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https://www.readbyqxmd.com/read/28103109/impaired-spermatogenesis-in-the-twitcher-mouse-a-morphological-evaluation-from-the-seminiferous-tubules-to-epididymal-transit
#1
Alice Luddi, Martina Gori, Laura Crifasi, Camilla Marrocco, Giuseppe Belmonte, Elvira Costantino-Ceccarini, Piomboni Paola
: Spermatogenesis is a complex process of proliferation and differentiation during male germ cell development whereby undifferentiated spermatogonial germ cells evolve into maturing spermatozoa. In this developmental process the interactions between different cell types are finely regulated, hence any disruption in these relationships leads to male infertility. The twitcher mouse, the murine model of Krabbe disease, is characterized by deficiency of galactosylceramidase, an enzyme also involved in the metabolism of the galactosyl-alkyl-acyl-glycerol, the precursor of sulfogalactosyl-alkyl-acyl-glycerol, the most abundant glycolipid in spermatozoa...
January 19, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28102387/anion-dependent-self-assembly-of-sandwich-13-metal-ni-ln-nanoclusters-with-a-long-chain-schiff-base-ligand
#2
Shiqing Wang, Xiaoping Yang, Jinjie Qian, Qipeng Li, Zhongning Chen, Lijie Zhang, Shaoming Huang, Chengri Wang, Richard A Jones
Two classes of Ni-Ln clusters [Ln4Ni3L3(OAc)6(NO3)3(OH)3] (Ln = Gd (1) and Tb (2)) and [Ln6Ni7L6(OAc)12(OH)6](OH)2 (Ln = Gd (3) and Dy (4)) were prepared using a specifically designed Schiff base ligand built around a flexible (CH2)2O(CH2)2O(CH2)2 chain. 1 and 2 exhibit cone-like structures, while 3 and 4 have nanosized sandwich architectures. The structures were studied by single-crystal X-ray diffraction and TEM, and magnetic properties were investigated.
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102356/unlocking-the-potential-of-sns2-transition-metal-catalyzed-utilization-of-reversible-conversion-and-alloying-reactions
#3
Zhi Xiang Huang, Ye Wang, Bo Liu, Dezhi Kong, Jun Zhang, Tupei Chen, Hui Ying Yang
The alloying-dealloying reactions of SnS2 proceeds with the initial conversion reaction of SnS2 with lithium that produces Li2S. Unfortunately, due to the electrochemical inactivity of Li2S, the conversion reaction of SnS2 is irreversible, which significantly limit its potential applications in lithium-ion batteries. Herein, a systematic understanding of transition metal molybdenum (Mo) as a catalyst in SnS2 anode is presented. It is found that Mo catalyst is able to efficiently promote the reversible conversion of Sn to SnS2...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101144/histopathological-findings-in-systemic-sclerosis-related-myopathy-fibrosis-and-microangiopathy-with-lack-of-cellular-inflammation
#4
Claudio Corallo, Maurizio Cutolo, Nila Volpi, Daniela Franci, Margherita Aglianò, Antonio Montella, Chiara Chirico, Stefano Gonnelli, Ranuccio Nuti, Nicola Giordano
OBJECTIVES: The objective of this study was to identify specific histopathological features of skeletal muscle involvement in systemic sclerosis (SSc) patients. METHODS: A total of 35 out of 112 SSc-patients (32%, including 81% female and 68% diffuse scleroderma) presenting clinical, biological and electromyographic (EMG) features of muscle weakness, were included. Patients underwent vastus lateralis biopsy, assessed for individual pathologic features including fibrosis [type I collagen (Coll-I), transforming growth factor β (TGF-β)], microangiopathy [cluster of differentiation 31 (CD31), pro-angiogenic vascular endothelial growth factor A (VEGF-A), anti-angiogenic VEGF-A165b], immune/ inflammatory response [CD4, CD8, CD20, human leucocyte antigens ABC (HLA-ABC)], and membranolytic attack complex (MAC)...
