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https://www.readbyqxmd.com/read/29334532/cost-effectiveness-and-improved-parent-and-provider-satisfaction-with-outpatient-management-of-pediatric-oncology-patients-with-low-risk-fever-and-neutropenia
#1
Abhishek Bavle, Amanda Grimes, Sibo Zhao, Daniel Zinn, Andrea Jackson, Binita Patel, Timothy Porea, Ankhi Dutta, Heidi Russell, Andras Heczey
On the basis of significant evidence for safety, the international pediatric fever and neutropenia committee recommends the identification and management of patients with "low-risk fever and neutropenia" (LRFN), outpatient with oral antibiotics, instead of traditional inpatient management. The aim of our study was to compare the cost-per-patient with these 2 strategies, and to evaluate parent and provider satisfaction with the outpatient management of LRFN. Between March 2016 and February 2017, 17 LRFN patients (median absolute neutrophil count, 90/μL) were managed at a single institution, per new guidelines...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29331062/benefits-of-increasing-transpiration-efficiency-in-wheat-under-elevated-co2-for-rainfed-regions
#2
Brendan Christy, Sabine Tausz-Posch, Michael Tausz, Richard Richards, Greg Rebetzke, Anthony Condon, Terry Mclean, Glenn Fitzgerald, Maryse Bourgault, Garry O'Leary
Higher transpiration efficiency (TE) has been proposed as a mechanism to increase crop yields in dry environments where water availability usually limits yield. The application of a coupled radiation and transpiration efficiency simulation model shows wheat yield advantage of a high TE cultivar (cv. Drysdale) over its almost identical low TE parent line (Hartog), from about -7 to 558 kg ha-1 (mean 187 kg ha-1 ) over the rainfed cropping region in Australia (221 to 1351 mm annual rainfall), under the present-day climate...
January 13, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29321127/effectiveness-of-a-technology-based-supportive-educational-parenting-program-on-parental-outcomes-in-singapore-protocol-for-a-randomized-controlled-trial
#3
Shefaly Shorey, Yvonne Peng Mei Ng, An Ling Siew, Joanne Yoong, Evalotte Mörelius
BACKGROUND: Supportive educational programs during the perinatal period are scarce in Singapore. There is no continuity of care available in terms of support from community care nurses in Singapore. Parents are left on their own most of the time, which results in a stressful transition to parenthood. There is a need for easily accessible technology-based educational programs that can support parents during this crucial perinatal period. OBJECTIVE: The aim of this study was to describe the study protocol of a randomized controlled trial on a technology-based supportive educational parenting program...
January 10, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29316926/rna-guided-single-double-gene-repressions-in-corynebacterium-glutamicum-using-an-efficient-crispr-interference-and-its-application-to-industrial-strain
#4
Jaehyun Park, Hyojung Shin, Sun-Mi Lee, Youngsoon Um, Han Min Woo
BACKGROUND: The construction of microbial cell factories requires cost-effective and rapid strain development through metabolic engineering. Recently, RNA-guided CRISPR technologies have been developed for metabolic engineering of industrially-relevant host. RESULTS: To demonstrate the application of the CRISPR interference (CRISPRi), we developed two-plasmid CRISPRi vectors and applied the CRISPRi in Corynebacterium glutamicum to repress single target genes and double target genes simultaneously...
January 9, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29316314/an-integrated-tool-for-microsatellite-isolation-and-validation-from-the-reference-genome-and-their-application-in-the-study-of-breeding-turnover-in-an-endangered-avian-population
#5
Xian Hou, Pengwei Xu, Zhenzhen Lin, Josephine d'URBAN-Jackson, Andrew Dixon, Batbayar Bold, Jiliang Xu, Xiangjiang Zhan
Accurate individual identification is required to estimate survival rates in avian populations. For endangered species, non-invasive methods of obtaining individual identification, such as using molted feathers as a source of DNA for microsatellite markers, are preferred because of less disturbance, easy sample preparation and high efficiency. With the availability of many avian genomes, a few pipelines isolating genome-wide microsatellites have been published, but it is still a challenge to isolate microsatellites from the reference genome efficiently...
January 9, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29314419/convergent-validity-of-actigraphy-with-polysomnography-and-parent-reports-when-measuring-sleep-in-children-with-down-syndrome
#6
A J Esbensen, E K Hoffman, E Stansberry, R Shaffer
BACKGROUND: There is a need for rigorous measures of sleep in children with Down syndrome as sleep is a substantial problem in this population and there are barriers to obtaining the gold standard polysomnography (PSG). PSG is cost-prohibitive when measuring treatment effects in some clinical trials, and children with Down syndrome may not cooperate with undergoing a PSG. Minimal information is available on the validity of alternative methods of assessing sleep in children with Down syndrome, such as actigraphy and parent ratings...
