keyword
MENU ▼
Read by QxMD icon Read
search

grk

keyword
https://www.readbyqxmd.com/read/27888281/the-actions-of-relaxin-family-peptides-on-signal-transduction-pathways-activated-by-the-relaxin-family-peptide-receptor-rxfp4
#1
Sheng Y Ang, Dana S Hutchinson, Bronwyn A Evans, Mohammed A Hossain, Nitin Patil, Ross A D Bathgate, Martina Kocan, Roger J Summers
The relaxin family peptide receptor 4 (RXFP4) is a G protein-coupled receptor (GPCR) expressed in the colorectum with emerging roles in metabolism and appetite regulation. It is activated by its cognate ligand insulin-like peptide 5 (INSL5) that is expressed in enteroendocrine L cells in the gut. Whether other evolutionarily related peptides such as relaxin-2, relaxin-3, or INSL3 activate RXFP4 signal transduction mechanisms with a pattern similar to or distinct from INSL5 is still unclear. In this study, we compare the signaling pathways activated by various relaxin family peptides to INSL5...
November 26, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27753817/ssa-05-4-differences-in-management-of-hypertension-between-ethnic-groups
#2
Brian Rayner
Although the consequences of hypertension are universal, Blacks (African Americans or Indigenous Africans) have been the subject of a differential approach to causation, outcome and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to Na retention by the kidney. As a result blood pressure (BP) response to diuretics and amlodipine is better than inhibitors of the renin-angiotensin-system in monotherapy. Target organ damage is more frequent and blood pressure (BP) is more difficult to control despite more intensive therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643380/ssa-05-4-differences-in-management-of-hypertension-between-ethnic-groups
#3
Brian Rayner
Although the consequences of hypertension are universal, Blacks (African Americans or Indigenous Africans) have been the subject of a differential approach to causation, outcome and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to Na retention by the kidney. As a result blood pressure (BP) response to diuretics and amlodipine is better than inhibitors of the renin-angiotensin-system in monotherapy. Target organ damage is more frequent and blood pressure (BP) is more difficult to control despite more intensive therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27609978/specific-immune-cell-and-cytokine-characteristics-of-human-testicular-germ-cell-neoplasia
#4
Britta Klein, Thomas Haggeney, Daniela Fietz, Sivanjah Indumathy, Kate L Loveland, Mark Hedger, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann, Hans-Christian Schuppe
STUDY QUESTION: Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for the understanding of the related testicular immunopathology? SUMMARY ANSWER: The unique immune environment of testicular germ cell neoplasia comprises B cells and dendritic cells as well as high transcript levels of IL-6 and other B cell supporting or T helper cell type 1 (Th1)-driven cytokines and thus differs profoundly from normal testis or inflammatory lesions associated with hypospermatogenesis...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27573285/regulatory-effects-of-grk2-on-gpcrs-and-non-gpcrs-and-possible-use-as-a-drug-target-review
#5
Chen-Chen Han, Yang Ma, Yifan Li, Yang Wang, Wei Wei
G protein-coupled receptor kinase 2 (GRK2) is a key member of the G protein-coupled receptor kinase (GRK) family. GRK2 activity is regulated by the C-terminus of GRK2 which contains a plekstrin homology domain and the N-terminus of GRK2 which contains the RGS homology domain with binding sites for several proteins and lipids such as G protein-coupled receptors (GPCRs), G protein, phospholipase C, phosphatidylinositol 4,5-bisphosphate, extracellular signal‑regulated kinase, protein kinase A and Gβγ...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27572922/c-terminal-residues-specific-to-vasa-among-dead-box-helicases-are-required-for-its-functions-in-pirna-biogenesis-and-embryonic-patterning
#6
Mehrnoush Dehghani, Paul Lasko
The DEAD-box RNA helicase Vasa (Vas, also known as DDX4) is required for germ cell development. In Drosophila, analysis of hypomorphic mutations has implicated maternally expressed Vas in germ cell formation and posterior embryonic patterning. vas-null females, which rarely complete oogenesis, exhibit defects in mitotic progression of germline stem cells, Piwi-interacting RNA (piRNA)-mediated transposon silencing, and translation of Gurken (Grk), an EGFR ligand. The carboxy-terminal region of Vas orthologs throughout the animal kingdom consists of several acidic residues as well as an invariant tryptophan in the penultimate or ultimate position (Trp660 in Drosophila melanogaster)...
