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Krzysztof Lyczko
A new polymorph of the title compound, [Re(NCS)(C7H8N2O)(CO)3], crystallizing in the space group P21/n, has been obtained and structurally characterized by the experiment and DFT calculations. In this complex, the rhenium(I) cation is octa-hedrally coordinated by three carbonyl groups in a facial configuration, the N,O-bidentate N-methyl-pyridine-2-carboxamide ligand and the N-bonded thio-cyanate anion. Neighbouring mol-ecules are linked into a three-dimensional network by inter-molecular N-H⋯S and C-H⋯S inter-actions...
October 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
David S Geller, Jonathan Morris, Ekaterina Revskaya, Mani Kahn, Wendong Zhang, Sajida Piperdi, Amy Park, Pratistha Koirala, Hillary Guzik, Charles Hall, Bang Hoang, Rui Yang, Michael Roth, Jonathan Gill, Richard Gorlick, Ekaterina Dadachova
INTRODUCTION: Osteosarcoma overall survival has plateaued around 70%, without meaningful improvements in over 30years. Outcomes for patients with overt metastatic disease at presentation or who relapse are dismal. In this study we investigated a novel osteosarcoma therapy utilizing radioimmunotherapy (RIT) targeted to IGF2R, which is widely expressed in OS. METHODS: Binding efficiency of the Rhenium-188((188)Re)-labeled IGF2R-specific monoclonal antibody (mAb) to IGF2R on OS17 OS cells was assessed with Scatchard plot analysis...
July 30, 2016: Nuclear Medicine and Biology
Shaodong Zhou, Jilai Li, Maria Schlangen, Helmut Schwarz
The thermal reaction of the diatomic rhenium nitride cation [ReN](+) with methane has been explored using FT-ICR mass spectrometry complemented by high-level quantum chemical calculations. Mechanistic aspects of the reaction have been addressed to uncover scenarios for the competitive generation of a methylene and a hydrogen cyanide ligand attached to the rhenium center. The role the nitrogen atom plays in the reactive [ReN](+) /CH4 couple is elucidated, and the cause of the rather different reactivities of [ReN](+) and its lighter congener [MnN](+) is revealed...
October 11, 2016: Angewandte Chemie
M P Coogan, J A Platts
fac-[Re(CO)3(dppz)] complexes of amido ligands generated in situ under basic conditions display an intense (ε = 16460 L mol(-1) cm(-1)) absorption band between 500-700 nm which are assigned to an n(amido,RNH-) → π* (dppz) inter-ligand charge transfer band offering an extraordinarily low energy charge separating absorption with potential for imaging and energy application.
October 13, 2016: Chemical Communications: Chem Comm
Sonia B Jiménez-Pulido, Nuria A Illán-Cabeza, Francisco Hueso-Ureña, Carmen R Maldonado, Purificación Sánchez-Sánchez, M Paz Fernández-Liencres, Manuel Fernández-Gómez, Miguel N Moreno-Carretero
The synthesis, structure and CO-releasing properties of a number of new tricarbonyl rhenium(i) complexes with 5-substituted-6-amino-1,3-dimethyluracils are reported and their structural features discussed on the basis of both spectral and X-ray crystallographic analyses. The 5-substituent library includes -N[double bond, length as m-dash]CH-2py (DAAUPic) and -CH[double bond, length as m-dash]N-N[double bond, length as m-dash]CH-2py (FDUHzPic) as additional metal binding components and chloride, acetonitrile or pyridine acting as ancillary ligands...
September 27, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Andrew T Lech, Christopher L Turner, Jialin Lei, Reza Mohammadi, Sarah H Tolbert, Richard B Kaner
Rhenium diboride (ReB2), containing corrugated layers of covalently bonded boron, is a superhard, metallic compound with a micro-hardness reaching as high as 40.5 GPa (under an applied load of 0.49 N). Tungsten diboride (WB2), which takes a structural hybrid between that of ReB2 and AlB2, where half of the boron layers are planar (as in AlB2) and half are corrugated (as in ReB2), has been shown to not be superhard. Here, we demonstrate that the ReB2-type structure can be maintained for solid solutions of tungsten in rhenium diboride with tungsten content up to a surprisingly large limit of nearly 50 at...
October 10, 2016: Journal of the American Chemical Society
David Santamaría-Pérez, Chris McGuire, Adam Makhluf, Abby Kavner, Raquel Chuliá-Jordán, Julio Pellicer-Porres, Domingo Martinez-García, Andrew Doran, Martin Kunz, Plácida Rodríguez-Hernández, Alfonso Muñoz
The role of carbon dioxide, CO2, as oxidizing agent at high pressures and temperatures is evaluated by studying its chemical reactivity with three transition metals: Au, Pt, and Re. We report systematic X-ray diffraction measurements up to 48 GPa and 2400 K using synchrotron radiation and laser-heating diamond-anvil cells. No evidence of reaction was found in Au and Pt samples in this pressure-temperature range. In the Re + CO2 system, however, a strongly-driven redox reaction occurs at P > 8 GPa and T > 1500 K, and orthorhombic β-ReO2 is formed...