January 5, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29311194/the-financial-cost-incurred-by-families-of-children-on-long-term-dialysis
#7
Abdulafeez Bello, Beauty Sangweni, Abdullah Mudi, Tholang Khumalo, Glenda Moonsamy, Cecil Levy
BACKGROUND: Costs of dialysis reported in countries where dialysis is government-funded are often those incurred by the state, and only a few take into account the financial burden to the family of the index patient. This study investigated the financial cost implication to families of pediatric patients on maintenance dialysis and how aid provided by the government alleviates their financial burden. METHODS: This descriptive cross-sectional study recruited 24 children on peritoneal dialysis (PD) and hemodialysis (HD), and a structured questionnaire was administered to the parents/caregivers of these patients to obtain information on their family size, total family income, cost of transportation, employment status of attending caregiver, and number of work days missed due to hospital visits...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29310901/why-do-we-not-want-to-recommend-influenza-vaccination-to-young-children-a-qualitative-study-of-australian-parents-and-primary-care-providers
#8
Ruby Biezen, Danilla Grando, Danielle Mazza, Bianca Brijnath
INTRODUCTION: Influenza vaccination has been shown to be safe and effective against influenza and in the prevention of complicating secondary respiratory illnesses. However, its uptake in young children remains low. This study explored the views, attitudes and practices of parents and primary care providers (PCPs) on their knowledge and acceptance of influenza vaccination in children under 5. METHODS: Using a cross-sectional qualitative research design, we conducted 30 in-depth interviews with PCPs (i...
January 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29305339/digital-clinical-communication-for-families-and-caregivers-of-children-or-young-people-with-short-or-long-term-conditions-rapid-review
#9
REVIEW
Xavier Armoiry, Jackie Sturt, Emma Elizabeth Phelps, Clare-Louise Walker, Rachel Court, Frances Taggart, Paul Sutcliffe, Frances Griffiths, Helen Atherton
BACKGROUND: The communication relationship between parents of children or young people with health conditions and health professionals is an important part of treatment, but it is unclear how far the use of digital clinical communication tools may affect this relationship. OBJECTIVE: The objective of our study was to describe, assess the feasibility of, and explore the impact of digital clinical communication between families or caregivers and health professionals...
January 5, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29305293/beyond-screening-for-chromosomal-abnormalities-advances-in-non-invasive-diagnosis-of-single-gene-disorders-and-fetal-exome-sequencing
#10
REVIEW
Jane Hayward, Lyn S Chitty
Emerging genomic technologies, largely based around next generation sequencing (NGS), are offering new promise for safer prenatal genetic diagnosis. These innovative approaches will improve screening for fetal aneuploidy, allow definitive non-invasive prenatal diagnosis (NIPD) of single gene disorders at an early gestational stage without the need for invasive testing, and improve our ability to detect monogenic disorders as the aetiology of fetal abnormalities. This presents clinicians and scientists with novel challenges as well as opportunities...
January 2, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29303706/fatigue-in-systemic-sclerosis-a-systematic-review
#11
REVIEW
Fabio Basta, Antonella Afeltra, Domenico Paolo Emanuele Margiotta
OBJECTIVES: To systematically review fatigue in systemic sclerosis (SSc) in terms of prevalence, features, correlates, predictors and management. METHODS: We performed a literature search in PubMed (Medline), EBSCO and COCHRANE databases up to June 2017 selecting articles regarding fatigue in SSc. The articles finally selected fulfilled the following eligibility criteria: written in English, referred to fatigue in SSc, reporting original data, including validated questionnaires measuring fatigue...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29303015/tests-of-the-attachment-and-developmental-dynamic-systems-theory-of-crime-addstoc-toward-a-differential-rdoc-diagnostic-and-treatment-approach
#12
Marc A Lindberg, Dana Zeid
The Attachment and Developmental Dynamic Systems Theory of Crime was tested on 206 male inmates. They completed measures tapping attachments, clinical issues, adverse childhood events, peer crime, and crime addictions. A significant path model was found, going from insecure parental attachments to adverse childhood events, and then on to the behavioral crime addiction and criminal peers scales. Peer crime was also predicted by insecure parent attachments and the crime addiction scale. Finally, the crime addiction, peer crime, and insecure parental attachment scales predicted frequencies of criminal behavior...
January 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29301586/effectiveness-of-a-psycho-educational-intervention-to-prevent-postpartum-parental-distress-and-enhance-infant-well-being-study-protocol-of-a-randomized-controlled-trial
#13
Marjolein Missler, Roseriet Beijers, Jaap Denissen, Annemieke van Straten
BACKGROUND: The first months after birth can be challenging for parents, leading to parental distress and decreased well-being. Parents with high levels of distress are found to respond less adequately and sensitively to their infant, which in turn affects infant well-being and health. The goal of this study is to examine the effectiveness of a psycho-educational intervention to prevent postpartum parental distress and enhance the quality of caregiving and infant well-being. In contrast to other interventions, this intervention will be (1) offered already before birth, (2) offered to all parents-to-be, regardless of their risk of postpartum distress, and (3) include fathers...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29300703/do-high-fidelity-wraparound-services-for-youth-with-serious-emotional-disturbances-save-money-in-the-long-term
#14
Angela Snyder, James Marton, Susan McLaren, Bo Feng, Mei Zhou
BACKGROUND: Treating youth with serious emotional disturbances (SED) is expensive often requiring institutional care. A significant amount of recent federal and state funding has been dedicated to expanding home and community-based services for these youth as an alternative to institutional care. High Fidelity Wraparound (Wrap) is an evolving, evidence-informed practice to help sustain community-based placements for youth with an SED through the use of intensive, customized care coordination among parents, multiple child-serving agencies, and providers...
