...
December 2017: Pharmaceutical Biology
Niña Theresa P Dungca
ETHNOPHARMACOLOGICAL RELEVANCE: Eclipta alba, also known as Eclipta prostrata, is a weed of the family Asteraceae found in tropical and subtropical regions widely used in herbal medicine, including treatment of renal diseases. AIM OF THE STUDY: This study aims to evaluate the protective effect of the methanolic leaf extract of Eclipta alba on gentamicin-induced nephrotoxicity in rats. MATERIALS AND METHODS: Nephrotoxicity was induced in rats by subcutaneous injection of gentamicin (80mg/kg/day for seven days)...
May 26, 2016: Journal of Ethnopharmacology
L V Ribeiro Neto, A P Oliveira, M V Lourenço, B W Bertoni, S C França, T M Rosa-Santos, S M Zingaretti
Here, we report a quick and low-cost method to improve plant transformation using Agrobacterium tumefaciens. This method involves the use of physical wounding, ultrasound, and an increase in exposure time to the bacteria. We show how the transformation rate increased from 0 to 14% when an ultrasound pulse of 10 s was used in conjunction with 96 h of bacterial exposure in Eclipta alba explants.
2015: Genetics and Molecular Research: GMR
Jae-Seung Lee, Ji-Hye Ahn, Yoon-Jin Cho, Ha-Yeong Kim, Yeong-In Yang, Kyung-Tae Lee, Dae-Sik Jang, Jung-Hye Choi
ETHNOPHARMACOLOGICAL RELEVANCE: Eclipta prostrate L. (syn. E. alba Hassk), commonly known as False Daisy, has been used in traditional medicine in Asia to treat a variety of diseases, including cancer. Although an anti-tumor effect has been suggested for E. prostrata, the exact anti-tumor effects and underlying molecular mechanisms of its bioactive compounds are poorly understood. The aim of this study was to identify compounds with anti-cancer activity from E. prostrata and to investigate their mechanism of action...
July 1, 2015: Journal of Ethnopharmacology
Shahnaz Begum, Mi Ra Lee, Li Juan Gu, Jamil Hossain, Chang Keun Sung
Eclipta alba (L.) Hassk (E. alba) is a traditionally acclaimed medicinal herb used for the promotion of hair growth. However, to the best of our knowledge, no report has been issued to date on its effects on genetically distorted hair follicles (HFs). In this study, we aimed to identify an agent (stimuli) that may be beneficial for the restoration of human hair loss and which may be used as an alternative to synthetic drugs. We investigated the effects of petroleum ether extract (PEE) and different solvent fractions of E...
February 2015: International Journal of Molecular Medicine
Shahnaz Begum, Mi Ra Lee, Li Juan Gu, Md Jamil Hossain, Hyun Kyoung Kim, Chang Keun Sung
Eclipta alba (L.) Hassk, Asiasarum sieboldii (Miq.) F. Maek (Asiasari radix), and Panax ginseng C. A. Mey (red ginseng) are traditionally acclaimed for therapeutic properties of various human ailments. Synergistic effect of each standardized plant extract was investigated for hair growth potential on nude mice, as these mutant mice genetically lack hair due to abnormal keratinization. Dried plant samples were ground and extracted by methanol. Topical application was performed on the back of nude mice daily up to completion of two hair growth generations...
2014: BioMed Research International
Jantu M Hazarika, Prasanta K Sarkar, Abichal Chattopadhyay, Tapan K Mandal, Samar Sarkar
Arsenic poisoning due to contaminated subsoil water is one of the most alarming environment hazards in West Bengal, India. Cattle are also affected by arsenic due to ingestion of arsenic contaminated water, paddy straw, crops and vegetables. Thirty milch cattle having arsenic content in the range of 3.5 to 4.5 mg/kg in hair were chosen for this experiment from cattle of five respective villages in Nadia District, West Bengal, India. The cattle were divided into three groups containing 10 animals each. Group I cattle were treated with turmeric powder (Curcuma longa) 20 g/day orally for 60 days...
April 2015: Environmental Science and Pollution Research International
Harshita Chaudhary, Prasant Kumar Jena, Sriram Seshadri
The present study investigates the anticancer and multidrug resistance (MDR) reversal potential of hydro-alcoholic Eclipta alba extract (EAE) through in vivo experiments. Diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were used for liver cancer induction in animal model, whereas for MDR induction, AAF was used. The level of antioxidant enzymes was studied in serum along with biochemical parameters. Cancer and MDR-induced liver cells have higher levels of reactive oxygen species (ROS) and, in turn, are responsible for the maintenance of the cancer phenotype...
2014: Nutrition and Cancer
S Mahar, A Prasad, P P Datta, J Jena
Ecliptaalba (Bhringraj) is an important traditional Indian medicinal plant reported to have antipyretic, anti-inflammatory, antihistaminic, hepatoprotective and anthelmintic effect well documented in literature. In the present study ethanolic leaf extract of eclipta alba (EEEA) was evaluated for its haemostatic activity by their ability to affect the screening test or modify the experimentally induced prolongation of test time on the basis of its folklore claim in normal, aspirin and heparin treated rabbits...
April 2014: Mymensingh Medical Journal: MMJ
Sidra Sidra, Shahzad Hussain, Farnaz Malik
Eclipta alba is a small branched perennial herb, which has been used as a traditional medicine in different countries mainly in tropical and subtropical regions of the world. The plant E. alba plays a significant role in the ayurvedic, traditional and unani systems of medicine. It is popularly known as "Bhringaraj". The herb has been known for its medicinal value and has been used as an analgesic, antimytotoxic, antihepatotoxic, antibacterial, antioxidant, antihaemorrhagic, antihyperglycemic and immunomodulatory and also recognized as a reincarnated plant...
