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https://www.readbyqxmd.com/read/29666002/clinical-pathologic-cytogenetic-and-molecular-profiling-in-self-identified-black-women-with-uterine-leiomyomata
#1
Mark A Hayden, Zehra Ordulu, C Scott Gallagher, Bradley J Quade, Raymond M Anchan, Nia Robinson Middleton, Serene S Srouji, Elizabeth A Stewart, Cynthia C Morton
Black women are disproportionately affected by uterine leiomyomata (UL), or fibroids, compared to other racial groups, having a greater lifetime risk of developing UL and an earlier age of diagnosis. In order to elucidate molecular and genetic mechanisms responsible for the increased prevalence and morbidity associated with UL in black women, clinical, pathologic, cytogenetic, and select molecular profiling (MED12 mutation analysis) of 75 self-reported black women undergoing surgical treatment for UL was performed...
April 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29665339/patterns-of-orofacial-clefting-in-new-york-city-from-1983-to-2010-trends-by-racial-background-birthplace-and-public-health-strategies
#2
Sydney C Butts, Simone Reynolds, Lyuba Gitman, Prayag Patel, Michael Joseph
OBJECTIVE: To determine the role of racial background, public health initiatives, and residence on the prevalence of orofacial clefts (OFCs) in New York City (NYC). DESIGN/METHODS: Retrospective review of OFC cases from the New York State Congenital Malformations Registry. PATIENTS/PARTICIPANTS: Patients born with an OFC and all live births to mothers residing in NYC between 1983 and 2010. MAIN OUTCOME MEASURES: Orofacial cleft birth prevalence by cleft type, race, and borough of maternal residence for each year and by time period around the implementation of public health interventions including folate supplementation...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29665027/genetic-variant-spectrum-in-265-chinese-patients-with-hemophagocytic-lymphohistiocytosis-molecular-analyses-of-prf1-unc13d-stx11-stxbp2-sh2d1a-and-xiap
#3
X Chen, F Wang, Y Zhang, W Teng, M Wang, D Nie, X Zhou, D Wang, H Zhao, P Zhu, H Liu
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening hyperinflammatory disease. This study aimed to investigate the frequencies and distributions of inherited variants in PRF1, UNC13D, STX11, STXBP2, SH2D1A, and XIAP genes in Chinese patients with HLH. A total of 265 patients diagnosed with HLH from January 2010 to December 2016 were recruited and analyzed for the six genes. Genetic variants were observed in 87 (32.83%) patients. 36 (13.58%) exhibited variants in UNC13D, 18 (6.79%) exhibited PRF1 variants, 10 (3...
April 17, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29664746/vitamin-d-deficiency-in-hepatitis-c-virus-infection-what-is-old-what-is-new
#4
Chao-Nan Jin, Jing-Dan Chen, Ji-Fang Sheng
In the past few years, a growing body of clinical evidence has highlighted the risk of vitamin D deficiency in patients with chronic hepatitis C and that vitamin D levels are associated with the course of hepatitis C virus (HCV) infection, adverse effects, and treatment response to peginterferon/ribavirin. Recently, studies have found that vitamin D status is related to drug resistance and increased risk of infection in patients with liver cirrhosis. Vitamin D-related gene polymorphisms have been found to explain the interactions between vitamin D deficiency and HCV infection, offering a new perspective toward understanding the current problems such as the development of insulin resistance and racial differences in sustained virological response...
April 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29664515/-normal-values-of-6-minute-walk-test-in-healthy-children-and-adolescents-a-systematic-review-and-meta-analysis
#5
Iván Rodríguez-Núñez, Felipe Mondaca, Bárbara Casas, Catalina Ferreira, Daniel Zenteno
INTRODUCTION: The 6-minute walk test (SMWT) is a submaximal exercise test widely used in the clinical setting, which allows the assessment of physical capacity in healthy and chronic children. For a proper interpretation of SMWT it is necessary to compare the value obtained by the patient with a normal value appropriate for the studied population. The aim of this study was to analyze the normal values of SMWT, in order to establish grouped normal values and to evaluate their association with anthropometric and racial variables in healthy children and adolescents...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664409/same-story-different-disease-it-is-time-to-change-the-storyline-for-racial-minorities-and-patients-of-lower-socioeconomic-status
#6
EDITORIAL
Khadijah Breathett
No abstract text is available yet for this article.
