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JOURNAL ARTICLE
Dipak Gandhi, Alok Semwal, Vikas Agrawal, Ravindra Jain, Harsh Srivastava, Preeth Shetty, Ravindra Chopra, Ravi Mehta, Chaitali Pilliwar, Ashok Jaiswal
Introduction and aims Mildly hypertonic saline is more effective in relieving symptoms of nasal congestion compared to placebo or isotonic saline. Recently, a unique device, delivering a soft mist of 2.3% hypertonic sea-salt saline (Nasoclear PureHaleTM ; Zydus Healthcare Ltd., India) has been introduced in India. The device uses a power-less manual technique to release the saline as a soft mist at 1 ml/min. Methods This is a retrospective, multi-centric, single-arm study to evaluate the safety and effectiveness of 2...
March 2024: Curēus
#2
JOURNAL ARTICLE
Sophie Rosenkjær, Victor Schwartz Hvingelby, Erik Lisbjerg Johnsen, Mette Møller, Elisa Carlino, Troels Staehelin Jensen, Lene Vase
BACKGROUND AND OBJECTIVES: In Parkinson's disease (PD) patients, verbal suggestions have been shown to modulate motor and clinical outcomes in treatment with subthalamic deep brain stimulation (DBS). Furthermore, DBS may alleviate pain in PD. However, it is unknown if verbal suggestions influence DBS' effects on pain. METHODS: Twenty-four people with PD and DBS had stimulation downregulated (80-60 to 20%) and upregulated (from 20-60 to 80%) in a blinded manner on randomized test days: (1) with negative and positive suggestions of pain for down- and upregulation, respectively, and (2) with no suggestions to effect (control)...
January 1, 2024: Scandinavian Journal of Pain
#3
Mohamed Ismail, Ritik Goyal, Menna-Allah A Elaskandrany, Michael Bebawy, Sahiba Singh, Claire Ruane, Weizheng Wang
Clostridium difficile ( C. difficile ) is a Gram-positive, spore-producing bacterium that often leads to pseudomembranous colitis, typically manifesting as watery diarrhea. The risk factors for C. difficile infection (CDI) include exposure to broad-spectrum antibiotics, immunocompromised states, advanced age, usage of proton pump inhibitors (PPI), and comorbid conditions such as chronic kidney disease (CKD). This report details a case involving a 23-year-old pregnant woman who presented with symptoms of abdominal pain and constipation...
February 2024: Curēus
#4
JOURNAL ARTICLE
Bahadar S Srichawla, Kendall Presti, Vincent Kipkorir, Idanis Berrios Morales
RATIONALE: Hodgkin lymphoma, a lymphatic system cancer, is treated by chemotherapy, radiation therapy, and hematopoietic stem cell transplantation. Posterior reversible encephalopathy syndrome (PRES) is a rare neurotoxic effect associated with several drugs and systemic conditions. This case study emphasizes the potential risks of intensive chemotherapy regimens and postulates the impact of the circle of Willis variants on the heterogeneity of hemispheric lesions in PRES. PATIENT CONCERNS: A 42-year-old woman diagnosed with stage IIA nodular sclerosing Hodgkin lymphoma and chronic thrombocytopenia presented after 6 years of initial diagnosis and 4 years post-haploidentical transplant...
February 23, 2024: Medicine (Baltimore)
#5
JOURNAL ARTICLE
M Cobo Marcos, J Comín-Colet, R de la Espriella, J Rubio Gracia, J L Morales-Rull, I Zegrí, P Llacer, P Diez-Villanueva, S Jiménez-Marrero, J de Juan Bagudá, C Ortiz Cortés, J Goirigolzarri-Artaza, J M García-Pinilla, E Barrios, S Del Prado Díaz, E Montero Hernández, M Sanchez-Marteles, J Nuñez
AIMS: Hypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy in the ambulatory setting have not been evaluated. We aimed to describe the design and baseline characteristics of the SALT-HF trial participants. METHODS AND RESULTS: 'Efficacy of Saline Hypertonic Therapy in Ambulatory Patients with HF' (SALT-HF) trial was a multicenter, double-blinded, and randomized study involving ambulatory patients who experienced worsening heart failure (WHF) without criteria for hospitalization...
