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https://www.readbyqxmd.com/read/29790514/theoretical-investigation-of-m-pb-12-2-and-m-sn-12-2-zintl-clusters-m-lr-n-lu-n-la-3-ac-3-and-n-0-1-2-3
#1
Meenakshi Joshi, Aditi Chandrasekar, Tapan K Ghanty
The positions of lawrencium (Lr), lutetium (Lu), actinium (Ac) and lanthanum (La) in the periodic table have been a controversial topic for quite some time. According to studies carried out by different groups with their justifications, these elements may potentially be placed in the d-block, p-block or all four in a 15 element f-block. The present work looks into this issue from a new perspective, which involves encapsulation of these four elements into Zintl ion clusters, Pb122- and Sn122-, followed by the determination of the structural, thermodynamic and electronic properties of these endohedral M@Pb122- and M@Sn122- clusters (M = Lrn+, Lun+ with n = 0, 1, 2, 3) using first principles based density functional theory (DFT)...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29789463/properties-of-ferrite-garnet-bi-lu-y-%C3%A2-fe-ga-%C3%A2-o-12-thin-film-materials-prepared-by-rf-magnetron-sputtering
#2
Mohammad Nur-E-Alam, Mikhail Vasiliev, Vladimir Belotelov, Kamal Alameh
This work is devoted to physical vapor deposition synthesis, and characterisation of bismuth and lutetium-substituted ferrite-garnet thin-film materials for magneto-optic (MO) applications. The properties of garnet thin films sputtered using a target of nominal composition type Bi0.9 Lu1.85 Y0.25 Fe4.0 Ga₁O12 are studied. By measuring the optical transmission spectra at room temperature, the optical constants and the accurate film thicknesses can be evaluated using Swanepoel's envelope method. The refractive index data are found to be matching very closely to these derived from Cauchy's dispersion formula for the entire spectral range between 300 and 2500 nm...
May 22, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29765763/crystal-structure-and-catalytic-activity-of-tetra-kis-%C3%AE-2-ethyl-2-6-di-tert-butyl-4-methyl-phenyl-phos-phato-%C3%AE%C2%BA-2-o-o-bis-ethyl-2-6-di-tert-butyl-4-methyl-phenyl-phosphato-%C3%AE%C2%BA-2-o-o-dilutetium-n-heptane-disolvate
#3
Mikhail E Minyaev, Alexander N Tavtorkin, Sof'ya A Korchagina, Ilya E Nifant'ev, Andrei V Churakov
The title complex, [Lu2 (C17 H28 O4 P)6 ]·2C7 H16 , was formed in the reaction between potassium 2,6-di- tert -butyl-4-methyl-phenyl ethyl phosphate, [K(2,6- t Bu2 -4-MeC6 H2 -O)(EtO)PO2 ], and LuCl3 (H2 O)6 in water, followed by vacuum drying and recrystallization from heptane. Its crystal structure has triclinic ( P [Formula: see text]) symmetry at 120 K. The lutetium tris-(phosphate) complex has a binuclear [Lu2 (μ-OPO)4 ] core and the organophosphate ligand exhibits κ2 O , O ' terminal and μ2 -κ1 O :κ1 O ' bridging coordination modes with the LuIII ion being sixfold coordinated...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29758498/accumulation-elimination-and-neuro-oxidative-damage-under-lanthanum-exposure-in-glass-eels-anguilla-anguilla
#4
Cátia Figueiredo, Tiago F Grilo, Clara Lopes, Pedro Brito, Mário Diniz, Miguel Caetano, Rui Rosa, Joana Raimundo
Rare earth elements (REEs) comprise elements from lanthanum to lutetium that together with yttrium and scandium are emergent contaminants of critical importance for numerous groundbreaking environmental technologies. Transfer to aquatic ecosystems is expected to increase, however, little information is known about their potential impacts in marine biota. Considering the endangered conservation status of the European eel (Anguilla anguilla) and the vulnerability of early fish life stages to contaminants, we exposed glass eels, through water, to an environmentally relevant concentration (120 ng...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29752180/-177-lu-psma-617-radionuclide-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-lupsma-trial-a-single-centre-single-arm-phase-2-study
#5
Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu
BACKGROUND: Progressive metastatic castration-resistant prostate cancer is a highly lethal disorder and new effective therapeutic agents that improve patient outcomes are urgently needed. Lutetium-177 [177 Lu]-PSMA-617, a radiolabelled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA) enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer. We aimed to investigate the safety, efficacy, and effect on quality of life of [177 Lu]-PSMA-617 in men with metastatic castration-resistant prostate cancer who progressed after standard treatments...