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29664406/racial-differences-in-characteristics-and-outcomes-of-patients-with-heart-failure-and-preserved-ejection-fraction-in-the-treatment-of-preserved-cardiac-function-heart-failure-trial
#7
Eldrin F Lewis, Brian Claggett, Amil M Shah, Jiankang Liu, Sanjiv J Shah, Inder Anand, Eileen O'Meara, Nancy K Sweitzer, Jean L Rouleau, James C Fang, Akshay S Desai, Tamrat M Retta, Scott D Solomon, John F Heitner, Thomas D Stamos, Robin Boineau, Bertram Pitt, Marc A Pfeffer
BACKGROUND: Black patients have been shown to have different baseline characteristics and outcomes compared with nonblack patients in cohort studies. However, few studies have focused on heart failure (HF) with preserved ejection fraction (HFpEF) patients. We aimed to determine the difference in cardiovascular outcomes in black and nonblack patients with HFpEF and to determine the relative efficacy and safety of spironolactone in black and nonblack patients. METHODS AND RESULTS: Patients with HFpEF, randomized to spironolactone versus placebo in the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) in North and South America, were grouped according to self-described black and nonblack race...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29664403/socioeconomic-disparities-in-adherence-and-outcomes-after-heart-transplant-a-unos-united-network-for-organ-sharing-registry-analysis
#8
Brian Wayda, Autumn Clemons, Raymond C Givens, Koji Takeda, Hiroo Takayama, Farhana Latif, Susan Restaino, Yoshifumi Naka, Maryjane A Farr, Paolo C Colombo, Veli K Topkara
BACKGROUND: There is mixed evidence of racial and socioeconomic disparities in heart transplant outcomes. Their underlying cause-and whether individual- or community-level traits are most influential-remains unclear. The current study aimed to characterize socioeconomic disparities in outcomes and identify time trends and mediators of these disparities. METHODS AND RESULTS: We used United Network for Organ Sharing registry data and included 33 893 adult heart transplant recipients between 1994 and 2014...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29663526/racial-ethnic-differences-in-the-prognostic-utility-of-left-ventricular-mass-index-for-incident-cardiovascular-disease
#9
Emmanuel Akintoye, Karim Mahmoud, Mohamed Shokr, Aubin Sandio, Sagar Mallikethi-Reddy, Muhammad Sheikh, Oluwole Adegbala, Alexander Egbe, Alexandros Briasoulis, Luis Afonso
BACKGROUND: Evidence exists for racial/ethnic differences in left ventricular mass index (LVMI). How this translates to future cardiovascular disease (CVD) events is unknown. HYPOTHESIS: The impact of racial/ethnic differences in LVMI on incident cardiovascular outcomes could have potential implications for the optimization of risk stratification strategies. METHODS: Using the prospectively collected database of the Multi-Ethnic Study of Atherosclerosis (MESA) involving 4 racial/ethnic groups (non-Hispanic Whites, Chinese, Blacks, and Hispanics) free of CVD at baseline, we assessed for racial/ethnic differences in the relationship between LVMI and incident CVD using a Cox model...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29663421/population-pharmacokinetic-analysis-of-busulfan-in-japanese-pediatric-and-adult-hct-patients
#10
Atsuko Kawazoe, Tomoo Funaki, Seongryul Kim
Busulfan is the most common chemotherapy agent used in allogeneic hematopoietic cell transplant (HCT) conditioning regimens. As narrow therapeutic index and interpatient variability exists in the effectiveness and toxicity of conditioning regimens, personalizing intravenous busulfan therapy is desirable. Population pharmacokinetic-based approaches have been applied to therapeutic drug monitoring for the purpose of personalizing therapy. A population pharmacokinetic analysis with the objective of personalizing therapy in Japanese patients was conducted by integrating pediatric patient data with adult patient data...
