keyword
https://read.qxmd.com/read/38295665/poliumoside-protects-against-type-2-diabetes-related-osteoporosis-by-suppressing-ferroptosis-via-activation-of-the-nrf2-gpx4-pathway
#21
JOURNAL ARTICLE
Chao-Yi Xu, Chun Xu, Yi-Ning Xu, Shi-Qi Du, Zi-Han Dai, Shu-Qing Jin, Gang Zheng, Cheng-Long Xie, Wen-Lai Fang
BACKGROUND: Type 2 diabetes is often linked with osteoporosis (T2DOP), a condition that accelerates bone degeneration and increases the risk of fractures. Unlike conventional menopausal osteoporosis, the diabetic milieu exacerbates the likelihood of fractures and osteonecrosis. In particular poliumoside (Pol), derived from Callicarpa kwangtungensis Chun, has shown promising anti-oxidant and anti-inflammatory effects. Yet, its influence on T2DOP remains to be elucidated. PURPOSE: The focus of this study was to elucidate the influence of Pol in HGHF-associated ferroptosis and its implications in T2DOP...
January 7, 2024: Phytomedicine
https://read.qxmd.com/read/38281848/effect-assessment-of-traditional-chinese-medicine-guilu-erxian-jiao-in-patients-with-osteoporosis-a-case-control-study-of-the-chang-gung-memorial-hospital
#22
JOURNAL ARTICLE
Yuan-Xin Lai, Chu-Yao Tseng, Huang-Yu Yang, Sien-Hung Yang, Pai-Wei Lee, Tsung-Hsien Yang
BACKGROUND: Osteoporosis is a chronic skeletal disease characterized by low bone mass and increased risk of fracture. In Taiwan, Guilu Erxian Jiao (GEJ) is the commonly used formula of Chinese herbal medicines for patients with osteoporosis. However, the effect of GEJ on subsequent fractures in the long term is unclear. This is the first long-term case-control study of the effects of GEJ on the rates of fracture in patients with osteoporosis. METHODS: We collected data from January 1, 2000 to December 31, 2019 from the Chang Gung Research Database...
January 14, 2024: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/38281199/does-crocin-create-new-hope-for-the-treatment-of-oral-problems-a-focus-on-periodontitis
#23
REVIEW
Atefe Rekabi, Arman Ram, Ahmad Nazari, Reza Arefnezhad, Fatemeh Rezaei-Tazangi
According to the World Health Organization (WHO) reports, oral health has an indispensable role in the maintenance of human public health. However, oral problems, especially periodontitis, are known as bad players in this issue. Periodontitis, as the most prevalent oral disease, is a type of chronic illness mediated by bacterial pathogens and immune system reactions, which is linked with the destruction of tooth-protecting tissues, such as alveolar bone and periodontal ligament. Periodontitis has a high prevalence (over 40% in the United States) and can be associated with other systemic ailments, for instance, arthritis, osteoporosis, metabolic syndrome, cancer, respiratory diseases, chronic kidney disease, and Alzheimer's disease...
January 28, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38278423/ginseng-panax-ginseng-leaf-extract-modulates-the-expression-of-heme-oxygenase-1-to-attenuate-osteoclast-differentiation
#24
JOURNAL ARTICLE
Hyuk Gyoon Lee, Jinwoo Hur, Jun Pil Won, Han Geuk Seo
Osteoporosis is an aging disease characterized by an imbalance between bone formation and resorption. However, drugs that inhibit bone resorption have various adverse effects. Ginseng (Panax ginseng), a prominent herbal medicine in East Asia for >2000 years, is renowned for its manifold beneficial properties, including antioxidant, anti-cancer, anti-diabetic, and anti-adipogenic activities. Despite its long history of use, the pharmacological functions of ginseng leaves are not yet fully comprehended...
January 24, 2024: Fitoterapia
https://read.qxmd.com/read/38243389/oligo-polysaccharides-from-cyathula-officinalis-and-achyranthes-bidentata-a-review-of-structures-and-bioactivities
#25
JOURNAL ARTICLE
Jun-Hong Chai, Ting-Ting He, Si-Liang Jiang, Xin-Hua Zhu, Qing-Yu Zhang, Ming-Chi Ji, Jun Liang, Yong-Gang Xia
OBJECTIVES: Oligo-/polysaccharides from Cyathula officinalis Kuan (COPs) and Achyranthes bidentata Blume (ABPs) have attracted researchers' attention in the fields of healthy food supplements and traditional Chinese medicine (Niúxī) due to their multiple bioactivities combined with their nontoxic and highly biocompatible nature. The purpose of this paper was to provide a systematic and comprehensive overview of the extraction, purification, and structural analysis methods, chemical characteristics, biological activities, and structure bioactivity relationship...
