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https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#1
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29474931/alpha-syntrophin-null-mice-are-protected-from-non-alcoholic-steatohepatitis-in-the-methionine-choline-deficient-diet-model-but-not-the-atherogenic-diet-model
#2
Lisa Rein-Fischboeck, Elisabeth M Haberl, Rebekka Pohl, Verena Schmid, Susanne Feder, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Adipose tissue dysfunction contributes to the pathogenesis of non-alcoholic steatohepatitis (NASH). The adapter protein alpha-syntrophin (SNTA) is expressed in adipocytes. Knock-down of SNTA increases preadipocyte proliferation and formation of small lipid droplets, which are both characteristics of healthy adipose tissue. To elucidate a potential protective role of SNTA in NASH, SNTA null mice were fed a methionine-choline-deficient (MCD) diet or an atherogenic diet which are widely used as preclinical NASH models...
February 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29474702/a-weight-loss-intervention-using-a-commercial-mobile-application-in-latino-americans-adelgaza-trial
#3
Yoshimi Fukuoka, Eric Vittinghoff, Julie Hooper
More than half of Latino adults living in the USA are expected to develop type 2 diabetes in their lifetime. Despite the growing interest in smartphone use for weight loss and diabetes prevention, relatively few clinical trials have evaluated the efficacy of mobile app-based interventions in Latino populations. The aim of this study was to evaluate the potential efficacy of an in-person weight loss intervention in conjunction with a commercially available Fitbit app in a Latino sample at risk for type 2 diabetes and explore significant predictors associated with weight loss...
February 21, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29474564/long-term-outcomes-of-total-correction-for-isolated-total-anomalous-pulmonary-venous-connection-lessons-from-50-years-experience
#4
Takahiko Sakamoto, Mitsugi Nagashima, Kentarou Umezu, Ryogo Houki, Jin Ikarashi, Junko Katagiri, Kenji Yamazaki
OBJECTIVES: Isolated total anomalous pulmonary venous connection (TAPVC) is a relatively rare congenital cardiac defect, while pulmonary venous obstruction (PVO) is associated with poor prognosis. We reviewed the long-term outcome of total correction for isolated TAPVC at our institute and analysed the risk factors for mortality and morbidity. METHODS: A total of 290 isolated TAPVC patients evaluated between 1965 and 2016 were divided into 2 groups: Group Early (n = 151) underwent surgery before 1989; Group Late (n = 139) underwent surgery after 1990...
February 20, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29474503/tree-cover-and-species-composition-effects-on-academic-performance-of-primary-school-students
#5
Sivajanani Sivarajah, Sandy M Smith, Sean C Thomas
Human exposure to green space and vegetation is widely recognized to result in physical and mental health benefits; however, to date, the specific effects of tree cover, diversity, and species composition on student academic performance have not been investigated. We compiled standardized performance scores in Grades 3 and 6 for the collective student body in 387 schools across the Toronto District School Board (TDSB), and examined variation in relation to tree cover, tree diversity, and tree species composition based on comprehensive inventories of trees on school properties combined with aerial-photo-based assessments of tree cover...
2018: PloS One
https://www.readbyqxmd.com/read/29474484/transgenerational-effects-of-prenatal-restricted-diet-on-gene-expression-and-histone-modifications-in-the-rat
#6
Joanna Nowacka-Woszuk, Izabela Szczerbal, Anna M Malinowska, Agata Chmurzynska
Dietary triggers acting on a developing fetus can affect the functioning of the body in later life; this can be observed on various levels, including epigenetic modifications and gene expression. Early-life programmed changes may be transmitted to successive generations. In this study, the impact of prenatal restricted diet was studied in four generations of rats. We hypothesized that this diet can induce changes in the expression of major genes involved in two epigenetic mechanisms: DNA methylation and histone modifications...
2018: PloS One
https://www.readbyqxmd.com/read/29474482/prevalence-of-several-somatic-diseases-depends-on-the-presence-and-severity-of-obstructive-sleep-apnea
#7
Ragnhild L Tveit, Sverre Lehmann, Bjørn Bjorvatn
STUDY OBJECTIVES: The objective was to investigate the prevalence of heart attack, angina pectoris, stroke, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, asthma and obesity in relation to the presence and severity of obstructive sleep apnea. METHODS: The sample consisted of 1887 patients, with mean age of 48.6 years (range 16-83 years), referred to a university hospital on suspicion of obstructive sleep apnea. The patients filled out a questionnaire asking whether they were previously diagnosed with the comorbidities in interest...
