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https://www.readbyqxmd.com/read/28926238/toward-chemical-accuracy-in-ab-initio-thermochemistry-and-spectroscopy-of-lanthanide-compounds-assessing-core-valence-correlation-second-order-spin-orbit-coupling-and-higher-order-effects-in-lanthanide-diatomics
#1
Victor G Solomonik, Alexander N Smirnov
The higher order (HO) correlation beyond the coupled-cluster single double (triple) CCSD(T) level of theory, second-order spin-orbit coupling (SOC), and core-valence (CV) correlation effects on bond length, re, vibrational frequency, ωe, and dissociation energy, De, are studied for a set of 17 lanthanide containing diatomics, including lanthanum, europium, ytterbium and lutetium oxides and halides. Convergence in the magnitudes of the SOC, CV, and HO corrections with respect to basis set size is examined using a sequence of double, triple, and quadruple-zeta basis sets, with the complete basis set (CBS) limit estimates provided in most cases...
September 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28912147/performance-of-a-pet-insert-for-high-resolution-small-animal-pet-mr-imaging-at-7t
#2
Greg Stortz, Jonathan D Thiessen, Daryl Bishop, Muhammad S Khan, Piotr Kozlowski, Fabrice Retière, Graham Schellenberg, Ehsan Shams, Xuezhu Zhang, Christopher J Thompson, Andrew Goertzen, Vesna Sossi
We present the characterization of a compact magnetic resonance (MR) compatible positron emission tomography (PET) insert for simultaneous pre-clinical PET/MR imaging. While specifically designed with the strict size constraint to fit inside the 114 mm inner diameter of the BGA-12S gradient coil used in the Bruker 70/20 and 94/20 series of small animal MR imaging (MRI) systems, the insert can be easily installed in any appropriate MRI scanner or used as a stand-alone PET system. Methods: The insert is made from a ring of 16 detector-blocks each made from depth-of-interaction capable dual-layer-offset arrays of cerium-doped lutetium-yttrium oxyorthosilicate crystals read out by silicon photomultiplier (SiPM) arrays...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28815804/octadentate-picolinic-acid-based-bispidine-ligand-for-radiometal-ions
#3
Peter Comba, Una Jermilova, Chris Orvig, Brian O Patrick, Caterina F Ramogida, Katharina Rück, Christina Schneider, Miriam Starke
The synthesis of the octadentate bispidine ligand H2bispa2 bearing two picolinic acid pendant arms and its coordination chemistry with metal ions with radionuclides relevant for nuclear medicine, i.e. indium(III) (111In), lutetium(III) (177Lu) and lanthanum(III) (as surrogate for 225Ac), are reported. The non-radioactive metal complexes of the N6O2-type bispa ligand were characterized by 1H and 13C nuclear magnetic resonance spectroscopy, elemental analysis, mass spectrometry and single crystal X-ray analysis...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28796505/toolbox-of-nonmetallocene-lanthanides-multifunctional-catalysts-in-group-transfer-polymerization
#4
Friederike Adams, Martin R Machat, Peter T Altenbuchner, Johannes Ehrmaier, Alexander Pöthig, Tolga N V Karsili, Bernhard Rieger
Herein, we present a fundamental study of isostructural 2-methoxyethylamino-bis(phenolate)-lanthanide complexes [(ONOO)(R)M(X)(THF)] (M = Lu, Y; R = (t)Bu, CMe2Ph, X = CH2TMS, collidine; THF = tetrahydrofuran; TMS = trimethylsilyl) for rare-earth metal-mediated group-transfer polymerization (GTP). This analysis includes the differentiation of electron-donating and nondonating vinyl monomers and two metal centers with regard to the ionic radius (yttrium and lutetium). In addition, highly nucleophilic alkyl initiators are compared with electron-donating heteroaromatic initiators...
August 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28777883/electro-kinetic-separation-of-rare-earth-elements-using-a-redox-active-ligand
#5
Huayi Fang, Bren E Cole, Yusen Qiao, Justin A Bogart, Thibault Cheisson, Brian C Manor, Patrick J Carroll, Eric J Schelter
Purification of rare earth elements is challenging due to their chemical similarities. All of the deployed separations methods rely on thermodynamic properties, such as distribution equilibria in solvent extraction. Rare earth metal separations based on kinetic differences have not been examined. Herein, we demonstrate a new approach for rare earth element separations by exploiting differences in the oxidation rates within a series of rare earth compounds containing the redox-active ligand: [((2-tBuNO)C6H4CH2)3N]3-...