May 7, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29747035/microscale-radiosynthesis-preclinical-imaging-and-dosimetry-study-of-18-f-ambf-3-tate-a-potential-pet-tracer-for-clinical-imaging-of-somatostatin-receptors
#6
Ksenia Lisova, Maxim Sergeev, Susan Evans-Axelsson, Andreea D Stuparu, Seval Beykan, Jeffrey Collins, Jason Jones, Michael Lassmann, Ken Herrmann, David Perrin, Jason T Lee, Roger Slavik, R Michael van Dam
BACKGROUND: Peptides labeled with positron-emitting isotopes are emerging as a versatile class of compounds for the development of highly specific, targeted imaging agents for diagnostic imaging via positron-emission tomography (PET) and for precision medicine via theranostic applications. Despite the success of peptides labeled with gallium-68 (for imaging) or lutetium-177 (for therapy) in the clinical management of patients with neuroendocrine tumors or prostate cancer, there are significant advantages of using fluorine-18 for imaging...
April 20, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29746106/improved-efficacy-of-synthesizing-m-iii-labeled-dota-complexes-in-binary-mixtures-of-water-and-organic-solvents-a-combined-radio-and-physicochemical-study
#7
Marylaine Pérez-Malo, Gergely Szabó, Elisabeth Eppard, Adrienn Vagner, Ernő Brücher, Imre Tóth, Alessandro Maiocchi, Eul Hyun Suh, Zoltán Kovács, Zsolt Baranyai, Frank Rösch
Typically, the synthesis of radiometal-based radiopharmaceuticals is performed in buffered aqueous solutions. We found that the presence of organic solvents like ethanol increased the radiolabeling yields of [68 Ga]Ga-DOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacatic acid). In the present study, the effect of organic cosolvents [ethanol (EtOH), isopropyl alcohol, and acetonitrile] on the radiolabeling yields of the macrocyclic chelator DOTA with several trivalent radiometals (gallium-68, scandium-44, and lutetium-177) was systematically investigated...
May 10, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29737156/a-comprehensive-study-of-poly-2-3-5-6-tetrafluoroaniline-from-electrosynthesis-to-heterojunctions-and-ammonia-sensing
#8
Mickaël Mateos, Rita Meunier-Prest, Olivier Heintz, Frederic Herbst, Jean-Moïse Suisse, Marcel Bouvet
In this work, we report for the first time on a comprehensive study of poly(2,3,5,6-tetrafluoroaniline (PTFANI). Contrary to the non fluorinated polyaniline or its analogues bearing one fluorine atom, PTFANI is a poorly conductive material. We present a comprehensive study of the electrosynthesized PTFANI from its monomer in acidic aqueous medium. PTFANI was fully characterized by a potential-pH diagram, spectroelectrochemistry, and electrochemical quartz crystal microbalance (EQCM) measurements, as well as by a morphological study...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29734118/multidose-formulation-of-ready-to-use-177-lu-psma-617-in-a-centralized-radiopharmacy-set-up
#9
Sudipta Chakraborty, K V Vimalnath, Rubel Chakravarty, H D Sarma, Ashutosh Dash
Lutetium-177-labeled PSMA inhibitor has emerged as a promising modality for targeted therapy of prostate carcinoma. A protocol for regular multidose formulation of ready-to-use 177 Lu-PSMA-617 has been developed based on detailed and systematic radiochemical investigations. The formulation meets the requirements of clinical use and can be shipped to nuclear medicine centres for administration up to 4 days from the date of formulation. The reported protocol would be useful toward facilitating widespread clinical utilization of 177 Lu-PSMA-617 in the management of prostate cancer...