2018: PloS One
https://www.readbyqxmd.com/read/29474465/strength-improvements-through-occlusal-splints-the-effects-of-different-lower-jaw-positions-on-maximal-isometric-force-production-and-performance-in-different-jumping-types
#8
Christian Maurer, Sebastian Heller, Jil-Julia Sure, Daniel Fuchs, Christoph Mickel, Eileen M Wanke, David A Groneberg, Daniela Ohlendorf
OBJECTIVE: The influence of the jaw position on postural control, body posture, walking and running pattern has been reported in the literature. All these movements have in common that a relatively small, but well controlled muscle activation is required. The induced effects on motor output through changed jaw positions have been small. Therefore, it has been questioned if it could still be observed in maximal muscle activation. METHOD: Twenty-three healthy, mid age recreational runners (mean age = 34...
2018: PloS One
https://www.readbyqxmd.com/read/29474435/sumo-polymeric-chains-are-involved-in-nuclear-foci-formation-and-chromatin-organization-in-trypanosoma-brucei-procyclic-forms
#9
Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Javier Gerardo De Gaudenzi, Vanina Eder Alvarez
SUMOylation is a post-translational modification conserved in eukaryotic organisms that involves the covalent attachment of the small ubiquitin-like protein SUMO to internal lysine residues in target proteins. This tag usually alters the interaction surface of the modified protein and can be translated into changes in its biological activity, stability or subcellular localization, among other possible outputs. SUMO can be attached as a single moiety or as SUMO polymers in case there are internal acceptor sites in SUMO itself...
2018: PloS One
https://www.readbyqxmd.com/read/29474404/role-of-acid-sensing-ion-channels-in-hypoxia-and-hypercapnia-induced-ventilatory-responses
#10
Neil D Detweiler, Kenneth G Vigil, Thomas C Resta, Benjimen R Walker, Nikki L Jernigan
Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown. We tested the hypotheses that ASICs contribute to hypoxic- and hypercapnic-ventilatory responses. Blood samples taken from conscious, unrestrained mice chronically instrumented with femoral artery catheters were used to assess arterial O2, CO2, and pH levels during exposure to inspired gas mixtures designed to cause isocapnic hypoxemia or hypercapnia...
2018: PloS One
https://www.readbyqxmd.com/read/29474386/peak-oxygen-uptake-in-paralympic-sitting-sports-a-systematic-literature-review-meta-and-pooled-data-analysis
#11
Julia Kathrin Baumgart, Berit Brurok, Øyvind Sandbakk
BACKGROUND: Peak oxygen uptake (VO2peak) in Paralympic sitting sports athletes represents their maximal ability to deliver energy aerobically in an upper-body mode, with values being influenced by sex, disability-related physiological limitations, sport-specific demands, training status and how they are tested. OBJECTIVES: To identify VO2peak values in Paralympic sitting sports, examine between-sports differences and within-sports variations in VO2peak and determine the influence of sex, age, body-mass, disability and test-mode on VO2peak...
2018: PloS One
https://www.readbyqxmd.com/read/29474358/technical-feasibility-study-for-production-of-tailored-multielectrode-arrays-and-patterning-of-arranged-neuronal-networks
#12
Matthias Schürmann, Norman Shepheard, Natalie Frese, Kevin Geishendorf, Holger Sudhoff, Armin Gölzhäuser, Ulrich Rückert, Christian Kaltschmidt, Barbara Kaltschmidt, Andy Thomas
In this manuscript, we first reveal a simple ultra violet laser lithographic method to design and produce plain tailored multielectrode arrays. Secondly, we use the same lithographic setup for surface patterning to enable controlled attachment of primary neuronal cells and help neurite guidance. For multielectrode array production, we used flat borosilicate glass directly structured with the laser lithography system. The multi layered electrode system consists of a layer of titanium coated with a layer of di-titanium nitride...
2018: PloS One
https://www.readbyqxmd.com/read/29474001/proteogenomic-analysis-to-identify-missing-proteins-from-haploid-cell-lines
#13
Seung-Eun Lee, JongKeon Song, Korbinian Bösl, André C Müller, Dijana Vitko, Keiryn L Bennett, Giulio Superti-Furga, Akhilesh Pandey, Richard K Kandasamy, Min-Sik Kim
Chromosome-centric Human Proteome Project aims at identifying and characterizing protein products encoded from all human protein-coding genes. As of early 2017, 19,837 protein-coding genes have been annotated in the neXtProt database including 2,691 missing proteins that have never been identified by mass spectrometry. Missing proteins may be low abundant in many cell types or expressed only in a few cell types in human body such as sperms in testis. In this study, we performed expression proteomics of two near haploid cell types such as HAP1 and KBM-7 to hunt for missing proteins...
February 23, 2018: Proteomics
https://www.readbyqxmd.com/read/29473915/infection-and-transport-of-herpes-simplex-virus-type-1-in-neurons-role-of-the-cytoskeleton
#14
REVIEW
Monica Miranda-Saksena, Christopher E Denes, Russell J Diefenbach, Anthony L Cunningham
Herpes simplex virus type 1 (HSV-1) is a neuroinvasive human pathogen that has the ability to infect and replicate within epithelial cells and neurons and establish a life-long latent infection in sensory neurons. HSV-1 depends on the host cellular cytoskeleton for entry, replication, and exit. Therefore, HSV-1 has adapted mechanisms to promote its survival by exploiting the microtubule and actin cytoskeletons to direct its active transport, infection, and spread between neurons and epithelial cells during primary and recurrent infections...
