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https://www.readbyqxmd.com/read/27921411/association-of-cd46-ivs1-1724-c-g-single-nucleotide-polymorphism-in-iranian-women-with-unexplained-recurrent-spontaneous-abortion-ursa
#1
Shiva Abdi-Shayan, Amir Monfaredan, Zahra Moradi, Mehrangiz Rajaii Oskoui, Tohid Kazemi
There are several known and unknown factors for unexplained recurrent spontaneous abortion (URSA). Among them, complement regulatory protein CD46 plays a pivotal role in preventing uncontrolled activation of complement and successful continuation of pregnancy. We aimed in this study to investigate the possible association of CD46 IVS1-1724 C>G polymorphism with RSA in Iranian women. 141 women with RSA and 153 women with normal pregnancy were enrolled in this study. RSA was confirmed as the history of having at least three consecutive abortions without any known immunologic, pathologic and genetic reason...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27921324/statins-and-mortality-the-untold-story
#2
Michael S Kostapanos, Moses S Elisaf
Statins are first-line evidence-based drugs for the management of dyslipidaemias and to reduce the risk of cardiovascular events. However, statin clinical trials have shown marginally significant benefits on mortality, especially in the primary prevention setting. A major limitation of those trials is their relatively short follow-up. A reduced number of fatal events within a 5-year follow-up make mortality benefits unlikely to arise. This is particularly relevant for the primary prevention trials, whereby the risk of cardiovascular death is low...
December 6, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27921300/living-in-violent-neighbourhoods-is-associated-with-gestational-weight-gain-outside-the-recommended-range
#3
Jessica Galin, Barbara Abrams, Stephanie A Leonard, Ellicott C Matthay, Dana E Goin, Jennifer Ahern
BACKGROUND: During pregnancy, most women do not meet gestational weight gain (GWG) guidelines, potentially resulting in adverse maternal and infant health consequences. Social environment determinants of GWG have been identified, but evidence on the relationship between neighbourhood violence and GWG is scant. Our study aims to examine the relationship between neighbourhood violence and GWG outside the recommended range. METHODS: We used statewide vital statistics and health care utilization data from California for 2006-12 (n = 2 364 793) to examine the relationship of neighbourhood violence (quarters of zip-code rates of homicide and assault) in the first 37 weeks of pregnancy with GWG (categorized using the Institute of Medicine's pregnancy weight gain guidelines)...
December 6, 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/27920829/clinical-and-genetic-features-of-australian-families-with-long-qt-syndrome-a-registry-based-study
#4
Charlotte Burns, Jodie Ingles, Andrew M Davis, Vanessa Connell, Belinda Gray, Lauren Hunt, Julie McGaughran, Christopher Semsarian
BACKGROUND: Familial long QT syndrome (LQTS) is a primary arrhythmogenic disorder caused by mutations in ion channel genes. The phenotype ranges from asymptomatic individuals to sudden cardiac arrest and death. LQTS is a rare but significant health problem for which global data should exist. This study sought to provide the first clinical and genetic description of Australian families with LQTS. METHODS: We performed a cross-sectional study to evaluate clinical and genetic features of families with LQTS...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27920589/dna-methylation-of-regulatory-regions-of-imprinted-genes-at-birth-and-its-relation-to-infant-temperament
#5
Bernard F Fuemmeler, Chien-Ti Lee, Adelheid Soubry, Edwin S Iversen, Zhiqing Huang, Amy P Murtha, Joellen M Schildkraut, Randy L Jirtle, Susan K Murphy, Cathrine Hoyo
BACKGROUND: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. METHODS: DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158). RESULTS: MEG3 DMR levels were positively associated with internalizing (β = 0.15, P = 0.044) and surgency (β = 0.19, P = 0.018) behaviors, after adjusting for birth weight, gender, gestational age at birth, maternal age at delivery, race/ethnicity, education level, smoking status, parity, and a history of anxiety or depression...
