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https://www.readbyqxmd.com/read/28930586/drug-repurposing-approaches-to-fight-dengue-virus-infection-and-related-diseases
#1
Lorenzo Botta, Mirko Rivara, Valentina Zuliani, Marco Radi
Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930153/selective-hdl-raising-human-apo-a-i-gene-therapy-counteracts-cardiac-hypertrophy-reduces-myocardial-fibrosis-and-improves-cardiac-function-in-mice-with-chronic-pressure-overload
#2
Ruhul Amin, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Mudit Mishra, Frank Jacobs, Bart De Geest
Epidemiological studies support an independent inverse association between high-density lipoprotein (HDL) cholesterol levels and heart failure incidence. The effect of selective HDL-raising adeno-associated viral serotype 8-human apolipoprotein (apo) A-I (AAV8-A-I) gene transfer on cardiac remodeling induced by transverse aortic constriction (TAC) was evaluated in C57BL/6 low-density lipoprotein receptor-deficient mice. Septal wall thickness and cardiomyocyte cross-sectional area were reduced by 16.5% (p < 0...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28929957/-serotype-distribution-and-antibiotic-resistance-of-streptococcus-pneumoniae-strains-isolated-from-the-adult-patients-in-a-turkish-%C3%A3-niversity-hospital
#3
Lütfiye Öksüz, Nezahat Gürler
Infections caused by Streptococcus pneumoniae are the most important cause of morbidity and mortality worldwide. S.pneumoniae is the most common cause of community-acquired pneumonia, especially in adults. Invasive pneumococcal disease can usually occur in the elderly, children and immunocompromised individuals. Usage of the vaccines for the protection against S.pneumoniae infections, is an effective method to reduce the burden of disease in both children and adults. Serotypes frequently isolated from purified capsular polysaccharides of S...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929313/an-anti-propionibacterium-acnes-antibody-shows-heterologous-resistance-to-an-actinobacillus-pleuropneumoniae-infection-independent-of-neutrophils-in-mice
#4
Jian-Fang Liu, Qiu-Yue Ma, Ri-Ning Zhu, Meng-Jun Cheng, Chun-Tong Bao, Jing-Min Gu, Chang-Jiang Sun, Paul Richard Langford, Wen-Yu Han, Lian-Cheng Lei
Porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by Actinobacillus pleuropneumoniae (APP) and results in tremendous economic losses for the pig breeding industry worldwide. Previous studies have demonstrated that Propionibacterium acnes (PA) could effectively prevent APP infection in mice and pigs. The humoral immune response played a primary role during this process and anti-PA antibody could mediate macrophages to kill the bacteria. However, the role of neutrophils in this process is currently unknown...
September 20, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28929009/meta-analysis-of-biomarkers-for-severe-dengue-infections
#5
Kuan-Meng Soo, Bahariah Khalid, Siew-Mooi Ching, Chau Ling Tham, Rusliza Basir, Hui-Yee Chee
BACKGROUND: Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness of standard management. Hence, this meta-analysis compared biomarker levels between dengue fever (DF) and severe dengue infections (SDI) to identify potential biomarkers for SDI. METHODS: Data concerning levels of cytokines, chemokines, and other potential biomarkers of DF, dengue hemorrhagic fever, dengue shock syndrome, and severe dengue were obtained for patients of all ages and populations using the Scopus, PubMed, and Ovid search engines...
