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Lucy F Matthews, Ivor W Jones
BACKGROUND: The kidneys are the dose-limiting organ in lutetium-177 DOTATATE therapy. Therefore, it is advisable to perform critical organ dosimetry focussed on renal dose in treated patients. A key uncertainty in such dose estimates is the use of standard phantoms to represent the individual patient. The primary aim of this study was to investigate the accuracy of methods for estimating kidney size, and hence absorbed kidney dose, by comparison with individual measurements from computed tomography (CT) imaging...
March 9, 2018: Nuclear Medicine Communications
Thomas J W Klein Nulent, Matthijs H Valstar, Bart de Keizer, Stefan M Willems, Laura A Smit, Abrahim Al-Mamgani, Ludwig E Smeele, Robert J J van Es, Remco de Bree, Wouter V Vogel
OBJECTIVES: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is used for detection and (re)staging of prostate cancer. However, healthy salivary, seromucous, and lacrimal glands also have high PSMA-ligand uptake. This study aimed to describe physiologic PSMA-ligand uptake distribution characteristics in the head and neck to aid in PSMA PET/CT interpretation and to identify possible new clinical applications for PSMA-ligand imaging. STUDY DESIGN: Thirty consecutive patients who underwent PSMA PET/CT for prostate cancer were evaluated...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Aaron D Lammer, Grégory Thiabaud, James T Brewster, Julie Alaniz, Jon A Bender, Jonathan L Sessler
Here, we report the use of gadolinium(III)-, lutetium(III)-, and lanthanum(III)-texaphyrins as bioinspired photocatalysts that promote a novel approach to the degradation of curcumin, a 1,3-diketo-containing natural product. Complexation of curcumin to the lanthanide centers of the texaphyrins yields stable species that display limited reactivity in the dark or under anaerobic conditions. However, upon exposure to mWatt intensity light (pocket flashlight) or simply under standard laboratory illumination in the presence of atmospheric oxygen, substrate oxidation occurs readily to generate curcumin-derived cleavage products...
March 2, 2018: Inorganic Chemistry
Marc Debliquy, Driss Lahem, Antonio Bueno-Martinez, Christophe Caucheteur, Marcel Bouvet, Isaline Recloux, Jean-Pierre Raskin, Marie-Georges Olivier
In this article, we describe a NO₂ sensor consisting of a coating based on lutetium bisphthalocyanine (LuPc₂) in mesoporous silica. The sensor exploits the absorption spectrum change of this material which strongly and reversibly decreases in contact with NO₂. NO₂ is measured by following the amplitude change in the reflected spectrum of the coating deposited on the tip of a silica fibre. As diffusion of NO₂ in LuPc₂ is slow, the response time could be slow. To reduce it, the active molecules are dispersed in a mesoporous silica matrix deposited by a sol-gel process (Evaporation Induced Self Assembly) avoiding the formation of large crystals...
March 1, 2018: Sensors
Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor, Frank Rösch
BACKGROUND: In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse DOTA-linker systems were conjugated in different amounts to HPMA homopolymers to coordinate trivalent radiometals Me(III)* = gallium-68, scandium-44, and lutetium-177. RESULTS: Short linkers and as low as 1...
February 27, 2018: EJNMMI Research
(no author information available yet)
The FDA recently approved the radiopharmaceutical lutetium Lu 177 dotatate to treat patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors. The approval was based on results of the phase III NETTER-1 trial.
February 27, 2018: Cancer Discovery
Hanna Napieczynska, Armin Kolb, Prateek Katiyar, Matteo Tonietto, Minhaz Ud-Dean, Ramona Stumm, Kristina Herfert, Carsten Calaminus, Bernd Pichler
The goal of this study was to validate the use of a magnetic resonance-compatible blood sampler (BS) with the detector system based on lutetium oxyorthosilicate scintillator and avalanche photodiodes for small animal positron emission tomography (PET). Methods: Five rats underwent a 60 min18 F-FDG study. For each animal, the arterial input function (AIF) was derived from the BS recording, from manual blood sampling (MS) and from the PET image. These AIFs were used for kinetic modelling of the striatum using the two tissue irreversible compartment model...