2016: Genetics & Epigenetics
https://www.readbyqxmd.com/read/27920553/meta-analysis-of-the-impact-of-thioprine-s-methyltransferase-polymorphisms-on-the-tolerable-6-mercaptopurine-dose-considering-initial-dose-and-ethnic-difference
#6
Myeong Gyu Kim, Minoh Ko, In-Wha Kim, Jung Mi Oh
A meta-analysis was conducted to decide whether to reduce an initial 6-mercaptopurine (6-MP) dose in TPMT heterozygote in the case of an initial 6-MP dose of <75 mg/m(2)/d and to compare the tolerable 6-MP dose among different ethnic groups. The study was undertaken according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The differences in mean values of the tolerable 6-MP dose were calculated by using Comprehensive Meta-Analysis version 3. The results of the meta-analysis indicated that the tolerable 6-MP dose was significantly lower in the TPMT heterozygote group (difference in mean values =11...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27920413/retinal-nerve-fiber-layer-thickness-in-a-healthy-turkish-population-measured-by-optical-coherence-tomography
#7
Mehmet Cubuk, Nedime Sahinoglu-Keskek, Sakir Ozgur Keskek
BACKGROUND: Normative optical coherence tomography (OCT) data is required for different subsets of the population as ethnic differences in retinal nerve fiber layer (RNFL) thickness have been reported. An OCT database for the normal Turkish population is not commercially available. OBJECTIVES: Quantify peripapillary RNFL thickness in a Turkish population. DESIGN: Cross-sectional, descriptive study. SETTING: Numune Training and Research Hospital, Adana, Turkey...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27920351/effects-of-pediatric-anticipatory-guidance-on-mothers-of-young-children
#8
Hui-Chin Hsu, Shih-Yu Lee, Chin-Man Lai, Wan-Ling Tsai, Hsiao-Tung Chiu
Provision of anticipatory guidance to parents during well-child visits is a defining component of pediatric primary care. Using nationally representative data from the 2000 U.S. National Survey of Early Childhood Health, this study addressed the questions of whether, how, and what mothers of children below age 3 with different ethnic/racial background could benefit from anticipatory guidance. Structural equation modeling results showed that across ethnic/racial groups, guidance was directly associated with decreased maternal stress and directly and indirectly associated with effective parenting practices in child development, discipline, and safety...
December 5, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27919863/applying-multiple-data-collection-tools-to-quantify-human-papillomavirus-vaccine-communication-on-twitter
#9
Philip M Massey, Amy Leader, Elad Yom-Tov, Alexandra Budenz, Kara Fisher, Ann C Klassen
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. There are several vaccines that protect against strains of HPV most associated with cervical and other cancers. Thus, HPV vaccination has become an important component of adolescent preventive health care. As media evolves, more information about HPV vaccination is shifting to social media platforms such as Twitter. Health information consumed on social media may be especially influential for segments of society such as younger populations, as well as ethnic and racial minorities...
December 5, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27919689/seasonal-dynamics-of-human-retinol-status-in-mobile-pastoralists-in-chad
#10
Lisa Crump, Mahamat Béchir, Bongo Naré Richard Ngandolo, Doumagoum Moto Daugla, Jan Hattendorf, Jakob Zinsstag
Vitamin A deficiency is a prevalent public health problem in Africa and South-East Asia, although national population based surveys are lacking in many countries. This study investigated seasonal variation of human retinol concentrations in Chadian mobile pastoralists to identify critical time periods for interventions addressing vitamin A deficiency. The repeated cross-sectional study design used convenience sampling during three seasons to include 327 Fulani, Gorane and Arab adult mobile pastoralists in nine camps in the Lake Chad area...
December 2, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27919572/non-fucosylated-cb-cd34-cells-represent-a-good-target-for-enforced-fucosylation-to-improve-engraftment-following-cord-blood-transplantation
#11
Simon N Robinson, Michael W Thomas, Paul J Simmons, Junjun Lu, Hong Yang, Jeannie A Javni, Elizabeth J Shpall, Patrick A Zweidler-Mckay
BACKGROUND AIMS: Despite ethnic diversity and ready availability of cryopreserved, human leukocyte antigen-typed cord blood (CB), delayed engraftment remains a significant hurdle to successful CB transplantation. Suboptimal homing of CB hematopoietic stem and progenitor cells (HSPCs) to the hematopoietic microenvironment (HM) is thought to be responsible and due to low levels of HSPC fucosylation. Fucosylation (decoration with sialyl-Lewis(X)) may improve HSPC homing to HM by increasing the strength of HSPC/E-selectin interactions, where E-selectin is constitutively expressed by HM microvasculature...
December 2, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27918880/racial-differences-in-hiv-and-hcv-risk-behaviors-transmission-and-prevention-knowledge-among-non-treatment-seeking-individuals-with-opioid-use-disorder
#12
Verena E Metz, Maria A Sullivan, Jermaine D Jones, Elizabeth Evans, Rachel Luba, Jonathan Vogelman, Sandra D Comer
In light of New York's recently reinforced strategy to end the AIDS epidemic by expanding testing, treatment, and access to pre-exposure prophylaxis (PrEP), we assessed drug use and sexual risk behaviors, along with HIV/Hepatitis C virus (HCV) transmission and prevention knowledge among non-treatment-seeking adults with opioid use disorder (OUD) in New York City. Over the course of 18 months, volunteers screening for research studies in the Opioid Laboratory at the New York State Psychiatric Institute completed a locally developed self-assessment questionnaire...
December 5, 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27918846/soy-food-intake-and-biomarkers-of-breast-cancer-risk-possible-difference-in-asian-women
#13
Gertraud Maskarinec, Dan Ju, Yukiko Morimoto, Adrian A Franke, Frank Z Stanczyk
Soy foods may protect against breast cancer in Asian but not in Western populations. We examined if the levels of various markers of breast cancer risk and inflammation, as well as the effects of soy food consumption on these markers, differ between Asian and non-Asian premenopausal women in two soy intervention trials. One study randomized 220 women to a 2-yr intervention and the other one randomized 96 women in a crossover design to examine the effects of consumption of 2 daily soy servings on nipple aspirate fluid (NAF) volume; estrogens in serum, NAF, and urine; insulin-like growth factor-1 (IGF-1), IGF-binding protein 3, and inflammatory markers in serum; and mammographic densities...
