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https://www.readbyqxmd.com/read/29144820/pheochromocytoma-a-genetic-and-diagnostic-update
#1
Leilani B Mercado-Asis, Katherine I Wolf, Ivana Jochmanova, David Taïeb
OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors derived from adrenal or extra-adrenal locations, respectively. Upon suspicion of PPGL, specific metabolomic, molecular, biochemical, imaging, and histopathological studies are performed to prove, localize, treat, and monitor disease progression. Recently, improved diagnostic tools allow physicians to accurately diagnose PPGL, even in patients presenting with small (less than 1 cm) or biochemically silent tumors, which previously delayed proper detection and treatment...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29134280/delayed-response-after-repeated-177-lu-psma-617-radioligand-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer
#2
Kambiz Rahbar, Martin Bögeman, Anna Yordanova, Maria Eveslage, Michael Schäfers, Markus Essler, Hojjat Ahmadzadehfar
PURPOSE: Radioligand therapy (RLT) using Lutetium-177 labeled PSMA-617 (Lu-PSMA) ligand is a new therapeutic option for salvage therapy in heavily pretreated patients with metastatic castration resistant prostate cancer. The aim of this retrospective study was to analyze response in patients receiving 3 cycles of Lu-PSMA. METHODS: Seventy-one patients (median age: 72 years; range 44-87) received 3 cycles of RLT with Lu-PSMA (mean administered activity: 6.016 ± 0...
November 13, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29120610/strategic-materials-in-the-automobile-a-comprehensive-assessment-of-strategic-and-minor-metals-use-in-passenger-cars-and-light-trucks
#3
Frank R Field, Timothy J Wallington, Mark P Everson, Randolph E Kirchain
A comprehensive component-level assessment of several strategic and minor metals (SaMMs) including copper, manganese, magnesium, nickel, tin, niobium, light rare earth elements (lanthanum, cerium, praseodymium, neodymium, promethium, and samarium), cobalt, silver, tungsten, heavy rare earth elements (yttrium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, and lutetium) and gold use in the 2013 model year Ford Fiesta, Focus, Fusion, and F-150 is presented. Representative material contents in cars and light-duty trucks are estimated using comprehensive, component-level data reported by suppliers...
November 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29097938/labelling-of-90-y-and-177-lu-dota-bioconjugates-for-targeted-radionuclide-therapy-a-comparison-among-manual-semiautomated-and-fully-automated-synthesis
#4
Michele Iori, Pier C Capponi, Sara Rubagotti, Luca Rosario Esposizione, Johanna Seemann, Riccardo Pitzschler, Thorsten Dreger, Debora Formisano, Elisa Grassi, Federica Fioroni, Annibale Versari, Mattia Asti
In spite of the hazard due to the radiation exposure, preparation of (90)Y- and (177)Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. In the present study the performance of a commercial automatic synthesizer based on disposable cassettes for the labelling of (177)Lu- and (90)Y-DOTA-conjugated biomolecules (namely, DOTATOC and PSMA-617) was evaluated and compared to a manual and a semiautomated approach. The dose exposure of the operators was evaluated as well. More than 300 clinical preparations of both (90)Y- and (177)Lu-labelled radiopharmaceuticals have been performed using the three different methods...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29074285/local-salvage-treatment-of-post-brachytherapy-recurrent-prostate-cancer-via-theranostic-application-of-psma-labeled-lutetium-177
#5
Mehmet Onur Demirkol, Murat Can Kiremit, Omer Acar, Okan Falay, Burcu Ucar, Tarik Esen
No abstract text is available yet for this article.
September 23, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29043399/immunohistochemical-evaluation-of-molecular-radiotherapy-target-expression-in-neuroblastoma-tissue
#6
Jennifer E Gains, Neil J Sebire, Veronica Moroz, Keith Wheatley, Mark N Gaze
PURPOSE: Neuroblastoma may be treated with molecular radiotherapy, (131)I meta-Iodobenzylguanidine and (177)Lu Lutetium DOTATATE, directed at distinct molecular targets: Noradrenaline Transporter Molecule (NAT) and Somatostatin Receptor (SSTR2), respectively. This study used immunohistochemistry to evaluate target expression in archival neuroblastoma tissue, to determine whether it might facilitate clinical use of molecular radiotherapy. METHODS: Tissue bank samples of formalin fixed paraffin embedded neuroblastoma tissue from patients for whom clinical outcome data were available were sectioned and stained with haematoxylin and eosin, and monoclonal antibodies directed against NAT and SSTR2...