April 26, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29731479/newly-developed-positron-emission-mammography-pem-device-for-the-detection-of-small-breast-cancer
#10
Ai Yanai, Masatoshi Itoh, Hisashi Hirakawa, Kazuhiko Yanai, Manabu Tashiro, Ryuichi Harada, Akira Yoshikawa, Seiichi Yamamoto, Noriaki Ohuchi, Takanori Ishida
Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT)...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29708636/securing-a-supramolecular-architecture-by-tying-a-stopper-knot
#11
David Leigh, Lucian Pirvu, Fredrik Schaufelberger, Daniel J Tetlow, Liang Zhang
We report on a rotaxane-like architecture secured by the in situ tying of an overhand knot in the tris(2,6-pyridyldicarboxamide) region of the axle through complexation with a lanthanide ion (Lu3+). The increase in steric bulk caused by the knotting entanglement locks a crown ether onto the thread. Removal of the lutetium ion unties the knot and, if the axle binding site for the ring is deactivated, the macrocycle spontaneously de-threads. If the binding interaction is switched on again, the crown ether re-threads over the 10 nm length of the untangled strand...
April 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29695720/blackbody-radiation-shift-assessment-for-a-lutetium-ion-clock
#12
K J Arnold, R Kaewuam, A Roy, T R Tan, M D Barrett
The accuracy of state-of-the-art atomic clocks is derived from the insensitivity of narrow optical atomic resonances to environmental perturbations. Two such resonances in singly ionized lutetium have been identified with potentially lower sensitivities compared to other clock candidates. Here we report measurement of the most significant unknown atomic property of both transitions, the static differential scalar polarizability. From this, the fractional blackbody radiation shift for one of the transitions is found to be -1...
April 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29682195/results-and-adverse-events-of-personalized-peptide-receptor-radionuclide-therapy-with-90-yttrium-and-177-lutetium-in-1048-patients-with-neuroendocrine-neoplasms
#13
Richard P Baum, Harshad R Kulkarni, Aviral Singh, Daniel Kaemmerer, Dirk Mueller, Vikas Prasad, Merten Hommann, Franz C Robiller, Karin Niepsch, Holger Franz, Arthur Jochems, Philippe Lambin, Dieter Hörsch
Introduction: Peptide receptor radionuclide therapy (PRRT) of patients with somatostatin receptor expressing neuroendocrine neoplasms has shown promising results in clinical trials and a recently published phase III study. Methods: In our center, 2294 patients were screened between 2004 and 2014 by 68 Ga somatostatin receptor (SSTR) PET/CT. Intention to treat analysis included 1048 patients, who received at least one cycle of 90 Yttrium or 177 Lutetium-based PRRT...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29675259/successful-neoadjuvant-peptide-receptor-radionuclide-therapy-for-an-inoperable-pancreatic-neuroendocrine-tumour
#14
Tiago Nunes da Silva, M L F van Velthuysen, Casper H J van Eijck, Jaap J Teunissen, J Hofland, Wouter W de Herder
Non-functional pancreatic neuroendocrine tumours (NETs) can present with advanced local or distant (metastatic) disease limiting the possibility of surgical cure. Several treatment options have been used in experimental neoadjuvant settings to improve the outcomes in such cases. Peptide receptor radionuclide therapy (PPRT) using beta emitting radiolabelled somatostatin analogues has been used in progressive pancreatic NETs. We report a 55-year-old female patient with a 12.8 cm pancreatic NET with significant local stomach and superior mesenteric vein compression and liver metastases...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29671080/-lutetium-177-psma-radioligand-therapy-consensus-within-the-framework-of-gkv-funded-care-between-the-university-hospitals-in-aachen-bonn-d%C3%A3-sseldorf-essen-and-cologne-and-the-mdk-nordrhein
#15
REVIEW
H Ahmadzadehfar, P Albers, A Bockisch, M Boegemann, C Böhme, W Burchert, M Dietlein, A Drzezga, U Fabry, G Feldmann, A Heidenreich, A Heinzel, K Herrmann, A Heyll, C Höhling, C Kreuzer, D Laufer, R Mengel, F M Mottaghy, H-W Müller, S C Müller, E Ost, K Rahbar, W Reifenhäuser, M Schäfers, C Schlenkhoff, M Schmidt, I Schmidt-Wolf, C Wildenhain, B Zimmer, M Essler
In the last 3 years, Lutetium-177 prostate-specific membrane antigen radioligand therapy (Lu-177-PSMA-RLT) has received increasing attention in nuclear medicine as a new form of treatment for castration-resistant metastatic prostate cancer. This therapy combines the radionuclide Lutetium-177, which has been therapeutically used in nuclear medicine for many years, with a molecular target of the transmembrane prostate-specific membrane antigen expressed by prostate cancer cells. Since there are no prospective randomized studies on Lu-177-PSMA-RLT and the question of reimbursement has repeatedly been the subject of review by the MDK Nordrhein (Medischenische Dienst der Krankenversicherung), there was a desire because of the increasing number of patients being treated to clarify under which circumstances Lu-177-PSMA-RLT can be reimbursed by German statutory health insurance...