October 6, 2016: Inorganic Chemistry
Joohoon Kang, Vinod K Sangwan, Joshua D Wood, Xiaolong Liu, Itamar Balla, David Lam, Mark C Hersam
Isopycnic density gradient ultracentrifugation (iDGU) has been widely applied to sort nanomaterials by their physical and electronic structure. However, the commonly used density gradient medium iodixanol has a finite maximum buoyant density that prevents the use of iDGU for high-density nanomaterials. Here, we overcome this limit by adding cesium chloride (CsCl) to iodixanol, thus increasing its maximum buoyant density to the point where the high-density two-dimensional nanomaterial rhenium disulfide (ReS2) can be sorted in a layer-by-layer manner with iDGU...
October 4, 2016: Nano Letters
Dustin Wayne Demoin, Ashley N Dame, William D Minard, Fabio Gallazzi, Gary L Seickman, Tammy L Rold, Nicole Bernskoetter, Michael E Fassbender, Timothy J Hoffman, Carol A Deakyne, Silvia S Jurisson
INTRODUCTION: Targeted radiotherapy using the bifunctional chelate approach with (186/188)Re(V) is challenging because of the susceptibility of monooxorhenium(V)-based complexes to oxidize in vivo at high dilution. A monoamine-monoamide dithiol (MAMA)-based bifunctional chelating agent was evaluated with both rhenium and technetium to determine its utility for in vivo applications. METHODS: A 222-MAMA chelator, 222-MAMA(N-6-Ahx-OEt) bifunctional chelator, and 222-MAMA(N-6-Ahx-BBN(7-14)NH2) were synthesized, complexed with rhenium, radiolabeled with (99m)Tc and (186)Re (carrier added and no carrier added), and evaluated in initial biological distribution studies...
August 31, 2016: Nuclear Medicine and Biology
Richard D Adams, Poonam Dhull, Vitaly Rassolov, Yuen Onn Wong
The electronically unsaturated compounds Re2(CO)8[μ-Au(NHC)](μ-Ph), 1, and Re2(CO)8[μ-Au(NHC)]2, 2, were obtained from the reaction of Re2(CO)8[μ-η(2)-C(H)═C(H)Bu(n)](μ-H) with MeAu(NHC), NHC = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene. Compound 1 was converted to the new compound Re2(CO)8[μ-Au(NHC)](μ-H), 3, by reaction with H2. Addition of CO to 3 yielded the new compound Re2(CO)9[Au(NHC)](μ-H), 4, which contains a terminally coordinated Au(NHC) group on one of the rhenium atoms, and the hydrido ligand was shifted to bridge the Re-Au bond...
October 17, 2016: Inorganic Chemistry
Xiaoyang Zhang, Pingrong Yu, Yanping Yang, Yaqin Hou, Cheng Peng, Zhigang Liang, Jing Lu, Baian Chen, Jiapei Dai, Boli Liu, Mengchao Cui
A series of 2-arylbenzothiazole derivatives conjugated with bis(aminoethanethiol) (BAT) chelating groups were designed and synthesized. A competitive binding assay-based screening was used to select seven rhenium complexes with potent binding affinity toward Aβ1-42 aggregates (Ki < 50 nM) for (99m)Tc labeling and further evaluation. The (99m)Tc-labeled probes showed good affinity and specificity to Aβ plaques in Tg mouse brain tissue in in vitro autoradiography studies. Moreover, [(99m)Tc]14b exhibited favorable brain pharmacokinetics in normal mice (2...
October 7, 2016: Bioconjugate Chemistry
Jun Nishida, Chang Yan, Michael D Fayer
Polarization-selective angle-resolved infrared pump-probe spectroscopy was developed and used to study the orientational dynamics of a planar alkylsiloxane monolayer functionalized with a rhenium metal carbonyl headgroup on an SiO2 surface. The technique, together with a time-averaged infrared linear dichroism measurement, characterized picosecond orientational relaxation of the headgroup occurring at the monolayer-air interface by employing several sets of incident angles of the infrared pulses relative to the sample surface...
October 12, 2016: Journal of the American Chemical Society
Amy M Wagner, Sarah A Strohecker, Elizabeth K Costello, Jeffrey A Rood, Kristi A Kneas
Osmium transition metal complexes are of particular interest in luminescence-based sensing applications because of their longer wavelength absorptions and emissions, relative to similar ruthenium and rhenium complexes, that allow for inexpensive excitation and minimize interferences from autofluorescence when the sensor is used in biological samples. Reported here are the photophysical properties of a series of water-soluble osmium complexes suitable for use in hydrogel-based sensors: [Os(bpy)2(sulf-dpp)]Cl2, [Os(phen)2(sulf-dpp)]Cl2, [Os(dpp)2(sulf-dpp)]Cl2, and [Os(CO)2Cl2(sulf-dpp)], where bpy is 2,2'-bipyridine, phen is 1,10-phenanthroline, dpp is 4,7-diphenyl-1,10-phenanthroline, and sulf-dpp is bathophenanthrolinedisulfonic acid disodium salt...
