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https://www.readbyqxmd.com/read/28215037/the-italian-dystonia-registry-rationale-design-and-preliminary-findings
#1
Giovanni Defazio, M Esposito, G Abbruzzese, C L Scaglione, G Fabbrini, G Ferrazzano, S Peluso, R Pellicciari, A F Gigante, G Cossu, R Arca, L Avanzino, F Bono, M R Mazza, L Bertolasi, R Bacchin, R Eleopra, C Lettieri, F Morgante, M C Altavista, L Polidori, R Liguori, S Misceo, G Squintani, M Tinazzi, R Ceravolo, E Unti, L Magistrelli, M Coletti Moja, N Modugno, M Petracca, N Tambasco, M S Cotelli, M Aguggia, A Pisani, M Romano, M Zibetti, A R Bentivoglio, A Albanese, P Girlanda, A Berardelli
The Italian Dystonia Registry is a multicenter data collection system that will prospectively assess the phenomenology and natural history of adult-onset dystonia and will serve as a basis for future etiological, pathophysiological and therapeutic studies. In the first 6 months of activity, 20 movement disorders Italian centres have adhered to the registry and 664 patients have been recruited. Baseline historical information from this cohort provides the first general overview of adult-onset dystonia in Italy...
February 18, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28215022/reciprocal-relations-between-the-trajectories-of-mothers-harsh-discipline-responsiveness-and-aggression-in-early-childhood
#2
Nazli Baydar, Berna Akcinar
Theoretical advances in the study of the development of aggressive behaviors indicate that parenting behaviors and child aggression mutually influence one another. This study contributes to the body of empirical research in this area by examining the development of child aggression, maternal responsiveness, and maternal harsh discipline, using 5-year longitudinal data from a nationally representative sample of Turkish children (n = 1009; 469 girls and 582 boys). Results indicated that: (i) maternal responsiveness and harsh discipline at age 3 were associated with the subsequent linear trajectory of aggression; (ii) reciprocally, aggressive behaviors at age 3 were associated with the subsequent linear trajectories of these two types of parenting behaviors; (iii) deviations from the linear trajectories of the child and mother behaviors tended to be short lived; and, (iv) the deviations of child behaviors from the linear trajectories were associated with the subsequent changes in mother behaviors after age 5...
February 18, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28214853/chronic-consumption-of-artificial-sweetener-in-packets-or-tablets-and-type-2-diabetes-risk-evidence-from-the-e3n-european-prospective-investigation-into-cancer-and-nutrition-study
#3
Guy Fagherazzi, Gaëlle Gusto, Aurélie Affret, Francesca Romana Mancini, Courtney Dow, Beverley Balkau, Françoise Clavel-Chapelon, Fabrice Bonnet, Marie-Christine Boutron-Ruault
BACKGROUND: The influence of artificial sweeteners on metabolic diseases is controversial. Artificially sweetened beverages have been associated with an increased risk of type 2 diabetes (T2D) but biases and reverse causation have been suspected to have influenced the observed association. In addition, it has been suggested that investigation into the relationship between the frequency and duration of the consumption of packet or tablet artificial sweeteners and T2D risk is necessary...
February 18, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28214707/shortcuts-to-a-functional-adipose-tissue-the-role-of-small-non-coding-rnas
#4
REVIEW
Bruna B Brandão, Beatriz A Guerra, Marcelo A Mori
Metabolic diseases such as type 2 diabetes are a major public health issue worldwide. These diseases are often linked to a dysfunctional adipose tissue. Fat is a large, heterogenic, pleiotropic and rather complex tissue. It is found in virtually all cavities of the human body, shows unique plasticity among tissues, and harbors many cell types in addition to its main functional unit - the adipocyte. Adipose tissue function varies depending on the localization of the fat depot, the cell composition of the tissue and the energy status of the organism...
