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https://www.readbyqxmd.com/read/28097209/fluorescence-guided-resection-of-brain-tumor-review-of-the-significance-of-intraoperative-quantification-of-protoporphyrin-ix-fluorescence
#1
REVIEW
Zheng Huang, Songsheng Shi, Haixia Qiu, Desheng Li, Jian Zou, Shaoshan Hu
Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/28093610/the-new-who-2016-classification-of-brain-tumors-what-neurosurgeons-need-to-know
#2
REVIEW
Rouzbeh Banan, Christian Hartmann
BACKGROUND: The understanding of molecular alterations of tumors has severely changed the concept of classification in all fields of pathology. The availability of high-throughput technologies such as next-generation sequencing allows for a much more precise definition of tumor entities. Also in the field of brain tumors a dramatic increase of knowledge has occurred over the last years partially calling into question the purely morphologically based concepts that were used as exclusive defining criteria in the WHO 2007 classification...
January 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28089420/regression-of-intracranial-meningioma-following-treatment-with-nivolumab-case-report-and-review-of-the-literature
#3
Efrat Gelerstein, Assaf Berger, Tali Jonas-Kimchi, Ido Strauss, Andrew A Kanner, Deborah T Blumenthal, Maya Gottfried, Nevo Margalit, Zvi Ram, Tal Shahar
The treatment of refractory meningiomas remains a challenge for both neurosurgeons and neuro-oncologists. There have been no clinical reports of the use or effects of anti-PD-1 therapy in patients with meningioma. We describe a patient whose intracranial meningioma decreased significantly in size after treatment with nivolumab, a monoclonal antibody targeting PD-1, for a concomitant advanced lung cancer. This is the first clinical report suggesting that antibodies targeting PD-1 are effective in treating meningioma...
January 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28081463/analysis-of-the-results-of-recurrent-intracranial-meningiomas-treated-with-re-radiosurgery
#4
Moinay Kim, Do Hee Lee, Hyun Jung Kim Rn, Young Hyun Cho, Jeong Hoon Kim, Do Hoon Kwon
OBJECTS: Meningioma is the most common intracranial neoplasm, comprising approximately 30% of all primary intracranial tumors (Claus et al., 2005) [1]. Treatment options include observation, microsurgical resection, stereotactic radiosurgery (SRS), and whole brain radiation therapy (WBRT). Gamma knife radiosurgery (GKRS) is a very effective treatment for intracranial meningiomas; previous studies showed the tumor control rate at 5-10 years of follow-up as 84.3%-100% in all cases (Feigl et al...
December 29, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28077490/improving-uniformity-in-brain-death-determination-policies-over-time
#5
Hilary H Wang, Panayiotis N Varelas, Galen V Henderson, Eelco F M Wijdicks, David M Greer
OBJECTIVE: To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS: We solicited official hospital guidelines in 2015 from these top 50 institutions, generated summary statistics of their criteria as benchmarked against the American Academy of Neurology Practice Parameters (AANPP) and the comparison 2006 cohort in 5 key categories, and statistically compared the 2 cohorts' compliance with the AANPP...
January 11, 2017: Neurology
https://www.readbyqxmd.com/read/28073808/fifteen-minute-consultation-assessment-of-a-child-with-suspected-shunt-problems
#6
Harpreet Singh Mangat, Chirag Patel, Desiderio Rodrigues
Cerebrospinal fluid diversion procedures have saved more lives than any other neurosurgical procedure. However, they do have a unique set of complications which a paediatrician in a district general hospital may encounter. Timely recognition and appropriate referral to the neurosurgeon is vital in order to avoid serious consequences and to have a favourable outcome.
January 10, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28069420/the-authors-herby-confirm-that-this-manuscript-has-neither-been-published-nor-submitted-to-any-other-journal-confocal-laser-endomicroscopy-in-neurosurgery-an-alternative-to-instantaneous-sections
#7
David Breuskin, Jacek Szczygielski, Steffi Urbschat, Yoo-Jin Kim, Joachim Oertel
INTRODUCTION: Intraoperative distinction of brain tumor from the surround brain is one of the crucial challenges in neurooncological surgery. In this study, confocal laser endomicroscope (CLE) findings were directly compared with intraoperative instantaneous sections by the neuropathologist in a blinded fashion. MATERIAL AND METHODS: The imaging device comprises of a rigid endoscope with Hopkins-Rod lenses and a red wave length laser with a scanning depth of 80 μm...