April 18, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29622939/pharmaceutical-approval-update
#16
Mary Choy
Netarsudil ophthalmic solution (Rhopressa) for the reduction of elevated intraocular pressure; ertugliflozin (Steglatro) for adults with type-2 diabetes; and lutetium lu 177 dotatate (Lutathera) for certain gastroenteropancreatic neuroendocrine tumors.
April 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29565650/recent-advances-in-theranostics-and-challenges-for-the-future
#17
J Harvey Turner
Theranostic nuclear oncology is on the cusp of adoption into routine clinical management of neuroendocrine tumours (NETs) following publication of the Phase 3 randomised controlled trial, NETTER-1. For the first time, level 1b evidence of efficacy and safety of 68-gallium/177-lutetium-DOTA-octreotate peptide receptor radionuclide therapy, of mid-gut neuroendocrine tumours was established. Multicentre Phase 2 studies of 68-gallium/177-lutetium-prostate specific membrane antigen theranostic approaches to management of end-stage metastatic castrate-resistant prostate cancer, are also very encouraging...
March 29, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29563507/in-situ-measurements-of-rare-earth-elements-in-deep-sea-sediments-using-nuclear-methods
#18
Jasmina Obhođaš, Davorin Sudac, Ilker Meric, Helge E S Pettersen, Milivoj Uroić, Karlo Nađ, Vlado Valković
The prospecting activities for finding new rare earth elements (REE) sources have increased greatly in recent years. One of the main discoveries was announced in 2011 by Japanese researchers who found large quantities of REE on the ocean seafloor at the sea depths greater than 4,000 m. The classic approach to investigate REE in deep sea sediments is to obtain sediment samples by drilling that is followed by laborious laboratory analysis. This is very expensive, time consuming and not appropriate for exploring vast areas...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29528911/the-effect-of-kidney-volume-estimation-on-dosimetry-in-lutetium-177-dotatate-therapy
#19
Lucy F Matthews, Ivor W Jones
BACKGROUND: The kidneys are the dose-limiting organ in lutetium-177 DOTATATE therapy. Therefore, it is advisable to perform critical organ dosimetry focussed on renal dose in treated patients. A key uncertainty in such dose estimates is the use of standard phantoms to represent the individual patient. The primary aim of this study was to investigate the accuracy of methods for estimating kidney size, and hence absorbed kidney dose, by comparison with individual measurements from computed tomography (CT) imaging...
June 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29523427/physiologic-distribution-of-psma-ligand-in-salivary-glands-and-seromucous-glands-of-the-head-and-neck-on-pet-ct
#20
Thomas J W Klein Nulent, Matthijs H Valstar, Bart de Keizer, Stefan M Willems, Laura A Smit, Abrahim Al-Mamgani, Ludwig E Smeele, Robert J J van Es, Remco de Bree, Wouter V Vogel
OBJECTIVES: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is used for detection and (re)staging of prostate cancer. However, healthy salivary, seromucous, and lacrimal glands also have high PSMA-ligand uptake. This study aimed to describe physiologic PSMA-ligand uptake distribution characteristics in the head and neck to aid in PSMA PET/CT interpretation and to identify possible new clinical applications for PSMA-ligand imaging. STUDY DESIGN: Thirty consecutive patients who underwent PSMA PET/CT for prostate cancer were evaluated...
May 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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