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https://www.readbyqxmd.com/read/29244800/hla-dq-genetics-in-children-with-celiac-disease-a-meta-analysis-suggesting-a-two-step-genetic-screening-procedure-starting-with-hla-dq-%C3%AE-chains
#1
Annalisa De Silvestri, Cristina Capittini, Dimitri Poddighe, Chiara Valsecchi, Gianluigi Marseglia, Sara Carlotta Tagliacarne, Valeria Scotti, Chiara Rebuffi, Annamaria Pasi, Miryam Martinetti, Carmine Tinelli
OBJECTIVES: through a meta-analysis, evaluating the distribution of the predisposing HLA genotype to Celiac Disease (CD) in children and providing insights for potential widened screening strategy. STUDY DESIGN: After a systematic search on the association between HLA class II and CD in children, 46 publications were obtained and assessed for eligibility. 13 eligible studies were submitted to data extraction and analysis (10 studies case-control and 3 cohort studies)...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244119/is-social-work-prepared-for-diversity-in-hospice-and-palliative-care
#2
Christine M Rine
The purpose of this article is to assess current and future trends in hospice and palliative care with the objective of informing culturally appropriate best practice for social work. Concern for the intersectionality of racial, ethnic, social, and other differences in end-of-life (EOL) care is imperative given the ever growing range of diversity characteristics among the increasing aging populations in the United States. A review of literature from the current decade that is pertinent to the profession contributes to the ability of social work to consider evidence and build agreement germane to EOL practice settings...
December 13, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29243937/long-term-coarse-pm-exposure-is-associated-with-asthma-among-children-in-medicaid
#3
Corinne A Keet, Joshua P Keller, Roger D Peng
RATIONALE: Short and long-term fine particulate matter (PM2.5) pollution is associated with asthma development and morbidity, but there is little data on the effects of long-term exposure to coarse PM (PM10-2.5) on respiratory health. OBJECTIVES: To understand the relationship between long-term fine and coarse PM exposure and asthma prevalence and morbidity among children. METHODS: A semi-parametric regression model that incorporated PM2.5 and PM10 monitor data and geographic characteristics was developed to predict two-year average PM2...
December 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29243553/disease-modeling-studies-using-induced-pluripotent-stem-cells-are-we-using-enough-controls
#4
Adiv A Johnson, Cynthia Andrews-Pfannkoch, Timothy J Nelson, Jose S Pulido, Alan D Marmorstein
The comparison of differentiated induced pluripotent stem cells (iPSCs) derived from patients with disease to differentiated iPSCs derived from healthy patients enables powerful disease modeling. By performing an informal retrospective survey of disease modeling studies published in high impact journals, we found that the median and average number of controls used in these studies were 1 and 1.6, respectively. The bulk of these studies did not control for age, gender and ethnicity. Since a large proportion of phenotypic differences observed between iPSC lines are due to genetic variation or variation between lines, this is an insufficient number of controls to confidently rule out standard variation...
December 15, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29243503/women-s-beliefs-about-what-causes-obesity-variation-by-race-ethnicity-and-acculturation-in-a-washington-state-sample
#5
Sarah Knerr, Rachel M Ceballos, Kwun Chuen Gary Chan, Shirley A A Beresford, Deborah J Bowen
OBJECTIVE: Individuals' beliefs about the causes of multifactorial health conditions (causal attributions) shape how they conceptualize and respond to health threats and are therefore important for health promotion. Studies of racial/ethnic and cultural variation in obesity causal beliefs, however, are scarce. To address this gap, this study described beliefs about the underlying causes of obesity (genetic inheritance, diet, and physical activity) in Hispanic and non-Hispanic White women participating in a longitudinal cohort study in South King County, Washington State (n = 1,002)...
December 15, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29242782/two-logics-of-policy-intervention-in-immigrant-integration-an-institutionalist-framework-based-on-capabilities-and-aspirations
#6
Philipp Lutz
The effectiveness of immigrant integration policies has gained considerable attention across Western democracies dealing with ethnically and culturally diverse societies. However, the findings on what type of policy produces more favourable integration outcomes remain inconclusive. The conflation of normative and analytical assumptions on integration is a major challenge for causal analysis of integration policies. This article applies actor-centered institutionalism as a new framework for the analysis of immigrant integration outcomes in order to separate two different mechanisms of policy intervention...