February 21, 2024: ESC Heart Failure
#6
JOURNAL ARTICLE
Maria Lysandrou, Julie Rice-Weimer, Sibelle Aurelie Yemele Kitio, Islam Elmitwalli, Allen Kadado, Walter Samora, Marco Corridore, Joseph D Tobias
BACKGROUND: During major orthopedic procedures, such as posterior spinal fusion (PSF), isotonic fluids, colloids, starches, or gelatins are commonly used to replace the preoperative fluid deficit and provide ongoing fluid resuscitation. Given recent concerns regarding the potential adverse physiologic effects of albumin solutions, we have modified our intraoperative practice to include the use of a novel 2% buffered hypertonic saline solution during major orthopedic procedures. We present our preliminary clinical experience with this novel fluid for intraoperative resuscitation and its impact on limiting the use of 5% albumin...
January 2024: Journal of Clinical Medicine Research
#7
JOURNAL ARTICLE
Cemal Cingi, Nuray Bayar Muluk, İbrahim Çukurova, Rıza Dündar, Ustün Osma, Cengiz Bal, Alaattin Zirek, Ali Budak, Ali Seyed Resuli, Asif Selimoğlu, Aslı Elif Tanuğur Samancı, Ayşe Karaoğullarından, Begüm Yılmaz, Bengi Arslan, Bilal Sizer, Celalettin Cihan, Çiğdem Fırat Koca, Deniz Avcı, Doğukan Aydenizöz, Ethem Ünver, Elvin Alaskarov, Emrah Gülmez, Fatih Gündoğan, Gözde Günay, Hasan Çetiner, Hilal Güngör, İsmail Salcan, Mahmut Emre Gündoğan, Makbule Özlem Akbay, Mehmet Akdağ, Mehmet Erkan Kaplama, Mehmet Yaşar, Mehtap Koparal, Murat Kar, Mustafa Altıntaş, Mümtaz Taner Torun, Nazım Bozan, Neslihan Sarı, Nihat Susaman, Nurten Küçük, Osman Erdoğan, Osman Gül, Özlem Sancaklı, Pınar Kundi, Rezzan Okyay Budak, Sait Karaman, Soner Taşar, Songül Demir, Şeyda Belli, Tarık Yağcı, Taylan Bilici, Turgut Çelik, Yavuz Sultan Selim Yıldırım, Ali Timucin Atayoglu, Reşat Kubilay Irkan, Duygu Zorlu, Demet Can
Objectives: This study aimed to evaluate how Rhinapi nasal spray affects symptoms of allergic rhinitis. Methods: In this prospective, multicenter, observational study, 10,000 patients (comprising 5028 males and 4972 females) exhibiting symptoms of allergic rhinitis (namely, nasal discharge, sneezing, nasal itching, and nasal obstruction) from different centers in different regions of Turkey were enrolled in the study between March 2022 and March 2023. All the patients wanted to participate in the study and were administered Rhinapi one puff to each nostril three times a day, for a period of 3 weeks...
January 29, 2024: Ear, Nose, & Throat Journal
#8
RANDOMIZED CONTROLLED TRIAL
Fang Xu, Yanan Li, Xupeng Wang, Ran Sun, Zilei Zheng, Qi Zhang, Mingyang Gao, Wei Tao, Juan Zhao, Qiujun Wang
BACKGROUND: Neuroinflammation may be a potential mechanism of postoperative delirium (POD) in geriatric patients, and hypertonic saline (HS) has immunomodulatory properties. The purpose of this study was to investigate whether HS could reduce the incidence of POD in elderly patients and its effect on neutrophil activation and inflammatory cytokine expression. METHODS: We studied the effect of pre-infusion of 4 mL/kg 3% hypertonic saline vs. 4 mL/kg 0.9% normal saline on POD in patients undergoing shoulder arthroscopy in a prospective, randomized, double-blind, controlled trial...