January 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28067696/multidisciplinary-evaluation-leads-to-the-decreased-utilization-of-lumbar-spine-fusion-an-observational-cohort-pilot-study
#8
Vijay Yanamadala, Yourie Kim, Quinlan D Buchlak, Anna K Wright, James Babington, Andrew Friedman, Robert S Mecklenburg, Farrokh Farrokhi, Jean-Christophe Leveque, Rajiv K Sethi
STUDY DESIGN: Observational cohort pilot study. OBJECTIVE: To determine the impact of multidisciplinary conference on treatment decisions for lumbar degenerative spine disease. SUMMARY OF BACKGROUND DATA: Multidisciplinary decision making improves outcomes in many disciplines. The lack of integrated systems for comprehensive care for spinal disorders has contributed to the inappropriate overutilization of spine surgery in the United States...
January 6, 2017: Spine
https://www.readbyqxmd.com/read/28064297/a-clinical-audit-of-interventional-pain-procedures-performed-as-part-of-the-newly-initiated-pain-service-in-a-local-neurosurgical-centre
#9
H C Khoo, B H Soon, A S Jaafar, A Abu Bakar, F Fadzil, K Palaniandy, S Paramasvaran, Y C Choy, C J Toh
Interventional Pain Procedures (IPPs) is a relatively new treatment modality for chronic pain in Malaysia. The Interventional Pain Service (IPS) newly set up in our institution is led by a pain neurosurgeon and provides a whole package of multimodal pain management including different range of IPPs. This clinical audit is to examine the quality of IPPs performed within the IPS in our institution since its initiation. A total of 87 IPPs were performed on 56 chronic pain patients over 3-year duration. As high as 81...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28061492/the-korean-spinal-neurosurgery-society-are-we-reimbursed-properly-for-spinal-neurosurgical-practices-under-the-korean-resource-based-relative-value-scale-service
#10
Woo-Keun Kwon, Joo Han Kim, Hong Joo Moon, Youn-Kwan Park
OBJECTIVES: The Korean Resource Based Relative Value Scale (K-RBRVS) was introduced in 2001 as an alternative of the previous medical fee schedule. Unfortunately, most neurosurgeons are unfamiliar with the details of the K-RBRVS and how it affects the reimbursement rates for the surgical procedures we perform. We summarize the K-RBRVS in brief, and discuss on how the relative value (RV) of the spinal neurosurgical procedures have changed since the introduction in 2001. METHODS: We analyzed the change of spinal procedure RVs since 2001, and compared it with the change of values in the brain neurosurgical procedures...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28052158/factors-associated-with-nontransfer-in-trauma-patients-meeting-american-college-of-surgeons-criteria-for-transfer-at-nontertiary-centers
#11
Quanhong Zhou, Matthew R Rosengart, Timothy R Billiar, Andrew B Peitzman, Jason L Sperry, Joshua B Brown
Importance: Secondary triage from nontertiary centers is vital to trauma system success. It remains unclear what factors are associated with nontransfer among patients who should be considered for transfer to facilities providing higher-level care. Objective: To identify factors associated with nontransfer among patients meeting American College of Surgeons (ACS) guideline criteria for transfer from nontertiary centers. Design, Setting, and Participants: A retrospective cohort study was performed using multilevel logistic regression to ascertain factors associated with nontransfer from nontertiary centers, including demographics, injury characteristics, and center resources...