January 18, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38234027/development-and-validation-of-a-sensitive-liquid-chromatography-tandem-mass-spectrometry-method-for-the-assay-of-12-substances-in-rat-plasma-and-its-application-to-rat-pharmacokinetics-of-epimedium-and-psoraleae-fructus-herb-pair-after-oral-administration
#26
JOURNAL ARTICLE
Linwei Wang, Xiaoying Yin, Huan Liu, Yangyang Wang, Zhixiong Li, Yuxuan Zhao, Haibo Xu, Chenggang Huang, Xingxing Diao
Epimedium (EM) and Psoraleae Fructus (PF) are a traditional herb combination often used as a fixed form to treat osteoporosis disease in the clinic. However, the intricate interactions of this pair remain unknown. In our study, we undertook a comprehensive examination of their compatibility behaviors. Concurrently, a precise and sensitive quantitation method was successfully developed and validated using liquid chromatography-tandem mass spectrometry for the determination of 12 components. This method was applied in analyzing herbal extracts and biological samples (both in the portal vein and systemic plasma), which was also used to study the pharmacokinetics of the herb pair...
January 2024: Journal of Separation Science
https://read.qxmd.com/read/38223808/plant-derived-natural-medicines-for-the-management-of-osteoporosis-a-comprehensive-review-of-clinical-trials
#27
REVIEW
Seyedeh Mahnaz Karimi, Mohammad Bayat, Roja Rahimi
BACKGROUND: Osteoporosis is a chronic and systemic skeletal disease that is defined by low bone mineral density (BMD) along with an increase in bone fragility and susceptibility to fracture. This study aimed to overview clinical evidence on the use of herbal medicine for management of osteoporosis. METHODS: Electronic databases including Pubmed, Medline, Cochrane library, and Scopus were searched until November 2022 for any clinical studies on the efficacy and/or safety of plant-derived medicines in the management of osteoporosis...
January 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38213257/identifying-the-effective-combination-of-acupuncture-and-traditional-chinese-medicinal-herbs-for-postmenopausal-osteoporosis-therapy-through-studies-of-their-molecular-regulation-of-bone-homeostasis
#28
JOURNAL ARTICLE
Ren Ping, Wang Quanwu, Bai Wei, Sun Miao, Liu Zheling, Gao Ming, Wang Liang, Peng Bo, X U Liguang
Worldwide, as the population age, osteoporosis is becoming increasingly common, and osteoporotic fractures have a significant economic burden. Postmenopausal women are the most susceptible to developing osteoporosis and the most critical time to prevent it is during the perimenopausal and early menopausal years. In this regard, we hypothesize rational combination of acupuncture and Traditional Chinese Medicine (TCM) in the form of herbal extract could prevent osteoporosis in women. Estrogen deficiency during menopause causes low-level inflammation that stimulates the formation of osteoclasts, the bone-resorbing cells, and simultaneously inhibits the viability and function of osteoblasts, the bone-forming cells...
February 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38176267/ginsenoside-rg1-modulates-pi3k-akt-pathway-for-enhanced-osteogenesis-via-gper
#29
JOURNAL ARTICLE
Zhongjing Jiang, Linhua Deng, Mengjun Li, Emmanuel Alonge, Yanling Wang, Yunjia Wang
BACKGROUND: Osteoporosis is a systemic skeletal disorder characterized by decreased bone density and the degradation of bone tissue microarchitecture. Ginsenoside Rg1, derived from Panax ginseng, has been a part of traditional Chinese medicine in China for centuries, particularly for treating osteoporosis. However, there remains limited research on the osteogenic potential of Rg1 within the glucocorticoid-induced osteoporosis (GIOP) model and its specific mechanisms. PURPOSE: The primary objective of this study is to investigate the osteogenic potential of Rg1 within the GIOP model and explore the signaling pathways associated with its in vivo and in vitro effects...