February 23, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Shelvin Kumar Vadi, Rajender Kumar, Bhagwant Rai Mittal, Ashwin Singh Parihar, Shrawan Kumar Singh
An 85-year-old man with prostate cancer for metastatic workup underwent Gallium Prostate-Specific Membrane Antigen (Ga-PSMA) PET/CT (Ga-PSMA PET/CT), which revealed unusual tracer uptake in the shaft and glans of penis as well as multiple systemic metastases in liver, skeletal, and lymph nodes. The penile lesion was proved to be metastatic adenocarcinoma from prostate on fine needle aspiration cytology. The patient underwent Lutetium (Lu)-labeled PSMA radioligand therapy, which also revealed diffuse tracer uptake in the penile shaft as well as other metastatic sites...
February 21, 2018: Clinical Nuclear Medicine
Lars Öhrström
No abstract text is available yet for this article.
February 20, 2018: Nature Chemistry
Jiří Chmela, Jean-Francois Greisch, Michael E Harding, Wim Klopper, Manfred M Kappes, Detlef Schooss
The gas-phase laser-induced photoluminescence of cationic mononuclear gadolinium and lutetium complexes involving two 9-oxo-phenalen-1-one ligands is reported. Performing measurements at a temperature of 83 K enables to resolve vibronic transitions. Via comparison to Franck-Condon computations, the main vibrational contributions to the ligand-centered phosphorescence are determined to involve rocking, wagging, and stretching of the 9-oxophenalen-1-one-lanthanoid coordination in the low energy range, intraligand bending and stretching in the medium to high energy range, rocking of the carbonyl and methine groups, as well as C-H stretching beyond...
February 16, 2018: Journal of Physical Chemistry. A
Suleman Surti, Joel S Karp
The advent of silicon photomultipliers (SiPMs) has introduced the possibility of increased detector performance in commercial whole-body PET scanners. The primary advantage of these photodetectors is the ability to couple a single SiPM channel directly to a single pixel of PET scintillator that is typically 4 mm wide (one-to-one coupled detector design). We performed simulation studies to evaluate the impact of three different event positioning algorithms in such detectors: i) a weighted energy centroid positioning (Anger logic), ii) identifying the crystal with maximum energy deposition (1<sup>st</sup> max crystal), and iii) identifying the crystal with second highest energy deposition (2<sup>nd</sup> max crystal)...
February 7, 2018: Physics in Medicine and Biology
Agnieszka Zielinska, Atsuro Takai, Hiroya Sakurai, Akinori Saeki, Marcin Leonowicz, Takashi Nakanishi
Synthesis and characterization of a novel, multifunctional, solvent-free room-temperature liquid based on alkylated double-decker lutetium (III) phthalocyanine (Pc₂Lu) are described. Lowering of the melting point and viscosity of intrinsically solid Pc₂Lu compounds has been achieved through the attachment of flexible, bulky, and long branched-alkyl chains, i.e. 2-octyldodecyl, to the periphery of the Pc₂Lu unit. The embedded Pc₂Lu unit maintains its inherent molecular functions, such as spin-active nature and electrochromic behavior in the liquid state...
January 31, 2018: Chemistry, An Asian Journal
Fabian P Schmidt, Armin Kolb, Bernd J Pichler
This study depicts the evaluation of a SiPM detector with depth of interaction (DOI) capability via a dual-sided readout that is suitable for high-resolution positron emission tomography and magnetic resonance (PET/MR) imaging. Two different 12×12 pixelated LSO scintillator arrays with a crystal pitch of 1.60 mm are examined. One array is 20 mm-long with a crystal separation by the specular reflector Vikuiti Enhanced Specular Reflector (ESR), and the other one is 18 mm-long and separated by the diffuse reflector Lumirror E60 (E60)...
January 31, 2018: Physics in Medicine and Biology
Devin John Van Elburg, Scott D Noble, Simone Hagey, Andrew L Goertzen
Optical coupling is an important factor in detector design as it improves optical photon transmission by mitigating internal reflections at light-sharing boundaries. In this work we compare optical coupling materials, namely double-sided acrylic polymer tapes and silicone optical grease (SiG), in the context of positron emission tomography (PET). Four double-sided tapes from 3M of varying thicknesses (0.229mm-1.016mm) and adhesive materials ('100MP', adhesive 100 'A100', 'VHB') were characterized with spectrophotometer measurements and photopeak amplitude and energy resolution measurements using lutetium-yttrium oxy-orthosilicate (LYSO) coupled to photomultiplier tubes (PMT) or silicon photomultipliers (SiPMs)...