December 5, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27918688/racial-ethnic-and-income-differences-in-obesity-among-older-adults-the-role-of-leisure-time-physical-activity-and-neighborhood-social-cohesion
#14
Chia-Yuan Yu
BACKGROUND: Few studies have examined the associations among social cohesion, physical activity, and obesity in older adults. This study explored the influences of social cohesion and leisure-time physical activity on obesity in older adults, and tested whether these relationships varied by race/ethnicity and income level. METHODS: A cross-sectional analysis of adults in the 2013 National Health Interview Study (NHIS) who were over 65 years of age (N=7714) was used...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27918684/racial-ethnic-differences-in-the-associations-between-physical-activity-and-sleep-duration-a-population-based-study
#15
Rosenda Murillo, Maya J Lambiase, Bonny J Rockette-Wagner, Andrea M Kriska, Jeffrey P Haibach, Rebecca C Thurston
BACKGROUND: This study examined associations between physical activity (recreational, non-recreational) and sleep duration among a nationally representative diverse sample of U.S. adults. METHODS: We used cross-sectional data from 9,205 National Health and Nutrition Examination Survey 2007-2012 participants aged 20-65 years who identified as White, Black, or Hispanic. Activity (i.e., recreation, occupation, and transportation activity) was categorized into quartiles...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27917998/medical-and-aesthetic-treatment-across-the-broad-spectrum-of-ethnicities-introduction
#16
Shilpi Khetarpal, Mara Weinstein Velez
The ethnic and racial composition of the US population is changing rapidly. There is a continuous rise of individuals with mixed ethnic backgrounds comprising skin of color. It is important for physicians to be comfortable addressing and treating the needs of this population, as it differs significantly from the white population.
December 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27917881/distinct-and-shared-determinants-of-cardiomyocyte-contractility-in-multi-lineage-competent-ethnically-diverse-human-ipscs
#17
Martin L Tomov, Zachary T Olmsted, Haluk Dogan, Eda Gongorurler, Maria Tsompana, Hasan H Otu, Michael Buck, Eun-Ah Chang, Jose Cibelli, Janet L Paluh
The realization of personalized medicine through human induced pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenomics, and bioinformatics that inform on genetic pathways directing tissue development and function. When possible, population diversity should be included in new studies as resources become available. Previously we derived replicate iPSC lines of African American, Hispanic-Latino and Asian self-designated ethnically diverse (ED) origins with normal karyotype, verified teratoma formation, pluripotency biomarkers, and tri-lineage in vitro commitment...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917490/ethnic-disparities-in-school-based-behavioral-health-service-use-for-children-with-psychiatric-disorders
#18
Jill Locke, Christina D Kang-Yi, Melanie Pellecchia, Steven Marcus, Trevor Hadley, David S Mandell
BACKGROUND: We examined racial/ethnic disparities in school-based behavioral health service use for children with psychiatric disorders. METHODS: Medicaid claims data were used to compare the behavioral healthcare service use of 23,601 children aged 5-17 years by psychiatric disorder (autism, attention deficit hyperactivity disorder [ADHD], conduct/oppositional defiant disorder, and "other") and by race/ethnicity (African-American, Hispanic, white, and other). Logistic and generalized linear regression analyses were used...
January 2017: Journal of School Health
https://www.readbyqxmd.com/read/27917300/household-structure-and-suburbia-residence-in-u-s-metropolitan-areas-evidence-from-the-american-housing-survey
#19
Gowoon Jung, Tse-Chuan Yang
Suburbs have demographically diversified in terms of race, yet little research has been done on household structures in suburbs. Using the 2011 American Housing Survey and 2009-2013 American Community Survey, this study investigates the distributions of household structures in suburbia and central cities, and the relationship between household structures and residential attainment. The findings of this research include: (1) The distribution of household structures differs between suburbia and central cities...
2016: Social Sciences
https://www.readbyqxmd.com/read/27917033/ethnic-and-gender-differences-in-strategies-used-by-adolescents-when-attempting-to-quit-or-reduce-smoking
#20
Ali M Yurasek, Leslie A Robinson, Gilbert Parra
Few adolescent smoking cessation programs have been able to match the success rate found in adult programs. The current study identified smoking cessation strategies used by adolescents and whether strategies differed as a function of ethnic, gender, or individual smoking-level. Participants were 136 high school students who made an attempt to quit or reduce their smoking. Logistic regressions revealed that individuals making an actual quit attempt and African American adolescents used cessation strategies presumed to be more effective...
2016: Journal of Child & Adolescent Substance Abuse
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