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Osteoporosis herbal

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https://www.readbyqxmd.com/read/29074841/a-network-pharmacology-approach-to-determine-the-active-components-and-potential-targets-of-curculigo-orchioides-in-the-treatment-of-osteoporosis
#1
Nani Wang, Guizhi Zhao, Yang Zhang, Xuping Wang, Lisha Zhao, Pingcui Xu, Dan Shou
BACKGROUND Osteoporosis is a complex bone disorder with a genetic predisposition, and is a cause of health problems worldwide. In China, Curculigo orchioides (CO) has been widely used as a herbal medicine in the prevention and treatment of osteoporosis. However, research on the mechanism of action of CO is still lacking. The aim of this study was to identify the absorbable components, potential targets, and associated treatment pathways of CO using a network pharmacology approach. MATERIAL AND METHODS We explored the chemical components of CO and used the five main principles of drug absorption to identify absorbable components...
October 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29058051/danshen-salvia-miltiorrhiza-protects-ovariectomized-rats-fed-with-high-saturated-fat-sucrose-diet-from-bone-loss
#2
X L Dong, W X Yu, C M Li, S He, L P Zhou, C W Poon, M S Wong
Dietary patterns may interfere with the efficacy of herbal intervention. Our results demonstrated the protective effects of Salvia miltiorrhiza aqueous extract (SMA) on bone metabolism were influenced by levels of dietary fat and sucrose in ovariectomized (OVX) rats through its actions on attenuating lipid deposition and oxidative stress in rats. INTRODUCTION: Salvia miltiorrhiza (SM), also known as Danshen, has been tested as an osteoporosis treatment in a series of small, short human trials that generally report improvements in bone property...
October 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29043101/protective-effect-of-rhus-verniciflua-stokes-extract-in-an-experimental-model-of-post-menopausal-osteoporosis
#3
Ji Heun Jeong, Jong Hoon An, Hui Yang, Do-Kyung Kim, Nam-Seob Lee, Young-Gil Jeong, Chun Soo Na, Dae Seung Na, Mi-Sook Dong, Seung Yun Han
Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor-binding affinities...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28983609/molecular-mechanisms-of-the-inhibitory-effects-of-jiangu-granule%C3%A2-containing-serum-on-rankl%C3%A2-induced-osteoclastogenesis
#4
Yunmei Huang, Yu Lin, Yinsheng Wu, Jianwei Zeng, Meiya Huang, Shiming Guo, Wenjuan Luo, Haiming Lin, Yanping Lin
Postmenopausal osteoporosis (PMOP) is characterized by increased bone loss due to enhanced osteoclastogenesis and bone resorption. A Chinese herbal formula, jiangugranule (JG), exhibited great efficacy in the clinical treatment of PMOP. However, the molecular mechanisms underlying the therapeutic effects remain unclear. The present study aimed to examine the effects of JG‑containing serum on receptor activator of nuclear factor‑κB (NF‑κB) ligand (RANKL)‑induced osteoclastogenesis. Osteoclast precursor RAW264...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28962172/psoralen-stimulates-osteoblast-proliferation-through-the-activation-of-nuclear-factor-%C3%AE%C2%BAb-mitogen-activated-protein-kinase-signaling
#5
Feimeng Li, Qihuo Li, Xiaoqing Huang, Yunting Wang, Chana Ge, Yong Qi, Wei Guo, Hongtao Sun
Osteoporosis is a systemic skeletal disease that leads to increased bone fragility and susceptibility to fracture. Approximately 50% of postmenopausal women develop osteoporosis as a result of postmenopausal estrogen deficiency. To reduce fractures related to osteoporosis in women, previous studies have focused on therapeutic strategies that aim to increase bone formation or decrease bone resorption. However, pharmacological agents that aim to improve bone fracture susceptibility exhibit side effects. Current studies are investigating natural alternatives that possess the benefits of selective estrogen receptor modulators (SERMs) without the adverse effects...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28926512/orthosiphon-stamineus-misai-kucing-ameliorated-postmenopausal-osteoporosis-in-rat-model
#6
Rubiatul Adawiyah Bokhari, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Orthosiphon stamineus (OS) or Misai Kucing (Java tea) is a popular herbal supplement from Southeast Asia for various metabolic, age-related diseases. This study investigated the potential use of OS leaf extracts to ameliorate osteoporosis in ovariectomized rats. METHODS: Fifty-six female Sprague-Dawley rats were randomly allocated into eight groups (n = 7): SHAM (healthy sham control); OVX (ovarietomized) nontreated rats (negative control); OVX + Remifemin (100 mg/kg body weight), and 2% green tea extract (positive controls); OVX + OS 50% ethanolic and aqueous extracts, both at either 150 or 300 mg/kg...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28893468/chinese-herbal-medicine-for-osteoporosis-a-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Yong-Xiang Jin, Peng Wu, Yi-Fan Mao, Bo Wang, Jia-Feng Zhang, Wen-Liang Chen, Zhong Liu, Xiao-Lin Shi
Osteoporosis is a major public health problem in the elderly population. Several studies have suggested that Chinese herbal medicine has antiosteoporotic activities that might be beneficial for osteoporosis. This study aimed to assess the effectiveness of Chinese herbal medicine in osteoporosis patients. We comprehensively searched for randomized controlled trials (until December 2016) that compared Chinese herbal medicine with Western medicine in adults with osteoporosis and reported bone mineral densities (BMDs)...