August 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28705917/curative-multi-cycle-radioimmunotherapy-monitored-by-quantitative-spect-ct-based-theranostics-using-bispecific-antibody-pretargeting-strategy-in-colorectal-cancer
#6
Sarah M Cheal, Edward K Fung, Miteshkumar V Patel, Blesida Punzalan, Hong Xu, Hong-Fen Guo, Pat B Zanzonico, Sebastien Monette, Karl Dane Wittrup, Nai-Kong Cheung, Steven M Larson
Radioimmunotherapy of solid tumors using antibody-targeted radionuclides has been limited by low therapeutic indices (TI). We recently reported a novel three-step pretargeted radioimmunotherapy (PRIT) strategy based on a glycoprotein A33 (GPA33)-targeting bispecific antibody (bsAb) and a small-molecule radioactive hapten, a complex of lutetium-177 ((177)Lu) and S-2-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid ((177)Lu-DOTA-Bn) that leads to high TIs for radiosensitive tissues such as blood (TI = 73) and kidney (TI = 12)...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28700244/targeted-yttrium-89-doxorubicin-drug-eluting-bead-a-safety-and-feasibility-pilot-study-in-a-rabbit-liver-cancer-model
#7
Johannes M Ludwig, Minzhi Xing, Yongkang Gai, Lingyi Sun, Dexing Zeng, Hyun S Kim
The purpose of this article is to evaluate feasibility and safety of the cancer targeting (radio)-chemoembolization drug-eluting bead (TRCE-DEB) concept drug SW43-DOX-L-NETA((89)Y) DEB for the intra-arterial treatment of VX2 rabbit liver tumors. The treatment compound comprises of the sigma-2 receptor ligand SW43 for cancer targeting, doxorubicin (DOX), and (89)yttrium ((89)Y) as nonradioactive surrogate for therapeutic (yttrium-90, lutetium-177) and imaging (yttrium-86) radioisotopes via the chelator L-NETA...
August 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28682792/performance-of-a-high-resolution-depth-encoding-pet-detector-using-barium-sulfate-reflector
#8
Zhonghua Kuang, Xiaohui Wang, Cheng Li, Xinhan Deng, Kai Feng, Zhanli Hu, Xin Fu, Ning Ren, Xianming Zhang, Yunfei Zheng, Dong Liang, Xin Liu, Hairong Zheng, Yongfeng Yang
Small animal positron emission tomography (PET) is a well-established imaging modality in preclinical biomedical research. The performance of current small animal PET scanners is mainly limited by the detector performance and depth-encoding detectors are required to simultaneously achieve high spatial resolution and high sensitivity. In this work, the performance of a high-resolution dual-ended readout lutetium-yttrium oxyorthosilicate (LYSO) array using barium sulfate powder (BaSO4) as the inter-crystal reflector was measured for the first time and compared to that of a LYSO array using the most commonly used enhanced specular reflector (ESR)...
July 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28679207/lu2-c2n-2n-82-84-86-crystallographic-evidence-of-direct-lu-lu-bonding-between-two-divalent-lutetium-ions-inside-fullerene-cages
#9
Wangqiang Shen, Lipiao Bao, Yongbo Wu, Changwang Pan, Shasha Zhao, Hongyun Fang, Yunpeng Xie, Peng Jin, Ping Peng, Fang-Fang Li, Xing Lu
Although most of the M2C2n-type metallofullerenes (EMFs) tend to form carbide cluster EMFs, we report herein that Lu-containing EMFs Lu2C2n (2n = 82, 84, 86) are actually dimetallofullerenes (di-EMFs), namely, Lu2@Cs(6)-C82, Lu2@C3v(8)-C82, Lu2@D2d(23)-C84, and Lu2@C2v(9)-C86. Unambiguous X-ray results demonstrate the formation of a Lu-Lu single bond between two lutetium ions which transfers four electrons in total to the fullerene cages, thus resulting in a formal divalent state for each Lu ion. Population analysis indicates that each Lu atom formally donates a 5d electron and a 6s electron to the cage with the remaining 6s electron shared with the other Lu atom to form a Lu-Lu single bond so that only four electrons are transferred to the fullerene cages with the formal divalent valence for each lutetium ion...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28613198/lu-177-psma-617-prostate-specific-membrane-antigen-inhibitor-therapy-in-patients-with-castration-resistant-prostate-cancer-stability-bio-distribution-and-dosimetry
#10
Levent Kabasakal, Türkay Toklu, Nami Yeyin, Emre Demirci, Mohammad Abuqbeitah, Meltem Ocak, Aslan Aygün, Emre Karayel, Hüseyin Pehlivanoğlu, Nalan Alan Selçuk
OBJECTIVE: The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617. METHODS: For this purpose, 7 patients who underwent Lu-177-PSMA therapy were included into the study. The injected Lu-177-PSMA-617 activity ranged from 3.6 to 7.4 GBq with a mean of 5.2±1.8 GBq. The stability of radiotracer in saline was calculated up to 48 h...