November 2013: Pakistan Journal of Pharmaceutical Sciences
M F Shaikh, J Sancheti, S Sathaye
In the present study, anticonvulsant activity of methanol extract of Eclipta alba (10-200 mg/kg) was studied using pentylenetetrazole- and picrotoxin-induced seizure models. Mechanism of effect of methanol extract of Eclipta alba was further elucidated by studying its GABAA receptor modulatory activity and its effect on levels of GABA in mice brain. Methanol extract of Eclipta alba exhibited potent anticonvulsant activity but has saturation of its pharmacological activity at 50 mg/kg. At the concentration of 10 mg/ml, contractions induced in guinea pig ileum was blocked by picrotoxin, but it didn't not show any increase in GABA levels in mice brain after treatment...
May 2013: Indian Journal of Pharmaceutical Sciences
A Ray, P Bharali, B K Konwar
The present study was undertaken to evaluate the mode of antibacterial activity of Eclalbasaponin isolated from Eclipta alba, against selected Gram-positive and Gram-negative bacteria. The probable chemical structure was determined by using various spectroscopic techniques such as Fourier transform infrared spectroscopy (FTIR) and mass spectroscopy. The antibacterial activity was evaluated by well diffusion technique, pH sensitivity, chemotaxis, and crystal violet assays. Eclalbasaponin showed clear zone of inhibition against both Bacillus subtilis and Pseudomonas aeruginosa and exhibited growth inhibition at the pH range of 5...
December 2013: Applied Biochemistry and Biotechnology
Harshita Chaudhary, Prasant Kumar Jena, Sriram Seshadri
The development of multidrug resistance (MDR) causes problems in the chemotherapy of human cancer. The present study was designed to evaluate and establish the role of Eclipta alba as MDR reversal agent using multidrug resistant hepatocellular carcinoma cell line (DR-HepG2). To develop DR-HepG2, hepatocellular carcinoma cell line (HepG2) was transfected with 2-Acetylaminofluorene (AAF) and Aflatoxin B1 (AFB). Cytotoxic effects of the Eclipta alba hydroalcoholic extract (EAE) and standard anti-ancer drug Doxorubicin (DOX) were determined in DR-HepG2 and the parental cells HepG2 using MTT assay...
2013: Nutrition and Cancer
A A Patil, B S Sachin, D B Shinde, P S Wakte
INTRODUCTION: Coumestan wedelolactone is an important phytocomponent from Eclipta alba (L.) Hassk. It possesses diverse pharmacological activities, which have prompted the development of various extraction techniques and strategies for its better utilization. The aim of the present study is to develop and optimize supercritical carbon dioxide assisted sample preparation and HPLC identification of wedelolactone from E. alba (L.) Hassk. METHODS: The response surface methodology was employed to study the optimization of sample preparation using supercritical carbon dioxide for wedelolactone from E...
July 2013: Annales Pharmaceutiques Françaises
Tanuja Singh, Nivedita Sinha, Anjali Singh
BACKGROUND: Limited data is available about the toxicity of herbal remedies used for self-medication. Since a popular medicinal plant Ecliptaalba contains various bioactive molecules, the present study aimed to observe the biochemical and histological changes in liver associated with acute oral toxicity (LD50) of aqueous extract of E. alba (L.) Hassk. in female Swiss albino mice. MATERIALS AND METHODS: For the acute oral toxicity study, the animals were divided into six groups of 6 mice each...
January 2013: Indian Journal of Pharmacology
Sudip Mukherjee, V Sushma, Sujata Patra, Ayan Kumar Barui, Manika Pal Bhadra, Bojja Sreedhar, Chitta Ranjan Patra
The biological approach to synthesis of AuNPs is eco-friendly and an ideal method to develop environmentally sustainable nanoparticles alternative to existing methods. We have developed a simple, fast, clean, efficient, low-cost and eco-friendly single-step green chemistry approach for the synthesis of biocompatible gold nanoparticles (AuNPs) from chloroauric acid (HAuCl(4)) using a water extract of Eclipta Alba leaves at room temperature. The AuNPs using Eclipta extract have been formed in very short time, even in less than 10 min...
November 16, 2012: Nanotechnology
Dinesh Manvar, Mahesh Mishra, Suriender Kumar, Virendra N Pandey
ETHNOPHARMACOLOGICAL RELEVANCE: Eclipta alba, traditionally known as bhringraj, has been used in Ayurvedic medicine for more than 1000 years in India. It is used for the treatment of infective hepatitis, liver cirrhosis, liver enlargement and other ailments of liver and gall bladder in India. The aim of this study was to evaluate anti-hepatitis C virus activity present in the Eclipta alba extract, perform bioassay based fractionation and identify anti-HCV phytochemicals from the active fractions...
December 18, 2012: Journal of Ethnopharmacology
Deepak Kumar, Raghuvir H Gaonkar, Rina Ghosh, Bikas C Pal
Eclipta alba (L.) Hassk is used traditionally in diabetes mellitus in India and the plant extract is reported to possess anti-diabetic activity. A bioactivity-guided isolation approach based on alpha-glucosidase inhibition was used to identify the constituents contributing towards the inhibition of the enzyme and probably contributing towards its anti-diabetic activity. Four echinocystic acid glycosides were thus isolated, of which eclalbasaponin VI, isolated from the n-butanol fraction, was found to be the most potent (IC50 54...
August 2012: Natural Product Communications
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