December 17, 2023: Phytomedicine
https://read.qxmd.com/read/38176266/mangiferin-attenuates-osteoporosis-by-inhibiting-osteoblastic-ferroptosis-through-keap1-nrf2-slc7a11-gpx4-pathway
#30
JOURNAL ARTICLE
Xuehui Deng, Bingfeng Lin, Fang Wang, Pingcui Xu, Nani Wang
BACKGROUND: Ferroptosis is a crucial contributor to impaired osteoblast function in osteoporosis. Mangiferin, a xanthonoid glucoside isolated from mangoes, exhibits anti-osteoporosis effects. However, its potential mechanism is not fully understood. PURPOSE: This study explores the potencies of mangiferin on osteoblastic ferroptosis and deciphers its direct target in the context of solute carrier family 7-member 11 (SLC7A11)/glutathione peroxidases 4 (GPX4) pathway...
February 2024: Phytomedicine
https://read.qxmd.com/read/38173067/new-emerging-aspect-of-herbal-extracts-for-the-treatment-of-osteoporosis-overview
#31
JOURNAL ARTICLE
Priyanka Kumari, Raj K Shirumalla, Vijay Bhalla, Md Sabir Alam
As the global population ages, osteoporosis is becoming a more common silent disease. Osteoporosis is characterized by decreased bone quality and strength, which increases the risk of fragility fractures in the elderly. According to estimates, 50% of women eventually suffer from an osteoporotic fracture. Due to increasing disability, more frequent hospital hospitalizations, and most critically, fragility fractures have been linked to a reduced quality of life. Osteoporotic fractures have been linked to an increased mortality risk; and must be considered in awareness as a serious health concern...
January 1, 2024: Current Rheumatology Reviews
https://read.qxmd.com/read/38157118/protective-effects-of-phellodendron-species-on-bone-health-a-novel-perspective-on-their-potentials-in-treating-osteoporosis-and-osteoarthritis
#32
REVIEW
Li Xin, Guo-Yao Tan, Qiang Zhang, Qun Zhang
Phellodendron (PN) species, traditionally used in Chinese medicine for centuries, hold promise as a potential treatment for osteoporosis (OP) and osteoarthritis (OA) due to their bioactive compounds. The bioactive compounds, including berberine and palmatine, exhibit anti-inflammatory, antioxidant, and bone-protective properties, contributing to their potential therapeutic benefits in promoting bone health and preventing bone loss. However, challenges such as the need for standardized preparation and dosing, limited clinical studies, and potential interactions with other medications hinder their clinical use...
December 29, 2023: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38142661/exploring-the-boost-of-steaming-with-wine-on-ligustri-lucidi-fructus-in-treating-postmenopausal-osteoporosis-based-on-superior-multi-component-structure-and-iron-bone-metabolism-coregulation
#33
JOURNAL ARTICLE
Jun Jiang, Baixiu Zhao, Jianpeng Xiao, Liang Shi, Wei Shang, Ye Shu, Zhiming Zhao, Junyi Shen, Jingjuan Xu, Hui Cai
BACKGROUND: Clinical studies indicated that postmenopausal osteoporosis (PMOP) often accompanied by iron overload risk factor, which exacerbated bone metabolism disorders and accelerated PMOP. Previous research found that multicomponent in Ligustri Lucidi Fructus (FLL) or wine-steamed FLL (WFLL) acted on the common targets of iron overload and PMOP simultaneously, which indicated that FLL and WFLL probably regulated iron/bone metabolism dually. Additionally, WFLL had more superior effect according to the theory of Chinese medicine for thousands of years...
December 12, 2023: Phytomedicine
https://read.qxmd.com/read/38131179/drynaria-rhizome-water-extract-alleviates-high%C3%A2-fat-diet%C3%A2-induced-obesity-in-mice
#34
JOURNAL ARTICLE
Tae-Young Gil, Junkyu Park, Yea-Jin Park, Hyo-Jung Kim, Divina C Cominguez, Hyo-Jin An
Drynaria rhizome is a herbal medicine used for strengthening bones and treating bone diseases in East Asia. Although obesity is considered to benefit bone formation, it has been revealed that visceral fat accumulation can promote osteoporosis. Given the complex relationship between bone metabolism and obesity, bone‑strengthening medicines should be evaluated while considering the effects of obesity. The present study investigated the effects of Drynaria rhizome extract (DRE) on high‑fat diet (HFD)‑induced obese mice...
February 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38130072/eupatilin-ameliorates-postmenopausal-osteoporosis-via-elevating-microrna-211-5p-and-repressing-jak2-stat3-pathway
#35
JOURNAL ARTICLE
Liu Hong, Chao Yang
Postmenopausal osteoporosis (PMOP) poses a significant threat to women's health worldwide. Eupatilin is a key bioactive component of the Chinese herbal medicine Artemisia asiatica Nakai. Recent research reports have proved the inhibitory function of Eupatilin in many diseases. MicroRNAs (miRNAs) are 21-23 nucleotide-long, single-stranded, noncoding RNA molecules generated endogenously, and many studies have indicated that miRNAs are involved in the development of osteoporosis. This study explored the role and potential mechanism of Eupatilin underlying PMOP...