October 17, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29031024/use-of-a-lyso-based-compton-camera-for-prompt-gamma-range-verification-in-proton-therapy
#7
Meei-Ling Jan, Ing-Tsung Hsiao, Hsuan-Ming Huang
PURPOSE: A Compton camera (CC), which measures prompt gammas (PGs) emitted during proton therapy, is a potentially useful imaging device for proton range verification. The aim of this study is to evaluate how well the reconstructed PG images obtained from various two-stage CC configurations reproduce the distal falloff of the PG emission. METHODS: We conducted Monte Carlo simulations to evaluate different two-stage CCs positioned orthogonal to a proton pencil beam irradiating a water phantom...
October 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29028502/dota-tetrazine-probes-with-modified-linkers-for-tumor-pretargeting
#8
Tilman Läppchen, Raffaella Rossin, Tiemen R van Mourik, Guillaume Gruntz, Freek J M Hoeben, Ron M Versteegen, Henk M Janssen, Johan Lub, Marc S Robillard
INTRODUCTION: Pretargeted radioimmunoimaging and -therapy approaches building on the bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) reaction between strained trans-cyclooctenes (TCO) and electron-deficient tetrazines (Tz) have yielded impressive results in recent years and have proven a vital alternative to biological pretargeting systems. After improvement of the TCO-antibody conjugates, we here report on our evaluation of a new series of radiolabeled Tz-probes. METHODS: Four new Tz-probes were synthesized, radiolabeled with lutetium-177, and characterized in vitro in terms of lipophilicity, reactivity, and stability in PBS and mouse serum...
September 14, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28986618/-177-lu-psma-therapy-current-evidence-for-use-in-the-treatment-of-patients-with-metastatic-prostate-cancer
#9
REVIEW
M Boegemann, A J Schrader, K Rahbar
BACKGROUND: Despite significant progress in the treatment of metastatic castration-resistant prostate cancer (mCRPC) in recent years (including agents targeting androgen receptor signaling, chemotherapy, and (223)Ra), most of these patients still succumb to prostate cancer. Recently, (177)lutetium prostate-specific membrane antigen radioligand therapy ((177)Lu-PSMA-RLT) has been increasingly used within compassionate use provisions in these patients in Germany and showed promising efficacy...
November 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28986509/why-targeting-psma-is-a-game-changer-in-the-management-of-prostate-cancer-%C3%A2-a-urologist-s-point-of-view
#10
Nicholas M Donin, Robert Reiter
Prostate-specific membrane antigen (PSMA), is a transmembrane glycoprotein that is highly expressed on prostate adenocarcinomas, exhibits only limited expression in benign and extra-prostatic tissues, and thus represents an ideal target for the diagnosis and management of prostate cancer. Since its discovery over 30 years ago, significant effort has been made to develop clinical technology targeting PSMA. The last 5 years have seen an explosion of development of new agents targeting PSMA for diagnostic and therapeutic use...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28978790/isomorphous-rare-earth-bis-bis-2-6-diisopropylphenyl-phosphate-complexes-and-their-self-assembly-into-two-dimensional-frameworks-by-intramolecular-hydrogen-bonds
#11
Mikhail E Minyaev, Ilya E Nifant'ev, Alexander N Tavtorkin, Sof'ya A Korchagina, Shadana Sh Zeynalova, Ivan V Ananyev, Andrei V Churakov
The crystal structures of rare-earth diaryl- or dialkylphosphate derivatives are poorly explored. Crystals of bis[bis(2,6-diisopropylphenyl)phosphato-κO]chloridotetrakis(methanol-κO)neodymium methanol disolvate, [Nd(C24H34O4P)Cl(CH4O)4]·2CH3OH, (1), and of the lutetium, [Lu(C24H34O4P)Cl(CH4O)4]·2CH3OH, (2), and yttrium, [Y(C24H34O4P)Cl(CH4O)4]·2CH3OH, (3), analogues have been obtained by reactions between lithium bis(2,6-diisopropylphenyl)phosphate and LnCl3(H2O)6 (in a 2:1 ratio) in methanol. Compounds (1)-(3) crystallize in the C2/c space group...