April 17, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29663170/racial-ethnic-disparities-and-incidence-of-malignant-peripheral-nerve-sheath-tumors-results-from-the-surveillance-epidemiology-and-end-results-program-2000-2014
#11
Erin C Peckham-Gregory, Roberto E Montenegro, David A Stevenson, David H Viskochil, Michael E Scheurer, Philip J Lupo, Joshua D Schiffman
BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are rare tumors, generally high-grade, and comprise ~ 5-10% of soft tissue sarcomas. Over two-thirds of MPNSTs metastasize, and upwards of 40% clinically recur. Etiologic risk factors for MPNSTs are historically understudied. There is evidence to suggest MPNST incidence differs across racial/ethnic groups in pediatric populations. Therefore, we sought to estimate differences in MPNST incidence by race/ethnicity among all ages in the United States...
April 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29662629/pre-diagnostic-biomarkers-of-metabolic-dysregulation-and-cancer-mortality
#12
Tomi Akinyemiju, Justin Xavier Moore, Suzanne E Judd, Maria Pisu, Michael Goodman, Virginia J Howard, Leann Long, Monika Safford, Susan C Gilchrist, Mary Cushman
INTRODUCTION: The obesogenic milieu is a pro-tumorigenic environment that promotes tumor initiation, angiogenesis and metastasis. In this prospective cohort, we examined the association between pre-diagnostic metabolic biomarkers, plasma adiponectin, resistin, leptin and lipoprotein (a), and the risk of cancer mortality. METHODS: Prospective data was obtained from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of Blacks and Whites followed from 2003 through 2012 for cancer mortality...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662251/motherhood-and-employment-among-whites-hispanics-and-blacks-a-life-course-approach
#13
Sandra M Florian
Research has shown that having children reduces women's employment; yet, how this effect differs for racial minorities has received less attention. Using random effects models and data from the National Longitudinal Survey of Youth ( N = 4,526), this study investigates the association between motherhood and employment among Whites, Hispanics, and Blacks over women's entire reproductive span. Results indicate that having children reduces labor force participation primarily by deterring full-time employment. This effect is stronger and lasts longer among Whites, smaller and shorter among Hispanics, and brief among Blacks...
February 2018: Journal of Marriage and the Family
https://www.readbyqxmd.com/read/29661151/n-terminal-pro-b-type-natriuretic-peptide-and-microsize-myocardial-infarction-risk-in-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#14
Madeline R Sterling, Raegan W Durant, Joanna Bryan, Emily B Levitan, Todd M Brown, Yulia Khodneva, Stephen P Glasser, Joshua S Richman, George Howard, Mary Cushman, Monika M Safford
BACKGROUND: N-terminal pro B-type peptide (NT-proBNP) has been associated with risk of myocardial infarction (MI), but less is known about the relationship between NT-proBNP and very small non ST-elevation MI, also known as microsize MI. These events are now routinely detectable with modern troponin assays and are emerging as a large proportion of all MI. Here, we sought to compare the association of NT-proBNP with risk of incident typical MI and microsize MI in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study...
April 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29661088/perceived-versus-actual-risk-of-type-2-diabetes-by-race-and-ethnicity
#15
Kyeongra Yang, Lynn M Baniak, Christopher C Imes, JiYeon Choi, Eileen R Chasens
Purpose The purpose of this study was to examine associations between perceived risk and actual risk of type 2 diabetes by race and/or ethnicity. Methods The study sample included 10 999 adults from the 2011 to 2014 National Health and Nutrition Examination Survey. Sociodemographic, clinical, and behavioral data were collected using interviews and physical examinations. Participants were asked if they felt at risk for diabetes or prediabetes and then asked the reasons why. Data analyses were conducted with SAS to properly analyze complex survey data...