February 23, 2018: Viruses
https://www.readbyqxmd.com/read/29473893/restoration-of-muscle-glycogen-and-functional-capacity-role-of-post-exercise-carbohydrate-and-protein-co-ingestion
#15
Abdullah F Alghannam, Javier T Gonzalez, James A Betts
The importance of post-exercise recovery nutrition has been well described in recent years, leading to its incorporation as an integral part of training regimes in both athletes and active individuals. Muscle glycogen depletion during an initial prolonged exercise bout is a main factor in the onset of fatigue and so the replenishment of glycogen stores may be important for recovery of functional capacity. Nevertheless, nutritional considerations for optimal short-term (3-6 h) recovery remain incompletely elucidated, particularly surrounding the precise amount of specific types of nutrients required...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29473704/effect-of-exenatide-qw-or-placebo-both-added-to-titrated-insulin-glargine-in-uncontrolled-type-2-diabetes-the-duration-7-randomized-study
#16
Cristian Guja, Juan P Frías, Aniko Somogyi, Serge Jabbour, Hui Wang, Elise Hardy, Julio Rosenstock
AIMS: To compare the efficacy and safety of adding the glucagon-like peptide-1 receptor agonist exenatide once weekly (QW) 2 mg or placebo among patients with type 2 diabetes inadequately controlled despite titrated insulin glargine (IG) ± metformin. METHODS: This multicentre, double-blind study randomized (1:1) patients with persistent hyperglycaemia after 8-week IG titration (glycated haemoglobin [HbA1c] 7.0-10.5% [53-91 mmol/mol]) to exenatide QW or placebo...
February 23, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29473694/comparing-apples-and-oranges-and-pears-and-kumquats-the-misuse-of-index-systems-for-processing-histopathology-data-in-fish-toxicological-bioassays
#17
Jeffrey C Wolf
Histopathology index systems involve the application of weighted scores to various diagnostic findings for the purpose of calculating overall organ and/or whole animal health measurements. Such systems were originally developed as tools for monitoring the general health of fish populations. More recently, index systems have been applied to hypothesis-based toxicological studies, the goal of which is to investigate whether a cause-and-effect relationship exists between exposure to a particular test substance or environmental contaminant and morphologic effects in fish tissues...
February 23, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29473673/mississippian-subadults-from-the-middle-cumberland-and-eastern-regions-of-tennessee-biological-indicators-of-population-interaction
#18
Rebecca Scopa Kelso
OBJECTIVES: Human subadult skeletal remains can provide a unique perspective into biosocial aspects of Mississippian period population interactions within and between the Middle Cumberland (MCR) and Eastern Tennessee Regions (ETR). The majority of previous studies have concentrated on adult skeletal remains, leaving out a large and extremely important population segment. METHODS: Skeletal indicators of disease, growth, body proportions, and metabolic stress were collected from subadult remains from five archaeological sites over several temporal periods...
February 23, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29473541/a-kinase-dependent-feedforward-loop-affects-crebb-stability-and-long-term-memory-formation
#19
Pei-Tseng Lee, Guang Lin, Wen-Wen Lin, Fengqiu Diao, Benjamin H White, Hugo J Bellen
In Drosophila , long-term memory (LTM) requires the cAMP-dependent transcription factor CREBB, expressed in the mushroom bodies (MB) and phosphorylated by PKA. To identify other kinases required for memory formation, we integrated Trojan exons encoding T2A-GAL4 into genes encoding putative kinases and selected for genes expressed in MB. These lines were screened for learning/memory deficits using UAS-RNAi knockdown based on an olfactory aversive conditioning assay. We identified a novel, conserved kinase, Meng-Po ( MP , CG11221 , SBK1 in human), the loss of which severely affects 3 hr memory and 24 hr LTM, but not learning...
February 23, 2018: ELife
https://www.readbyqxmd.com/read/29473380/longitudinal-prospective-observational-type-study-about-determinants-of-renal-resistive-index-variations-in-chronic-renal-failure-patients-treated-with-conventional-medical-and-dietetic-therapy
#20
Simone Brardi, Gabriele Cevenini, Vanni Giovannelli, Giuseppe Romano
OBJECTIVE: This longitudinal prospective observational type study was conceived with the aim to examine the impact on renal resistive index (RRI) of the variables that we can manipulate with therapeutic and or dietetic interventions in a chronic kidney disease population in order to known which of these variables was statistically related to changes in RRI and therefore could become the object of the greatest therapeutic effort. MATERIAL AND METHODS: This study was undertaken between May 2016 to May 2017 in the outpatient nephrology and urology clinic of San Donato Hospital in Arezzo...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
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