2017: PeerJ
https://www.readbyqxmd.com/read/28928418/novel-and-classical-human-astroviruses-in-stool-and-cerebrospinal-fluid-comprehensive-screening-in-a-tertiary-care-hospital-switzerland
#6
Samuel Cordey, Diem-Lan Vu, Marie-Celine Zanella, Lara Turin, Aline Mamin, Laurent Kaiser
Classical human astroviruses (HAstV) are the third most common cause of non-bacterial acute gastroenteritis. Due to the lack of routine molecular assays, novel HAstV are underdiagnosed and the magnitude of their contribution to clinical disease remains unknown. To better understand their prevalence and the susceptible patient profile, we conducted a comprehensive screening of novel and classical HAstV in stool and cerebrospinal fluid (CSF) samples collected for clinical care in a tertiary care hospital using a specially designed rRT-PCR panel for the detection of novel (MLB1-3 and VA1-4) and classical HAstV...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28928210/analysis-of-individuals-from-a-dengue-endemic-region-helps-define-the-footprint-and-repertoire-of-antibodies-targeting-dengue-virus-3-type-specific-epitopes
#7
Daniela V Andrade, Leah C Katzelnick, Doug G Widman, Angel Balmaseda, Aravinda M de Silva, Ralph S Baric, Eva Harris
The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels and kinetics of serum antibodies directed to such epitopes among populations in regions where dengue is endemic. Here, we use a recombinant DENV4 (rDENV4/3-M14) displaying a major DENV3 type-specific quaternary epitope recognized by human monoclonal antibody 5J7 to measure the proportion, magnitude, and kinetics of DENV3 type-specific neutralizing antibody responses targeting this epitope...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28927474/first-detection-and-characterization-of-salmonella-spp-in-poultry-and-swine-raised-in-backyard-production-systems-in-central-chile
#8
R Alegria-Moran, D Rivera, V Toledo, A I Moreno-Switt, C Hamilton-West
Little is known about Salmonella serovars circulating in backyard poultry and swine populations worldwide. Backyard production systems (BPS) that raise swine and/or poultry are distributed across Chile, but are more heavily concentrated in central Chile, where industrialized systems are in close contact with BPS. This study aims to detect and identify circulating Salmonella serovars in poultry and swine raised in BPS. Bacteriological Salmonella isolation was carried out for 1744 samples collected from 329 BPS in central Chile...
September 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28923133/genetic-evidence-for-a-novel-variant-of-the-pilus-island-1-backbone-protein-in-group-b-streptococcus
#9
Sarah Teatero, Alefiya Neemuchwala, Kunlin Yang, Janice Gomes, Taryn B T Athey, Irene Martin, Walter Demczuk, Allison McGeer, Nahuel Fittipaldi
PURPOSE: Pili contribute significantly to the pathogenesis of infection of group B Streptococcus (GBS) by facilitating adhesion and invasion of host cells. GBS pilin subunits (the backbone pilin protein, BP, and the ancillary pilin proteins, AP) as well as the specific enzymes required for pilus assembly are encoded by genes located in two separate genomic regions, known as pilus island 1 (PI-1) and PI-2. Our aim was to characterize the pilus profile of a collection of GBS isolates from metropolitan Toronto, Canada...
September 19, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28923132/characterization-of-environmental-pseudomonas-aeruginosa-using-multilocus-sequence-typing-scheme
#10
Júlia Radó, Edit Kaszab, Tünde Petrovics, Judit Pászti, Balázs Kriszt, Sándor Szoboszlay
PURPOSE: The objectives of this study were to examine environmental (hydrocarbon degrading) Pseudomonas aeruginosa isolates with Multilocus Sequence Typing (MLST) and to determine their relevant features, such as serotype, virulence genes, biofilm forming ability and hydrocarbon degrading capacity. METHODOLOGY: The diversity of environmental isolates was assessed with an MLST scheme. Investigation of virulence determinants included serotyping, hemolytic activity test and the detection of virulence genes exoS, exoY, exoT, exoU, exoA...
September 19, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28922943/differential-prevalence-of-antibodies-against-adeno-associated-virus-in-healthy-children-and-patients-with-mucopolysaccharidosis-iii-perspective-for-aav-mediated-gene-therapy
#11
Haiyan Fu, Aaron S Meadows, Ricardo J Pineda, Krista L Kunkler, Kristen V Truxal, Kim L McBride, Kevin Flanigan, Douglas M McCarty
Recombinant AAV vectors are promising gene therapy tools. However, pre-existing antibodies (Abs) to many useful AAV serotypes pose a critical challenge for the translation of gene therapies. As part of AAV gene therapy program for treating MPS III patients, we investigated the seroprevalence profiles of AAV1-9 and rh74 in MPS IIIA/IIIB patients and in healthy children. Using ELISA for αAAV-IgG, we observed significantly higher sero-prevalence for AAV1 and AAVrh74 in 2-7y-old MPS III patients than in healthy controls...