February 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28214690/safety-and-efficacy-of-a-polyherbal-formulation-for-the-management-of-dyslipidemia-and-hyperglycemia-in-patients-with-advanced-stage-of-type-2-diabetes
#5
Mahdi Zarvandi, Hassan Rakhshandeh, Mohammad Abazari, Reza Shafiee-Nick, Ahmad Ghorbani
The present clinical trial was designed to evaluate the safety and efficacy of a polyherbal formulation (PHF) consisted of Allium sativum, Aloe vera, Nigella sativa, Plantago psyllium, Silybum marianum and Trigonella foenum-graecum for controlling dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes. An open-label phase I trial was carried out on 30 patients who had hyperlipidemia and hyperglycemia before the beginning of the trial in spite of receiving statins and oral hypoglycemic drugs...
February 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28214531/the-skeletal-developmental-toxicity-of-chlormequat-chloride-and-its-underlying-mechanisms
#6
Dan Huang, Shuang Wu, Xiaohong Hou, Lixia Jia, Qinghe Meng, Hongqian Chu, Jianjun Jiang, Lanqin Shang, Weidong Hao
Chlormequat Chloride (CCC), a widely used plant growth regulator, could decrease body weight in animals; however, the mechanism has not been well studied. This study was designed to evaluate the skeletal development toxicity of CCC on pubertal male Sprague-Dawley (SD) rats and to investigate whether CCC impacts the development of chondrocyte, osteoblast and osteoclast through growth hormone (GH) and insulin like growth factor 1 (IGF-I). Rats from 23 to 70 on postnatal days were exposed to CCC daily by gavage at doses of 0, 75, 150, and 300mg/kg bw/d...
February 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28214199/primary-acinic-cell-carcinoma-of-the-lung-with-psammoma-bodies-a-case-report-and-review-of-literature
#7
Xiu-Peng Zhang, Gui-Yang Jiang, Qing-Fu Zhang, Hong-Tao Xu, Qing-Chang Li, En-Hua Wang
Salivary gland-type tumors are rare in the lung. Primary acinic cell carcinoma of the lung is extremely rare. Here, we report a case of primary acinic cell carcinoma of the lung with prominent psammoma bodies. A 31-year-old man came to our hospital with a tumor in the basal segment of the lower lobe of the right lung. The tumor tissue displayed solid, acinar, or microcystic structures at different regions. A large amount of psammoma bodies were scattered in more than half of the tumor. The majority of the tumor cells were round or polygonal in shape, with abundant acidophilic granular or vacuolated cytoplasm...
January 19, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214151/association-of-types-of-dyspnea-including-bendopnea-with-cardiopulmonary-disease-in-primary-care
#8
Diana María Martínez Cerón, Maria Luiza Garcia Rosa, Antônio Jose Lagoeiro Jorge, Wolney de Andrade Martins, Evandro Tinoco Mesquita, Monica Di Calafriori Freire, Dayse Mary da Silva Correia, Hye Chung Kang
INTRODUCTION: Dyspnea is the symptom most commonly reported by patients with heart failure (HF) and/or pulmonary disease, the obese and the elderly. Recently 'bendopnea' (shortness of breath when bending forward) has been described in patients with HF. OBJECTIVE: To determine the association of exertional dyspnea, orthopnea, paroxysmal nocturnal dyspnea and bendopnea with chronic disease, especially heart failure, and their phenotypes in primary care. METHODS: This cross-sectional study included 633 individuals aged between 45 and 99 years enrolled in a primary care program in Niteroi, Brazil...
February 14, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28213947/select-noxious-stimuli-induce-changes-on-corneal-nerve-morphology
#9
Deborah M Hegarty, Sam M Hermes, Katherine Yang, Sue A Aicher
The surface of the cornea contains the highest density of nociceptive nerves of any tissue in the body. These nerves are responsive to a variety of modalities of noxious stimuli and can signal pain even when activated by low threshold stimulation. Injury of corneal nerves can lead to altered nerve morphology, including neuropathic changes which can be associated with chronic pain. Emerging technologies that allow imaging of corneal nerves in vivo are spawning questions regarding the relationship between corneal nerve density, morphology and function...
