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https://www.readbyqxmd.com/read/28538730/blocking-fsh-induces-thermogenic-adipose-tissue-and-reduces-body-fat
#1
Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E DeMambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C Shin, Rauf Latif, Priyanthan Thangeswaran, Animesh Gupta, Jianhua Li, Valeria Shnayder, Samuel T Robinson, Yue Eric Yu, Xingjian Zhang, Feiran Yang, Ping Lu, Yu Zhou, Ling-Ling Zhu, Douglas J Oberlin, Terry F Davies, Michaela R Reagan, Aaron Brown, T Rajendra Kumar, Solomon Epstein, Jameel Iqbal, Narayan G Avadhani, Maria I New, Henrik Molina, Jan B van Klinken, Edward X Guo, Christoph Buettner, Shozeb Haider, Zhuan Bian, Li Sun, Clifford J Rosen, Mone Zaidi
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action...
May 24, 2017: Nature
https://www.readbyqxmd.com/read/28538471/foreign-body-response-to-silicone-in-cochlear-implant-electrodes-in-the-human
#2
Jennifer T O'Malley, Barbara J Burgess, Donald Galler, Joseph B Nadol
HYPOTHESIS: Silicone as part of a cochlear implant electrode may be responsible for a foreign body response in the human. BACKGROUND: Clinical evidence of a foreign body response to a cochlear implant has been reported. In a previous study, particulate material found within the fibrous sheath and within macrophages surrounding a cochlear implant has been identified as being consistent with platinum. However, to date, there has been no histologic evidence of a role for silicone in this cellular immune response...
May 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28538451/similar-anatomical-reduction-and-lower-complication-rates-with-the-sinus-tarsi-approach-compared-with-the-extended-lateral-approach-in-displaced-intra-articular-calcaneal-fractures
#3
Tim Schepers, Manouk Backes, Siem A Dingemans, Vincent M de Jong, Jan S K Luitse
OBJECTIVES: To investigate whether the sinus tarsi approach (STA) allows for a similar anatomical reduction of the posterior talocalcaneal facet as the extended lateral approach (ELA) and compare the rate of postoperative wound complications. DESIGN: Retrospective. SETTING: Level 1 trauma center. PATIENTS: All consecutive patients from 2012 to 2015 with a closed displaced intra-articular calcaneal fracture Sanders type II and III surgically treated with the ELA (N = 60) and the STA (N = 65)...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538386/safety-and-efficiency-of-sglt2-inhibitor-combining-with-insulin-in-subjects-with-diabetes-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
Yingying Yang, Shi Chen, Hui Pan, Yun Zou, Bo Wang, Guixia Wang, Huijuan Zhu
BACKGROUND: We aimed to assess the safety and efficiency of the novel sodium glucose co-transporter 2 (SGLT2) inhibitor in combinations with insulin for type 1 and type 2 diabetes mellitus (T1DM and T2DM). METHODS: We searched Medline, Pubmed, Embase, and the Cochrane Collaboration Library from January 2010 to December 2016 without restriction of language. FDA data and Clinical Trials (http://www.clinicaltrials.gov) were also searched. Study selection, data extraction, and evaluation of risk of bias were performed by 2 persons independently...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538362/statistical-analysis-of-organ-morphometric-parameters-and-weights-in-south-iranian-adult-autopsies
#5
Saeid Gholamzadeh, Mohammad Zarenezhad, Mahmoud Montazeri, Marzieh Zareikordshooli, Ghazaleh Sadeghi, Abdorrasoul Malekpour, Sanaz Hoseni, Mohammadreza Bahrani, Razieh Hajatmand
Organ weight is one important indicator to discern normal from abnormal condition in forensic pathology as well as in clinical medicine. The present study aimed to investigate morphometric parameters and organ weights of southern Iranian adults, which can be fundamental sources to be compared to abnormal cases.Morphometric parameters and weights of 6 organs (heart, liver, kidney, spleen, appendix, and brain), which were harvested from 501 southern Iranian adults (385 males and 116 females) during ordinary postmortem examination, were measured...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538319/reliability-and-accuracy-of-a-standardized-shallow-water-running-test-to-determine-cardiorespiratory-fitness
#6
Elizabeth F Nagle, Mary E Sanders, Bethany B Gibbs, Barry A Franklin, Jacquelyn A Nagle, Philip J Prins, Caleb D Johnson, Robert J Robertson
Nagle, EF, Sanders, ME, Gibbs, BB, Franklin, BA, Nagle, JA, Prins, PJ, Johnson, CD, and Robertson, RJ. Reliability and accuracy of a standardized shallow water running test to determine cardiorespiratory fitness. J Strength Cond Res 31(6): 1669-1677, 2017-A standardized fitness assessment is critical for the development of an individualized exercise prescription. Although the benefits of aquatic exercise have been well established, there remains the need for a standardized nonswimming protocol to accurately assess cardiorespiratory fitness (CRF) in shallow water...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538318/do-fencers-require-a-weapon-specific-approach-to-strength-and-conditioning-training
#7
Anthony N Turner, Chris J Bishop, Jon A Cree, Michael L Edwards, Shyam Chavda, Paul J Read, David M J Kirby
Turner, AN, Bishop, CJ, Cree, JA, Edwards, ML, Chavda, S, Read, PJ, and Kirby, DMJ. Do fencers require a weapon-specific approach to strength and conditioning training? J Strength Cond Res 31(6): 1662-1668, 2017-There are 3 types of weapons used in Olympic fencing: the épée, foil, and sabre. The aim of this study was to determine if fencers exhibited different physical characteristics across weapons. Seventy-nine male (n = 46) and female (n = 33) national standard fencers took part in this study. Fencers from each weapon (male and female), i...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538297/effect-of-game-design-goal-type-and-player-numbers-on-the-physiological-and-physical-demands-of-hurling-specific-small-sided-games
#8
Shane Malone, Kieran D Collins