October 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28826891/traditional-uses-phytochemistry-pharmacology-and-toxicology-of-the-genus-cimicifuga-a-review
#8
REVIEW
Yaqing Guo, Tong Yin, Xiaoming Wang, Fan Zhang, Guixiang Pan, Hong Lv, Xianrui Wang, John Owoicho Orgah, Yan Zhu, Honghua Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Cimicifuga have long been used as an ethnomedicine in China, Europe, and North America for its high medicinal value and health benefits. Their dried rhizomes are widely used for treating wind-heat headache, toothache, aphtha, sore throat, measles, spot poison, archoptosis, and uterine prolapse. In addition, it is used as a dietary supplement for preventing women menopausal symptoms and osteoporosis. AIM OF THE REVIEW: This paper aims to provide up-to-date information on the genus Cimicifuga, including botanical characterization, medicinal resources, traditional medicinal uses, phytochemistry, quality control, pharmacological research as well as the toxicology...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28821095/an-o-acetyl-glucomannan-from-the-rhizomes-of-curculigo-orchioides-structural-characterization-and-anti-osteoporosis-activity-in-vitro
#9
Xueqian Wang, Mengliu Zhang, Dawei Zhang, Shumei Wang, Chunyan Yan
Osteoporosis is characterized by a reduction in bone mass and bone mineral density, which weakens the bone. Due to the side effects associated with drugs that are currently used to treat this disease, an increasing number of studies have focused on the research of effective ingredients derived from natural products. In particular, polysaccharides extracted from Chinese herbal medicines have received increasing attention. In this study, we isolated a homogeneous polysaccharide (COP90-1) from the dried rhizomes of Curculigo orchioides, a famous traditional Chinese medicine that is widely used in China, and determined its structure using the combined methods of chemical and spectral analyses...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28804568/preventive-effects-of-kudzu-root-on-bone-loss-and-cartilage-degradation-in-ovariectomized-rat
#10
Yunyun Luo, Shuang Zheng, Yujia Ding, Yueqin Dai, Yi Zhou, Ruifeng Xiang, Anne C Bay-Jensen, Morten A Karsdal, Per Qvist, Qinlong Zheng
The clinical utility of Traditional Chinese Medicine (TCM) herbs/roots extracts in osteoporosis (OP) and osteoarthritis (OA) has been described in multiple reports, but there have been few studies of TCM for preventing bone loss and cartilage degradation simultaneously. Six-month-old female Sprague-Dawley rats each were subjected to ovariectomized (OVX) or sham surgery and treated orally once daily with herbal extracts or vehicle. Body weight was recorded weekly, and blood samples were collected from fasting animals at different time points...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28743091/performance-comparison-of-two-herbal-and-industrial-medicines-using-nanoparticles-with-a-starch-cellulose-shell-and-alginate-core-for-drug-delivery-in-vitro-studies
#11
Akbar Esmaeili, Sahar Behzadi
In this study, the performance of two kinds of industrial and herbal drugs encapsulated in nanoparticles with a shell of starch and cellulose and an alginate core were examined as a new technique for nanoparticle drug delivery. The test method involved creating a suspension of starch and alginate, which was then dried, mixed with cellulose, and heated to form core-shell nanoparticles. The industrial drug calcitonin and an extract of the herb Amaranthus retroflexcus L. were added separately and in combination to the nanoparticles, and the performance of each configuration was evaluated...
October 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28738286/emodin-suppresses-cadmium-induced-osteoporosis-by-inhibiting-osteoclast-formation
#12
Xiao Chen, Shuai Ren, Guoying Zhu, Zhongqiu Wang, Xiaolin Wen
Environmental level of cadmium (Cd) exposure can induce bone loss. Emodin, a naturally compound found in Asian herbal medicines, could influence osteoblast/osteoclast differentiation. However, the effects of emodin on Cd-induced bone damage are not clarified. The aim of this study was to investigate the role of emodin on Cd-induced osteoporosis. Sprague-Dawley male rats were divided into three groups which were given 0mg/L, 50mg Cd/L and 50mg Cd/L plus emodin (50mg/kg body weight). Bone histological investigation, microCT analysis, metabolic biomarker determination and immunohistochemical staining were performed at the 12th week...