2017: Comparative Migration Studies
https://www.readbyqxmd.com/read/29242751/prevalence-of-non-communicable-disease-risk-factors-in-three-sites-across-papua-new-guinea-a-cross-sectional-study
#7
Patricia Rarau, Gwendalyn Vengiau, Hebe Gouda, Suparat Phuanukoonon, Isi H Kevau, Chris Bullen, Robert Scragg, Ian Riley, Geoffrey Marks, Masahiro Umezaki, Ayako Morita, Brian Oldenburg, Barbara McPake, Justin Pulford
Papua New Guinea (PNG) is a culturally, environmentally and ethnically diverse country of 7.3 million people experiencing rapid economic development and social change. Such development is typically associated with an increase in non-communicable disease (NCD) risk factors. Aim: To establish the prevalence of NCD risk factors in three different regions across PNG in order to guide appropriate prevention and control measures. Methods: A cross-sectional survey was undertaken with randomly selected adults (15-65 years), stratified by age and sex recruited from the general population of integrated Health and Demographic Surveillance Sites in West Hiri (periurban), Asaro (rural highland) and Karkar Island (rural island), PNG...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29241943/gender-disparities-in-park-use-and-physical-activity-among-residents-of-high-poverty-neighborhoods-in-los-angeles
#8
Kathryn P Derose, Bing Han, Stephanie Williamson, Deborah A Cohen
INTRODUCTION: Physical inactivity is more prevalent among women than men and is related to poor health outcomes. Neighborhood parks constitute an important resource for physical activity (PA), however, previous studies of park users have found fewer women being physically active. METHODS: We conducted a hierarchical mixed-effect regression analysis of the independent associations between gender and park use and PA among a population-based sample in high-poverty neighborhoods in Los Angeles...
December 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29240897/factors-influencing-women-in-physical-activity-programs-in-malaysia
#9
C Hanlon, S Khoo, T Morris, R Eime
The majority of research on factors associated with women participation in physical activity (PA) has been in developed countries with limited research in developing countries. Few women in Malaysia are active at the recommended levels for health, and activity rates are less than developed countries. Little research has focused specially on physically active Malaysian women and the factors that contribute to them becoming and staying active in PA programs. This lack of knowledge hinders the tailored development and implementation of PA programs to meet their needs...
December 11, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29240822/acne-keloidalis-nuchae-in-asian-a-single-institutional-experience
#10
Kiyong Na, Sang Ho Oh, Sang Kyum Kim
Acne keloidalis nuchae, a type of folliculitis involving the back of the neck, is common in black men, although rare cases have been reported in patients of other ethnicities. We analyzed the clinicopathological features of acne keloidalis nuchae in 17 Asians. Patients' age at the time of presentation ranged from 20 to 69 years. Most patients experienced the disease over 2 years (range, 3 months-20 years); follow-up data were available for 11 (65%) patients (range, 2-95 months). Nine (53%) patients had comorbidities, but none had a history of other skin disease or a family history of acne keloidalis nuchae...
2017: PloS One
https://www.readbyqxmd.com/read/29240737/morbidity-from-intentional-self-harm-among-pacific-peoples-in-new-zealand-1996-2015
#11
Jemaima Tiatia-Seath, Roy Lay-Yee, Martin von Randow
AIM: The aim of this study was to describe trends in intentional self-harm for Pacific peoples in New Zealand by reviewing official data over the period 1996-2015. METHOD: Publicly funded hospitalisations where the external cause was intentional self-harm were examined and areas of interest were identified and are presented. RESULTS: Over a 19-year period (1996-2015), there were 1,608 intentional self-harm events for Pacific peoples (2.8%) out of 58,643 intentional self-harm events nationally for New Zealand's total population...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240589/infrared-skin-thermometry-validating-and-comparing-techniques-to-detect-periwound-skin-infection
#12
Asfandyar Mufti, Ranjani Somayaji, Patricia Coutts, R Gary Sibbald
OBJECTIVE: Diagnosis of wound infection can be challenging because it relies on a combination of clinical signs and symptoms that are often nonspecific. Increased periwound cutaneous temperature is a classic sign of deep and surrounding wound infection, and its quantitative measurement is one of the most reliable and valid clinical signs of deep and surrounding skin infection at the bedside. Skin surface temperature differences may be detected using commercially available noncontact infrared thermometers...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240274/complement-factor-h-gene-polymorphism-rs6677604-and-the-risk-severity-and-progression-of-iga-nephropathy-a-systematic-review-and-meta-analysis
#13
See Cheng Yeo, Xinyang Liu, Adrian Liew
BACKGROUND & AIM: Complement activation plays a key role in the pathogenesis of IgA nephropathy (IgAN). Several studies have reported an association between complement factor H gene rs6677604 polymorphism and susceptibility to IgAN; however, attempts at validating this relationship had yielded inconsistent results. We performed a systematic review and meta-analysis to clarify the association between rs6677604 and IgAN susceptibility, disease severity and chronic progression. METHODS: A comprehensive database search was performed to identify eligible studies...
December 14, 2017: Nephrology
https://www.readbyqxmd.com/read/29239285/predictors-of-coverage-of-the-national-maternal-pertussis-and-infant-rotavirus-vaccination-programmes-in-england
#14
L Byrne, C Ward, J M White, G Amirthalingam, M Edelstein
This study assessed variation in coverage of maternal pertussis vaccination, introduced in England in October 2012 in response to a national outbreak, and a new infant rotavirus vaccination programme, implemented in July 2013. Vaccine eligible patients were included from national vaccine coverage datasets and covered April 2014 to March 2015 for pertussis and January 2014 to June 2016 for rotavirus. Vaccine coverage (%) was calculated overall and by NHS England Local Team (LT), ethnicity and Index of Multiple Deprivation (IMD) quintile, and compared using binomial regression...