Malone, S and Collins, K. Effect of game design, goal type, and player numbers on the physiological and physical demands of hurling-specific small-sided games. J Strength Cond Res 31(6): 1493-1499, 2017-The current study examined the effect that game design modification, goal type, and player numbers on the running performance and physiological demands of small-sided hurling games (SSG). Forty-eight hurling players (age, 25.5 ± 3.2 years; height, 178.9 ± 3.2 cm; body mass, 78.5 ± 4.5 kg) performed 4 types of SSG (possession [P], normal play [NP], regular goals [RG] and small goals [SG]) in 4-a-side, 5-a-side, and 6-a-side formats...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538152/apoptotic-bax-at-oxidatively-stressed-mitochondrial-membranes-lipid-dynamics-and-permeabilization
#9
Artur Peter Günther Dingeldein, Šárka Pokorná, Martin Lidman, Tobias Sparrman, Radek Šachl, Martin Hof, Gerhard Gröbner
Mitochondria are crucial compartments of eukaryotic cells because they function as the cellular power plant and play a central role in the early stages of programmed cell death (apoptosis). To avoid undesired cell death, this apoptotic pathway is tightly regulated by members of the Bcl-2 protein family, which interact on the external surface of the mitochondria, i.e., the mitochondrial outer membrane (MOM), and modulate its permeability to apoptotic factors, controlling their release into the cytosol. A growing body of evidence suggests that the MOM lipids play active roles in this permeabilization process...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28538134/trial-of-cannabidiol-for-drug-resistant-seizures-in-the-dravet-syndrome
#10
Orrin Devinsky, J Helen Cross, Linda Laux, Eric Marsh, Ian Miller, Rima Nabbout, Ingrid E Scheffer, Elizabeth A Thiele, Stephen Wright
BACKGROUND: The Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. We studied cannabidiol for the treatment of drug-resistant seizures in the Dravet syndrome. METHODS: In this double-blind, placebo-controlled trial, we randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to receive either cannabidiol oral solution at a dose of 20 mg per kilogram of body weight per day or placebo, in addition to standard antiepileptic treatment...
May 25, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28538106/intramuscular-triglyceride-content-precedes-impaired-glucose-metabolism-without-evidence-for-mitochondrial-dysfunction-during-early-development-of-a-diabetic-phenotype
#11
Zachary J Callahan, Michael James Oxendine, Paul J Schaeffer
The incidence of type 2 diabetes is highly correlated with obesity; however, there is a lack of research elucidating the temporal progression. Transgenic FVB/N UCP-dta mice, which develop a diabetic phenotype, and their non-transgenic littermates were fed either a high-fat or normal-chow diet and were studied at 6, 9, 12, 15, 18, 21, and 24 weeks of age in order to test the hypothesis that increased lipid accumulation in skeletal muscle causes mitochondrial dysfunction, leading to the development of insulin resistance...
May 24, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28537928/differences-in-risk-factors-of-malignancy-between-men-and-women-with-type-2-diabetes-a-retrospective-case-control-study
#12
Mariusz Dąbrowski, Elektra Szymańska-Garbacz, Zofia Miszczyszyn, Tadeusz Dereziński, Leszek Czupryniak
BACKGROUND: The aim of this multicenter, retrospective, case-control study was to identify differences in risk factors of malignancy between men and women with type 2 diabetes. RESULTS: Among women the most prevalent malignancies were: breast and uterine cancers (35.6% and 14.4% respectively), while among men there were: colorectal and prostate cancers (24.5% and 13.3% respectively). In both gender metformin use was associated with lower cancer risk. Obesity and insulin treatment in dose-dependent and time-varying manner were associated with significantly increased risk of malignancy in females...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535629/-association-between-sorcs1-rs1416406-and-therapeutic-effect-of-exenatide
#13
L M Zhou, W Xu, X M Yan, M X Y Li, H Liang, J P Weng
Objective: To study the relationship between SORCS1 gene rs1416406 and efficiency of exenatide. Methods: Between August 2010 and August 2012, a hundred and one newly diagnosed patients with type 2 diabetes mellitus (T2DM) were from CONFIDENCE study covering 25 university-affiliated hospitals in 13 provinces of China. All patients received exenatide treatment for 48 weeks. Hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), body mass index (BMI), oral glucose tolerance test (OGTT) glucose and insulin levels were measured before and after therapy...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28535567/radiation-dose-and-procedure-time-for-994-ct-guided-spine-pain-control-procedures
#14
Matthew S Lazarus, Rebecca B Forman, Alan L Brook, Todd S Miller
BACKGROUND: Image guidance for spine pain control procedures, including epidural steroid injection, nerve root block, and facet block, can be performed with either computed tomography (CT) or conventional fluoroscopy. CT has the advantage of improved anatomic localization and use of air for contrast; however, there are concerns that CT leads to higher radiation dose and longer procedure time. OBJECTIVE: To evaluate procedure time and radiation dose for multiple types of spine pain control procedures performed under CT guidance...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535477/the-effect-of-crash-characteristics-on-cyclist-injuries-an-analysis-of-virginia-automobile-bicycle-crash-data
#15
Erin Robartes, T Donna Chen
This paper examines bicyclist, automobile driver, vehicle, environmental, and roadway characteristics that influence cyclist injury severity in order to determine which factors should be addressed to mitigate the worst bicyclist injuries. An ordered probit model is used to examine single bicycle-single vehicle crashes from Virginia police crash report data from 2010 to 2014. Five injury severity levels are considered: fatalities, severe injuries, minor or possible injuries, no apparent injuries, and no injury...