July 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28714404/current-and-emerging-strategies-in-osteoporosis-management
#13
Stefka Ivanova, Liliya Vasileva
The abnormal loss of bone tissue is defined as osteoporosis. Increased risk of fractures, low bone mineral density (BMD) and loss of the structural and biomechanical properties of the bone tissue characterize this pathological condition. Physiologically bone undergoes a continuous remodeling process involving balance between the activity of osteoblast and osteoclast. Disruption in this balanced condition increases the risk of osteoporosis. Both sexes are affected, but with higher prevalence in women after menopause...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28512501/effect-of-traditional-chinese-medicine-product-qiangguyin-on-bone-mineral-density-and-bone-turnover-in-chinese-postmenopausal-osteoporosis
#14
Zhen-Yu Shi, Xin-Gen Zhang, Chun-Wen Li, Kang Liu, Bo-Cheng Liang, Xiao-Lin Shi
Introduction. The aim of this study was to investigate the efficacy of herbal formula QiangGuYin (QGY) in postmenopausal women. Materials and Methods. A total of 240 participants from six clinical centers were randomly to receive alendronate 70 mg/week, QGY granules 20 g/day, and placebo. Primary end points were BMD changes over 6 and 12 months; secondary end points were bone turnover markers changes at 3, 6, 9, and 12 months. Safety was monitored by clinical adverse events reported during the follow-up...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28325144/therapeutic-potential-and-outlook-of-alternative-medicine-for-osteoporosis
#15
Tao Wang, Qian Liu, William Tjhioe, Jinmin Zhao, Aiping Lu, Ge Zhang, Ren Xiang Tan, Mengyu Zhou, Jiake Xu, Hao Tian Feng
Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy...
2017: Current Drug Targets
https://www.readbyqxmd.com/read/28119100/antiosteoporotic-effect-of-hemidesmus-indicus-linn-on-ovariectomised-rats
#16
Sharad Desai, Parth Babaria, Madhavi Nakarani, Kunal Shah, Archana Paranjape
PHARMACOLOGICAL RELEVANCE: Root of Hemidesmus indicus (L). R. Br., an herbal drug of India is traditionally used to prevent or treat female hormonal disturbance related disorders and assuaging symptoms of menopausal conditions. AIM OF THE STUDY: Lack of scientific data for potential use in bone loss, the present study was undertaken to investigate the effects of ethanol extract of Hemidesmus indicus root for osteoporosis in ovariectomised rats. MATERIALS AND METHODS: Thirty wistar female rats were randomly divided into five groups...
March 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28115834/effects-of-chinese-herbal-formula-erxian-decoction-for-treating-osteoporosis-a-systematic-review
#17
Jin-Yu Li, Yu-Song Jia, Li-Min Chai, Xiao-Hong Mu, Sheng Ma, Lin Xu, Xu Wei
PURPOSE: The aim is to systematically assess the effectiveness and safety of Chinese herbal formula Erxian decoction (EXD) for treating osteoporosis. MATERIALS AND METHODS: Six databases were searched from inception through September 17, 2016, without language restriction. All randomized controlled trials of EXD for osteoporosis were included. One or more outcome measures including fracture, change in bone mineral density (BMD), pain symptom improvement, bone biochemical markers, quality of life, adverse event or adverse drug reaction were evaluated...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28074748/possible-parkinson-s-disease-induced-by-chronic-manganese-supplement-ingestion
#18
Michael J Schuh
OBJECTIVE: The objective is to report a case of possible neurotoxicity resulting from an incorrect dietary supplement for osteoporosis taken at a toxic dose. SUMMARY: The case study examined here is a 37-year-old African-American female who consumed excessive manganese over a period of years, resulting in Parkinson's disease (PD). This patient was referred to the pharmacist pharmacotherapy service by a neurology physician. PD has been shown in the medical literature to be caused by chronic exposure to high levels of manganese...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28040510/du-huo-ji-sheng-tang-and-its-active-component-ligusticum-chuanxiong-promote-osteogenic-differentiation-and-decrease-the-aging-process-of-human-mesenchymal-stem-cells
#19
Jir-You Wang, Wei-Ming Chen, Che-Sheng Wen, Shih-Chieh Hung, Pei-Wen Chen, Jen-Hwey Chiu
ETHNOPHARMACOLOGICAL RELEVANCE: Postmenopausal osteoporosis is the most common bone disease worldwide. Information concerning the effects of herbal medicines on mesenchymal cell osteogenesis and senescence remains lacking. AIM OF THIS STUDY: This study was designed to investigate the effects of Du-Huo-Ji-Sheng-Tang (DHJST), a Chinese herbal medicine and its active component Ligusticum chuanxiong on osteogenic differentiation and the aging process of human mesenchymal cells (hMSCs)...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27959402/effects-of-herbal-epimedium-on-the-improvement-of-bone-metabolic-disorder-through-the-induction-of-osteogenic-differentiation-from-bone-marrow-derived-mesenchymal-stem-cells
#20
Do Rim Kim, Ji Eun Lee, Kyung Jun Shim, Jin Hyoung Cho, Ho Chul Lee, Seong Kyu Park, Mun Seog Chang
Herbal Epimedium (HE) has been commonly used as a tonic, antirheumatic agent and in the treatment of bone‑associated diseases including osteoporosis. Treatment for osteoporosis is important to increase bone mass density and maintain to balance of bone remodeling. The present study was performed to investigate the effects of HE on mouse bone marrow mesenchymal stem cell (mBMMSC) proliferation and osteogenic differentiation, using MTT assays, proliferating cell nuclear antigen (PCNA) detection and apoptosis and differentiation assays...
January 2017: Molecular Medicine Reports
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