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https://www.readbyqxmd.com/read/29055272/engaging-psychiatrists-in-the-diagnosis-of-psychogenic-nonepileptic-seizures-what-can-they-contribute
#1
Massimiliano Beghi, Giuseppe Erba, Cesare Maria Cornaggia, Giorgia Giussani, Elisa Bianchi, Gianni Porro, Michela Russo, Ettore Beghi
PURPOSE: To investigate if psychiatrists could predict the diagnosis of psychogenic nonepileptic seizures (PNES) by reviewing videos of seizures of various types and to compare the accuracy and the criteria leading to the diagnosis used by psychiatrists with those used by epileptologists. METHODS: Four board-certified psychiatrists were asked to review 23 videos capturing representative events of 21 unselected consecutive patients admitted to an epilepsy center for long-term video-EEG monitoring...
October 16, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29055138/effects-of-a-bone-graft-substitute-consisting-of-porous-gradient-ha-zro2-and-gelatin-chitosan-slow-release-hydrogel-containing-bmp-2-and-bmscs-on-lumbar-vertebral-defect-repair-in-rhesus-monkey
#2
Rong-Xue Shao, Ren-Fu Quan, Tuo Wang, Wei-Bin Du, Gao-Yong Jia, Dong Wang, Long-Bao Lv, Cai-Yin Xu, Xi-Cheng Wei, Jin-Fu Wang, Di-Sheng Yang
Dense biomaterial plays an important role in bone replacement. However, it fails to induce bone-cell migration into graft material. In the present study, a novel bone-graft substitute (BGS) consisting of porous gradient HA/ZrO2 composite (PGHC) and gelatin/chitosan slow-release hydrogel containing BMP-2 and BMSCs was designed and prepared to repair lumbar vertebral defects. The morphological characteristics of the BGS evaluated by scanning electron microscope showed that it had a three-dimensional network structure with uniformly distributed chitosan microspheres on the surfaces of the graft material and the interior of the pores...
October 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29055125/vascular-endothelial-growth-factor-vegf-related-single-nucleotide-polymorphisms-rs10738760-and-rs6921438-are-not-associated-with-diabetic-retinopathy-dr-in-slovenian-patients-with-type-2-diabetes-mellitus-t2dm
#3
Rifet Terzić, Ines Cilenšek, Ruda Zorc Pleskovič, Sara Mankoč, Aleksandra Milutinović
Diabetic retinopathy (DR) is a complication of diabetes characterized by vascular permeability, increased tissue ischemia, and angiogenesis. One of the most important proteins involved in angiogenesis is vascular endothelial growth factor (VEGF, also known as VEGFA). A previous study demonstrated that two single nucleotide polymorphisms (SNPs), rs6921438 and rs10738760, account for nearly half the variation in circulating VEGF levels. The aim of our study was to assess the association between rs6921438 and rs10738760 and DR in Slovenian patients with type 2 diabetes mellitus (T2DM)...
October 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29054981/immunoadsorption-in-anti-gbm-glomerulonephritis-case-report-in-a-child-and-literature-review
#4
Guillaume Dorval, Mathilde Lion, Sophie Guérin, Saoussen Krid, Louise Galmiche-Rolland, Rémi Salomon, Olivia Boyer
Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that is characterized by rapidly progressive glomerulonephritis that may be associated with pulmonary hemorrhage. Anti-GBM GN is caused by autoantibodies (classically type G immunoglobulin) directed against the α3 subunit of type IV collagen. Without any appropriate treatment, the disease is generally fulminant, and patient and kidney survival is poor. The current guidelines recommend the use of plasma exchanges and immunosuppressive drugs...
October 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29054536/decreasing-body-mass-index-is-associated-with-cerebrospinal-fluid-markers-of-alzheimer-s-pathology-in-mci-and-mild-dementia
#5
Jules Mathys, Mehdi Gholamrezaee, Hugues Henry, Armin von Gunten, Julius Popp
BACKGROUND: Several studies have identified an association between body mass index (BMI) and the incidence and severity of Alzheimer's disease (AD) but this relationship is not fully understood. OBJECTIVE: The primary objective of this study was to assess the possible association between BMI and cerebrospinal fluid (CSF) biomarkers of AD pathology in subjects with normal cognition and cognitive impairment. The secondary objective was to test whether BMI may contribute to improve the accuracy of a clinical model to predict AD pathology in memory clinic patients with cognitive impairment...