October 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28926238/toward-chemical-accuracy-in-ab-initio-thermochemistry-and-spectroscopy-of-lanthanide-compounds-assessing-core-valence-correlation-second-order-spin-orbit-coupling-and-higher-order-effects-in-lanthanide-diatomics
#12
Victor G Solomonik, Alexander N Smirnov
The higher order (HO) correlation beyond the coupled-cluster single double (triple) CCSD(T) level of theory, second-order spin-orbit coupling (SOC), and core-valence (CV) correlation effects on bond length, re, vibrational frequency, ωe, and dissociation energy, De, are studied for a set of 17 lanthanide containing diatomics, including lanthanum, europium, ytterbium, and lutetium oxides and halides. Convergence in the magnitudes of the SOC, CV, and HO corrections with respect to basis set size is examined using a sequence of double, triple, and quadruple-ζ basis sets, with the complete basis set (CBS) limit estimates provided in most cases...
October 3, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28912147/performance-of-a-pet-insert-for-high-resolution-small-animal-pet-mr-imaging-at-7t
#13
Greg Stortz, Jonathan D Thiessen, Daryl Bishop, Muhammad S Khan, Piotr Kozlowski, Fabrice Retière, Graham Schellenberg, Ehsan Shams, Xuezhu Zhang, Christopher J Thompson, Andrew Goertzen, Vesna Sossi
We present the characterization of a compact magnetic resonance (MR) compatible positron emission tomography (PET) insert for simultaneous pre-clinical PET/MR imaging. While specifically designed with the strict size constraint to fit inside the 114 mm inner diameter of the BGA-12S gradient coil used in the Bruker 70/20 and 94/20 series of small animal MR imaging (MRI) systems, the insert can be easily installed in any appropriate MRI scanner or used as a stand-alone PET system. Methods: The insert is made from a ring of 16 detector-blocks each made from depth-of-interaction capable dual-layer-offset arrays of cerium-doped lutetium-yttrium oxyorthosilicate crystals read out by silicon photomultiplier (SiPM) arrays...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28815804/octadentate-picolinic-acid-based-bispidine-ligand-for-radiometal-ions
#14
Peter Comba, Una Jermilova, Chris Orvig, Brian O Patrick, Caterina F Ramogida, Katharina Rück, Christina Schneider, Miriam Starke
The synthesis of the octadentate bispidine ligand bearing two picolinic acid pendant arms (H2 bispa(2) ), and its coordination chemistry with radionuclides relevant for nuclear medicine, namely indium(III) ((111) In), lutetium(III) ((177) Lu), and lanthanum(III) (as surrogate for (225) Ac), are reported. The non-radioactive metal complexes of the N6 O2 -type bispa ligand were characterized by (1) H and (13) C NMR spectroscopy, elemental analysis, mass spectrometry and single-crystal X-ray analysis. Experimental structural data, computational analysis, complex stabilities determined by potentiometric titration, and "radiostabilities" determined by competition studies in the presence of human serum reveal complex stabilities of H2 bispa(2) comparable to those of the macrocyclic "gold standard" DOTA...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28796505/toolbox-of-nonmetallocene-lanthanides-multifunctional-catalysts-in-group-transfer-polymerization
#15
Friederike Adams, Martin R Machat, Peter T Altenbuchner, Johannes Ehrmaier, Alexander Pöthig, Tolga N V Karsili, Bernhard Rieger
Herein, we present a fundamental study of isostructural 2-methoxyethylamino-bis(phenolate)-lanthanide complexes [(ONOO)(R)M(X)(THF)] (M = Lu, Y; R = (t)Bu, CMe2Ph, X = CH2TMS, collidine; THF = tetrahydrofuran; TMS = trimethylsilyl) for rare-earth metal-mediated group-transfer polymerization (GTP). This analysis includes the differentiation of electron-donating and nondonating vinyl monomers and two metal centers with regard to the ionic radius (yttrium and lutetium). In addition, highly nucleophilic alkyl initiators are compared with electron-donating heteroaromatic initiators...
August 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28777883/electro-kinetic-separation-of-rare-earth-elements-using-a-redox-active-ligand
#16
Huayi Fang, Bren E Cole, Yusen Qiao, Justin A Bogart, Thibault Cheisson, Brian C Manor, Patrick J Carroll, Eric J Schelter
Purification of rare earth elements is challenging due to their chemical similarities. All of the deployed separation methods rely on thermodynamic properties, such as distribution equilibria in solvent extraction. Rare-earth-metal separations based on kinetic differences have not been examined. Herein, we demonstrate a new approach for rare-earth-element separations by exploiting differences in the oxidation rates within a series of rare earth compounds containing the redox-active ligand [{2-(tBuN(O))C6 H4 CH2 }3 N](3-) ...