September 19, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28922566/streptococcus-pneumoniae-and-chronic-endobronchial-infections-in-childhood
#12
Kim M Hare, Amanda J Leach, Heidi C Smith-Vaughan, Anne B Chang, Keith Grimwood
Streptococcus pneumoniae (pneumococcus) is the main cause of bacterial pneumonia worldwide and has been studied extensively in this context. However, its role in chronic endobronchial infections and accompanying lower airway neutrophilic infiltration has received little attention. Severe and recurrent pneumonia are risk factors for chronic suppurative lung disease (CSLD) and bronchiectasis; the latter causes considerable morbidity and, in some populations, premature death in children and adults. Protracted bacterial bronchitis (PBB) is another chronic endobronchial infection associated with substantial morbidity...
September 18, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28921940/attribution-of-human-infections-with-shiga-toxin-producing-escherichia-coli-stec-to-livestock-sources-and-identification-of-source-specific-risk-factors-the-netherlands-2010-2014
#13
L Mughini-Gras, W van Pelt, M van der Voort, M Heck, I Friesema, E Franz
Shiga toxin-producing Escherichia coli (STEC) is a zoonotic pathogen of public health concern whose sources and transmission routes are difficult to trace. Using a combined source attribution and case-control analysis, we determined the relative contributions of four putative livestock sources (cattle, small ruminants, pigs, poultry) to human STEC infections and their associated dietary, animal contact, temporal and socio-econo-demographic risk factors in the Netherlands in 2010/2011-2014. Dutch source data were supplemented with those from other European countries with similar STEC epidemiology...
September 17, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28920571/recurrent-seasonal-outbreak-of-an-emerging-serotype-of-shiga-toxin-producing-escherichia-coli-stec-o55-h7-stx2a-in-the-south-west-of-england-july-2014-to-september-2015
#14
Noëleen McFarland, Nick Bundle, Claire Jenkins, Gauri Godbole, Amy Mikhail, Tim Dallman, Catherine O'Connor, Noel McCarthy, Emer O'Connell, Juli Treacy, Girija Dabke, James Mapstone, Yvette Landy, Janet Moore, Rachel Partridge, Frieda Jorgensen, Caroline Willis, Piers Mook, Chas Rawlings, Richard Acornley, Charlotte Featherstone, Sharleen Gayle, Joanne Edge, Eleanor McNamara, Jeremy Hawker, Sooria Balasegaram
The first documented British outbreak of Shiga toxin-producing Escherichia coli (STEC) O55:H7 began in the county of Dorset, England, in July 2014. Since then, there have been a total of 31 cases of which 13 presented with haemolytic uraemic syndrome (HUS). The outbreak strain had Shiga toxin (Stx) subtype 2a associated with an elevated risk of HUS. This strain had not previously been isolated from humans or animals in England. The only epidemiological link was living in or having close links to two areas in Dorset...
September 7, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28920482/fowl-aviadenovirus-serotype-1-confirmed-as-the-aetiological-agent-of-gizzard-erosions-in-replacement-pullets-and-layer-flocks-in-great-britain-by-laboratory-and-in-vivo-studies
#15
Beatrice Grafl, Cristina Garcia-Rueda, Peter Cargill, Alisdair Wood, Alex Schock, Dieter Liebhart, Anna Schachner, Michael Hess
An investigation into the aetiology and pathogenesis of adenoviral gizzard erosion has been conducted following three natural outbreaks affecting one flock of 6-week-old replacement pullets and two consecutive placements of free range layers at the age of 21 and 23 weeks. Affected flocks showed increased mortality (0.12-0.30% per week), and gizzard lesions were consistent with fowl aviadenovirus (FAdV) involvement. To substantiate the initial findings, a selection of archived formalin-fixed paraffin-embedded gizzard samples from another 12 pullet and layer flocks, for which macroscopic and histopathological diagnosis of the disease were recorded in Great Britain during the period 2009-2016, were also investigated...