February 18, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28213819/conditional-knockout-of-activin-like-kinase-1-alk-1-leads-to-heart-failure-without-maladaptive-remodeling
#10
Kevin J Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J Aronovitz, Emily E Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M Blanton, Richard H Karas, S Paul Oh, Navin K Kapur
Activin like kinase-1 (AlK-1) mediates signaling via the transforming growth factor beta (TGFβ) family of ligands. AlK-1 activity promotes endothelial proliferation and migration. Reduced AlK-1 activity is associated with arteriovenous malformations. No studies have examined the effect of global AlK-1 deletion on indices of cardiac remodeling. We hypothesized that reduced levels of AlK-1 promote maladaptive cardiac remodeling. To test this hypothesis, we employed AlK-1 conditional knockout mice (cKO) harboring the ROSA26-CreER knock-in allele, whereby a single dose of intraperitoneal tamoxifen triggered ubiquitous Cre recombinase-mediated excision of floxed AlK-1 alleles...
February 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28213763/the-lactobacillus-rhamnosus-and-lactobacillus-fermentum-strains-from-human-biotopes-characterized-with-mlst-and-toxin-antitoxin-gene-polymorphism
#11
E U Poluektova, R A Yunes, M V Epiphanova, V S Orlova, V N Danilenko
The diversity of Lb. rhamnosus and Lb. fermentum strains isolated from feces, saliva, and the vaginal cavity of 18-22-year-old healthy women residing in central regions of the Russian Federation has been characterized. The results obtained using multilocus sequence typing were identical to those obtained with the analysis of genetic and genomic polymorphism in TA systems. Different as well as identical Lb. rhamnosus and Lb. fermentum sequence types (ST) were isolated from various parts of the body of the same person...
February 17, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28213735/microalgae-based-advanced-municipal-wastewater-treatment-for-reuse-in-water-bodies
#12
REVIEW
Jing-Han Wang, Tian-Yuan Zhang, Guo-Hua Dao, Xue-Qiao Xu, Xiao-Xiong Wang, Hong -Ying Hu
Reuse of secondary municipal effluent from wastewater treatment plants in water bodies could effectively alleviate freshwater resource shortage. However, excessive nutrients must be efficiently removed to prevent eutrophication. Compared with other means of advanced wastewater treatment, microalgae-based processes display overwhelming advantages including efficient and simultaneous N and P removal, no requirement of additional chemicals, O2 generation, CO2 mitigation, and potential value-added products from harvested biomass...
February 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28213614/reproductive-dysfunction-and-associated-pathology-in-women-undergoing-military-training
#13
REVIEW
Robert M Gifford, R M Reynolds, J Greeves, R A Anderson, D R Woods
INTRODUCTION: Evidence from civilian athletes raises the question of whether reproductive dysfunction may be seen in female soldiers as a result of military training. Such reproductive dysfunction consists of impaired ovulation with or without long-term subfertility. METHODS: A critical review of pertinent evidence following an extensive literature search. RESULTS: The evidence points towards reduced energy availability as the most likely explanation for exercise-induced reproductive dysfunction...
February 17, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28213494/plc%C3%AE%C2%B51-regulates-sdf-1%C3%AE-induced-lymphocyte-adhesion-and-migration-to-sites-of-inflammation
#14
Marianne Strazza, Inbar Azoulay-Alfaguter, Michael Peled, Alan V Smrcka, Edward Y Skolnik, Shekhar Srivastava, Adam Mor
Regulation of integrins is critical for lymphocyte adhesion to endothelium and migration throughout the body. Inside-out signaling to integrins is mediated by the small GTPase Ras-proximate-1 (Rap1). Using an RNA-mediated interference screen, we identified phospholipase Cε 1 (PLCε1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1α)-induced Rap1 activation. We have shown that SDF-1α-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor...