September 23, 2016: Journal of Fluorescence
Yanli Li, Yan Hu, Jie Xiao, Guobing Liu, Xiao Li, Yanzhao Zhao, Hui Tan, Hongcheng Shi, Dengfeng Cheng
SP94 (SFSIIHTPILPL), a novel peptide, has shown specific binding to hepatocellular carcinoma (HCC) cells. We aimed to investigate the capability of SP94 as a targeting probe for HCC imaging and therapy following labeling with technetium-99m ((99m)Tc) and rhenium-188 ((188)Re). HYNIC-SP94 was prepared by solid phase synthesis and then labeled with (99m)Tc. Cell competitive binding, internalization assay, in vitro and in vivo stability, biodistribution and micro-single photon emission computed tomography /computed tomography (SPECT/CT) imaging studies were performed to investigate the capability of (99m)Tc tricine-EDDA/HYNIC-SP94 as a specific HCC imaging probe...
2016: Scientific Reports
Jianhua Jia, Kaixiang Zhou, Jiapei Dai, Boli Liu, Mengchao Cui
An array of complexes, (99m)Tc/Re-labeled cyclopentadienyl tricarbonyl and 2-phenyl/pyridylbenzothiazoles, conjugated through an ester linkage were tested as potential β-amyloid (Aβ) probes for SPECT imaging. The [CpRe/(99m)Tc(CO)3] complexes were prepared by double ligand transfer reactions from ferrocene precursors, and the X-ray structure of one rhenium surrogate revealed a classical "piano stool" like geometry. Several of the rhenium complexes displayed high affinity for Aβ1-42 aggregates in in vitro inhibition assays, and they could intensely stain Aβ deposits on brain sections from transgenic mice and Alzheimer's disease (AD) patients...
September 2, 2016: European Journal of Medicinal Chemistry
Barbara V da Silva, Bianca N M Silva
BACKGROUND: Trypanosomiasis and leishmaniasis cause severe infections in humans and domestic animals in the tropics. Although typical diseases in Latin America, globalization and the migration of infected people has spread these diseases to countries in North America, Asia and Europe. Currently available drugs are not effective in the chronic phase, as well as causing side effects and the development of resistance. RESULTS: Among the chemical groups studied as potential anti-T...
September 9, 2016: Medicinal Chemistry
Hirendra Nath Banerjee, Ava Boston, Alexis Barfield, Monet Stevenson, Fazlul H Sarkar, Dipak Giri, Angela Winstead, Jeanette A Krause, Santosh K Mandal
No abstract text is available yet for this article.
July 2016: International Journal of Scientific Research (Ahmedabad, India)
Angelo Frei, David Sidler, Pennie Mokolokolo, Henrik Braband, Thomas Fox, Bernhard Spingler, Andreas Roodt, Roger Alberto
The self-exchange kinetics of CO ligands in the solvated forms of the commonly used complex [MBr3(CO)3](2-) (M = Re, (99)Tc) were investigated in-depth by (13)C NMR spectroscopy in organic solvents such as dimethylformamide and methanol. The two homologues exhibit surprisingly different chemical behavior. In the case of rhenium, the stable intermediate [NEt4][ReBr2(CO)4] was isolated and characterized by (13)C NMR and IR spectroscopy as well as by single-crystal X-ray diffraction. For technetium, no such intermediate could be identified...
September 19, 2016: Inorganic Chemistry
Liang-Ting Lin, Chun-Yuan Chang, Chih-Hsien Chang, Hsin-Ell Wang, Shih-Hwa Chiou, Ren-Shyan Liu, Te-Wei Lee, Yi-Jang Lee
Human head and neck squamous cell carcinoma (HNSCC) is usually treated by surgical resection with adjuvant radio-chemotherapy. In this study, we examined whether the radiopharmaceutical 188Re-liposome could suppress the growth of HNSCC followed by an investigation of molecular mechanisms. The orthotopic HNSCC tumor model was established by human hypopharyngeal FaDu carcinoma cells harboring multiple reporter genes. The drug targeting and therapeutic efficacy of 188Re-liposome were examined using in vivo imaging, bio-distribution, pharmacokinetics, and dosimetry...
August 29, 2016: Oncotarget
Min Zhang, Shuo Shi, Rui Guo, Yin Miao, Biao Li
Although survival rates for cervical cancer have improved, they need further improvement in patients with distant metastases. The sodium iodine symporter (NIS) gene has often been used in cancer therapy and imaging. We examined the therapeutic effects of rhenium-188 (188Re) in a cervical cancer xenograft model expressing the NIS gene under the control of the tumor-specific human telomerase reverse transcriptase (hTERT) promoter. We constructed two recombinant lentiviral vectors expressing enhanced green fluorescent protein (eGFP) or the NIS gene driven by the hTERT promoter...
October 2016: Oncology Reports
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