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Caveat emptor

David D Lee, Kristopher P Croome, Kaitlyn R Musto, Jose Melendez, Ghassan Tranesh, Raouf Nakhleh, C Burcin Taner, Justin H Nguyen, Tushar Patel, Denise M Harnois
Background While hepatocellular carcinoma (HCC) has become a common indication for liver transplantation (LT), intrahepatic cholangiocarcinoma (ICC) and combined-Hepatocellular-cholangiocarcioma (cHCC-CC) are historically contraindicated due to their aggressive behavior. Based on recent experiences, some groups have proposed a clinical trial investigating the role of LT for patients with early CC, defined as a single lesion ≤ 2cm. The purpose of this study is to assess the clinicopathologic features and outcomes following LT for patients who were initially diagnosed with HCC and subsequently found to have either ICC or cHCC-CC on explant...
March 7, 2018: Liver Transplantation
Emmert Roberts, Ben Carter, Allan H Young
BACKGROUND: International guideline recommendations for the use of folate and its derivatives in the treatment of unipolar depressive disorders are confused and contradictory, perhaps reflecting wide variations in the underpinning evidence base. INTRODUCTION: We discuss differing methods of evidence synthesis in the formulation of international guideline recommendations. As an example we evaluated the efficacy of folate and its derivatives in unipolar depression via systematic review and meta-analysis...
February 1, 2018: Journal of Psychopharmacology
Robert A Byrne, Tibor Schuster
No abstract text is available yet for this article.
October 21, 2017: Lancet
Debbie L Cohen, Raymond R Townsend
No abstract text is available yet for this article.
October 2017: Journal of Clinical Hypertension
John Riefler
No abstract text is available yet for this article.
September 2017: American Journal of the Medical Sciences
Robert W Bailey, Kevin E Vowles
Screening tests represent a critical tool in chronic pain treatment for predicting aberrant opioid use, which has emerged as a significant public health issue. Nevertheless, there remains a significant potential for the misapplication of screeners in this context. The potential difficulties in evaluating the diagnostic efficiency of screeners have been well established, particularly with regard to the effect that the prevalence of a disorder has on predictive value. The wide range in the reported prevalence of aberrant opioid use behaviors makes it difficult to interpret data obtained from popular screeners for assessing the potential for the aberrant use of opioids...
December 2017: Journal of Pain: Official Journal of the American Pain Society
Gary M Heir
No abstract text is available yet for this article.
April 2017: Journal of the American Dental Association
Josephine C Adams
In a recent publication in Bioscience Reports "Contaminants in commercial preparations of 'purified' small leucine-rich proteoglycans may distort mechanistic studies", Brown et al. identified by mass spectrometry and immunoblotting that certain commercial preparations of the small leucine-rich proteoglycans (SLRPs) decorin and biglycan, in fact, contained a mix of several proteoglycans that also included fibromodulin and aggrecan. The preparations were thus not suitable to study specific activities of decorin or biglycan...
June 30, 2017: Bioscience Reports
J Sanz, R P Gale
No abstract text is available yet for this article.
March 2017: Bone Marrow Transplantation
Sonia R Talwar, Amarita S Randhawa, Erica H Dankiewicz, Nancy T Crudele, J David Haddox
BACKGROUND: Healthcare professionals and consumers refer to online drug-information compendia (eg, Epocrates and WebMD) to learn about prescription medications, including opioid analgesics. With the significant risks associated with opioids, including abuse, misuse, and addiction, any of which can result in life-threatening overdose, it is important for those seeking information from online compendia to have access to current, accurate, and complete drug information to help support clinical treatment decisions...
July 2016: Journal of Opioid Management
(no author information available yet)
Caveat emptor ('Let the buyer beware').
July 8, 2016: British Dental Journal
Fabio Angeli, Gianpaolo Reboldi, Paolo Verdecchia
No abstract text is available yet for this article.
August 2016: Journal of Hypertension
David M Harlan
No abstract text is available yet for this article.
July 2016: Diabetes Care
Barry Schlansky, Carmel Shachar
No abstract text is available yet for this article.
August 2016: Liver Transplantation
Daniel F Hayes
Physicians have provided personalized care with as much precision as possible for several centuries. However, increasingly sophisticated understanding of the human genome and of cancer biology has permitted identification of genetic and phenotypic distinctions that might permit development of new tumor biomarker tests for risk categorization, screening, differential diagnosis, prognosis, prediction, and monitoring. Both commercial and academic laboratories are offering tests for single analytes, panels of tests of single analytes, multiparameter assays coalesced into a signature, and total genomic, transcriptomic, or proteomic analyses...
2016: American Society of Clinical Oncology Educational Book
Thomas R Vetter, Gerald McGwin, Jean-Francois Pittet
No abstract text is available yet for this article.
July 2016: Anesthesia and Analgesia
Thomas F Imperiale, Douglas K Rex
No abstract text is available yet for this article.
September 2016: Gastrointestinal Endoscopy
Christopher P Filson
No abstract text is available yet for this article.
June 2016: Nature Reviews. Urology
Mark I Evans, Ronald J Wapner, Richard L Berkowitz
The past few years have seen extraordinary advances in prenatal genetic practice led by 2 major technological advances; next-generation sequencing of cell-free DNA in the maternal plasma to noninvasively identify fetal chromosome abnormalities, and microarray analysis of chorionic villus sampling and amniotic fluid samples, resulting in increased cytogenetic resolution. Noninvasive prenatal screening of cell-free DNA has demonstrated sensitivity and specificity for trisomy 21 superior to all previous screening approaches with slightly lower performance for other common aneuploidies...
September 2016: American Journal of Obstetrics and Gynecology
Martijn Arns, Sandra K Loo, M Barry Sterman, Hartmut Heinrich, Jonna Kuntsi, Philip Asherson, Tobias Banaschewski, Daniel Brandeis
Recently several new tests have received US Federal Drug Administration (FDA) marketing approval as aids in the diagnostic process for attention deficit hyperactivity disorder (ADHD), including the Neuropsychiatric electroencephalogram (EEG)-Based ADHD Assessment Aid (NEBA) Health test. The NEBA test relies upon an EEG-based measure, called the theta to beta ratio (TBR). Although this measure has yielded large differences between ADHD and non-ADHD groups in studies prior to 2009, recent studies and a meta-analysis could not replicate these findings...
May 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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