January 16, 2018: Physics in Medicine and Biology
Makoto Hosono, Hideharu Ikebuchi, Yoshihide Nakamura, Nobutaka Nakamura, Takahiro Yamada, Sachiko Yanagida, Asami Kitaoka, Kiyotaka Kojima, Hiroyasu Sugano, Seigo Kinuya, Tomio Inoue, Jun Hatazawa
Here we present the guideline for the treatment of neuroendocrine tumors using Lu-177-DOTA-TATE on the basis of radiation safety aspects in Japan. This guideline was prepared by a study supported by Ministry of Health, Labour, and Welfare, and approved by Japanese Society of Nuclear Medicine. Lu-177-DOTA-TATE treatment in Japan should be carried out according to this guideline. Although this guideline is applied in Japan, the issues for radiation protection shown in this guideline are considered internationally useful as well...
January 15, 2018: Annals of Nuclear Medicine
Michael S Hofman, Rodney J Hicks, Tobias Maurer, Matthias Eiber
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is overexpressed in prostate cancer. Radiolabeled small molecules that bind with high affinity to its active extracellular center have emerged as a potential new diagnostic standard of reference for prostate cancer, resulting in images with extraordinary tumor-to-background contrast. Currently, gallium 68 (68 Ga)-PSMA-11 (or HBED-PSMA) is the most widely used radiotracer for PSMA positron emission tomography (PET)/computed tomography (CT) or PSMA PET/magnetic resonance (MR) imaging...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Grzegorz Wójciuk, Marcin Kruszewski
BACKGROUND: Ghrelin is a peptide consisting of 28 aminoacids and an octadecyl side chain (acyl group) binding to the growth hormone secretagogue receptor type 1a (GHS-R1a). Its des-acylated form, des-acyl ghrelin (DAG) binds to the corticotropin releasing factor receptor type 2a (CRF2a) located on endocrine cancer cells such as the prostate carcinoma cell line DU 145. AIM: The aim of this study is to develop a new DAG-based carrier of radionuclides with potential application in therapy...
February 2018: Nuclear Medicine Communications
Anastassia Löser, Sarah M Schwarzenböck, Martin Heuschkel, Holger S Willenberg, Bernd J Krause, Jens Kurth
OBJECTIVES: Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (Lu)-DOTATATE is regarded as a safe treatment option with promising results for patients with neuroendocrine neoplasia (NEN). We aimed to study the absorbed organ and tumor doses, the renal and hematological toxicity as well as their mutual interaction. Another aim was the identification of adverse effects as possible predictors which may affect survival. METHODS: A total of 30 (14 female and 16 male) patients with inoperable/metastatic NEN were treated with 7...
March 2018: Nuclear Medicine Communications
Justin Ferdinandus, John Violet, Shahneen Sandhu, Michael S Hofman
PURPOSE OF REVIEW: Prostate-specific membrane antigen (PSMA) theranostics offers a new approach for a personalized and targeted treatment for metastatic prostate cancer. Lutetium-177-labelled PSMA-ligands (Lu-PSMA) is a radionuclide therapy that is directed to PSMA expressing prostate cancer. Clinical experience with Lu-PSMA in men with advanced prostate cancer is growing. The purpose of this review is to outline the mechanism of action of this therapy, summarize recent efficacy and toxicity data and highlight future direction and challenges in establishing Lu-PSMA treatment as part of routine clinical practice...
December 22, 2017: Current Opinion in Urology
Christian Turra
Rare earth elements (REE) are a group of chemical elements that include lanthanoids (lanthanum to lutetium), scandium and yttrium. In the last decades, the REE demand in the industry and other areas has increased significantly. In general, REE have shown low concentrations in soils, plants, water and atmosphere, but they may accumulate in such environments due to anthropogenic inputs. In areas where there is REE contamination, the slow accumulation of these elements in the environment could become problematic...
December 15, 2017: International Journal of Environmental Health Research
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