December 21, 2023: Environmental Toxicology
https://read.qxmd.com/read/38107794/alternative-medical-therapy
#36
REVIEW
Jawahar Tulsidas Jethwa
BACKGROUND: Complementary/alternative medicine" (CAM) is defined as a diverse range of medical treatments, largely non-allopathic, mostly traditional, and not integrated into the authoritarian healthcare system. Interestingly for some schools, allopathy is alternative/complementary therapy. Osteoporosis is an ever-known disease treated before the era of allopathic medicine. Even though the customary medical system of India is among the most well-known in the world, every continent has its own alternative therapies for various chronic diseases...
December 2023: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38103318/zuogui-pill-disrupt-the-malignant-cycle-in-breast-cancer-bone-metastasis-through-the-piezo1-notch-1-gpx4-pathway-and-active-molecules-fishing
#37
JOURNAL ARTICLE
Baohong Li, Zichao Chen, Zhenyong Zhang, Hui Liu, Dongli Han, Haolin Yang, Zhen Zhang
BACKGROUND: Breast cancer bone metastasis is closely associated with the bone microenvironment. Zuogui Pill (ZGP), a clinically approved formulation in China, effectively regulates the bone microenvironment for the prevention and treatment of osteoporosis. PURPOSE: Few reports have utilized the ZGP for bone metastasis models. This study investigated the intervention and bone-protective properties of ZGP against breast cancer bone metastasis, explored the potential mechanism, and screened for its active compositions by molecules fishing...
December 10, 2023: Phytomedicine
https://read.qxmd.com/read/38100921/catalpol-attenuates-osteoporosis-in-ovariectomized-rats-through-promoting-osteoclast-apoptosis-via-the-sirt6-er%C3%AE-fasl-axis
#38
JOURNAL ARTICLE
Shuai Chen, Jie Jin, Ziqing Xu, Huawei Han, Lan Wu, Zhiwei Li
BACKGROUND: Catalpol, a major active component of the Chinese herb Rehmannia glutinosa, possesses various pharmacological benefits, including anti-inflammatory, antidiabetic, and antitumor properties. Recent studies have reported that catalpol can attenuate bone loss and enhance bone formation. Nevertheless, the molecular mechanisms underlying its effects on osteoporosis pathogenesis remain unclear. PURPOSE: We investigated whether catalpol had a protective effect against postmenopausal osteoporosis (PMOP) and explored its exact mechanism of action...
December 5, 2023: Phytomedicine
https://read.qxmd.com/read/38076660/molecular-mechanism-of-achyranthis-bidentatae-radix-and-morindae-officinalis-radix-in-osteoporosis-therapy-an-investigation-based-on-network-pharmacology-molecular-docking-and-molecular-dynamics-simulations
#39
JOURNAL ARTICLE
Junwu Wang, Yilong Huang, Lanhong Guo, Jingfeng Li, Shifeng Zhou
OBJECTIVE: To investigate the targets and mechanism of Achyranthis bidentatae radix and Morindae officinalis radix (ABR-MOR) for the treatment of osteoporosis (OP) by utilizing network pharmacology, molecular docking technology (MDT) and molecular dynamics simulation (MDS). METHODS: The main drug active ingredients (DAIs) and target genes of ABR-MOR were screened by the TCMSP database. The relevant targets of OP were obtained from GeneCards, DisGeNET, and CTD databases...
December 2023: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/37923747/to-investigate-the-mechanism-of-yiwei-decoction-in-the-treatment-of-premature-ovarian-insufficiency-related-osteoporosis-using-transcriptomics-network-pharmacology-and-molecular-docking-techniques
#40
JOURNAL ARTICLE
Weisen Fan, Yan Meng, Jing Zhang, Muzhen Li, Yingjie Zhang, Xintian Qu, Xin Xiu
To investigate the molecular mechanism of Yiwei Decoction (YWD) in preventing Premature ovarian insufficiency (POI)-related osteoporosis from the hypothalamic perspective , and to screen for the key active and acting molecules in YWD. Cyclophosphamide was used to create the POI rat model. Groups A, B, and C were established. The Model + YWD group was group A, the model control group was group B, and the normal control group was group C. ELISA was used to determine serum GnRH and FSH levels after gavage...
November 3, 2023: Scientific Reports
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