December 11, 2023: BMC Anesthesiology
#9
JOURNAL ARTICLE
Jennifer L Cooper, Andrew R Karduna
Shoulder pain is a complex, prevalent problem that is multifactorial in nature. While there are many potential causes, one common suspect is the rotator cuff musculature. The purpose of the present study was to induce pain in the supraspinatus muscle of healthy subjects and observe the resulting changes in muscle activity. Eight muscles on 23 subjects were assessed using electromyography: anterior, middle, and posterior deltoid; pectoralis major; upper trapezius; latissimus dorsi; serratus anterior; supraspinatus; and infraspinatus...
November 7, 2023: Journal of Applied Biomechanics
#10
Sana Arshid, Saad Ehsan Ullah, Junaid Imran, Meeran Asher Syed, Aakash Choradia, Nicole Gousy, Sukhman Boparai, Mudassir Shoaib, Bidhan Bikram Shah, Aadarsh Netha
BACKGROUND: Inhaled hypertonic saline (HS) is an effective mucolytic agent in patients with cystic fibrosis (CF). However, adverse events can impair the clinical utility of hypertonic saline (HS) in this patient population. In this study, we aimed to investigate the effectiveness of hyaluronic acid (HA) in reducing these adverse events. METHODS: A literature search was conducted across three electronic databases (Medline, Cochrane Central, and EMBASE) from inception through February 2023...
2023: Canadian Journal of Respiratory Therapy: CJRT
#11
JOURNAL ARTICLE
Felix C Ringshausen, Adam J Shapiro, Kim G Nielsen, Henryk Mazurek, Massimo Pifferi, Karl H Donn, Menno M van der Eerden, Michael R Loebinger, Maimoona A Zariwala, Margaret W Leigh, Michael R Knowles, Thomas W Ferkol
BACKGROUND: Mucociliary clearance is dysfunctional in people with primary ciliary dyskinesia, resulting in the accumulation of dehydrated mucus in the airways that is difficult to clear. We undertook a study to assess the benefit on lung function of treatment with a nebulised epithelial sodium channel (ENaC) blocker, idrevloride, with or without hypertonic saline, in people with primary ciliary dyskinesia. METHODS: The CLEAN-PCD trial was a phase 2, randomised, double-blind, placebo-controlled crossover trial conducted at 32 tertiary adult and paediatric care centres and university hospitals in Canada, Denmark, Germany, Italy, the Netherlands, Poland, the UK, and the USA...
August 31, 2023: Lancet Respiratory Medicine
#12
REVIEW
Carlos Diaz-Arocutipa, Jack Denegri-Galvan, Lourdes Vicent, Marcos Pariona, Mamas A Mamas, Adrian V Hernandez
We assessed the effects of hypertonic saline solution (HSS) plus furosemide versus furosemide alone in patients with acute decompensated heart failure (ADHF). We searched four electronic databases for randomized controlled trials (RCTs) until June 30, 2022. The quality of evidence (QoE) was assessed using the GRADE approach. All meta-analyses were performed using a random-effects model. A trial sequential analysis (TSA) was also conducted for intermediate and biomarker outcomes. Ten RCTs involving 3013 patients were included...
August 2023: Clinical Cardiology
#13
JOURNAL ARTICLE
Ganimeta Bakalović, Tarik Jarkoč, Nedim Begić, Orhan Lepara, Dejan Bokonjić, Dušan Mihajlović, Amela Pasić, Almir Fajkić
Aim Compare the efficacy of nebulized hypertonic saline and normal saline in the treatment of infants hospitalized for bronchiolitis. Methods This retrospective study was conducted at the Department of Pulmonology, Paediatric Clinic, Clinical Centre University of Sarajevo, covering the period from January 2015 to December 2019 and comprising 380 children aged between 1 and 12 months having bronchiolitis. One group received nebulized hypertonic saline (NHS, 3% NaCl)), and another group received nebulized normal saline (NNS, 0...