October 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29054483/risk-and-associates-of-incident-hip-fracture-in-type-1-diabetes-the-fremantle-diabetes-study
#6
Emma J Hamilton, Wendy A Davis, David G Bruce, Timothy M E Davis
AIMS: To determine the relative risk of incident hip fracture in patients with type 1 diabetes and matched controls, to examine baseline associates of incident hip fracture in the patients with type 1 diabetes, and to compare hip fracture rates in age- and sex- matched patients with type 1 versus type 2 diabetes. METHODS: Longitudinal observational study of 121 adults with type 1 diabetes (mean±SD age 43.0±15.5 years, 59.5% male) and 484 age- and sex-matched adults without diabetes...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29054476/extracellular-vesicles-as-emerging-targets-in-cancer-recent-development-from-bench-to-bedside
#7
REVIEW
Kerui Wu, Fei Xing, Shih-Ying Wu, Kounosuke Watabe
Extracellular vesicles (EVs) have emerged as important players of cancer initiation and progression through cell-cell communication. They have been recognized as critical mediators of extracellular communications, which promote transformation, growth invasion, and drug-resistance of cancer cells. Interestingly, the secretion and uptake of EVs are regulated in a more controlled manner than previously anticipated. EVs are classified into three groups, (i) exosomes, (ii) microvesicles (MVs), and (iii) apoptotic bodies (ABs), based on their sizes and origins, and novel technologies to isolate and distinguish these EVs are evolving...
October 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29054337/dental-pulp-stem-cells-dpscs-increase-prostate-cancer-cell-proliferation-and-migration-under-in-vitro-conditions
#8
Ayşegül Doğan, Selami Demirci, Hüseyin Apdik, Ezgi Avşar Apdik, Fikrettin Şahin
Cancer as a multistep and complicated disease is regulated by several molecular and cellular events. Cancer treatment could be managed at the early stages when the tumor is confined in the tissue. However, disseminated cancer cells metastasize to other body parts and generate new tumors resulting in mortality. Mesenchymal stem cells (MSCs) are found in different body parts and helps adult tissue regeneration. The role of MSCs in cancer progression has emerged as one of the important aspects in cancer biology and is the aim of interest in recent years...
October 16, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/29054111/dipeptidyl-peptidase-4-inhibitors-attenuates-the-decline-of-skeletal-muscle-mass-in-patients-with-type-2-diabetes
#9
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
BACKGROUND: Activation of dipeptidyl peptidase 4 (DPP4) has been reported to be associated with impairment of insulin signaling in skeletal muscle mass, presumably leading to loss of muscle function. This study was aimed to investigate whether the use of DPP4 inhibitors (DPP4i) could attenuate the progressive loss of muscle mass in patients with type 2 diabetes. METHODS: A total 105 patients with type 2 diabetes (mean age 62 ± 12 years; 39% female) were studied in this retrospective observational study...
October 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29053995/effects-of-a-whey-protein-supplementation-on-oxidative-stress-body-composition-and-glucose-metabolism-among-overweight-people-affected-by-diabetes-mellitus-or-impaired-fasting-glucose-a-pilot-study
#10
Chiara Flaim, Michael Kob, Angela M Di Pierro, Markus Herrmann, Lucio Lucchin
Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans & Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. 2007]. WP have unpleasant taste and smell [Patel 2015], but a new WP isolate (ProLYOtin®) seems to be more palatable...