August 29, 2016: Development Genes and Evolution
https://www.readbyqxmd.com/read/27565865/grk5-knockout-mice-generated-by-talen-mediated-gene-targeting
#7
Tsevelmaa Nanjidsuren, Chae-Won Park, Bo-Woong Sim, Sun-Uk Kim, Kyu-Tae Chang, Myung-Hwa Kang, Kwan-Sik Min
Transcription activator-like effector nucleases (TALENs) are a new type of engineered nuclease that is very effective for directed gene disruption in any genome sequence. We investigated the generation of mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene. Flow cytometry showed that the activity of the TALEN mRNAs targeted to exons 1, 3, and 5 was 8.7%, 9.7%, and 12...
October 2016: Animal Biotechnology
https://www.readbyqxmd.com/read/27541735/cardiac-%C3%AE-2-adrenergic-receptor-phosphorylation-at-ser355-356-regulates-receptor-internalization-and-functional-resensitization
#8
Xiaofang Fan, Xuejiang Gu, Ru Zhao, Qingqing Zheng, Lan Li, Wenbing Yang, Lu Ding, Feng Xue, Junming Fan, Yongsheng Gong, Yongyu Wang
Previous studies have demonstrated that β2-adrenergic receptors (β2ARs) can be phosphorylated by G protein-coupled receptor kinases (GRKs) and protein kinase A (PKA), affecting β2AR internalization and desensitization. However, the exact physiological function of β2ARs in cardiomyocytes is unknown. In this study, we showed that neonatal mouse cardiomyocytes had different contraction and internalization responses to sustained or repeated, transient agonist stimulation. Specifically, short-time stimulation (10 min) with epinephrine or norepinephrine increased the cardiomyocyte contraction rate, reaching a maximum at 5 min, followed by a slow decline...
2016: PloS One
https://www.readbyqxmd.com/read/27378756/chapter-three-ubiquitination-and-protein-turnover-of-g-protein-coupled-receptor-kinases-in-gpcr-signaling-and-cellular-regulation
#9
P Penela
G-protein-coupled receptors (GPCRs) are responsible for regulating a wide variety of physiological processes, and distinct mechanisms for GPCR inactivation exist to guarantee correct receptor functionality. One of the widely used mechanisms is receptor phosphorylation by specific G-protein-coupled receptor kinases (GRKs), leading to uncoupling from G proteins (desensitization) and receptor internalization. GRKs and β-arrestins also participate in the assembly of receptor-associated multimolecular complexes, thus initiating alternative G-protein-independent signaling events...
2016: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/27348044/agonist-activated-bombyx-corazonin-receptor-is-internalized-via-an-arrestin-dependent-and-clathrin-independent-pathway
#10
Jingwen Yang, Zhangfei Shen, Xue Jiang, Huipeng Yang, Haishan Huang, Lili Jin, Yajie Chen, Liangen Shi, Naiming Zhou
Agonist-induced internalization plays a key role in the tight regulation of the extent and duration of G protein-coupled receptor signaling. Previously, we have shown that the Bombyx corazonin receptor (BmCrzR) activates both Gαq- and Gαs-dependent signaling cascades. However, the molecular mechanisms involved in the regulation of the internalization and desensitization of BmCrzR remain to be elucidated. Here, vectors for expressing BmCrzR fused with enhanced green fluorescent protein (EGFP) at the C-terminal end were used to further characterize BmCrzR internalization...
