Harry Ramcharran, Jason H T Bates, Joshua Satalin, Sarah Blair, Penny L Andrews, Donald P Gaver, Louis A Gatto, Guirong Wang, Auyon J Ghosh, Benjamin Robedee, James Vossler, Nader M Habashi, Nirav Daphtary, Michaela Kollisch-Singule, Gary F Nieman
Ventilator-induced lung injury (VILI) is a significant risk for patients with acute respiratory distress syndrome (ARDS). Management of the patient with ARDS is currently dominated by the use of low tidal volume mechanical ventilation, the presumption being that this mitigates overdistension (OD) injury to the remaining normal lung tissue. Evidence exists, however, that it may be more important to avoid cyclic recruitment and derecruitment (RD) of lung units, although the relative roles of OD and RD in VILI remain unclear...
November 1, 2022: Journal of Applied Physiology