January 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28100648/multi-scale-structural-analysis-of-plant-er-pm-contact-sites
#5
Heather E McFarlane, Eun Kyoung Lee, Laura S van Bezouwen, Bradford Ross, Abel Rosado, A Lacey Samuels
Membrane contact sites (MCS) are recognized across eukaryotic systems as important nanostructures. Endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCS) are involved in excitation-contraction coupling, signalling, and plant responses to stress. In this report, we perform a multi-scale structural analysis of Arabidopsis EPCS that combine live cell imaging, quantitative transmission electron microscopy (TEM), and electron tomography over a developmental gradient. To place EPCS in the context of the entire cortical ER, we examined GFP-HDEL in living cells over a developmental gradient, then SYT1-GFP was used as a specific marker of EPCS...
January 18, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28099950/nano-particles-assembled-porous-core-shell-znmn2o4-microspheres-with-superb-performance-for-lithium-batteries
#6
Tong Zhang, Huijuan Yue, Hailong Qiu, Wei Yingjin, Chunzhong Wang, Gang Chen, Zhang Dong
Porous ZnMn2O4 microspheres were prepared via a facile co-precipitation method followed by calcination at various temperatures and evaluated as anode materials for Lithium ion batteries. The sample prepared at 600��C outperformed the other samples in terms of electrochemical performance with high reversible capacity, high-rate capability, and excellent cycling performance. The capacity of the sample remained as high as 999 mAh g-1 at a current rate of 100 mA g-1 after 50 cycles ��� one of the best ever reported for ZnMn2O4-based materials...
January 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28099847/leukocytes-breach-endothelial-barriers-by-insertion-of-nuclear-lobes-and-disassembly-of-endothelial-actin-filaments
#7
Sagi Barzilai, Sandeep Kumar Yadav, Steven Morrell, Francesco Roncato, Eugenia Klein, Liat Stoler-Barak, Ofra Golani, Sara W Feigelson, Assaf Zemel, Sussan Nourshargh, Ronen Alon
The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM). Mononuclear and polymorphonuclear leukocytes generate gaps of similar micron-scale size when squeezing through inflamed endothelial barriers in vitro and in vivo. To elucidate how leukocytes squeeze through these barriers, we co-tracked the endothelial actin filaments and leukocyte nuclei in real time. Nuclear squeezing involved either preexistent or de novo-generated lobes inserted into the leukocyte lamellipodia. Leukocyte nuclei reversibly bent the endothelial actin stress fibers...
January 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/28099813/photoactive-donor-acceptor-composite-nanoparticles-dispersed-in-water
#8
Laurie Parrenin, Gildas Laurans, Eleni Pavlopoulou, Guillaume Fleury, Gilles Pecastaings, Cyril Brochon, Laurence Vignau, Georges Hadziioannou, Eric Cloutet
A major issue that inhibits large-scale fabrication of organic solar modules is the use of chlorinated solvents considered as toxic and hazardous. In this work, composite particles of poly[N-9'-heptadecanyl-2,7-carbazole-alt-5,5-(4,7-di-2-thienyl-2',1',3'-benzothiadiazole] (PCDTBT) and [6,6]-Phenyl C71 butyric acid methyl ester (PC71BM) were obtained in water from a versatile and a ready-to-market methodology based on miniemulsion post-polymerization. Depending on experimental conditions, size-controlled particles comprising both the electron-donor and the electron-acceptor were obtained and characterized using transmission electron microscopy (TEM), atomic force microscopic (AFM), small-angle neutron scattering (SANS), UV-visible absorption and fluorescence spectroscopies...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28099664/costs-of-public-pharmaceutical-services-in-rio-de-janeiro-compared-to-farm%C3%A3-cia-popular-program
#9
Rondineli Mendes da Silva, Rosângela Caetano
OBJECTIVE: To analyze the costs of public pharmaceutical services compared to Farmácia Popular Program (Popular Pharmacy Program). METHODS: Comparison between prices paid by Aqui Tem Farmácia Popular Program (Farmácia Popular is available here) with the full costs of medicine provision by the Municipal Health Department of Rio de Janeiro. The comparison comprised 25 medicines supplied by both the municipal pharmaceutical service and Aqui Tem Farmácia Popular Program...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28099551/cholesterol-and-prevention-of-atherosclerotic-events-limits-of-a-new-frontier
#10
Luís Eduardo Teixeira de Macedo, Faerstein E
Control of atherosclerotic cardiovascular disease - a highly prevalent condition and one of the main causes of mortality in Brazil and worldwide - is a recurrent subject of great interest for public health. Recently, three new guidelines on dyslipidemia and atherosclerosis prevention have been published. The close release of these important publications is a good opportunity for comparison: the Brazilian model has greater sensitivity, the English model does not work with risk stratification, and the American model may be overestimating the risk...
