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https://www.readbyqxmd.com/read/28914009/luminescent-diagnostics-of-skin-defects-in-the-near-infrared-range
#1
Yuriy V Alekseev, Valentina D Rumyantseva, Anastasiya S Gorshkova, Anastasiya E Shchelkunova, Igor P Shilov, Andrey V Ivanov
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28893727/development-of-a-virtual-reality-exposure-tool-as-psychological-preparation-for-elective-pediatric-day-care-surgery-methodological-approach-for-a-randomized-controlled-trial
#2
Robin Eijlers, Jeroen S Legerstee, Bram Dierckx, Lonneke M Staals, Johan Berghmans, Marc P van der Schroeff, Rene Mh Wijnen, Elisabeth Mwj Utens
BACKGROUND: Preoperative anxiety in children is highly prevalent and is associated with adverse outcomes. Existing psychosocial interventions to reduce preoperative anxiety are often aimed at distraction and are of limited efficacy. Gradual exposure is a far more effective way to reduce anxiety. Virtual reality (VR) provides a unique opportunity to gradually expose children to all aspects of the operating theater. OBJECTIVE: The aims of our study are (1) to develop a virtual reality exposure (VRE) tool to prepare children psychologically for surgery; and (2) to examine the efficacy of the VRE tool in a randomized controlled trial (RCT), in which VRE will be compared to care as usual (CAU)...
September 11, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28875852/molecular-modeling-studies-of-novel-fluoroquinolone-molecules
#3
Naresh Kumar Katari, Tejeswara Rao Allaka, Venkataramireddy Veeramreddy, Jaya Shree Anireddy
BACKGROUND: Fluoroquinolones have been the centre of considerable scientific and clinical interest due to their broad spectrum pharmacological activities. Pefloxacin is an analogue of norfloxacin, which is a 3rd generation of fluoroquinolone [5] antibiotic similar to ciprofloxacin. Pefloxacin is used to treat a variety of bacterial infections like respiratory tract, ear, nose and throat (ENT) infections, skin infections, urinary tract infections. Hydrazone as a pharmacophore unit that attract the medicinal chemists because of structure activity relationship (SAR) studies of fluoroquinolones especially the functionality at C-3 position...
August 29, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28864539/signals-from-the-adipose-microenvironment-and-the-obesity-cancer-link-a-systematic-review
#4
REVIEW
Caroline Himbert, Mahmoud Delphan, Dominique Scherer, Laura W Bowers, Stephen Hursting, Cornelia M Ulrich
Obesity and its associated metabolic dysregulation are established risk factors for many cancers. However, the biologic mechanisms underlying this relationship remain incompletely understood. Given the rising rates of both obesity and cancer worldwide, and the challenges for many people to lose excess adipose tissue, a systematic approach to identify potential molecular and metabolic targets is needed to develop effective mechanism-based strategies for the prevention and control of obesity-driven cancer. Epidemiologic, clinical, and preclinical data suggest that within the growth-promoting, proinflammatory microenvironment accompanying obesity, crosstalk between adipose tissue (comprised of adipocytes, macrophages and other cells) and cancer-prone cells may occur via obesity-associated hormones, cytokines, and other mediators that have been linked to increased cancer risk and/or progression...
September 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28856469/evaluation-of-clinical-value-of-videokymography-for-diagnosis-and-treatment-of-voice-disorders
#5
Ketaki Vasant Phadke, Jitka Vydrová, Romana Domagalská, Jan G Švec
This study aimed at determining the clinical value of videokymography (VKG) as an additional tool for the assessment of voice disorders. 105 subjects with voice disorders were examined by an experienced laryngologist. A questionnaire was used to specify diagnosis, diagnostic confidence, and treatment recommendations before and after VKG. The first part of questionnaire was filled by the laryngologist for each patient after routine ear-nose-throat evaluation, including stroboscopy, the second part after the subsequent VKG examination...