May 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28535371/repression-of-interstitial-identity-in-nephron-progenitor-cells-by-pax2-establishes-the-nephron-interstitium-boundary-during-kidney-development
#16
Natalie Naiman, Kaoru Fujioka, Mari Fujino, M Todd Valerius, S Steven Potter, Andrew P McMahon, Akio Kobayashi
The kidney contains the functional units, the nephrons, surrounded by the renal interstitium. Previously we discovered that, once Six2-expressing nephron progenitor cells and Foxd1-expressing renal interstitial progenitor cells form at the onset of kidney development, descendant cells from these populations contribute exclusively to the main body of nephrons and renal interstitial tissues, respectively, indicating a lineage boundary between the nephron and renal interstitial compartments. Currently it is unclear how lineages are regulated during kidney organogenesis...
May 22, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28535306/examination-of-psychosocial-and-physiological-risk-for-bulimic-symptoms-in-youth-with-type-1-diabetes-transitioning-to-an-insulin-pump-a-pilot-study
#17
Claire M Peterson, Deborah Young-Hyman, Sarah Fischer, Jessica T Markowitz, Andrew B Muir, Lori M Laffel
This study tested hypotheses drawn from a risk model positing that psychosocial risk plus disease-related and treatment factors contribute to bulimic symptoms in youth with type 1 diabetes (T1D) transitioning to an insulin pump. The goal of this study was to examine whether disease-related factors, particularly disease- and treatment-based disruption in hunger and satiety, contribute to report of bulimic symptoms in youth with T1D after accounting for psychosocial risk factors. 43 youth (ages 10-17, 54% female) with established T1D were recruited before transition from multiple daily injections to insulin-pump therapy from three tertiary pediatric diabetes centers...
May 23, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28534192/nonunion-and-delayed-union-in-lateral-open-wedge-distal-femoral-osteotomies-a-legitimate-concern
#18
Franz Liska, Andreas Voss, Florian B Imhoff, Lukas Willinger, Andreas B Imhoff
INTRODUCTION: Due to a supposed high rate of nonunions in lateral open wedge distal femur osteotomy (LOWDFO), the medial closing wedge technique has been favoured for a long time. The aim of this study was to report the occurrence of delayed- and nonunions following LOWDFO. We hypothesized that the occurrence of nonunions needing revision surgery is comparable to medial closing osteotomies. METHODS: Forty-one patients were treated with LOWDFO with a minimum follow-up of 12 months...
May 23, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28534164/an-evaluation-of-patient-experience-during-percutaneous-breast-biopsy
#19
Jean M Seely, Fraser Hill, Susan Peddle, Jackie Lau
OBJECTIVE: Percutaneous breast biopsy in a tertiary referral high volume breast centre: can we improve the patient experience? PURPOSE: The study was performed to evaluate patient experience during ultrasound-guided (UGB) and vacuum-assisted stereotactic breast biopsy (SBB) and determine what factors could improve the patient experience. METHODS: Consecutive patients who underwent image guided breast biopsy from 01- 05/30, 2015 were approached in a structured telephone interview to evaluate pain and bruising from the procedure...
May 22, 2017: European Radiology
https://www.readbyqxmd.com/read/28534140/protective-effects-of-neural-crest-derived-stem-cell-conditioned-media-against-ischemia-reperfusion-induced-lung-injury-in-rats
#20
Chung-Kan Peng, Shu-Yu Wu, Shih-En Tang, Min-Hui Li, Shih-Shiuan Lin, Shi-Jye Chu, Kun-Lun Huang
Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that NCSC-CM has anti-inflammatory properties that could protect against IR-induced lung injury in rats. In this study, NCSC-CM was derived from rat NCSCs. Typical acute lung injury was induced by 30-min ischemia followed by 90-min reperfusion in adult male Sprague-Dawley rats...
May 23, 2017: Inflammation
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