May 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053968/multiscale-3d-genome-rewiring-during-mouse-neural-development
#11
Boyan Bonev, Netta Mendelson Cohen, Quentin Szabo, Lauriane Fritsch, Giorgio L Papadopoulos, Yaniv Lubling, Xiaole Xu, Xiaodan Lv, Jean-Philippe Hugnot, Amos Tanay, Giacomo Cavalli
Chromosome conformation capture technologies have revealed important insights into genome folding. Yet, how spatial genome architecture is related to gene expression and cell fate remains unclear. We comprehensively mapped 3D chromatin organization during mouse neural differentiation in vitro and in vivo, generating the highest-resolution Hi-C maps available to date. We found that transcription is correlated with chromatin insulation and long-range interactions, but dCas9-mediated activation is insufficient for creating TAD boundaries de novo...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053868/lagos-ne-a-multi-scaled-geospatial-and-temporal-database-of-lake-ecological-context-and-water-quality-for-thousands-of-u-s-lakes
#12
Patricia A Soranno, Linda C Bacon, Michael Beauchene, Karen E Bednar, Edward G Bissell, Claire K Boudreau, Marvin G Boyer, Mary T Bremigan, Stephen R Carpenter, Jamie W Carr, Kendra S Cheruvelil, Samuel T Christel, Matt Claucherty, Sarah M Collins, Joseph D Conroy, John A Downing, Jed Dukett, C Emi Fergus, Christopher T Filstrup, Clara Funk, Maria J Gonzalez, Linda T Green, Corinna Gries, John D Halfman, Stephen K Hamilton, Paul C Hanson, Emily N Henry, Elizabeth M Herron, Celeste Hockings, James R Jackson, Kari Jacobson-Hedin, Lorraine L Janus, William W Jones, John R Jones, Caroline M Keson, Katelyn B S King, Scott A Kishbaugh, Jean-Francois Lapierre, Barbara Lathrop, Jo A Latimore, Yuehlin Lee, Noah R Lottig, Jason A Lynch, Leslie J Matthews, William H McDowell, Karen E B Moore, Brian P Neff, Sarah J Nelson, Samantha K Oliver, Michael L Pace, Donald C Pierson, Autumn C Poisson, Amina I Pollard, David M Post, Paul O Reyes, Donald O Rosenberry, Karen M Roy, Lars G Rudstam, Orlando Sarnelle, Nancy J Schuldt, Caren E Scott, Nicholas K Skaff, Nicole J Smith, Nick R Spinelli, Joseph J Stachelek, Emily H Stanley, John L Stoddard, Scott B Stopyak, Craig A Stow, Jason M Tallant, Pang-Ning Tan, Anthony P Thorpe, Michael J Vanni, Tyler Wagner, Gretchen Watkins, Kathleen C Weathers, Katherine E Webster, Jeffrey D White, Marcy K Wilmes, Shuai Yuan
Background: Understanding the factors that affect water quality and the ecological services provided by freshwater ecosystems is an urgent global environmental issue. Predicting how water quality will respond to global changes not only requires water quality data, but also information about the ecological context of individual water bodies across broad spatial extents. Because lake water quality is usually sampled in limited geographic regions, often for limited time periods, assessing the environmental controls of water quality requires compilation of many datasets across broad regions and across time into an integrated database...
October 19, 2017: GigaScience
https://www.readbyqxmd.com/read/29053857/uv-reflection-properties-of-plumage-and-skin-of-domesticated-turkeys-meleagris-gallopavo-f-dom-as-revealed-by-uv-photography
#13
T Bartels, J-H Lütgeharm, M Wähner, J Berk
Reflection and fluorescence properties of feathered and non-feathered body regions of white- and bronze-colored fattening turkeys of various ages were examined by ultraviolet (UV) photography. The examinations were carried out on 20 white-feathered fattening turkeys (B.U.T. 6; 10 males, 10 females) and 20 bronze-feathered fattening turkeys (Grelier 708; 10 males, 10 females) over a period of 21 weeks. The turkeys were photographed once a wk under long-wave UV (UVA) radiation illumination (λ = 344-407 nm) using a digital camera...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053824/chemogenetic-locus-coeruleus-activation-restores-reversal-learning-in-a-rat-model-of-alzheimer-s-disease
#14
Jacki M Rorabaugh, Termpanit Chalermpalanupap, Christian A Botz-Zapp, Vanessa M Fu, Natalie A Lembeck, Robert M Cohen, David Weinshenker
Clinical evidence suggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a critical early step in Alzheimer's disease progression. Yet, an accurate preclinical model of these phenotypes that includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus innervation and deficits locus coeruleus/norepinephrine modulated behaviours, does not exist, hampering the identification of underlying mechanisms and the development of locus coeruleus-based therapies...