August 30, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28853603/the-besmart-best-supportive-management-for-adults-referred-with-tonsillopharyngitis-multicentre-observational-study
#6
MULTICENTER STUDY
A S Lau, C Mamais, E McChesney, N S Upile, C Vaughan, J Veitch, J R Abbas, A Markey, N G Brown, M Evans, J Thomas, M Gaines, Z Shehata, M D Wilkie, S C Leong
Introduction Tonsillopharyngitis is the most common ear, nose and throat emergency admission, with 80,000 episodes recorded in England in 2015-2016. Despite this, there is a paucity of evidence addressing the supportive management of tonsillopharyngitis in inpatients. The aim of this retrospective multicentre observational study was to consider the Best Supportive Management for Adults Referred with Tonsillopharyngitis (BeSMART) in the inpatient setting, and to establish any associations between practice and outcomes...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28853427/ear-nose-and-throat-ent-aspects-of-obstructive-sleep-apnea-syndrome-osas-diagnosis-and-therapy
#7
Desiderio Passali, Maria Carla Spinosi, Francesco Maria Passali
This article analyzes the role played by the ear, nose and throat (ENT) specialist in the diagnosis and treatment of the Obstructive Sleep Apnea Syndrome (OSAS). DIAGNOSIS: The instrumental methods of investigation of otolaryngology expertise are fiberoptic rhinolaryngoscopy and sleep endoscopy. To better define and treat OSAS it is essential to define location, extension and degree of obstruction. The major limitation of rhinolaryngoscopy is that it is conducted while the patient is awake...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28839865/transnasal-endoscopy-no-gagging-no-panic
#8
Clare Parker, Estratios Alexandridis, John Plevris, James O'Hara, Simon Panter
BACKGROUND: Transnasal endoscopy (TNE) is performed with an ultrathin scope via the nasal passages and is increasingly used. This review covers the technical characteristics, tolerability, safety and acceptability of TNE and also diagnostic accuracy, use as a screening tool and therapeutic applications. It includes practical advice from an ear, nose, throat (ENT) specialist to optimise TNE practice, identify ENT pathology and manage complications. METHODS: A Medline search was performed using the terms "transnasal", "ultrathin", "small calibre", "endoscopy", "EGD" to identify relevant literature...
October 2016: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28834348/relapsing-polychondritis%C3%A2-diagnosed-by-fusion-images-of-gallium-67-on-single-photon-emission-computed-tomography-computed-tomography
#9
Kazuhisa Nakano, Takafumi Aritomi, Naoaki Ohkubo, Yoshiya Tanaka
A 64-year-old man has revealed dry cough and severe pain of ear, nose and throat for several weeks. After visiting clinics and hospitals, he was introduced to our hospital and was diagnosed as relapsing polychondritis (RP) based on McAdam's criteria. The involvement in auricular, nasal and tracheal cartilage was clearly shown by fusion images of gallium-67 on single photon emission computed tomography and computed tomography (SPECT/CT) (A, B). High-dose glucocorticoid (GC) therapy markedly improved relevant signs, symptoms and inflammatory reactions as well as gallium uptake in cartilage detected by gallium-SPECT/CT (C)...
August 22, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28826305/clinical-evaluation-of-intravenous-ampicillin-as-empirical-antimicrobial-treatment-of-acute-epiglottitis
#10
Ann Marlene Gram Kjaerulff, Maria Rusan, Tejs Ehlers Klug
INTRODUCTION: The significant pathogens in acute epiglottitis (AE) are poorly defined in the post Haemophilus influenza type b-vaccine era. Furthermore, there is a lack of clinical evaluations of antibiotic regimens in patients with AE. We aimed to evaluate the effectiveness of empiric intravenous ampicillin in the treatment of patients with AE. MATERIALS & METHODS: All patients admitted with AE to the Ear-Nose-Throat Department, Aarhus University Hospital, Denmark, from 2001 to 2015 were included...
August 21, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28811907/factors-associated-with-antibiotic-prescriptions-for-the-viral-origin-diseases-in-office-based-practices-2006-2012
#11
Sara Imanpour, Obioma Nwaiwu, Darcy K McMaughan, Bethany DeSalvo, Adnan Bashir
OBJECTIVE: To test the potential association between time spent with a doctor and antibiotic overprescriptions in case of the common cold, runny nose, bronchitis, chest colds, flu, sore throats, and fluid in the middle ear. DESIGN: Cross-sectional study. SETTING: Office-based physicians in the US. PARTICIPANTS: A total of 261,623 patient visits recorded to office-based physicians in the US. MAIN OUTCOME MEASURES: The interest outcome was unnecessary antibiotic prescription...
August 2017: JRSM Open
https://www.readbyqxmd.com/read/28810456/components-of-preoperative-anxiety-a-qualitative-study
#12
Amy King, Jim Bartley, Deborah L Johanson, Elizabeth Broadbent
Limited research has explored preoperative anxiety through qualitative methodologies. This study aimed to identify specific factors that contribute to preoperative anxiety. A total of 17 patients awaiting general, plastic reconstructive and hand, orthopaedic, or ear, nose, and throat/otorhinolaryngology surgery were interviewed about their concerns in a public hospital. Thematic analysis identified five main sources of anxiety: surgical procedures, surgical complications, symptoms, recovery process, and organisation and delivery of care...
May 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28805238/ultrasound-assessment-of-gastric-contents-in-children-undergoing-elective-ear-nose-and-throat-surgery-a-prospective-cohort-study
#13
F-P Desgranges, A-C Gagey Riegel, C Aubergy, M de Queiroz Siqueira, D Chassard, L Bouvet
Ultrasound examination of the gastric antrum allows reliable assessment of gastric contents and volume. Postoperative assessment of gastric contents before recovery from anaesthesia could help the physician to choose the most appropriate extubation technique after surgery in children. In this prospective observational study, we assessed whether significant changes occurred in gastric contents during the intra-operative period in children undergoing elective ear, nose and throat (ENT) surgery. Children aged between six months and 16 years were recruited consecutively...