August 1, 2023: Medicinski Glasnik
#14
JOURNAL ARTICLE
Afaf Albalawi
BACKGROUND: Evidence is limited regarding the optimal therapeutic approach for neuropsychiatric symptoms associated with Parkinson's disease dementia (PDD). Selective serotonin reuptake inhibitors (SSRIs) are widely used for mood disorders and behavioral symptoms in older adults with cognitive impairment, but they have limited efficacy in patients with PDD. The effect of SSRIs on hemostasis is also unclear. This report describes a patient with PDD who developed deep venous thrombosis (DVT) and hyponatremia after initiating citalopram treatment...
June 1, 2023: BMC Geriatrics
#15
JOURNAL ARTICLE
Jonathan Espinosa, Umair Rehman, Firas Kaddouh
BACKGROUND: Iron plays an important role in the development of perihematomal edema (PHE) in the setting of intracerebral hemorrhage (ICH). Cerebral iron is increased via direct hemoglobin release in ICH, and several studies have investigated the use of iron-chelating agents to mitigate its toxicity. However, the effect of systemic iron administration, corroborating the reverse concept, has never been investigated or reported clinically. We report the first case of systemic iron administration in the setting of hemorrhagic traumatic brain injury (TBI)...
May 30, 2023: BMC Neurology
#16
JOURNAL ARTICLE
Brian L Erstad
No abstract text is available yet for this article.
July 21, 2023: American Journal of Health-system Pharmacy: AJHP
#17
JOURNAL ARTICLE
(no author information available yet)
Cystic fibrosis (CF) is one of the most common autosomal recessive genetic diseases in Caucasians, but CF patients in China are rare, and it was listed as the first batch of rare diseases in China in 2018. In recent years, CF has been gradually recognized in China, and the number of CF patients reported in China in the past 10 years is more than 2.5 times the total number in the previous 30 years, and the total number of CF patients is estimated to be more than 20 000. The research progress of CF gene modification has led to the innovation of CF treatment...
April 12, 2023: Chinese Journal of Tuberculosis and Respiratory Diseases
#18
JOURNAL ARTICLE
Nicholas Johnson, Michael J Saunders, Christopher J Womack, Stephanie P Kurti
The purpose of this study was to determine: (1) whether pulmonary function is reduced, and airway reactivity is increased after recovery from COVID-19 in individuals who did not have severe illness, and (2) whether physical activity levels had any impact on pulmonary function or airway reactivity. An exploratory aim of the study was also to assess whether number of symptoms was associated with pulmonary function outcomes. The maximal flow volume loop (MFVL) was used to measure pulmonary function in individuals who had previously tested positive for COVID-19 (COV; n = 20, 23...
March 21, 2023: Applied Physiology Nutrition and Metabolism
#19
JOURNAL ARTICLE
Murat Duyan, Nafis Vural
Background Hyponatremia is a common electrolyte balance disorder. It may result in brain edema and increased intracranial pressure (ICP). Optic nerve sheath diameter (ONSD) measurement remains an increasingly sought-after method in many situations associated with ICP elevations. The aim of our study was to investigate the relationship between the change of ONSD before and after hypertonic saline (3% sodium chloride) treatment and the clinical improvement with increased sodium levels in patients with symptomatic hyponatremia who presented to the emergency department...
January 2023: Curēus
#20
REVIEW
Saad Ehsan Ullah, Mohammad Munim Zahoor, Swatika Gupta, Sukhman Boparai, Muhammad Muneeb, Shahda A H Eltieb, Abhirami Shankar, Harriet Mmaitsi Kidiavai, Rimsha Rahim Vohra, Anjuli Devi, Zainab Asif Bhura, Zaid Muhammad Aslam, Mudassir Shoaib
BACKGROUND: Inhaled hypertonic saline (HS) reduces pulmonary exacerbations in patients with cystic fibrosis (CF) aged 6 or more years. However, the effectiveness of HS in improving clinical outcomes in younger children aged 6 or less years is not established. This study examines the efficacy of HS in younger CF patients. METHODS: Searches were conducted across three databases (Medline, Cochrane Central and EMBASE) from inception through July 2022. Randomized controlled trials assessing the impact of HS in younger CF patients were included...
2023: Canadian Journal of Respiratory Therapy: CJRT
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