September 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053735/characterization-of-the-first-knock-out-aldh7a1-zebrafish-model-for-pyridoxine-dependent-epilepsy-using-crispr-cas9-technology
#15
Nikita Zabinyakov, Garrett Bullivant, Feng Cao, Matilde Fernandez Ojeda, Zheng Ping Jia, Xiao-Yan Wen, James J Dowling, Gajja S Salomons, Saadet Mercimek-Andrews
Pyridoxine dependent epilepsy (PDE) is caused by likely pathogenic variants in ALDH7A1 (PDE-ALDH7A1) and inherited autosomal recessively. Neurotoxic alpha-amino adipic semialdehyde (alpha-AASA), piperideine 6-carboxylate and pipecolic acid accumulate in body fluids. Neonatal or infantile onset seizures refractory to anti-epileptic medications are clinical features. Treatment with pyridoxine, arginine and lysine-restricted diet does not normalize neurodevelopmental outcome or accumulation of neurotoxic metabolites...
2017: PloS One
https://www.readbyqxmd.com/read/29053732/body-typing-of-children-and-adolescents-using-3d-body-scanning
#16
Henry Loeffler-Wirth, Mandy Vogel, Toralf Kirsten, Fabian Glock, Tanja Poulain, Antje Körner, Markus Loeffler, Wieland Kiess, Hans Binder
Three-dimensional (3D-) body scanning of children and adolescents allows the detailed study of physiological development in terms of anthropometrical alterations which potentially provide early onset markers for obesity. Here, we present a systematic analysis of body scanning data of 2,700 urban children and adolescents in the age range between 5 and 18 years with the special aim to stratify the participants into distinct body shape types and to describe their change upon development. In a first step, we extracted a set of eight representative meta-measures from the data...
2017: PloS One
https://www.readbyqxmd.com/read/29053606/lung-toxicity-of-condensed-aerosol-from-e-cig-liquids-influence-of-the-flavor-and-the-in-vitro-model-used
#17
Rossella Bengalli, Emanuele Ferri, Massimo Labra, Paride Mantecca
The diffusion of e-cigarette (e-CIG) opens a great scientific and regulatory debate about its safety. The huge number of commercialized devices, e-liquids with almost infinite chemical formulations and the growing market demand for a rapid and efficient toxicity screen system that is able to test all of these references and related aerosols. A consensus on the best protocols for the e-CIG safety assessment is still far to be achieved, since the huge number of variables characterizing these products (e.g., flavoring type and concentration, nicotine concentration, type of the device, including the battery and the atomizer)...
October 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29053605/flexible-sensors-for-pressure-therapy-effect-of-substrate-curvature-and-stiffness-on-sensor-performance
#18
Iryna Khodasevych, Suresh Parmar, Olga Troynikov
Flexible pressure sensors are increasingly being used in medical and non-medical applications, and particularly in innovative health monitoring. Their efficacy in medical applications such as compression therapy depends on the accuracy and repeatability of their output, which in turn depend on factors such as sensor type, shape, pressure range, and conformability of the sensor to the body surface. Numerous researchers have examined the effects of sensor type and shape, but little information is available on the effect of human body parameters such as support surfaces' curvature and the stiffness of soft tissues on pressure sensing performance...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053582/zinc-supplementation-improves-glucose-homeostasis-in-high-fat-fed-mice-by-enhancing-pancreatic-%C3%AE-cell-function
#19
Vinícius Cooper-Capetini, Diogo Antonio Alves de Vasconcelos, Amanda Roque Martins, Sandro Massao Hirabara, José Donato, Angelo Rafael Carpinelli, Fernando Abdulkader
Zinc is an essential component of the insulin granule and it possibly modulates insulin secretion and signaling. Since insulin resistance is a hallmark in the development of type 2 diabetes mellitus, this study aimed at investigating if zinc supplementation is able to improve glucose tolerance and β-cell function in a model of insulin resistance. Male C57BL/6 mice were distributed in four groups according to the diet: normal fat (NF); normal fat supplemented with ZnCl₂ (NFZ); high-fat (HF); and, high-fat chow supplemented with ZnCl₂ (HFZ)...
October 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29053081/pcl-and-pcl-based-materials-in-biomedical-applications
#20
Elbay Malikmammadov, Tugba Endogan Tanir, Aysel Kiziltay, Vasif Hasirci, Nesrin Hasirci
Biodegradable polymers have met withan increasing demand in medical usage over the last decades. One of such polymers is poly(ε-caprolactone) (PCL), whichis a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strengthcan be adjusted, and therefore,it can be usedunderharsh mechanical, physical and chemical conditions without significant loss of its properties...
October 20, 2017: Journal of Biomaterials Science. Polymer Edition
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