June 1, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28558243/ion-transport-mechanisms-in-liquid-liquid-interface
#11
Baofu Qiao, John V Muntean, Monica Olvera de la Cruz, Ross J Ellis
Interfacial liquid-liquid ion transport is of crucial importance to biotechnology and industrial separation processes including nuclear elements and rare earths. A water-in-oil microemulsion is formulated here with density and dimensions amenable to atomistic molecular dynamics simulation, facilitating convergent theoretical and experimental approaches to elucidate interfacial ion transport mechanisms. Lutetium(III) cations are transported from the 5 nm diameter water pools into the surrounding oil using an extractant (a lipophilic ligand)...
June 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28538080/formulation-and-characterization-of-lutetium-177-labeled-stannous-tin-colloid-for-radiosynovectomy
#12
Geetanjali Arora, Manoranjan Singh, Pragati Jha, Sarthak Tripathy, Chandrasekhar Bal, Anirban Mukherjee, Shamim A Shamim
OBJECTIVE: Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, followed by in-vitro and in-vivo characterization. METHODS: Stannous chloride (SnCl2) solution and Lu were heated together, the pH was adjusted, and the particles were recovered by centrifugation...
May 19, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28533641/image-findings-of-a-rare-case-of-neuroendocrine-tumor-metastatic-to-orbital-extraocular-muscle-in-gallium-68-dotanoc-positron-emission-tomography-computed-tomography-and-therapy-with-lutetium-177-dotatate
#13
Koramadai Karuppusamy Kamaleshwaran, Jephy Joseph, Indra Upadhya, Ajit Sugunan Shinto
Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1-13% of all orbital masses. In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit, followed by metastasis from the lung, prostate, and gastrointestinal tract. Carcinoid tumors are rare neuroendocrine neoplasms derived from enterochromaffin cells, which are found primarily in the gastrointestinal tract and bronchial tree. Liver metastases are the classic presentation of distant disease...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28533634/estimation-of-whole-body-radiation-exposure-to-nuclear-medicine-personnel-during-synthesis-of-177-lutetium-labeled-radiopharmaceuticals
#14
Geetanjali Arora, Rajesh Mishra, Praveen Kumar, Madhav Yadav, Sanjana Ballal, Chandrasekhar Bal, Nishikant Avinash Damle
PURPOSE OF THE STUDY: With rapid development in the field of nuclear medicine therapy, radiation safety of the personnel involved in synthesis of radiopharmaceuticals has become imperative. Few studies have been done on estimating the radiation exposure of personnel involved in the radio labeling of (177)Lu-compounds in western countries. However, data from the Indian subcontinent are limited. We have estimated whole body radiation exposure to the radiopharmacist involved in the labeling of: (177)Lu-DOTATATE, (177)Lu-PSMA-617, and (177)Lu-EDTMP...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28471845/early-efficacy-of-and-toxicity-from-lutetium-177-dotatate-treatment-in-patients-with-progressive-metastatic-net
#15
Deborah Pencharz, Martin Walker, Mehmet Yalchin, Ann-Marie Quigley, Martyn Caplin, Christos Toumpanakis, Shaunak Navalkissoor
OBJECTIVE: Lutetium-177 DOTA-D-Phe1-Tyr3-octreotide (Lu-DOTATATE) is a treatment option for patients with well-differentiated metastatic neuroendocrine tumours. Our centre started administering this therapy in 2012. The aim of this study was therefore to analyse the first cohort of patients treated with Lu-DOTATATE to determine its early efficacy and toxicity. PATIENTS AND METHODS: We retrospectively analysed patient, tumour and treatment characteristics, end-of-treatment outcome, time to progression and toxicity in 79 consecutive patients treated with Lu-DOTATATE who had progressive NET according to Response Evaluation Criteria in Solid Tumours criteria...