February 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28213463/membrane-transport-across-polarized-epithelia
#15
Maria Daniela Garcia-Castillo, Daniel J-F Chinnapen, Wayne I Lencer
Polarized epithelial cells line diverse surfaces throughout the body forming selective barriers between the external environment and the internal milieu. To cross these epithelial barriers, large solutes and other cargoes must undergo transcytosis, an endocytic pathway unique to polarized cell types, and significant for the development of cell polarity, uptake of viral and bacterial pathogens, transepithelial signaling, and immunoglobulin transport. Here, we review recent advances in our knowledge of the transcytotic pathway for proteins and lipids...
February 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28213398/foxo-integration-of-insulin-signaling-with-glucose-and-lipid-metabolism
#16
Sojin Lee, Henry H Dong
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the amino DNA binding domain, known as "forkhead box" domain. They mediate the inhibitory action of insulin or insulin-like growth factor on key functions involved in cell metabolism, growth, differentiation, oxidative stress, senescence, autophagy and aging. Genetic mutations in FoxO genes or abnormal expression of FoxO proteins are associated with metabolic disease, cancer or altered lifespan in humans and animals...
February 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28213338/a-uniaxial-cyclic-compression-method-for-characterizing-the-rheological-and-textural-behaviors-of-mechanically-dewatered-sewage-sludge
#17
Fenglin Liang, Martial Sauceau, Gilles Dusserre, Patricia Arlabosse
The mechanically dewatered sewage sludge with total solid content around 20% on a weight basis is very similar to yield stress fluid, its complex transition between solid and fluid states is not perfectly reversible and especially challenging in terms of pumping, land spreading and drying. To characterize the rheological and textural properties of highly concentrated sludge, a specific methodology based on uniaxial single and cyclic compression tests is developed. Three types of sludge samples (fresh original, fresh premixed and aged original ones) are extruded into cylinders and pressed between two parallel plates using a material testing machine...
February 7, 2017: Water Research
https://www.readbyqxmd.com/read/28213167/the-effect-of-peripheral-neuropathy-on-lower-limb-muscle-strength-in-diabetic-individuals
#18
Jean P Ferreira, Cristina D Sartor, Ângela M O Leal, Isabel C N Sacco, Tatiana O Sato, Ivana L Ribeiro, Alice S Soares, Jonathan E Cunha, Tania F Salvini
BACKGROUND: Skeletal muscle strength is poorly described and understood in diabetic participants with diabetic peripheral neuropathy. This study aimed to investigate the extensor and flexor torque of the knee and ankle during concentric, eccentric, and isometric contractions in men with diabetes mellitus type 2 with and without diabetic peripheral neuropathy. METHODS: Three groups of adult men (n=92), similar in age, body mass index, and testosterone levels, were analyzed: 33 non-diabetic controls, 31 with type 2 diabetes mellitus, and 28 with diabetic peripheral neuropathy...
February 9, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28213071/pla2g6-accumulates-in-lewy-bodies-in-park14-and-idiopathic-parkinson-s-disease
#19
Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
The histopathological hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is the occurrence of insoluble fibrillary aggregates known as Lewy bodies, in which phosphorylated α-synuclein (α-syn) is a major component. To date, familial PD-linked gene products, including α-syn, parkin, PINK-1, DJ-1 and LRRK2, are known to be involved in Lewy body formation. Phospholipase A2, group VI (PLA2G6) is the causative gene for PARK14-linked parkinsonism (PARK14), a familial form of juvenile-onset dystonia parkinsonism...
February 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28213010/the-pathogenesis-and-pathophysiology-of-gestational-diabetes-mellitus-deductions-from-a-three-part-longitudinal-metabolomics-study-in-china
#20
REVIEW
Kai P Law, Hua Zhang
Gestational diabetes mellitus (GDM) is a form of diabetes that is first recognised during pregnancy, with no evidence of pre-existing type 1 or type 2 diabetes. The prevalence of GDM has been rising steadily over the past few decades, coinciding with the ongoing epidemic of obesity and type 2 diabetes. Although GDM normally disappears after delivery, women who have been previously diagnosed with GDM are at a greater risk of developing gestational diabetes in subsequent pregnancies, and type 2 diabetes later in life...
February 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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