January 12, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28099008/critical-analysis-of-rate-constants-and-turnover-frequency-in-nucleic-acid-templated-reactions-reaching-terminal-velocity
#11
Dalu Chang, Eric Lindberg, Nicolas Winssinger
Nucleic acid-templated reactions have attracted significant attention for nucleic acid sensing and imaging. The level of signal amplification obtained from templated reactions is a function of the template turnover, wherein the template acts as the catalyst. Herein, we report the application of a pyridinium linker that immolates upon photocatalytic reduction with a ru-thenium complex to yield the fastest nucleic acid tem-plated reaction reported to date. We show that the tem-plated reaction turnover is limited by the duplex dissoci-ation kinetics beyond probes longer than a 6-mer and proceeded fastest for a 5-mer PNA probe...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28098967/synthesis-of-fluorinated-graphene-coal-layered-double-hydroxide-composites-as-electrode-materials-for-supercapacitors
#12
Weijun Peng, Hongqiang Li, Shaoxian Song
CoAl-layered double hydroxide/fluorinated graphene (CoAl-LDH/FGN) composites were fabricated via a two-step hydrothermal method. The synthesized CoAl-LDH/FGN composites have been characterised by Powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Transmission electron microscopy (TEM), Field-emission scanning electron microscopy (FESEM) and Energy dispersive X-ray spectroscopy (EDS), and Electrochemical measurements. The results indicated that the fluorinated carbon with various configuration forms were grafted onto the framework of graphene, and the C-F bond configuration and fluorine content could be tuned by the fluorination time...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098315/a-ph-responsive-wormlike-micellar-system-of-a-noncovalent-interaction-based-surfactant-with-a-tunable-molecular-structure
#13
Wanli Kang, Pengxiang Wang, Haiming Fan, Hongbin Yang, Caili Dai, Xia Yin, Yilu Zhao, Shujun Guo
Responsive wormlike micelles are very useful in a number of applications, whereas it is still challenging to create dramatic viscosity changes in wormlike micellar systems. Here we developed a pH-responsive wormlike micellar system based on a noncovalent constructed surfactant, which is formed by the complexation of N-erucamidopropyl-N,N-dimethylamine (UC22AMPM) and citric acid at the molar ratio of 3 : 1 (EACA). The phase behavior, aggregate microstructure and viscoelasticity of EACA solutions were investigated by macroscopic appearance observation, rheological and cryo-TEM measurements...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28098229/novel-synthesis-of-zno-pmma-nanocomposites-for-photocatalytic-applications
#14
Alessandro Di Mauro, Maria Cantarella, Giuseppe Nicotra, Giovanna Pellegrino, Antonino Gulino, Maria Violetta Brundo, Vittorio Privitera, Giuliana Impellizzeri
The incorporation of nanostructured photocatalysts in polymers is a strategic way to obtain novel water purification systems. This approach takes the advantages of: (1) the presence of nanostructured photocatalyst; (2) the flexibility of polymer; (3) the immobilization of photocatalyst, that avoids the recovery of the nanoparticles after the water treatment. Here we present ZnO-polymer nanocomposites with high photocatalytic performance and stability. Poly (methyl methacrylate) (PMMA) powders were coated with a thin layer of ZnO (80 nm thick) by atomic layer deposition at low temperature (80 °C)...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097914/nanostructured-lipid-carriers-nlc-for-the-delivery-of-natural-molecules-with-antimicrobial-activity-production-characterization-and-in-vitro-studies
#15
Rita Cortesi, Giuseppe Valacchi, Ximena M Muresan, Markus Drechsler, Catia Contado, Elisabetta Esposito, Alessandro Grandini, Alessandra Guerrini, Giuseppe Forlani, Gianni Sacchetti
This study describes the preparation, characterization and in vitro activity of nanostructured lipid carriers (NLC) encapsulating natural molecules with antimicrobial activity, such as plumbagin, hydroquinon, eugenol, alpha-asarone and alpha-tocopherol. NLC were prepared by melt and ultrasonication method, characterized by Cryo-TEM for morphology and SdFFF for dimensional distribution and active encapsulation yields. In vitro tests were conducted on bacteria, fungi and human cell cultures. In vitro tests demonstrated that plumbagin is strongly toxic towards F...