July 19, 2016: Biochemistry
https://www.readbyqxmd.com/read/27232975/c-src-insulin-like-growth-factor-i-receptor-g-protein-coupled-receptor-kinases-and-focal-adhesion-kinase-are-enriched-into-prostate-cancer-cell-exosomes
#11
Rachel M DeRita, Brad Zerlanko, Amrita Singh, Huimin Lu, Renato V Iozzo, Jeffrey L Benovic, Lucia R Languino
It is well known that Src tyrosine kinase, insulin-like growth factor 1 receptor (IGF-IR), and focal adhesion kinase (FAK) play important roles in prostate cancer (PrCa) development and progression. Src, which signals through FAK in response to integrin activation, has been implicated in many aspects of tumor biology, such as cell proliferation, metastasis, and angiogenesis. Furthermore, Src signaling is known to crosstalk with IGF-IR, which also promotes angiogenesis. In this study, we demonstrate that c-Src, IGF-IR, and FAK are packaged into exosomes (Exo), c-Src in particular being highly enriched in Exo from the androgen receptor (AR)-positive cell line C4-2B and AR-negative cell lines PC3 and DU145...
January 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27185880/occludin-s471-phosphorylation-contributes-to-epithelial-monolayer-maturation
#12
Mark T Bolinger, Aniket Ramshekar, Helen V Waldschmidt, Scott D Larsen, Maria C Bewley, John M Flanagan, David A Antonetti
Multiple organ systems require epithelial barriers for normal function, and barrier loss is a hallmark of diseases ranging from inflammation to epithelial cancers. However, the molecular processes regulating epithelial barrier maturation are not fully elucidated. After contact, epithelial cells undergo size-reductive proliferation and differentiate, creating a dense, highly ordered monolayer with high resistance barriers. We provide evidence that the tight junction protein occludin contributes to the regulation of epithelial cell maturation upon phosphorylation of S471 in its coiled-coil domain...
August 1, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27180008/the-expanding-grk-interactome-implications-in-cardiovascular-disease-and-potential-for-therapeutic-development
#13
REVIEW
Jonathan Hullmann, Christopher J Traynham, Ryan C Coleman, Walter J Koch
Heart failure (HF) is a global epidemic with the highest degree of mortality and morbidity of any disease presently studied. G protein-coupled receptors (GPCRs) are prominent regulators of cardiovascular function. Activated GPCRs are "turned off" by GPCR kinases (GRKs) in a process known as "desensitization". GRKs 2 and 5 are highly expressed in the heart, and known to be upregulated in HF. Over the last 20 years, both GRK2 and GRK5 have been demonstrated to be critical mediators of the molecular alterations that occur in the failing heart...
August 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27178731/g-protein-coupled-receptor-kinases-as-regulators-of-dopamine-receptor-functions
#14
REVIEW
Eugenia V Gurevich, Raul R Gainetdinov, Vsevolod V Gurevich
Actions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors that belong to the superfamily of G protein-coupled receptors (GPCRs). Mammals have five dopamine receptor subtypes, D1 through D5. D1 and D5 couple to Gs/olf and activate adenylyl cyclase, whereas D2, D3, and D4 couple to Gi/o and inhibit it. Most GPCRs upon activation by an agonist are phosphorylated by GPCR kinases (GRKs). The GRK phosphorylation makes receptors high-affinity binding partners for arrestin proteins. Arrestin binding to active phosphorylated receptors stops further G protein activation and promotes receptor internalization, recycling or degradation, thereby regulating their signaling and trafficking...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27145805/overexpression-of-grk6-attenuates-neuropathic-pain-via-suppression-of-cxcr2-in-rat-dorsal-root-ganglion
#15
Yuan Zhou, Rong-Ji Li, Meng Li, Xuelian Liu, Hong-Yan Zhu, Zhong Ju, Xiuhua Miao, Guang-Yin Xu
G protein-coupled kinase (GRK) 6 is a member of the GRK family that mediates agonist-induced desensitization and signaling of G protein-coupled receptors (GPCRs), thus involving in a wide variety of processes including inflammation and nociception. Recent studies have indicated that chemokines play an important role in chronic pain via increased expression of respective GPCRs. This study was designed to investigate the role of GRK6 and its interaction with substrate chemokine receptors in dorsal root ganglion (DRG) in a rat model of neuropathic pain induced by chronic constriction injury (CCI)...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27088110/grk2-putting-the-brakes-on-the-circadian-clock
#16
Lucia Mendoza-Viveros, Arthur H Cheng, Hai-Ying M Cheng
G protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases that terminate G protein-coupled receptor (GPCR) signaling by phosphorylating the receptor and inducing its internalization. In addition to their canonical function, some GRKs can phosphorylate non-GPCR substrates and regulate GPCR signaling in a kinase-independent manner. GPCRs are abundantly expressed in the suprachiasmatic nucleus (SCN), a structure in the mammalian brain that serves as the central circadian pacemaker...