May 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28440324/lutetium-177-labelled-anti-prostate-specific-membrane-antigen-antibody-and-ligands-for-the-treatment-of-metastatic-castrate-resistant-prostate-cancer-a-systematic-review-and-meta-analysis
#16
R J S Calopedos, V Chalasani, R Asher, L Emmett, H H Woo
BACKGROUND: Promising therapeutic results of the prostate-specific membrane antigen (PSMA) ligand have been shown when labelling with lutetium-177 ((177)Lu). We performed a systematic review and meta-analysis to assess the therapeutic response of (177)Lu-PSMA in the treatment of metastatic castration-resistant prostate cancer (mCRPC). METHODS: A systematic review was conducted using electronic databases up to December 2016. Two reviewers independently extracted data and assessed methodological quality...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28430624/photosensitizers-in-prostate-cancer-therapy
#17
REVIEW
Taher Gheewala, Troy Skwor, Gnanasekar Munirathinam
The search for new therapeutics for the treatment of prostate cancer is ongoing with a focus on the balance between the harms and benefits of treatment. New therapies are being constantly developed to offer treatments similar to radical therapies, with limited side effects. Photodynamic therapy (PDT) is a promising strategy in delivering focal treatment in primary as well as post radiotherapy prostate cancer. PDT involves activation of a photosensitizer (PS) by appropriate wavelength of light, generating transient levels of reactive oxygen species (ROS)...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28428192/long-term-efficacy-survival-and-safety-of-177-lu-dota-0-tyr-3-octreotate-in-patients-with-gastroenteropancreatic-and-bronchial-neuroendocrine-tumors
#18
Tessa Brabander, Wouter A van der Zwan, Jaap J M Teunissen, Boen L R Kam, Richard A Feelders, Wouter W de Herder, Casper H J van Eijck, Gaston J H Franssen, Eric P Krenning, Dik J Kwekkeboom
Purpose: Bronchial and gastroenteropancreatic neuroendocrine tumors (NET) are slow-growing tumors, which frequently express somatostatin receptors on their cell membranes. These receptors are targets for therapy with Lutetium-177-labeled somatostatin analogues. We have treated over 1,200 patients with peptide receptor radionuclide therapy (PRRT) with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) since the year 2000 and present the results on efficacy, survival, and toxicity of this therapy.Experimental Design: For safety analysis, 610 patients treated with a cumulative dose of at least 100 mCi (3...
August 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28412013/investigation-of-the-imaging-characteristics-of-the-albira-ii-small-animal-pet-system-for-18-f-68-ga-and-64-cu
#19
Ali Asgar Attarwala, Yvonne Wanjiku Karanja, Deni Hardiansyah, Chiara Romanó, Mareike Roscher, Björn Wängler, Gerhard Glatting
AIM: In this study the performance characteristics of the Albira II PET sub-system and the response of the system for the following radionuclides (18)F, (68)Ga and (64)Cu was analyzed. MATERIALS AND METHODS: The Albira II tri-modal system (Bruker BioSpin MRI GmbH, Ettlingen, Germany) is a pre-clinical device for PET, SPECT and CT. The PET sub-system uses single continuous crystal detectors of lutetium yttrium orthosilicate (LYSO). The detector assembly consists of three rings of 8 detector modules...
April 12, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28398905/an-integrated-model-of-scintillator-reflector-properties-for-advanced-simulations-of-optical-transport
#20
Emilie Roncali, Mariele Stockhoff, Simon R Cherry
Accurately modeling the light transport in scintillation detectors is essential to design new detectors for nuclear medicine or high energy physics. Optical models implemented in software such as Geant4 and GATE suffer from important limitations that we addressed by implementing a new approach in which the crystal reflectance was computed from 3D surface measurements. The reflectance was saved in a look-up-table (LUT) then used in Monte Carlo simulation to determine the fate of optical photons. Our previous work using this approach demonstrated excellent agreement with experimental characterization of crystal light output in a limited configuration, i...
April 11, 2017: Physics in Medicine and Biology
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