September 18, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28919697/16s-ribosomal-rna-sequencing-and-molecular-serotyping-of-avibacterium-paragallinarum-isolated-from-indian-field-conditions
#16
Vihang Vithalrao Patil, Debendranath Mishra, Dilip Vithalrao Mane
AIM: This study was aimed at identifying Indian field isolates of Avibacterium paragallinarum on both molecular as well as serological levels that cause infectious coryza in chickens. MATERIALS AND METHODS: Species-specific polymerase chain reaction (HPG-2 PCR), and 16S ribosomal RNA (rRNA) sequencing were employed for molecular identification. Whereas, multiplex PCR technique was used for serological identification of Indian field isolates of A. paragallinarum...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28919197/imported-poultry-meat-as-a-source-of-extended-spectrum-cephalosporin-resistant-cmy-2-producing-salmonella-heidelberg-and-s-minnesota-in-european-union-2014-2015
#17
Joana Campos, Joana Mourão, Leonor Silveira, Margarida Saraiva, Cristina Belo Correia, Ana Paula Maçãs, Luísa Peixe, Patrícia Antunes
Extended-spectrum cephalosporin (ESC)-resistant Salmonella has been described at low level in EU, nevertheless the increasing importation of poultry meat could be an important source of epidemic strains carrying ESC-resistant genes. We evaluated ESC resistance and characterized genetic platforms as well as the clonal relatedness of Salmonella isolates from poultry meat products imported into Portugal. All Salmonella isolates recovered from samples of fresh meat destined to be imported into the EU in the scope of Portuguese official border control between 2014 and 2015 were studied...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28918489/yersinia-enterocolitica-biotype-1a-a-possible-new-trigger-of-reactive-arthritis
#18
Riitta Tuompo, Timo Hannu, Elisa Huovinen, Leila Sihvonen, Anja Siitonen, Marjatta Leirisalo-Repo
Yersinia enterocolitica (YE) biotype 1A is generally considered non-pathogenic, and the role of it in causing reactive musculoskeletal complications is unclear. We evaluated the capability of YE biotype 1A to induce reactive arthritis (ReA) and other reactive musculoskeletal symptoms. Analysis of self-reported musculoskeletal symptoms was supplemented with a telephone interview (with a permission to acquire copies of patient files from a local physician or hospital) and/or clinical examination of subjects with recent musculoskeletal symptoms after a positive stool culture for YE...
September 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28918235/identification-of-bluetongue-virus-serotypes-1-4-and-17-co-infections-in-sheep-flocks-during-outbreaks-in-brazil
#19
Lorena Lima Barbosa Guimarães, Júlio César Câmara Rosa, Ana Carolina Diniz Matos, Raquel Aparecida S Cruz, Maria Isabel Maldonado Coelho Guedes, Fernanda Alves Dorella, Henrique César Pereira Figueiredo, Saulo Petinatti Pavarini, Luciana Sonne, Zélia Inês Portela Lobato, David Driemeier
Bluetongue (BT) is a vector-borne viral disease caused by the Bluetongue virus (BTV), an Orbivirus from the Reoviridae family, affecting domestic and wild ruminants. BTV circulation in Brazil was first reported in 1978, and several serological surveys indicate that the virus is widespread, although with varied prevalence. In 2014, BT outbreaks affected sheep flocks in Rio Grande do Sul state, causing significant mortality (18.4%; 91/495) in BTV-infected sheep. In total, seven farms were monitored, and one or two sheep from each farm that died due to clinical signs of BT were necropsied...
September 5, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28918229/design-of-modified-botulinum-neurotoxin-a1-variants-with-a-shorter-persistence-of-paralysis-and-duration-of-action
#20
Daniel Scheps, Manuela López de la Paz, Marcel Jurk, Fred Hofmann, Jürgen Frevert
Botulinum neurotoxins (BoNTs) are classified by their antigenic properties into seven serotypes (A-G) and in addition by their corresponding subtypes. They are further characterized by divergent onset and duration of effect. Injections of low doses of botulinum neurotoxins cause localized muscle paralysis that is beneficial for the treatment of several medical disorders and aesthetic indications. Optimizing the therapeutic properties could offer new treatment opportunities. This report describes a rational design approach to modify the pharmacological properties by mutations in the C-terminus of BoNT/A1 light chain (LC)...
September 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
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