October 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28705917/curative-multicycle-radioimmunotherapy-monitored-by-quantitative-spect-ct-based-theranostics-using-bispecific-antibody-pretargeting-strategy-in-colorectal-cancer
#17
Sarah M Cheal, Edward K Fung, Mitesh Patel, Hong Xu, Hong-Fen Guo, Pat B Zanzonico, Sebastien Monette, K Dane Wittrup, Nai-Kong V Cheung, Steven M Larson
Radioimmunotherapy of solid tumors using antibody-targeted radionuclides has been limited by low therapeutic indices (TIs). We recently reported a novel 3-step pretargeted radioimmunotherapy (PRIT) strategy based on a glycoprotein A33 (GPA33)-targeting bispecific antibody and a small-molecule radioactive hapten, a complex of (177)Lu and S-2-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid ((177)Lu-DOTA-Bn), that leads to high TIs for radiosensitive tissues such as blood (TI = 73) and kidney (TI = 12)...
November 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28700244/targeted-yttrium-89-doxorubicin-drug-eluting-bead-a-safety-and-feasibility-pilot-study-in-a-rabbit-liver-cancer-model
#18
Johannes M Ludwig, Minzhi Xing, Yongkang Gai, Lingyi Sun, Dexing Zeng, Hyun S Kim
The purpose of this article is to evaluate feasibility and safety of the cancer targeting (radio)-chemoembolization drug-eluting bead (TRCE-DEB) concept drug SW43-DOX-L-NETA((89)Y) DEB for the intra-arterial treatment of VX2 rabbit liver tumors. The treatment compound comprises of the sigma-2 receptor ligand SW43 for cancer targeting, doxorubicin (DOX), and (89)yttrium ((89)Y) as nonradioactive surrogate for therapeutic (yttrium-90, lutetium-177) and imaging (yttrium-86) radioisotopes via the chelator L-NETA...
August 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28682792/performance-of-a-high-resolution-depth-encoding-pet-detector-using-barium-sulfate-reflector
#19
Zhonghua Kuang, Xiaohui Wang, Cheng Li, Xinhan Deng, Kai Feng, Zhanli Hu, Xin Fu, Ning Ren, Xianming Zhang, Yunfei Zheng, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
Small animal positron emission tomography (PET) is a well-established imaging modality in preclinical biomedical research. The performance of current small animal PET scanners is mainly limited by the detector performance and depth-encoding detectors are required to simultaneously achieve high spatial resolution and high sensitivity. In this work, the performance of a high-resolution dual-ended readout lutetium-yttrium oxyorthosilicate (LYSO) array using barium sulfate powder (BaSO4) as the inter-crystal reflector was measured for the first time and compared to that of a LYSO array using the most commonly used enhanced specular reflector (ESR)...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28679207/lu2-c2n-2n-82-84-86-crystallographic-evidence-of-direct-lu-lu-bonding-between-two-divalent-lutetium-ions-inside-fullerene-cages
#20
Wangqiang Shen, Lipiao Bao, Yongbo Wu, Changwang Pan, Shasha Zhao, Hongyun Fang, Yunpeng Xie, Peng Jin, Ping Peng, Fang-Fang Li, Xing Lu
Although most of the M2C2n-type metallofullerenes (EMFs) tend to form carbide cluster EMFs, we report herein that Lu-containing EMFs Lu2C2n (2n = 82, 84, 86) are actually dimetallofullerenes (di-EMFs), namely, Lu2@Cs(6)-C82, Lu2@C3v(8)-C82, Lu2@D2d(23)-C84, and Lu2@C2v(9)-C86. Unambiguous X-ray results demonstrate the formation of a Lu-Lu single bond between two lutetium ions which transfers four electrons in total to the fullerene cages, thus resulting in a formal divalent state for each Lu ion. Population analysis indicates that each Lu atom formally donates a 5d electron and a 6s electron to the cage with the remaining 6s electron shared with the other Lu atom to form a Lu-Lu single bond so that only four electrons are transferred to the fullerene cages with the formal divalent valence for each lutetium ion...
July 17, 2017: Journal of the American Chemical Society
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