December 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/29297424/household-context-and-psychosocial-impact-of-childhood-multidrug-resistant-tuberculosis-in-kwazulu-natal-south-africa
#15
M Loveday, B Sunkari, I Master, A Daftary, V Mehlomakulu, S Hlangu, B J Marais
SETTING: Referral hospital for drug-resistant tuberculosis (TB) in KwaZulu-Natal, South Africa. OBJECTIVES: We conducted interviews with primary care givers of children admitted with multidrug-resistant TB (MDR-TB) during a 3-month period in 2015 to identify broader household challenges. RESULTS: We interviewed 26 care givers, most of whom were women (85%). Most households had been decimated by TB/MDR-TB and human immunodeficiency virus (HIV) infection, and were dependent upon government grants...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297403/exclusion-of-married-adolescents-in-a-study-of-gestational-diabetes-mellitus-a-case-study
#16
Mala Ramanathan, K Sakeena
A study on gestational diabetes mellitus (GDM) among 200 married women in Malappruam, Kerala, India, chose to exclude married women below the age of 18 from participation. Marriages before age 18 are not considered legally valid and persons below age 18 do not have the status of an adult. Parents are considered the legal guardians of married women under age 18, but because marriages are patrilocal, obtaining consent from parents would have time costs. Further, obtaining parental consent may also be considered disrespectful of the in-laws...
December 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29297108/psychosocial-profiles-of-parents-of-children-with-undiagnosed-diseases-managing-well-or-just-managing
#17
Allyn McConkie-Rosell, Stephen R Hooper, Loren D M Pena, Kelly Schoch, Rebecca C Spillmann, Yong-Hui Jiang, Heidi Cope, Christina Palmer, Vandana Shashi
Little is known about the psychosocial profiles of parents who have a child with an undiagnosed chronic illness. The National Institutes of Health Undiagnosed Diseases Network (UDN) evaluates individuals with intractable medical findings, with the objective of discovering the underlying diagnosis. We report on the psychosocial profiles of 50 parents whose children were accepted to one of the network's clinical sites. Parents completed questionnaires assessing anxiety, depression, coping self-efficacy, and health care empowerment at the beginning of their child's UDN clinical evaluation...
January 2, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29288550/a-questionnaire-survey-for-parents-in-nara-prefecture-japan-about-mumps-vaccination
#18
Taito Kitano, Hiroki Nishikawa, Masayuki Onaka, Mariko Ishihara, Atsuko Nishiyama, Sayaka Yoshida
OBJECTIVES: Although the mumps vaccine has not been included in the national immunization program (NIP) in Japan, it has been shown that a two-dose routine vaccine program would be highly cost-effective. In this study, we performed a questionnaire-based study to investigate how many Japanese parents want the mumps vaccine to be included in the NIP with proper information. MATERIALS AND METHODS: The questionnaire was given to parents who visited the Pediatrics or NICU department of Nara Prefecture General Medical Center, Nara City, Japan, between March 1, 2017 and August 31, 2017...
December 30, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29288334/population-cost-effectiveness-of-the-triple-p-parenting-programme-for-the-treatment-of-conduct-disorder-an-economic-modelling-study
#19
Filipa Sampaio, Jan J Barendregt, Inna Feldman, Yong Yi Lee, Michael G Sawyer, Mark R Dadds, James G Scott, Cathrine Mihalopoulos
Parenting programmes are the recommended treatments of conduct disorders (CD) in children, but little is known about their longer term cost-effectiveness. This study aimed to evaluate the population cost-effectiveness of one of the most researched evidence-based parenting programmes, the Triple P-Positive Parenting Programme, delivered in a group and individual format, for the treatment of CD in children. A population-based multiple cohort decision analytic model was developed to estimate the cost per disability-adjusted life year (DALY) averted of Triple P compared with a 'no intervention' scenario, using a health sector perspective...
December 29, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29276324/cost-effectiveness-of-a-school-readiness-intervention-for-foster-children
#20
Frances L Lynch, John F Dickerson, Katherine C Pears, Philip A Fisher
Objective: Many young children in foster care suffer from emotional and behavior problems due to neglect and abuse. These problems can lead to difficulties in school, and functioning in school is linked to long-term health and development. Early intervention to reduce emotional and behavioral issues can help children successfully transition to school, which can improve long-term outcomes. However, communities need information on relative costs and benefits associated with programs to make informed choices...
October 2017: Children and Youth Services Review
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