February 1, 2016: Receptors & Clinical Investigation
https://www.readbyqxmd.com/read/27050625/structure-based-design-synthesis-and-biological-evaluation-of-highly-selective-and-potent-g-protein-coupled-receptor-kinase-2-inhibitors
#17
Helen V Waldschmidt, Kristoff T Homan, Osvaldo Cruz-Rodríguez, Marilyn C Cato, Jessica Waninger-Saroni, Kelly M Larimore, Alessandro Cannavo, Jianliang Song, Joseph Y Cheung, Paul D Kirchhoff, Walter J Koch, John J G Tesmer, Scott D Larsen
G protein-coupled receptors (GPCRs) are central to many physiological processes. Regulation of this superfamily of receptors is controlled by GPCR kinases (GRKs), some of which have been implicated in heart failure. GSK180736A, developed as a Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor, was identified as an inhibitor of GRK2 and co-crystallized in the active site. Guided by its binding pose overlaid with the binding pose of a known potent GRK2 inhibitor, Takeda103A, a library of hybrid inhibitors was developed...
April 28, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27049755/g-protein-coupled-receptor-kinase-3-regulates-breast-cancer-migration-invasion-and-metastasis
#18
Matthew J Billard, David J Fitzhugh, Joel S Parker, Jaime M Brozowski, Marcus W McGinnis, Roman G Timoshchenko, D Stephen Serafin, Ruth Lininger, Nancy Klauber-Demore, Gary Sahagian, Young K Truong, Maria F Sassano, Jonathan S Serody, Teresa K Tarrant
Triple negative breast cancer (TNBC) is a heterogeneous disease that has a poor prognosis and limited treatment options. Chemokine receptor interactions are important modulators of breast cancer metastasis; however, it is now recognized that quantitative surface expression of one important chemokine receptor, CXCR4, may not directly correlate with metastasis and that its functional activity in breast cancer may better inform tumor pathogenicity. G protein coupled receptor kinase 3 (GRK3) is a negative regulator of CXCR4 activity, and we show that GRK expression correlates with tumorigenicity, molecular subtype, and metastatic potential in human tumor microarray analysis...
2016: PloS One
https://www.readbyqxmd.com/read/26928607/granzyme-m-and-k-release-in-human-experimental-endotoxemia
#19
Annette C Wensink, Maryse A Wiewel, Lieneke H Jongeneel, Marianne Boes, Tom van der Poll, C Erik Hack, Niels Bovenschen
Granzymes are serine proteases involved in killing of tumor cells and virally infected cells. However, granzymes are also upregulated in blood under inflammatory conditions and contribute to cytokine release and processing. Here, we show that granzyme M (GrM) and to a lesser extent GrK are transiently elevated in the circulation following LPS administration in humans. GrM is released upon stimulation of whole blood with LPS or the gram-negative bacteria Escherichia coli BL21, Pseudomonas aeruginosa, and Neisseria meningitidis...
July 2016: Immunobiology
https://www.readbyqxmd.com/read/26902407/%C3%AE-hederin-inhibits-g-protein-coupled-receptor-kinase-2-mediated-phosphorylation-of-%C3%AE-2-adrenergic-receptors
#20
Janka Schulte-Michels, Anne Wolf, Stefan Aatz, Katharina Engelhard, Anne Sieben, Manuel Martinez-Osuna, Felix Häberlein, Hanns Häberlein
BACKGROUND: Recently is has been shown that α- and β-hederin increase the β2-adrenergic responsiveness of alveolar type II cells (A549) and human airway smooth muscle cells (HASM), respectively, by inhibiting the internalization of β2-adrenergic receptors (β2AR) under stimulating conditions. Internalization of β2AR is initiated by phosphorylations of certain serines and threonines by cAMP dependent protein kinase A (PKA) and G protein-coupled receptor kinases (GRK). PURPOSE: To evaluate the effect of α-hederin on PKA and GRK2 mediated phosphorylation of GFP-tagged β2AR...
January 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
keyword
keyword
68421
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"