December 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29239269/pharmacogenetic-landscape-of-dpyd-variants-in-south-asian-populations-by-integration-of-genome-scale-data
#15
Judith M Hariprakash, Shamsudheen K Vellarikkal, Pavithran Keechilat, Ankit Verma, Rijith Jayarajan, Vishal Dixit, Rowmika Ravi, Vigneshwar Senthivel, Anoop Kumar, Paras Sehgal, Akhilesh K Sonakar, Sakshi Ambawat, Anil K Giri, Arun Philip, Akhila Sivadas, Mohammed Faruq, Dwaipayan Bharadwaj, Sridhar Sivasubbu, Vinod Scaria
AIM: Adverse drug reactions to 5-Fluorouracil(5-FU) is frequent and largely attributable to genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims at understanding the pharmacogenetic landscape of DPYD variants in south Asian populations. MATERIALS & METHODS: Systematic analysis of population scale genome wide datasets of over 3000 south Asians was performed. Independent evaluation was performed in a small cohort of patients...
December 14, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29239247/correlations-between-polymorphisms-in-the-uridine-diphosphate-glucuronosyltransferase-1a-and-c-c-motif-chemokine-receptor-5-genes-and-infection-with-the-hepatitis-b-virus-in-three-ethnic-groups-in-china
#16
Chan Zhang, Yan He, Ke-Ren Shan, Kui Tan, Ting Zhang, Chan-Juan Wang, Zhi-Zhong Guan
Objective To determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A ( UGT1A) and the C-C motif chemokine receptor 5 ( CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China. Methods The study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29239060/prevalence-and-predictors-of-depression-pain-and-fatigue-in-older-versus-younger-adult-cancer-survivors
#17
Lisa A Bevilacqua, Deirdre Dulak, Elizabeth Schofield, Tatiana D Starr, Christian J Nelson, Andrew J Roth, Jimmie C Holland, Yesne Alici
BACKGROUND: As the number of older adults in the United States continues to grow, there will be increasing demands on health care providers to address the needs of this population. Cancer is of particular importance, with over half of all cancer survivors over age 65. In addition, depression, pain, and fatigue are concerns for older adults with cancer and have been linked to poorer physical outcomes. METHODS: For this retrospective chart review, 1012 eligible participants were identified via a query of the Electronic Medical Record for all patients referred to one of four Survivorship Clinics at Memorial Sloan Kettering Cancer Center...
December 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29238631/ethnic-and-age-disparities-in-patients-taking-long-acting-injectable-atypical-antipsychotics
#18
Mateen Soleman, Nikki Lam, Benjamin K Woo
Introduction This study will determine whether different ethnicities and different age groups receive equal amounts of long-acting atypical antipsychotics in comparison to their oral equivalents. Methods Secondary analyses of data from the Los Angeles County Department of Health Services Electronic Health Record (total N=63,134 inpatient visits) were performed. Chi-squared statistics were used to compare ethnicity and age with the use of either risperidone injectable or paliperidone palmitate (r-LAIs) versus risperidone oral...
October 12, 2017: Curēus
https://www.readbyqxmd.com/read/29238378/association-of-macrophage-migration-inhibitory-factor-gene-polymorphisms-with-chronic-periodontitis-in-a-south-eastern-iranian-population
#19
Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mohammad Hashemi, Somayeh Ansarimoghaddam, Bita Moudi, Nadia Sheibak
Background: Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It plays a vital role in immune response against the oral disease. MIF is a regulator of innate immunity, and bacterial antigens can stimulate serum level of this protein. In experimental gingivitis, the expression level of MIF increases and this increment positively correlates with oral plaque index. The single nucleotide polymorphisms in the gene encoding the MIF protein can control the function of MIF...
November 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29237717/particulate-matter-air-pollution-exposure-and-heart-disease-mortality-risks-by-race-and-ethnicity-in-the-united-states-1997-2009-nhis-with-mortality-followup-through-2011
#20
Jennifer D Parker, Nataliya Kravets, Ambarish Vaidyanathan
Background -Most U.S. studies of mortality and air pollution have been conducted on largely non-Hispanic white study populations. However, many health and mortality outcomes differ by race and ethnicity, and non-Hispanic white persons experience lower air pollution exposures than those who are non-Hispanic black or Hispanic. This study examines whether associations between air pollution and heart disease mortality differ by race/ethnicity. Methods -We used data from the 1997-2009 National Health Interview Survey linked to mortality records through December 2011 and annual estimates of fine particulate matter (PM2...
December 13, 2017: Circulation
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