January 18, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28097599/biosynthesis-characterization-and-bioactivities-evaluation-of-silver-and-gold-nanoparticles-mediated-by-the-roots-of-chinese-herbal-angelica-pubescens-maxim
#16
Josua Markus, Dandan Wang, Yeon-Ju Kim, Sungeun Ahn, Ramya Mathiyalagan, Chao Wang, Deok Chun Yang
A facile synthesis and biological applications of silver (DH-AgNps) and gold nanoparticles (DH-AuNps) mediated by the aqueous extract of Angelicae Pubescentis Radix (Du Huo) are explored. Du Huo is a medicinal root belonging to Angelica pubescens Maxim which possesses anti-inflammatory, analgesic, and antioxidant properties. The absorption spectra of nanoparticles in varying root extract and metal ion concentration, pH, reaction temperatures, and time were recorded by ultraviolet-visible (UV-Vis) spectroscopy...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28097285/localization-in-an-idealized-heterogeneous-elastic-sheet
#17
Bekele J Gurmessa, Andrew B Croll
Localized deformation is ubiquitous in many natural and engineering materials as they approach failure, and a significant effort has been made to understand localization processes with simple continuum models. Real materials are much more commonly heterogeneous but it is unclear exactly how heterogeneity affects outcomes. In this work we study the response of an idealized heterogenous elastic sheet on a soft foundation as it is uniaxially compressed. The patterned surface layers are created by selective ultraviolet/ozone treatment of the top surface of a polydimethylsiloxane (PDMS) sample using a TEM grid as a mask...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28096619/detection-identification-and-differentiation-of-sheep-pox-virus-and-goat-pox-virus-from-clinical-cases-in-giza-governorate-egypt
#18
M A Mahmoud, M H Khafagi
AIM: To isolate, identify, and differentiate Capripoxviruses (CaPV) (sheep pox virus and goat pox virus) infections by egg inoculation, transmission electron microscopy (TEM), and 30 kDa RNA polymerase subunit gene-based polymerase chain reaction (PCR) (RPO30) in clinically affected animals in Hawamdia township of Giza Governorate, Egypt. MATERIALS AND METHODS: A total of 37 scab samples were collected from clinically suspected field cases of sheep pox and goat pox...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28095688/effect-of-gold-nanoparticle-size-and-coating-on-labeling-monocytes-for-ct-tracking
#19
Peter Chhour, Johoon Kim, Barbara Benardo, Alfredo Tovar, Shaameen Mian, Harold I Litt, Victor A Ferrari, David P Cormode
With advances in cell therapies, interest in cell tracking techniques to monitor the migration, localization, and viability of these cells continues to grow. X-ray computed tomography (CT) is a cornerstone of medical imaging but has been limited in cell tracking applications due to its low sensitivity toward contrast media. In this study, we investigate the role of size and surface functionality of gold nanoparticles for monocyte uptake to optimize the labeling of these cells for tracking in CT. We synthesized gold nanoparticles (AuNP) that range from 15 to 150 nm in diameter and examined several capping ligands, generating 44 distinct AuNP formulations...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28094948/liquid-cell-electron-microscopy-of-nanoparticle-self-assembly-driven-by-solvent-drying
#20
Won Chul Lee, Byung Hyo Kim, Sun Choi, Shoji Takeuchi, Jungwon Park
Drying a colloidal solution of nanoparticles is a versatile method to construct self-assembled structures of nanoparticles. However, mechanistic understanding has mostly relied onto empirical knowledge obtained from the final structures of self-assembly as relevant processes during solvent drying are likely kinetic and far from equilibrium. Here, we present in situ TEM studies of nanoparticle self-assembly under various conditions, including the concentrations of the initial solution and the types of nanoparticles and substrates...
January 17, 2017: Journal of Physical Chemistry Letters
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