Kamilla Kolding Bendixen, Sofie Forsberg-Pho, Giulia Dazio, Emeli Elisabeth Hansen, Sarah Kronborg Eriksen, Samantha Epistolio, Elisabetta Merlo, Renzo Boldorini, Tiziana Venesio, Alessandra Movilia, Cecilia Caprera, Eva Christensen Arnspang, Michael Børgesen, Ulf Bech Christensen, Milo Frattini, Rasmus Koefoed Petersen
In recent years, immune checkpoint inhibitors have proved immense clinical progression in the treatment of certain cancers. The efficacy of immune checkpoint inhibitors is correlated with mismatch repair system deficiency and is exceptionally administered based exclusively on this biological mechanism independent of the cancer type. The promising effect of immune checkpoint inhibitors has left an increasing demand for analytical tools evaluating the mismatch repair status. The analysis of microsatellite instability (MSI), reflecting an indirect but objective manner the inactivation of the mismatch repair system, plays several roles in clinical practice and, therefore, its evaluation is of high relevance...
2024: PloS One