April 1, 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29659953/test-retest-reproducibility-of-adult-reported-high-school-diet-varies-among-racially-and-ethnically-diverse-us-men-and-women
#16
Kristen D Brantley, Terryl J Hartman, Alpa V Patel, Susan M Gapstur, W D Flanders, Marjorie L McCullough
Background: Adolescent diet is thought to play an important role in future chronic disease risk. However, few studies have examined the reproducibility of adult-reported adolescent diet, and evidence for possible differences in reproducibility by demographic characteristics is limited. Objective: We assessed the ability of adults to consistently report past high school diet over a 1-y period and examined differences in reproducibility by selected demographic characteristics...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659728/racial-disparities-in-invasive-methicillin-resistant-staphylococcus-aureus-infections-2005-2014
#17
Nicole Gualandi, Yi Mu, Wendy M Bamberg, Ghinwa Dumyati, Lee H Harrison, Lindsey Lesher, Joelle Nadle, Sue Petit, Susan M Ray, William Schaffner, John Townes, Mariana McDonald, Isaac See
Background: Despite substantial attention to the individual topics, little is known about the relationship between racial disparities and antimicrobial-resistant and/or healthcare-associated infection trends, such as infections due to methicillin-resistant Staphylococcus aureus (MRSA). Methods: We analyzed CDC's Emerging Infections Program 2005-2014 surveillance data (9 U.S. states) to determine whether reductions in invasive MRSA incidence (isolated from normally sterile body sites) affected racial disparities in rates...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29658817/racial-and-ethnic-differences-in-advance-care-planning-results-of-a-statewide-population-based-survey
#18
Melissa A Clark, Sharina D Person, Anna Gosline, Atul A Gawande, Susan D Block
BACKGROUND: Few studies have focused on racial and ethnic differences in advance care planning other than advance directives among population-based samples of adults across the lifespan. METHODS: Using data from a statewide random-digit dial telephone survey of adults 18 years or older (n = 1851), we investigated racial and ethnic differences in (1) designation of a healthcare agent (HCA); and (2) communication of goals, values, and preferences for end-of-life care with healthcare providers, a HCA, or other family members and friends...
April 16, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29657944/driving-outcomes-among-older-adults-a-systematic-review-on-racial-and-ethnic-differences-over-20-years
#19
Ganesh M Babulal, Monique M Williams, Sarah H Stout, Catherine M Roe
The population of older adults (aged 65 years and older) in the United States will become more racially and ethnically diverse in the next three decades. Additionally, the growth of the aging population will come with an expansion in the number of older drivers and an increased prevalence of chronic neurological conditions. A major gap in the aging literature is an almost exclusive focus on homogenous, non-Hispanic white samples of older adults. It is unclear if this extends to the driving literature. A systematic review of SCOPUS, PubMed, CINAHL Plus, and Web of Science examined articles on driving and racial/ethnic differences among older adults...
March 2018: Geriatrics
https://www.readbyqxmd.com/read/29657583/-i-m-black-and-i-m-proud-a-majority-ecological-context-protects-affective-aspects-of-black-identity-under-stereotype-threat
#20
Andre' Oliver, Ghilamichael Andemeskel, Carlise R King, Lyndsey Wallace, Serie McDougal, Kenneth P Monteiro, Avi Ben-Zeev
We provide evidence that stereotype threat, a phenomenon that causes stigmatized individuals to experience group-based evaluative concerns (Steele in Am Psychol 52:613-629, 1997; Whistling Vivaldi and other clues to how stereotypes affect us, W.W. Norton, New York, 2010), impacts affective aspects of Black identity as a function of majority versus minority ecological contexts. Black/African-American students, enrolled in either Africana Studies (Black ecological majority) or Psychology (Black ecological minority), completed private and public regard subscales from the Multidimensional Inventory of Black Identity (Sellers et al...
December 2017: Race and Social Problems
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