January 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28051982/single-neurosurgeon-operative-experience-at-craig-joint-theater-hospital-during-the-afghanistan-surge-november-2010-to-april-2011-part-ii-humanitarian-cases
#12
John Joseph Steele
BACKGROUND: The Afghanistan Surge saw NATO troops working with their Afghan partners to remove Taliban governance and replace it with a more democratic model. As part of this endeavor, medical support for both trauma and humanitarian cases was needed. OBJECTIVE: Identify and discuss disease trends to better prepare for future combat medical treatments. METHODS: Retrospective review of operative experience from a neurosurgeon from November 2010 to April 2011...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28051981/single-neurosurgeon-operative-experience-at-craig-joint-theater-hospital-during-the-afghanistan-surge-november-2010-to-april-2011-part-i-neurotrauma-cases
#13
John Joseph Steele
BACKGROUND: The Afghanistan Surge saw NATO troops working with their Afghan partners to remove Taliban governance and replace it with a more democratic model. As part of this effort, medical support for both trauma and humanitarian cases was needed. OBJECTIVE: Identify and discuss disease trends to better prepare for future combat medical care. METHODS: Retrospective review of operative experience from a single neurosurgeon from November 2010 to April 2011...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28048752/tu-a-brb-02-panel-member
#14
L Ma
: Brain stereotactic radiosurgery (SRS) and spine stereotactic body radiation therapy (SBRT) are commonly treated by a multidisciplinary team of neurosurgeons, radiation oncologists, and medical physicists. However the treatment objectives, constraints, and technical considerations involved can be quite different between the two techniques. In this interactive session an expert panel of speakers will present clinical brain SRS and spine SBRT cases in order to demonstrate real-world considerations for ensuring safe and accurate treatment delivery and to highlight the significant differences in approach for each treatment site...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047859/th-ab-207a-10-sub-msv-cerebral-ct-perfusion-imaging-using-prior-image-constrained-compressed-sensing-a-prospective-clinical-trial
#15
K Li, P Yang, M Cathey, J Tang, H Rowley, P Turski, V Prabhakaran, C Strother, G-H Chen
PURPOSE: A prospective clinical study was conducted to assess whether sub-mSv cerebral CT perfusion (CTP) imaging can be achieved using the Prior Image Constrained Compressed Sensing (PICSS) reconstruction algorithm. METHODS: Following a standard dose (SD) CTP acquisition, 31 patients (median age, 62 years; 15 M/16 F; median BMI, 27) underwent an additional reduced dose (RD) CTP acquisition at 20% of the standard dose level. Several algorithms (PICCS, ASIR, and FBP) were used to reconstruct CTP source images of the RD series...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047547/su-f-t-647-linac-based-stereotactic-radiosurgery-srs-in-the-treatment-of-trigeminal-neuralgia-detailed-description-of-srs-procedural-technique-and-reported-clinical-outcomes
#16
D Pokhrel, S Sood, R Badkul, H Jiang, T Stepp, P Camarata, F Wang
PURPOSE: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. METHODS: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009-2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047533/su-f-j-96-comparison-of-frame-based-and-mutual-information-registration-techniques-for-ct-and-mr-image-sets
#17
R Popple, M Bredel, I Brezovich, M Dobelbower, W Fisher, J Fiveash, B Guthrie, K Riley, X Wu
PURPOSE: To compare the accuracy of CT-MR registration using a mutual information method with registration using a frame-based localizer box. METHODS: Ten patients having the Leksell head frame and scanned with a modality specific localizer box were imported into the treatment planning system. The fiducial rods of the localizer box were contoured on both the MR and CT scans. The skull was contoured on the CT images. The MR and CT images were registered by two methods...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047363/tu-a-brb-00-panel-discussion-sbrt-srs-case-studies-brain-and-spine
#18
David Schlesinger
: Brain stereotactic radiosurgery (SRS) and spine stereotactic body radiation therapy (SBRT) are commonly treated by a multidisciplinary team of neurosurgeons, radiation oncologists, and medical physicists. However the treatment objectives, constraints, and technical considerations involved can be quite different between the two techniques. In this interactive session an expert panel of speakers will present clinical brain SRS and spine SBRT cases in order to demonstrate real-world considerations for ensuring safe and accurate treatment delivery and to highlight the significant differences in approach for each treatment site...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047299/su-f-t-252-an-investigation-of-gamma-knife-frame-definition-error-when-using-a-pre-planning-workflow
#19
P Johnson
PURPOSE: To determine causal factors related to high frame definition error when treating GK patients using a pre-planning workflow. METHODS: 160 cases were retrospectively reviewed. All patients received treatment using a pre-planning workflow whereby stereotactic coordinates are determined from a CT scan acquired after framing using a fiducial box. The planning software automatically detects the fiducials and compares their location to expected values based on the rigid design of the fiducial system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047275/tu-a-brb-03-panel-member
#20
B Winey
: Brain stereotactic radiosurgery (SRS) and spine stereotactic body radiation therapy (SBRT) are commonly treated by a multidisciplinary team of neurosurgeons, radiation oncologists, and medical physicists. However the treatment objectives, constraints, and technical considerations involved can be quite different between the two techniques. In this interactive session an expert panel of speakers will present clinical brain SRS and spine SBRT cases in order to demonstrate real-world considerations for ensuring safe and accurate treatment delivery and to highlight the significant differences in approach for each treatment site...
June 2016: Medical Physics
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