August 14, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28802377/an-innovative-approach-to-improve-ear-nose-and-throat-surgical-access-for-remote-living-cape-york-indigenous-children
#14
Susan P Jacups, Denise Newman, Deborah Dean, Ann Richards, Kate M McConnon
INTRODUCTION: On a background of high rates of severe otitis media (OM) with associated hearing loss, children from the Torres Strait and Cape York region requiring ear, nose and throat (ENT) surgery, faced waiting times exceeding three years. After numerous clinical safety incidents were raised, indicating a failure of the current system to deliver appropriate care, the governing Hospital and Health service opted to deliver surgical care through an alternate process. ENT surgeries were performed on 16 consented children from two remote locations via the private health care system, funded by a health provider partnership...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28795066/otolaryngological-presentations-in-times-of-terror-profile-from-a-tertiary-health-center-in-north-central-nigeria
#15
Adeyi A Adoga, Daniel D Kokong, Kenneth N Ozoilo
OBJECTIVES: To report the incidence, socio-demographic characteristics, otorhinolaryngological presentations and outcomes of management of patients at the Jos University Teaching Hospital following terror attacks. METHODS: A prospective descriptive hospital based study of consecutive patients presenting with ear, nose and throat injuries as a result of bomb blasts and ethno-religious crises within a six-year period and managed at the Jos University Teaching Hospital were studied for age, gender, ear, nose and throat presentations, injury mechanism, interventions and outcome of interventions...
July 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/28774844/assessing-old-and-new-diagnostic-tests-for-gastroesophageal-reflux-disease
#16
Michael F Vaezi, Daniel Sifrim
A detailed critique of objective measurements of gastroesophageal reflux disease (GERD) would improve management of patients suspecting of having reflux, leading to rational selection of treatment and better outcomes. Many diagnostic tests for GERD have been developed over the past decades. We analyze their development, positive- and negative-predictive values, and ability to predict response to treatment. These features are important for development of medical, surgical, and endoscopic therapies for GERD. We discuss the value of available diagnostic tests and review their role in management of patients with persistent reflux symptoms despite adequate medical or surgical treatment...
July 31, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28764159/otomycosis-in-a-rural-community-attending-a-tertiary-care-hospital-assessment-of-risk-factors-and-identification-of-fungal-and-bacterial-agents
#17
Priti Agarwal, Leimapokpam Sumitra Devi
INTRODUCTION: Otomycosis is one of the frequently encountered fungal infections of external auditory canal, commonly seen in tropical and subtropical regions of the world. Various host (local, systemic) and environmental factors can predispose a person to otomycosis. Although clinical presentations along with otoscopic findings of the patients are well suggestive of fungal infection, proper identification of causative agents is mandatory in order to prevent recurrences and complications...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762075/incidence-and-5-year-survival-rate-for-head-and-neck-cancers-in-grenada-compared-to-the-african-american-population-over-the-period-1991-2010
#18
Maira du Plessis, Robert Hage
Very little data exist on the incidence and burden of cancer in the individual Caribbean countries. Some data are available for larger areas, reported under a bigger geographical region; Latin America and the Caribbean, but many of the individual countries are not included. One of the main reasons is a lack of official cancer registries. Data are usually collected from hospital records or private physician records, and since it is not in an official registry, these data are not always accessible for inclusion in databases such as SEER and GLOBOCAN...
July 31, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28740272/the-modification-of-rotation-advancement-flap-made-in-1950
#19
Predrag Knežević, Marko Vuletić, Igor Blivajs, Emil Dediol, Darko Macan, Mišo Virag
The early techniques of cleft lip repair involved the straight-line technique, the triangular flap technique or some kind of geometric line (triangular, quadrangular closure). A turning point in cleft lip surgery was in 1955 when doctor. Millard presented his method: the rotation-advancement technique or flap, at the First International Congress of Plastic Surgery in Stockholm. Today, the technique, with or without some modifications, is used by more than 85% of cleft surgeons around the world. We are presenting a patient with complete unilateral cleft lip and palate who underwent surgery sixty-five years ago...
March 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28737067/confirmed-and-suspected-foreign-body-injuries-in-children-during-2008-2013-a-hospital-based-single-center-study-in-oulu-university-hospital
#20
J-J Sinikumpu, W Serlo
INTRODUCTION: Foreign body injuries are common in children. Most of them are not serious but they can be fatal. A suspected foreign body injury in a child results in a high rate of hospitalizations, exposure to radiation, and need for intervention. This study aimed to analyze the current epidemiology of in-hospital or out of hospital treated foreign object injuries and suspected foreign body injuries in children. MATERIAL AND METHODS: All children <16 years of age (N = 152) who suffered or were suspected to suffer (N = 63) from a foreign body injury and were treated in a pediatric trauma unit of Oulu University Hospital, Oulu, Finland, over a 6-year study period (2008-2013) were included...
March 1, 2017: Scandinavian Journal of Surgery: SJS
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